| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling-Hu Cai, Xiang-Yu Chen, Wei Qian, Chuan-Chuan Liu, Li-Jia Yuan, Liang Zhang, Chao Nie, Zhen Liu, Yue Li, Tian Li, Ming-Hua Li. DDB2 and MDM2 genes are promising markers for radiation diagnosis and estimation of radiation dose independent of trauma and burns. Functional & integrative genomics. vol 23. issue 4. 2023-09-09. PMID:37688632. |
totally, 33 multi-type ray co-induced genes were obtained at first from the differentially expressed genes (degs) and key genes identified by weighted gene co-expression network analysis (wgcna), and these genes were mainly enriched in dna damage, cellular apoptosis, and p53 signaling pathway. |
2023-09-09 |
2023-10-07 |
human |
| Mathew R Schnorenberg, Katrina M Hawley, Anika T Thomas-Toth, Elyse A Watkins, Yu Tian, Jeffrey M Ting, Logan B Leak, Isadora M Kucera, Michal M Raczy, Andrew L Kung, Jeffrey A Hubbell, Matthew V Tirrell, James L LaBell. Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma. ACS nano. 2023-09-09. PMID:37688780. |
in this work, we elucidated an opportunity for therapeutic synergy in dlbcl by reactivating tumor protein p53 with a stapled peptide, atsp-7041, thereby priming cells for apoptosis and enhancing their sensitivity to bcl-2 family modulation with a bh3-mimetic, abt-263 (navitoclax). |
2023-09-09 |
2023-10-07 |
Not clear |
| Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medin. Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea. Chemosphere. 2023-09-09. PMID:37689151. |
herein, findings indicate that both compounds induced oxidative damage and increased the expression of genes associated with apoptosis (bax, bcl2, p53, and casp3). |
2023-09-09 |
2023-10-07 |
zebrafish |
| Yan Wang, Jing-Miao Wang, Yuan Xiao, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Lan Zhang, Yu-Wen Gan, Xing-Miao Liang, David Wan-Cheng L. SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells. Aging. vol 15. 2023-09-08. PMID:37683133. |
in contrast, overexpression of dbc1 enhances oxidative stress-induced apoptosis, and this process depends on p53. |
2023-09-08 |
2023-10-07 |
mouse |
| El-Habib Dakir, Consuelo Gajate, Faustino Mollined. Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-08. PMID:37683591. |
here, we found that edelfosine was the most potent alkylphospholipid analog in inducing apoptosis in three different human prostate cancer cell lines (lncap, pc3, and du145) with distinct androgen dependency, and differing in tumor suppressor phosphatase and tensin homolog (pten) and p53 status. |
2023-09-08 |
2023-10-07 |
mouse |
| Cuicui Zhuang, Jinhui Zhao, Shiyao Zhang, Muhammad Shahi. Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells. Microbial pathogenesis. 2023-09-08. PMID:37683833. |
moreover, expressions of p53 and p21 promptly improved after e. coli infection, however, pifithrin-α (specific inhibitor of p53) inhibited p53-p21 pathway, apoptosis, cell cycle arrest and pyroptosis. |
2023-09-08 |
2023-10-07 |
cattle |
| Qiuxiang Cai, Yajuan Li, Yung-Fu Chang, Zhaoxin Tang, Hui Zhang, Qingmei Xi. Pasteurella multocida causes liver injury in ducks by mediating inflammatory, apoptotic and autophagic pathways. Microbial pathogenesis. 2023-09-08. PMID:37683832. |
tumor necrosis factor induced hepatocyte apoptosis was implicated in a wide range of liver diseases; the release of tnf-α and activation with nf-κb further incite apoptotic pathways,such as bax/bcl2/caspase to promote apoptotic genes apaf1, bax, caspase3, bcl-2, p53, and cytc expression. |
2023-09-08 |
2023-10-07 |
Not clear |
