| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriele Baniulyte, Serene A Durham, Lauren E Merchant, Morgan A Sammon. Shared Gene Targets of the ATF4 and p53 Transcriptional Networks. Molecular and cellular biology. 2023-08-03. PMID:37533313. |
the master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. |
2023-08-03 |
2023-08-14 |
Not clear |
| Steve Harakeh, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Ajay Kumar, Hanaa M Tashkandi, Mohammed Moulay, Alia M Aldahlawi, Petr Slama, Shafiul Haqu. Apoptosis induction in human hepatoma cell line HepG2 cells by trans- Anethole via activation of mitochondria-mediated apoptotic pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-02. PMID:37531780. |
trans-anethole strongly induced apoptosis in hepg2 cells by significantly upregulating the protein expressions of p53, caspase-3 and caspase-9 were assessed by western blotting analysis which highlighted apoptosis-inducing capacity of trans-anethole against hepg2 cells. |
2023-08-02 |
2023-08-14 |
human |
| Lanni Song, Chen Li, Jia Yu, Yixin Yang, Xuechen Tian, Siew Woh Cho. The anti-cancer effect and mechanism of animal scale-derived extract on malignant melanoma cells. Scientific reports. vol 13. issue 1. 2023-08-02. PMID:37532809. |
transcriptome analysis suggests that pse may cause cell cycle arrest in melanoma cells and promote apoptosis mainly by up-regulating the p53 signaling pathway and down-regulating the pi3k-akt signaling pathway. |
2023-08-02 |
2023-08-14 |
human |
| Lanni Song, Chen Li, Jia Yu, Yixin Yang, Xuechen Tian, Siew Woh Cho. The anti-cancer effect and mechanism of animal scale-derived extract on malignant melanoma cells. Scientific reports. vol 13. issue 1. 2023-08-02. PMID:37532809. |
pse shows a significant inhibition effect on melanoma cell proliferation and cell migration in vitro, causes cell cycle arrest and promotes apoptosis through p53 and pi3k-akt pathways. |
2023-08-02 |
2023-08-14 |
human |
| Hwa Jin Kim, Sue Jin Moon, Jeong Hoon Ki. Mechanistic insights into the dual role of CCAR2/DBC1 in cancer. Experimental & molecular medicine. 2023-07-31. PMID:37524873. |
based on its ability to stimulate apoptosis by activating and stabilizing p53, ccar2 was initially considered to be a tumor suppressor. |
2023-07-31 |
2023-08-14 |
Not clear |
| Litao Zhen. Analysis of hepatocellular carcinoma associated with hepatitis B virus. Journal of cellular and molecular medicine. 2023-07-30. PMID:37517004. |
although the integration of dsdna into the hepatocyte genome seems to be the main cause of mutation, since the discovery of their function, viral proteins have been shown to regulate the p53 pathway or p13k/akt pathway to prevent host cell apoptosis, causing uncontrolled proliferation of liver cells leading to the formation of solid tumours. |
2023-07-30 |
2023-08-14 |
human |
| Ahmad Najem, Mohammad Krayem, Serena Sabbah, Matilde Pesetti, Fabrice Journe, Ahmad Awada, Laurent Désaubry, Ghanem E Ghane. Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies. Cells. vol 12. issue 14. 2023-07-29. PMID:37508519. |
we designed and identified novel specific phb inhibitors that can inhibit melanoma cell growth in 3d spheroid models and a large panel of representative cell lines with different molecular subtypes, including those with intrinsic and acquired resistance to mapki, by significantly moderating both mapk (craf-erk axis) and pi3k/akt pathways, and inducing apoptosis through the mitochondrial pathway and up-regulation of p53. |
2023-07-29 |
2023-08-14 |
Not clear |
| Fabio Casciano, Enrico Zauli, Massimo Busin, Lorenzo Caruso, Saleh AlMesfer, Samar Al-Swailem, Giorgio Zauli, Angeli Christy Y. State of the Art of Pharmacological Activators of p53 in Ocular Malignancies. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509256. |
the biological activity of p53 is not strictly limited to cell cycle arrest but also includes the regulation of homeostasis, dna repair, apoptosis, and senescence. |
2023-07-29 |
2023-08-14 |
human |
| Yiannis Drosos, Eumorphia G Konstantakou, Aggeliki-Stefania Bassogianni, Konstantinos-Stylianos Nikolakopoulos, Dimitra G Koumoundourou, Sophia P Markaki, Ourania E Tsitsilonis, Gerassimos E Voutsinas, Dimitrios Valakos, Ema Anastasiadou, Dimitris Thanos, Athanassios D Velentzas, Dimitrios J Stravopodi. Microtubule Dynamics Deregulation Induces Apoptosis in Human Urothelial Bladder Cancer Cells via a p53-Independent Pathway. Cancers. vol 15. issue 14. 2023-07-29. PMID:37509392. |
most importantly, we revealed that paclitaxel triggered a robust dna-damage response and apoptosis program without activating the p53 pathway. |
2023-07-29 |
