| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuqian Hu, Hui Xu, Conghua Xie, Yan Meng, Xiaojuan X. Inhibition of human cervical cancer development through p53-dependent pathways induced by the specified triple helical β-glucan. International journal of biological macromolecules. 2023-08-16. PMID:37586625. |
from the in vitro data, the potential mechanism of anti-cervical cancer was preliminarily revealed as follows: lnt was firstly recognized by the human cervical cancer cell line of hela and induced cell proliferation inhibition through p21 and apoptosis via a mitochondrion-dependent pathway by targeting the tumor suppressor of p53, indicated by an increase in reactive oxygen species (ros) generation and a loss of mitochondrial membrane potential (Δψ |
2023-08-16 |
2023-09-07 |
human |
| Nabanita Mukherjee, Debmalya Bhunia, Prabir Kumar Garai, Prasenjit Mondal, Surajit Barman, Surajit Ghos. Designed novel nuclear localizing anticancer peptide targets p53 negative regulator MDM2 protein. Journal of peptide science : an official publication of the European Peptide Society. 2023-08-15. PMID:37580909. |
modulation of mdm2-p53 interaction via fabrication of an mdm2-interacting peptide could be a useful strategy to inhibit subsequent proteasomal degradation of p53 and initiation of p53 signaling leading to the initiation of p53-mediated apoptosis of tumor cells. |
2023-08-15 |
2023-09-07 |
Not clear |
| Johannes P Suwita, Calvin K Voong, Elina Ly, James A Goodrich, Jennifer F Kuge. Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements. PloS one. vol 18. issue 8. 2023-08-15. PMID:37582100. |
the transcriptional activator p53 is a tumor suppressor protein that controls cellular pathways important for cell fate decisions, including cell cycle arrest, senescence, and apoptosis. |
2023-08-15 |
2023-09-07 |
human |
| Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibae. Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment. Frontiers in immunology. vol 14. 2023-08-14. PMID:37575245. |
resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and sirt-1 in the crc tumor microenvironment. |
2023-08-14 |
2023-08-16 |
Not clear |
| Shin Kim, Dong Eun Kim, Hyunsu Kang, Victor Sukbong Hong, Jieun Jeon, Jinho Lee, Ki-Suk Kim, Jong-Wook Par. KMU-191 Induces Apoptosis in Human Clear Cell Renal Cell Carcinoma Caki Cells Through Modulation of Bcl-xL, Mcl-1 (L), c-FLIP (L), and p53 Proteins. Journal of Cancer. vol 14. issue 12. 2023-08-14. PMID:37576393. |
kmu-191 induces apoptosis in human clear cell renal cell carcinoma caki cells through modulation of bcl-xl, mcl-1 (l), c-flip (l), and p53 proteins. |
2023-08-14 |
2023-08-16 |
human |
| Ian C Lock, Nathan H Leisenring, Warren Floyd, Eric S Xu, Lixia Luo, Yan Ma, Erin C Mansell, Diana M Cardona, Chang-Lung Lee, David G Kirsc. Mis-splicing Drives Loss of Function of p53 bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577531. |
challenging this dogma, mouse models have revealed that p53 driven apoptosis and cell cycle arrest are dispensable for tumor suppression. |
2023-08-14 |
2023-08-16 |
mouse |
| Adriana Cortés, Javier Marqués, Álvaro Pejenaute, Elena Ainzúa, Eduardo Ansorena, Gloria Abizanda, Felipe Prósper, Carlos de Miguel, Guillermo Zalb. Endothelial NOX5 overexpression induces changes in the cardiac gene profile: potential impact in myocardial infarction? Journal of physiology and biochemistry. 2023-08-11. PMID:37566320. |
we found many alterations in the mrna expression of components involved in cardiac fibrosis as collagen type i or tgf-β and in key players of cardiac apoptosis such as akt, bcl-2, or p53. |
2023-08-11 |
2023-08-16 |
mouse |
| Mazin Aboobaida Abdalla Abdelaziz, Vinod Kumar Nelson, Murali Kumarasamy, Ramalingam Perama. Anticancer effect of polyphenolic acid enriched fractions from Grewia bracteata Roth on tumor cells and their p53 gene independent ROS mediated apoptosis in colon cancer cells. Toxicon : official journal of the International Society on Toxinology. 2023-08-11. PMID:37567418. |
anticancer effect of polyphenolic acid enriched fractions from grewia bracteata roth on tumor cells and their p53 gene independent ros mediated apoptosis in colon cancer cells. |
2023-08-11 |
2023-08-16 |
Not clear |
| Zhihui Dou, Xuetian Zhang, Wei Su, Taotao Zhang, Fei Ye, Dapeng Zhao, Xiaohua Chen, Qiang Li, Hong Zhang, Cuixia D. Indisulam exerts anticancer effects via modulation of transcription, translation and alternative splicing on human cervical cancer cells. American journal of cancer research. vol 13. issue 7. 2023-08-10. PMID:37559979. |
indisulam increased tap73 expression and triggered mitochondrial apoptosis independent of p53 status in hela cells. |
2023-08-10 |
2023-08-16 |
human |
| Xiangyu Zeng, Fei Zhao, Jie Jia, Xianxiong Ma, Qi Jiang, Ruizhi Zhang, Chengguo Li, Tao Wang, Weizhen Liu, Yalan Hao, Kaixiong Tao, Zhenkun Lou, Peng Zhan. Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib. Cancer research. 2023-08-09. PMID:37556508. |