| Chunguang Sun, Lin Lia. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023-09-06. PMID:37670707. |
antithyroid cancer studies of shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial-mesenchymal transition; induced cell cycle arrest; induced dna damage and apoptosis by producing excessive reactive oxygen species; upregulated bax; increased the stability of p53; decreased the expression of mdm2; downregulated slug and mmp-2, mmp-9, and mmp-14; repressed the phosphorylation of erk and akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of dnmt1; reduced the pten gene methylation; increased the expression of pten, leading to the inhibition of migration; increased lc3-ii to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βii-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. |
2023-09-06 |
2023-10-07 |
mouse |
| Atta Ullah, Muhammad Waqas, Sobia Ahsan Halim, Muhammad Daud, Afnan Jan, Ajmal Khan, Ahmed Al-Harras. Sirtuin 1 inhibition: a promising avenue to suppress cancer progression through small inhibitors design. Journal of biomolecular structure & dynamics. 2023-09-04. PMID:37661778. |
its association with the tumor suppressor protein p53 is essential for controlling the growth of cells, apoptosis, and response to dna damage. |
2023-09-04 |
2023-09-07 |
Not clear |
| Atta Ullah, Muhammad Waqas, Sobia Ahsan Halim, Muhammad Daud, Afnan Jan, Ajmal Khan, Ahmed Al-Harras. Sirtuin 1 inhibition: a promising avenue to suppress cancer progression through small inhibitors design. Journal of biomolecular structure & dynamics. 2023-09-04. PMID:37661778. |
by raising p53 acetylation, encouraging apoptosis, and reducing cell proliferation, inhibiting sirt1's catalytic domain, which interacts with p53, shows potential as a cancer treatment. |
2023-09-04 |
2023-09-07 |
Not clear |
| Sahar Abdi Sarkami, Sajjad Molavipordanjani, Saeed Abediankenari, Javad Akhtari, Pooria Gill, Hossein Ghalehnoei, Shabanali Khodashenas Lemon. Engineering HEK293T cell line by lentivirus to produce miR34a-loaded exosomes. Molecular biology reports. 2023-09-02. PMID:37658928. |
as an rna, mir-34a is involved in p53 function and cancer cell apoptosis. |
2023-09-02 |
2023-09-07 |
Not clear |
| Banghua Zhang, Zhi-Yuan Chen, Zhengyu Jiang, Shiyu Huang, Xiu-Heng Liu, Lei Wan. Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis. Journal of agricultural and food chemistry. 2023-08-30. PMID:37646396. |
furthermore, experimental data validated that cad evidently decreased the reactive oxygen species (ros) production and malondialdehyde (mda) content while depressing the mrna and protein expression of inflammatory markers (tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), and il-1β) and inhibiting apoptosis as evidenced by decreased levels of p53, bax, cleaved caspase-3, and apoptotic rate in renal i/r and uuo models. |
2023-08-30 |
2023-09-07 |
human |
| Yi Cai, Qianyue Lai, Xuan Zhang, Yu Zhang, Man Zhang, Shaoju Gu, Yuan Qin, Jingshen Hou, Li Zha. Kinesin superfamily member 15 knockdown inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 27. issue 5. 2023-08-29. PMID:37641808. |
furthermore, we discovered that silencing kif15 inhibits cell proliferation, migration, and invasion while promoting apoptosis, and that kif15's effect on npc cell growth is mediated through the pi3k/akt and p53 signaling pathways. |
2023-08-29 |
2023-09-07 |
mouse |
| Ananya Dutta, Titli Panchali, Amina Khatun, Sreenivasa Rao Jarapala, Koushik Das, Kuntal Ghosh, Sudipta Chakrabarti, Shrabani Pradha. Anti-cancer potentiality of linoelaidic acid isolated from marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on MCF-7 cell line. Scientific reports. vol 13. issue 1. 2023-08-29. PMID:37644076. |
