| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sahdeo Prasad, Rajiv Lal. Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 73. 2022-07-03. PMID:35780653. |
these protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. |
2022-07-03 |
2023-08-14 |
Not clear |
| Yafei Zhang, Hongwei Lu, Hong Ji, Yiming L. p53 upregulated by HIF-1α promotes gastric mucosal epithelial cells apoptosis in portal hypertensive gastropathy. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2022-07-02. PMID:35780066. |
p53 upregulated by hif-1α promotes gastric mucosal epithelial cells apoptosis in portal hypertensive gastropathy. |
2022-07-02 |
2023-08-14 |
Not clear |
| Yafei Zhang, Hongwei Lu, Hong Ji, Yiming L. p53 upregulated by HIF-1α promotes gastric mucosal epithelial cells apoptosis in portal hypertensive gastropathy. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2022-07-02. PMID:35780066. |
however, whether hif-1α and p53 are involved in mucosal apoptosis and whether hif-1α induces phg by mediating p53 remains unclear. |
2022-07-02 |
2023-08-14 |
Not clear |
| Ao Qi, Wenxiu Ru, Yangkai Liu, Yu Yang, Jia Tang, Haiyan Yang, Shuling Yang, Kaixing Qu, Xianyong Lan, Chuzhao Lei, Bizhi Huang, Hong Che. Deletions in GSN gene associated with growth traits of four Chinese cattle breeds. Molecular genetics and genomics : MGG. 2022-07-02. PMID:35780194. |
gelatin can not only negatively regulate the pro-apoptotic effect of p53 protein, but also promote apoptosis by blocking the interaction between actin and deoxyribonuclease, so, the gsn gene was selected as a candidate gene in this study. |
2022-07-02 |
2023-08-14 |
cattle |
| Mine Sulak, Gurbet Celik Turgut, Alaattin Se. Cerium Oxide Nanoparticles Biosynthesized Using Fresh Green Walnut Shell in Microwave Environment and their Anticancer Effect on Breast Cancer Cells. Chemistry & biodiversity. 2022-06-30. PMID:35770449. |
based on the present results, it was concluded that conps can induce apoptosis by acting on p53 at the transcriptional level and may cause cell death by suppressing nf-κb-mediated transcription. |
2022-06-30 |
2023-08-14 |
Not clear |
| Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G Proud, Denis L J Lafontaine, Tsuyoshi Osaw. Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors. Nature communications. vol 13. issue 1. 2022-06-28. PMID:35764642. |
failure to accumulate pre-rrnas under nutrient stress leads to perturbed ribosome assembly upon nutrient restoration and subsequent apoptosis via ul5/ul18-mediated activation of p53. |
2022-06-28 |
2023-08-14 |
Not clear |
| Chengtao Sun, Mengzhen Li, Lian Zhang, Feifei Sun, Huimou Chen, Yanjie Xu, Yingxia Lan, Li Zhang, Suying Lu, Jia Zhu, Junting Huang, Juan Wang, Yang Hu, Yanfen Feng, Yizhuo Zhan. IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma. Cell death & disease. vol 13. issue 6. 2022-06-27. PMID:35760783. |
mechanistically, ido1 inhibition decreased the expression of mdm2, a major negative regulator of p53, and restored p53 expression in oci-ly3 and oci-ly10 cells, resulting in cell cycle arrest and apoptosis. |
2022-06-27 |
2023-08-14 |
Not clear |
| Monika Morawska-Kochman, Agnieszka Śmieszek, Klaudia Marcinkowska, Krzysztof Mariusz Marycz, Kamil Nelke, Krzysztof Zub, Tomasz Zatoński, Marek Bochni. Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-Evaluation at mRNA and miRNA Levels. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740420. |
the expression of transcripts was determined by rt-qpcr and included the detection of markers associated with cell survival and apoptosis, i.e., bax, p53, p21, casp3, casp9, c-myc, ccnd1, bric5, and apaf1. |
2022-06-24 |
2023-08-14 |
human |
| Monika Morawska-Kochman, Agnieszka Śmieszek, Klaudia Marcinkowska, Krzysztof Mariusz Marycz, Kamil Nelke, Krzysztof Zub, Tomasz Zatoński, Marek Bochni. Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)-Evaluation at mRNA and miRNA Levels. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740420. |
the obtained results indicated increased apoptosis determined by a tunel assay in csrwnp patients and accompanied by an increased expression of bax, p21, p53, casp3, casp9, c-myc, and apaf-1 transcripts and decreased mrna levels of bcl-2 and birc5. |
2022-06-24 |
2023-08-14 |
human |
| Diana Gomes, Shivani Yaduvanshi, Samuel Silvestre, Ana Paula Duarte, Adriana O Santos, Christiane P Soares, Veerendra Kumar, Luís Passarinha, Ângela Sous. Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells. Cancers. vol 14. issue 12. 2022-06-24. PMID:35740499. |
taxifolin and lucidin as potential e6 protein inhibitors: p53 function re-establishment and apoptosis induction in cervical cancer cells. |
2022-06-24 |
2023-08-14 |
human |
| Diana Gomes, Shivani Yaduvanshi, Samuel Silvestre, Ana Paula Duarte, Adriana O Santos, Christiane P Soares, Veerendra Kumar, Luís Passarinha, Ângela Sous. Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells. Cancers. vol 14. issue 12. 2022-06-24. PMID:35740499. |