the reduction in p53 subsequently attenuated cell apoptosis and promoted tolerance of gist cells to im. |
2023-08-09 |
2023-08-16 |
Not clear |
| Kai Zhang, Jianzhao Liao, Zhuoying Hu, Quanwei Li, Lianmei Hu, Jianying Guo, Ying Li, Hui Zhang, Jiaqiang Pan, Zhaoxin Tan. Mitochondria-mediated apoptosis and endoplasmic reticulum stress are involved in the toxicity induced by copper in the porcine spleen. Environmental science and pollution research international. 2023-08-05. PMID:37542695. |
furthermore, cu exposure could induce apoptosis, as demonstrated by the increased expression level of related proteins and genes bak, bax, caspase-3, p53, and cytc. |
2023-08-05 |
2023-08-14 |
Not clear |
| Mahtab Shahriari Felordi, Mehdi Alikhani, Zahra Farzaneh, Mahmoud Alipour Choshali, Marzieh Ebrahimi, Hamidreza Aboulkheyr Es, Abbas Piryaei, Mustapha Najimi, Massoud Vosoug. (-)-Epigallocatechin-3-gallate induced apoptosis by dissociation of c-FLIP/Ku70 complex in gastric cancer cells. Journal of cellular and molecular medicine. 2023-08-04. PMID:37537749. |
egcg induced apoptosis in mkn-45 cells with substantial up-regulation of p53 and p21, down-regulation of c-myc and cyclin d1 as well as cell cycle arrest in s and g2/m check points. |
2023-08-04 |
2023-08-14 |
Not clear |
| Fei Wang, Ali Bashiri Dezfouli, Mohammad Khosravi, Wolfgang Sievert, Stefan Stangl, Melissa Schwab, Zhiyuan Wu, Katja Steiger, Hu Ma, Gabriele Multhof. Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70. Cell death discovery. vol 9. issue 1. 2023-08-04. PMID:37542074. |
cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and hsp70. |
2023-08-04 |
2023-08-14 |
Not clear |
| Fei Wang, Ali Bashiri Dezfouli, Mohammad Khosravi, Wolfgang Sievert, Stefan Stangl, Melissa Schwab, Zhiyuan Wu, Katja Steiger, Hu Ma, Gabriele Multhof. Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70. Cell death discovery. vol 9. issue 1. 2023-08-04. PMID:37542074. |
this study provides new insights into the potential mechanisms of cbd-induced mutual antagonism of apoptosis and macroautophagy using wild type (hct116 p53wt, ls174t p53wt), knockout (hct116 p53 |
2023-08-04 |
2023-08-14 |
Not clear |
| Gabriele Baniulyte, Serene A Durham, Lauren E Merchant, Morgan A Sammon. Shared Gene Targets of the ATF4 and p53 Transcriptional Networks. Molecular and cellular biology. 2023-08-03. PMID:37533313. |
the master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle arrest and apoptosis, via transcriptional control of a broad gene network. |
2023-08-03 |
2023-08-14 |
Not clear |
| Steve Harakeh, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Ajay Kumar, Hanaa M Tashkandi, Mohammed Moulay, Alia M Aldahlawi, Petr Slama, Shafiul Haqu. Apoptosis induction in human hepatoma cell line HepG2 cells by trans- Anethole via activation of mitochondria-mediated apoptotic pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-02. PMID:37531780. |
trans-anethole strongly induced apoptosis in hepg2 cells by significantly upregulating the protein expressions of p53, caspase-3 and caspase-9 were assessed by western blotting analysis which highlighted apoptosis-inducing capacity of trans-anethole against hepg2 cells. |
2023-08-02 |
2023-08-14 |
human |
| Lanni Song, Chen Li, Jia Yu, Yixin Yang, Xuechen Tian, Siew Woh Cho. The anti-cancer effect and mechanism of animal scale-derived extract on malignant melanoma cells. Scientific reports. vol 13. issue 1. 2023-08-02. PMID:37532809. |
transcriptome analysis suggests that pse may cause cell cycle arrest in melanoma cells and promote apoptosis mainly by up-regulating the p53 signaling pathway and down-regulating the pi3k-akt signaling pathway. |
2023-08-02 |
2023-08-14 |
human |
| Lanni Song, Chen Li, Jia Yu, Yixin Yang, Xuechen Tian, Siew Woh Cho. The anti-cancer effect and mechanism of animal scale-derived extract on malignant melanoma cells. Scientific reports. vol 13. issue 1. 2023-08-02. PMID:37532809. |
pse shows a significant inhibition effect on melanoma cell proliferation and cell migration in vitro, causes cell cycle arrest and promotes apoptosis through p53 and pi3k-akt pathways. |
2023-08-02 |
2023-08-14 |
human |
| Hwa Jin Kim, Sue Jin Moon, Jeong Hoon Ki. Mechanistic insights into the dual role of CCAR2/DBC1 in cancer. Experimental & molecular medicine. 2023-07-31. PMID:37524873. |
based on its ability to stimulate apoptosis by activating and stabilizing p53, ccar2 was initially considered to be a tumor suppressor. |
2023-07-31 |
2023-08-14 |
Not clear |
| Litao Zhen. Analysis of hepatocellular carcinoma associated with hepatitis B virus. Journal of cellular and molecular medicine. 2023-07-30. PMID:37517004. |
although the integration of dsdna into the hepatocyte genome seems to be the main cause of mutation, since the discovery of their function, viral proteins have been shown to regulate the p53 pathway or p13k/akt pathway to prevent host cell apoptosis, causing uncontrolled proliferation of liver cells leading to the formation of solid tumours. |
2023-07-30 |
2023-08-14 |
human |