to decipher the mode of apoptosis western blotting was performed in which the expression pattern of several proteins (p53, il-10, and il-1ra) established the apoptosis in the studied cell lines after linoelaidic acid exposure. |
2023-08-29 |
2023-09-07 |
human |
| Sayanta Dutta, Sushweta Mahalanobish, Sukanya Saha, Mullicka Mandal, Sanchari Begam, Pritam Sadhukhan, Sumit Ghosh, Goutam Brahmachari, Parames C Si. Biological evaluation of the novel 3,3'-((4-nitrophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) derivative as potential anticancer agents via the selective induction of reactive oxygen species-mediated apoptosis. Cellular signalling. 2023-08-28. PMID:37640193. |
this compound was able to induce apoptosis and cell-cycle arrest by modulating the p53 mediated apoptotic pathways via the generation of ros, decreasing mitochondrial membrane potential, and causing dna fragmentation. |
2023-08-28 |
2023-09-07 |
human |
| Rosa I Luna-Ramirez, Sean W Limesand, Ravi Goyal, Alexander L Pendleton, Gonzalo Rincón, Xi Zeng, Guillermo Luna-Nevárez, Javier R Reyna-Granados, Pablo Luna-Neváre. Blood Transcriptomic Analyses Reveal Functional Pathways Associated with Thermotolerance in Pregnant Ewes Exposed to Environmental Heat Stress. Genes. vol 14. issue 8. 2023-08-26. PMID:37628641. |
the top-three signaling pathways were p53, rig-i-like receptor and foxo, which suggested gene participation in biological processes such as apoptosis, cell signaling and immune response to external stressors. |
2023-08-26 |
2023-09-07 |
Not clear |
| Senxia Zhao, Yibin Li, Gang Li, Juanping Ye, Rong Wang, Xiaoting Zhang, Fei Li, Chang Gao, Junbiao Li, Jie Jiang, Yanjun M. PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer. European journal of pharmacology. 2023-08-25. PMID:37625683. |
these differentially expressed genes were primarily enriched in biological processes such as cell cycle regulation and cell apoptosis, which are closely linked to the p53 and apoptosis pathways. |
2023-08-25 |
2023-09-07 |
mouse |
| Huanhuan Wang, Fuze She, Fu Chen, Kun Li, Shunyi Qi. Selenium-Chitosan Protects Porcine Endometrial Epithelial Cells from Zearalenone-induced Apoptosis via the JNK/SAPK Signaling Pathway. Biological trace element research. 2023-08-23. PMID:37610602. |
furthermore, 3.0 µmol/l se-cts ameliorated the increase in the expression of c-jun n-terminal kinase (jnk), apoptosis signal-regulated kinase (ask1), and c-jun induced by zea (p < 0.01) and the reduction in mitogen-activated protein kinase kinase 4 (mkk4) and protein 53 (p53) expression (p < 0.01), while 1.5 µmol/l se-cts improved the expression of ask1 and c-jun induced by zea (p < 0.05). |
2023-08-23 |
2023-09-07 |
Not clear |
| Mohammad Mahdi Khanifar, Zahra Zafari, Mohsen Sheykhhasa. Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study. Pathology, research and practice. vol 249. 2023-08-23. PMID:37611430. |
p53 is regarded as a crucial tumor suppressor gene which promotes cell-cycle arrest, dna repair, senescence or apoptosis in response to cellular stresses. |
2023-08-23 |
2023-09-07 |
human |
| Sara Moghadasi, Ehsan Razeghian, Mehdi Shamsara, Farid Heidar. The effects of PFT-µ on spermatogonial stem cell viability and Pluripotency. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2023-08-23. PMID:37611547. |
we evaluated the effect of small molecule pifithrin-mu (pft-µ) as a well-known inhibitor of p53 on ssc biological processes such as viability, apoptosis, and gene expression pattern. |
2023-08-23 |
2023-09-07 |
human |