| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naeem Abdul Ghafoor, Aysegul Yildi. Targeting MDM2-p53 Axis through Drug Repurposing for Cancer Therapy: A Multidisciplinary Approach. ACS omega. vol 8. issue 38. 2023-10-02. PMID:37779953. |
mouse double minute 2 (mdm2) is a key regulator of the tumor suppressor protein p53, which plays a critical role in regulating cellular growth, apoptosis, and dna repair. |
2023-10-02 |
2023-10-07 |
mouse |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
intracellular fgf1 protects cells from apoptosis through direct interaction with p53. |
2023-10-02 |
2023-10-07 |
Not clear |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
here, we show that expression of fgf1 increases the survival of cells treated with various apoptosis inducers, but only when wild-type p53 is present. |
2023-10-02 |
2023-10-07 |
Not clear |
| Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewsk. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53. Cellular and molecular life sciences : CMLS. vol 80. issue 10. 2023-10-02. PMID:37783936. |
we therefore postulate that intracellular fgf1 protects cells from apoptosis by directly interacting with p53. |
2023-10-02 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
licochalcone a induces g2/m phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: in-vitro and in-vivo study. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
combining multiple databases and network pharmacology, we found that the mechanism of lca inhibiting ec may be closely related to p53 signaling pathway, cell cycle regulation and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
lca significantly up-regulated p53 protein and gene expression, thereby inducing apoptosis and cycle arrest. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
lca administration inhibited tumor growth by activating p53 signaling pathways and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Che. Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study. European journal of pharmacology. vol 958. 2023-09-30. PMID:37758012. |
in conclusion, lca is an excellent candidate for ec treatment by regulating p53 pathway to induce g2/m phase arrest and apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Yasuhiro Takano, Satomi Yogosawa, Yuta Imaizumi, Hiroshi Kamioka, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshid. DYRK2 promotes chemosensitivity via p53-mediated apoptosis after DNA damage in colorectal cancer. Cancer science. 2023-09-30. PMID:37776195. |
conversely, the combination of adenovirus-mediated overexpression of dyrk2 with 5-fluorouracil or oxaliplatin enhanced apoptosis and chemosensitivity through p53-ser46 phosphorylation in p53 wild-type colorectal cancer cells. |
2023-09-30 |
2023-10-07 |
mouse |
| Hao Wang, Wei Yu, Yibo Wang, Ruihao Wu, Yifei Dai, Ye Deng, Shijun Wang, Jinxiang Yuan, Rubin Ta. p53 contributes to cardiovascular diseases via mitochondria dysfunction: A new paradigm. Free radical biology & medicine. 2023-09-30. PMID:37776918. |
in this comprehensive review, we delve into the mechanisms how p53 influences mitochondrial dysfunction, including energy metabolism, mitochondrial oxidative stress, mitochondria-induced apoptosis, mitochondrial autophagy, and mitochondrial dynamics, in various cvds. |
2023-09-30 |
2023-10-07 |
Not clear |
| Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G Park, Joshua LaBae. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. NPJ breast cancer. vol 9. issue 1. 2023-09-29. PMID:37773066. |
to test whether neomorphic functions of specific tp53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed mcf10a-derived cell lines expressing the ten most common missense mutant p53 proteins and observed a wide spectrum of phenotypic changes in cell survival, resistance to apoptosis and anoikis, cell migration, invasion and 3d mammosphere architecture. |
2023-09-29 |
2023-10-07 |
Not clear |
| Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760996. |
