| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shantanu Gupta, Daner A Silveira, Ronaldo F Hashimot. A Boolean model of the oncogene role of FAM111B in lung adenocarcinoma. Computational biology and chemistry. vol 106. 2023-07-24. PMID:37487252. |
our model indicates that the cell fate between the two cellular phenotypes, arrest, and apoptosis, at the g2/m checkpoint is non-deterministic and is controlled by p53. |
2023-07-24 |
2023-08-14 |
Not clear |
| Zekai Huang, Markus Kaller, Heiko Hermekin. CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34. Cell death and differentiation. 2023-07-24. PMID:37488217. |
concomitant deletion of mir-34a and mir-34b/c resulted in significantly reduced suppression of proliferation after p53 activation, enhanced migration, invasion and emt, as well as reduced sensitivity to chemotherapeutics, increased stress-induced autophagic flux, decreased apoptosis and upregulation of autophagy-related genes after 5-fu treatment. |
2023-07-24 |
2023-08-14 |
Not clear |
| Minerva, Amrita Bhat, Sonali Verma, Gresh Chander, Rajeshwer Singh Jamwal, Bhawani Sharma, Audesh Bhat, Taruna Katyal, Rakesh Kumar, Ruchi Sha. Cisplatin-based combination therapy for cancer. Journal of cancer research and therapeutics. vol 19. issue 3. 2023-07-20. PMID:37470570. |
dna damage is followed by several signaling pathways like induced oxidative stress, upregulated p53, mitogen-activated protein kinase (mapk), and jun n-terminal kinases (jnk) or akt pathways along with induced apoptosis. |
2023-07-20 |
2023-08-14 |
Not clear |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
besides, bbf led to apoptosis in leydig cells, and decreased expressions of p-akt and bcl2, while improving the expressions of p53, bax and cleaved caspase-3 in vivo and in vitro. |
2023-07-20 |
2023-08-14 |
mouse |
| Chao-Feng Shi, Fei Han, Xiao Jiang, Zhonghao Zhang, Yingqing Li, Jiankang Wang, Shengqi Sun, Jin-Yi Liu, Jia Ca. Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-20. PMID:37473983. |
similarly, p53 inhibitor pifithrin-α also significantly enhanced the cell vitality, alleviated the apoptosis of tm3 cells induced by bbf, and decreased the expressions of bax and cleaved caspase-3, with the up-regulation of bcl2. |
2023-07-20 |
2023-08-14 |
mouse |
| Mao-Hong Luo, Ya He, Hong Li, Teng-Xiang Chen, Shan Lei, Jin-Juan Zhang, Lu Wan. [Oenothein B inhibits proliferation and migration of breast cancer cells by regulating P53]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 14. 2023-07-20. PMID:37475082. |
therefore, this study showed that oeb inhibited the proliferation, migration, and invasion of breast cancer mcf-7 and mda-mb-231 cells, and promoted the apoptosis of breast cancer mcf-7 and mda-mb-231 cells, which may be related to the targeted regulation of p53. |
2023-07-20 |
2023-08-14 |
Not clear |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
mir-34a targets sirt1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
this study is to investigate the function of mir-34a and interactions between mir-34a, sirt1, and p53 in sevoflurane-induced neuronal apoptosis and autophagy in neonatal mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Xiang Xu, Caifeng Li, Junping Zou, Liang Li. MiR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice. Experimental neurology. 2023-07-19. PMID:37467842. |
mir-34a promotes sevoflurane-stimulated neuronal apoptosis and autophagy in neonatal mice by inhibiting sirt1 expression and subsequent p53 deacetylation. |
2023-07-19 |
2023-08-14 |
mouse |
| Yingying Zhao, Rui Ma, Chuyue Wang, Rong Hu, Weili Wu, Xiang Sun, Baotao Chen, Wen Zhang, You Chen, Jiajian Zhou, Ping Yua. CAPG interference induces apoptosis and ferroptosis in colorectal cancer cells through the P53 pathway. Molecular and cellular probes. 2023-07-19. PMID:37468079. |
capg interference induces apoptosis and ferroptosis in colorectal cancer cells through the p53 pathway. |
2023-07-19 |
2023-08-14 |
Not clear |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
p53 plays a critical role in the regulation of apoptosis and cell cycle arrest, metabolism and insulin resistance. |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
the aim of this study was to investigate the impact of p53 pathway in enhancing apoptosis and abnormal function of granulosa cells. |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results of this study represent the possible role of p53 pathway in pathogenesis of pcos particularly, through the enhancement of apoptosis in granulosa cells. |
2023-07-19 |
2023-08-14 |
human |
| Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang, Shuyan Dai, Xiaojuan Chen, Ye Zhang, Zhuchu Chen, Youjun Li, Ming Guo, Yongheng Che. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nature communications. vol 14. issue 1. 2023-07-18. PMID:37463921. |
the tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with bcl-2 family proteins, but the molecular mechanism is not well understood. |
2023-07-18 |
2023-08-14 |
Not clear |
| Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang, Shuyan Dai, Xiaojuan Chen, Ye Zhang, Zhuchu Chen, Youjun Li, Ming Guo, Yongheng Che. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nature communications. vol 14. issue 1. 2023-07-18. PMID:37463921. |
overall, our study provides a structural basis for the interaction between p53 and bcl-2, and suggests a molecular mechanism by which p53 regulates transcription-independent apoptosis by antagonizing the interaction of bcl-2 with pro-apoptotic bcl-2 family members. |
2023-07-18 |
2023-08-14 |
Not clear |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
further, acridine orange staining exhibited more apoptosis in treated groups with increased p53, caspase-3, caspase-9 and decreased bcl-2 gene expression. |
2023-07-16 |
2023-08-14 |
human |
| Hyun-Min Kim, Xiaoyu Zheng, Ethan Le. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446210. |
while p53 has been extensively studied in cancer research, specifically in relation to fundamental cellular processes, including gene transcription, apoptosis, and cell cycle progression, its association with histone modifiers has received limited attention. |
2023-07-14 |
2023-08-14 |
Not clear |
| Noha A T Abbas, Shaimaa S El-Sayed, Samaa Salah Abd El-Fatah, Walaa M Sarhan, Eman M A Abdelghany, Omnia Sarhan, Shireen S Mahmou. Mechanistic aspects of ameliorative effects of Eicosapentanoic acid ethyl ester on methotrexate-evoked testiculopathy in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-14. PMID:37450014. |
methotrexate-induced testicular apoptosis (caspase-3 and p53) was suppressed upon epa-e treatment. |
2023-07-14 |
2023-08-14 |
rat |