in particular, lucidin and taxifolin were able to inhibit e6-mediated p53 degradation, selectively reduce the viability, and induce apoptosis in hpv-positive cells. |
2022-06-24 |
2023-08-14 |
human |
| Jinyun Wang, Satoshi Yano, Kun Xie, Yoshihisa Ohata, Taichi Har. Genome-Wide RNA Sequencing Analysis in Human Dermal Fibroblasts Exposed to Low-Dose Ultraviolet A Radiation. Genes. vol 13. issue 6. 2022-06-24. PMID:35741736. |
differentially expressed genes were identified and subjected to gene ontology and reactome pathway analysis, which revealed enrichment in genes in the senescence-associated secretory phenotype, apoptosis, respiratory electron transport, and transcriptional regulation by tumor suppressor p53 pathways. |
2022-06-24 |
2023-08-14 |
human |
| Mayada Mohamed Mabrouk Zayed, Heba A Sahyon, Nemany A N Hanafy, Maged A El-Kemar. The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53. Pharmaceutics. vol 14. issue 6. 2022-06-24. PMID:35745733. |
the treated hepg-2 cells with ap-ch-bsa-fanps demonstrated the induction of apoptosis by increasing p53 gene expression, arresting the cell cycle, increasing caspase-9 levels, and decreasing both the mmp9 gene and |
2022-06-24 |
2023-08-14 |
Not clear |
| Yibin Yang, Xia Zhu, Ying Huang, Hongyu Zhang, Yongtao Liu, Ning Xu, Guihong Fu, Xiaohui A. RNA-Seq and 16S rRNA Analysis Revealed the Effect of Deltamethrin on Channel Catfish in the Early Stage of Acute Exposure. Frontiers in immunology. vol 13. 2022-06-24. PMID:35747138. |
moreover, the kegg pathway and go enrichment analyses showed that the apoptosis signaling pathway was significantly enriched, and apoptosis-related degs, including cathepsin l, p53, bax, and caspase-3, were also detected. |
2022-06-24 |
2023-08-14 |
Not clear |
| Muhammad Habiburrahman, Muhammad Prasetio Wardoyo, Stefanus Sutopo, Nur Rahadian. Potential of Molecular and clinical oncology. vol 17. issue 1. 2022-06-24. PMID:35747597. |
this role is achieved through the wnt/β-catenin pathway, prevention of apoptosis through destabilization of p53, and bridging inflammation and tumorigenesis through the nuclear factor (nf)-κb pathway, causing chronic inflammation and activation of tumorigenic genes. |
2022-06-24 |
2023-08-14 |
Not clear |
| Jay R Dave, Sayali S Chandekar, Shubhanath Behera, Kaushik U Desai, Pradnya M Salve, Neha B Sapkal, Suhas T Mhaske, Ankush M Dewle, Parag S Pokare, Megha Page, Ajay Jog, Pankaj A Chivte, Rupesh K Srivastava, Geetanjali B Toma. Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age. Science advances. vol 8. issue 25. 2022-06-24. PMID:35749495. |
an increased expression of p53 and sirt1 with donor age was correlated to their ability of eliminating tumorigenic events through apoptosis or autophagy, respectively. |
2022-06-24 |
2023-08-14 |
mouse |
| Chao Yu, Tingting Li, Jialu Li, Binbin Cui, Na Liu, George Bayliss, Shougang Zhuan. Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury. Journal of cellular and molecular medicine. 2022-06-23. PMID:35734954. |
mechanistically, eed226 treatment inhibited cisplatin-induced phosphorylation of p53 and foxo3a, two transcriptional factors contributing to apoptosis, and preserved expression of sirtuin 3 and pgc1α, two proteins associated with mitochondrial protection in vivo and in vitro. |
2022-06-23 |
2023-08-14 |
Not clear |
| Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferr. Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. European journal of histochemistry : EJH. vol 66. issue 3. 2022-06-21. PMID:35726536. |
the main nash hallmarks have been confirmed in this model, as well as an increase in apoptosis, and ki67 and p53 expression in the liver. |
2022-06-21 |
2023-08-14 |
mouse |
| Vera V Grinkevich, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Margareta Wilhelm, Perdita E Barran, Andrei L Okorokov, Galina Selivanova, Joanna E Zawacka-Panka. Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule. Frontiers in molecular biosciences. vol 9. 2022-06-20. PMID:35720128. |
using biochemical assays and molecular docking, we identified the binding site of two p53 reactivating molecules, rita (reactivation of p53 and induction of tumor cell apoptosis) and protoporphyrin ix (ppix). |
2022-06-20 |
2023-08-14 |
Not clear |
| Ibrahim Bozgeyik, Mehtap Koparal, Bilal Ege, Esra Bozgeyik, Muhammed Yusuf Kurt, Onur Ceyla. Deciphering miRNAs associated with cellular stress response and apoptosis mechanisms regulated by p53 activity in patients with lower lip cancer. Pathology, research and practice. vol 236. 2022-06-20. PMID:35724459. |
deciphering mirnas associated with cellular stress response and apoptosis mechanisms regulated by p53 activity in patients with lower lip cancer. |
2022-06-20 |
2023-08-14 |
Not clear |