in investigating the function of se-cad, we found that immunodepletion of se-cad from the media of a549 cells untreated or treated with bdnf, nicotine, or epinephrine reduced activation of egfr and igf-1r, decreased pi3k and erk1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using h1299 cells under all conditions tested. |
2023-09-28 |
2023-10-07 |
Not clear |
| Kyuho Jeong, Jihyun Je, Theodomir Dusabimana, Hwajin Kim, Sang Won Par. Early Growth Response 1 Contributes to Renal IR Injury by Inducing Proximal Tubular Cell Apoptosis. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762598. |
interestingly, egr-1 overexpression enhanced p53 levels and tubular apoptosis, while the knockdown of egr-1 reduced p53 levels and tubular apoptosis after h |
2023-09-28 |
2023-10-07 |
mouse |
| Kishan Das, Neelima Bhatt, Ajith Manayil Parambil, Kajal Kumari, Raj Kumar, Kamla Rawat, Paulraj Rajamani, Himadri B Bohidar, Ahmed Nadeem, Saravanan Muthupandian, Ramovatar Meen. Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core-Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis. Journal of functional biomaterials. vol 14. issue 9. 2023-09-27. PMID:37754862. |
increased cytochrome c levels, regulation of pro-apoptotic gene expression (e.g., p53, bax), and down-regulation of bcl-2 all suggested cellular apoptosis occurred via the intrinsic pathway. |
2023-09-27 |
2023-10-07 |
Not clear |
| Weichen Hong, Yuhao Liu, Jiatian Liang, Chunyu Jiang, Meijin Yu, Wei Sun, Bin Huang, Na Dong, Lu Kang, You Tan. Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis. Toxics. vol 11. issue 9. 2023-09-27. PMID:37755744. |
further, the anti-apoptotic gene bcl-2 decreased; on the contrary, four pro-apoptotic genes (p53, bax, cyt c, and caspase-3) increased under pb treatment, meaning that pb caused apoptosis via the p53-cyt c-caspase-3 pathway. |
2023-09-27 |
2023-10-07 |
chicken |
| Helena Folly-Kossi, Joshua D Graves, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Li. DNA2 nuclease inhibition confers synthetic lethality in cancers with mutant p53 and synergizes with PARP inhibitors. Cancer research communications. 2023-09-27. PMID:37756561. |
the tumor suppressor p53 promotes tumor suppressive activities including cell cycle inhibition, apoptosis, senescence, autophagy, and dna repair. |
2023-09-27 |
2023-10-07 |
human |
| Svetlana B Parfenyuk, Olga V Glushkova, Mars G Sharapov, Maksim O Khrenov, Sergey M Lunin, Anna A Kuzekova, Elvira K Mubarakshina, Tatyana V Novoselova, Dmitrii A Cherenkov, Elena G Novoselov. Protective Effects of Peroxiredoxin 6 in Pro-Inflammatory Response Model Using Raw 264.7 Macrophages. Biochemistry. Biokhimiia. vol 88. issue 8. 2023-09-27. PMID:37758314. |
our studies confirm this, since exposure to lps led to activation of the expression of p53 gene, a marker of apoptosis. |
2023-09-27 |
2023-10-07 |
Not clear |
| Svetlana B Parfenyuk, Olga V Glushkova, Mars G Sharapov, Maksim O Khrenov, Sergey M Lunin, Anna A Kuzekova, Elvira K Mubarakshina, Tatyana V Novoselova, Dmitrii A Cherenkov, Elena G Novoselov. Protective Effects of Peroxiredoxin 6 in Pro-Inflammatory Response Model Using Raw 264.7 Macrophages. Biochemistry. Biokhimiia. vol 88. issue 8. 2023-09-27. PMID:37758314. |
peroxiredoxin 6 added within the first hours of the development of acute pro-inflammatory response suppressed the p53 gene expression, indicating protective effect of prdx6 that reduced apoptosis in the raw 264.7 macrophages. |
2023-09-27 |
2023-10-07 |
Not clear |
| Mingyuan Wang, Qiong Huang, Min Liu, Tianjiao Zhao, Xiangping Song, Qiaohui Chen, Yongqi Yang, Yayun Nan, Zerun Liu, Yuntao Zhang, Wei Wu, Kelong A. Precisely Inhibiting Excessive Intestinal Epithelial Cell Apoptosis to Efficiently Treat Inflammatory Bowel Disease with Oral Pifithrin-α Embedded Nanomedicine (OPEN). Advanced materials (Deerfield Beach, Fla.). 2023-09-25. PMID:37747308. |
accordingly, we are the first to develop an oral pifithrin-α (pftα, a highly specific p53 inhibitor) embedded nanomedicine (open) to effectively treat ibd by inhibiting excessive iec apoptosis. |
2023-09-25 |
2023-10-07 |
Not clear |