2023-08-14 |
human |
| Chunsheng Lu, Yuehui Liang, Ya Cheng, Chan Peng, Yuanyuan Sun, Kangle Liu, Yingqing Li, Yixia Lou, Xiao Jiang, Aihua Zhang, Jinyi Liu, Jia Cao, Fei Ha. Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-28. PMID:37506861. |
microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling. |
2023-07-28 |
2023-08-14 |
mouse |
| Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Büsselberg, Ajaikumar B Kunnumakkara, Mehdi Shakibae. Resveratrol as sensitizer in colorectal cancer plasticity. Cancer metastasis reviews. 2023-07-28. PMID:37507626. |
chemotherapy as monotherapy can lead to significant side effects and chemoresistance that can be linked to several resistance-activating biological processes, including an increase in inflammation, cellular plasticity, multidrug resistance (mdr), inhibition of the sentinel gene p53, and apoptosis. |
2023-07-28 |
2023-08-14 |
Not clear |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
the tumor suppressor p53 induces cell growth arrest and/or apoptosis in response to stress, including endoplasmic reticulum (er) stress. |
2023-07-27 |
2023-08-14 |
human |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
it has been documented that the p53 gene is mutated in more than 50% of human tumors and loses its tumor suppressor function, suggesting that er stress-induced apoptosis might not rely on p53. |
2023-07-27 |
2023-08-14 |
human |
| Shengnan Sun, Yong Yi, Zhi-Xiong Jim Xiao, Hu Che. ER stress activates TAp73α to promote colon cancer cell apoptosis via the PERK-ATF4 pathway. Journal of Cancer. vol 14. issue 11. 2023-07-27. PMID:37497416. |
in this study, we found that activation of er stress promotes p53 null colon cancer cell apoptosis concomitant with an increased level of the tap73α protein, a homologue of p53 |
2023-07-27 |
2023-08-14 |
human |
| So-Young Lee, Geun-Hye Hong, Ji Hyung Chung, Kun-Young Par. Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. Journal of medicinal food. 2023-07-27. PMID:37498372. |
besides, wdsd regulated the protein expression of apoptosis (bcl-2-associated x protein [bax], b cell lymphoma-2 [bcl-2], b cell lymphoma-extra large [bcl-xl], and caspase 9, caspase 3), and p53, p21, and proinflammatory cytokines (interleukin [il]-6, tumor necrosis factor [tnf]- |
2023-07-27 |
2023-08-14 |
mouse |
| Laura Breda, Tyler E Papp, Michael P Triebwasser, Amir Yadegari, Megan T Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A Grupp, Stella T Chou, Houping Ni, Barbara L Mui, Ying K Tam, Drew Weissman, Stefano Rivella, Hamideh Parhi. In vivo hematopoietic stem cell modification by mRNA delivery. Science (New York, N.Y.). vol 381. issue 6656. 2023-07-27. PMID:37499029. |
furthermore, in vivo delivery of pro-apoptotic puma (p53 up-regulated modulator of apoptosis) mrna with cd117/lnp affected hsc function and permitted nongenotoxic conditioning for hsct. |
2023-07-27 |
2023-08-14 |
Not clear |
| Jie Gu, Liguo Guo, Jun Hu, Guixiang Ji, Daqiang Yi. Potential adverse outcome pathway (AOP) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (Danio rerio). The Science of the total environment. 2023-07-27. PMID:37499828. |
furthermore, emb exposure resulted in abnormal cardiac function and vascular development, triggering neutrophil migration and aggregation toward the pericardial and dorsal vascular regions, and finalized apoptosis in the zebrafish heart region, these phenomena were further deciperred by the transcriptome analysis that the toll-like receptor pathway, p53 pathway, and apoptotic pathway were significantly affected by emb exposure. |
2023-07-27 |
2023-08-14 |
zebrafish |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
we used immunoblotting to analyze the effect of manganese, iron alone, or their combined exposure on the activation of caspase9, p53, bax, and bcl2 apoptosis signaling pathways. |
2023-07-27 |
2023-08-14 |
Not clear |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
and we also found that the apoptosis rate increased, mitochondrial membrane potential decreased, apoptosis-related proteins caspase9, p53, bax, and bcl2 expression increased, and caspase3 activity increased. |
2023-07-27 |
2023-08-14 |
Not clear |
| Camila S Silva, Tetyana Kudlyk, Volodymyr P Tryndyak, Nathan C Twaddle, Bonnie Robinson, Qiang Gu, Frederick A Beland, Suzanne C Fitzpatrick, Jyotshna Kanung. Gene expression analyses reveal potential mechanism of inorganic arsenic-induced apoptosis in zebrafish. Journal of applied toxicology : JAT. 2023-07-27. PMID:37501093. |
our data suggest that the p53 pathway is likely responsible for sodium arsenite-induced apoptosis. |
2023-07-27 |
2023-08-14 |
human |