| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingqing Zhao, Wei He, Zhouheng Liu, Liangliang Huang, Xiaoli Yang, Yong Liu, Rui Chen, Xun Min, Yan Yan. LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX. Cell death discovery. vol 9. issue 1. 2023-11-14. PMID:37963859. |
herein, lass2 overexpression was found to significantly inhibit proliferation, migration, invasion and induce apoptosis in hepatoma cells with wild-type (hb cell line hepg2) and mutated p53 (hcc cell line hcclm3 and cca cell line hucct1). |
2023-11-14 |
2023-11-20 |
Not clear |
| Siham Abdulzehra, Davoud Jafari-Gharabaghlou, Nosratollah Zargham. Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells. Heliyon. vol 9. issue 11. 2023-11-13. PMID:37954331. |
genes such as caspase-3, caspase-9, p53, and survivin are involved in apoptosis induction. |
2023-11-13 |
2023-11-20 |
Not clear |
| Nidhi Nigam, Jasmine George, Smita Srivastava, Preeti Roy, Kulpreet Bhui, Madhulika Singh, Yogeshwer Shukl. Retraction Note: Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis. Cancer chemotherapy and pharmacology. 2023-11-13. PMID:37955742. |
retraction note: induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in b[a]p-induced mouse skin tumorigenesis. |
2023-11-13 |
2023-11-20 |
mouse |
| Qingqing Wang, Huaifeng Liu, Zhiheng Wang, Yuxin Chen, Shujing Zhou, Xinyi Hu, Yangfei Xu, Xinxin Zhang, Yuanyuan Wang, Yu Gao, Shujing L. Circadian gene Per3 promotes astroblastoma progression through the P53/BCL2/BAX signalling pathway. Gene. 2023-11-11. PMID:37951372. |
the interference of per3 inhibited the migration and invasion of astroblastoma cells, while promoted the astroblastoma cell apoptosis and the expression of the apoptosis genes cleaved-casp3, p53, and bax. |
2023-11-11 |
2023-11-20 |
Not clear |
| Qingqing Wang, Huaifeng Liu, Zhiheng Wang, Yuxin Chen, Shujing Zhou, Xinyi Hu, Yangfei Xu, Xinxin Zhang, Yuanyuan Wang, Yu Gao, Shujing L. Circadian gene Per3 promotes astroblastoma progression through the P53/BCL2/BAX signalling pathway. Gene. 2023-11-11. PMID:37951372. |
the overexpression of per3 promoted the migration and invasion of astroblastoma cells, while inhibited the astroblastoma cell apoptosis and the expression of apoptosis genes cleaved-casp3, p53, and bax. |
2023-11-11 |
2023-11-20 |
Not clear |
| Di Zhang, Chenyang Lu, Yewen Zhou, Xuan Luo, Hongzhou Guo, Jinglin Zhang, Qiao Gao, Hui Liu, Chongxing Shang, Sheng Cu. CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway. Biology of reproduction. 2023-11-09. PMID:37944068. |
ck1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through gsk3β pathway and inhibiting foxa2 expression through p53 pathway. |
2023-11-09 |
2023-11-20 |
mouse |
| Di Zhang, Chenyang Lu, Yewen Zhou, Xuan Luo, Hongzhou Guo, Jinglin Zhang, Qiao Gao, Hui Liu, Chongxing Shang, Sheng Cu. CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway. Biology of reproduction. 2023-11-09. PMID:37944068. |
collectively, these studies reveal a role for ck1α in regulating uterine adenogenesis and provide evidence that ck1α is a novel factor regulating uterine adenogenesis by inhibiting epithelial cell apoptosis through gsk3β pathway and regulating foxa2 expression through p53 pathway. |
2023-11-09 |
2023-11-20 |
mouse |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
analysis was performed using the mtt assay to assess cell viability, flow cytometry to measure the apoptosis level, sa-β-gal staining to observe cellular senescence, and western blot to assess protein levels of trpv1, p16, p53, p21, matrix metalloproteinase (mmp)-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
both uvb irradiation and capsaicin (cap) treatment upregulated the expression of trpv1 in hacat cells, inhibited cell proliferation, promoted apoptosis, and increased the expression of p16, p53, p21, mmp-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shuhan Wang, Na Liu, Minfeng Zhou, Qifeng Lin, Mengqi Zhang, Yuju Cai, Guo Chen, Shenglan Yan. Herba Patriniae and its component Isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-08. PMID:37939611. |
herba patriniae and its component isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation. |
2023-11-08 |
2023-11-20 |
Not clear |
| Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shuhan Wang, Na Liu, Minfeng Zhou, Qifeng Lin, Mengqi Zhang, Yuju Cai, Guo Chen, Shenglan Yan. Herba Patriniae and its component Isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via p53 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-08. PMID:37939611. |
moreover, hp promoted apoptosis and suppressed cell proliferation by activating the p53 signaling pathway in a dose-dependent manner, while a similar effect was observed for isovitexin (the primary component of hp). |
2023-11-08 |
2023-11-20 |
Not clear |
| Masaoki Kohzaki, Keiji Suzuki, Akira Ootsuyama, Ryuji Okazak. Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation. npj aging. vol 9. issue 1. 2023-11-07. PMID:37935713. |
preirradiation also suppressed irradiation-induced 53bp1 repair foci in the small intestines, splenic apoptosis, and p53 activity in young mice but not middle-aged mice. |
2023-11-07 |
2023-11-20 |
mouse |
| Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi, Yibin Peng, Fan Xin, Yi Lin, Qiong Wu, Xu Lin, Wannan Che. Hepatitis B doubly spliced protein (HBDSP) promotes hepatocellular carcinoma cell apoptosis via ETS1/GATA2/YY1-mediated p53 transcription. Journal of virology. 2023-11-06. PMID:37929990. |
hepatitis b doubly spliced protein (hbdsp) promotes hepatocellular carcinoma cell apoptosis via ets1/gata2/yy1-mediated p53 transcription. |
2023-11-06 |
2023-11-08 |
Not clear |
| Monika Pebam, Mohammad Sadik Ali, Sajmina Khatun, Aravind Kumar Renga. IR-775 - Hyptis loaded bioactive nanoparticles for enhanced phyto-photothermal therapy of breast cancer cells. Photodiagnosis and photodynamic therapy. 2023-11-05. PMID:37926327. |
tumor ablation was facilitated by reactive oxygen species production and hyperthermia, leading to dna damage and apoptosis due to overexpression of ɣ-h2ax, cathepsin b, and p53, which halted cancer cell proliferation. |
2023-11-05 |
2023-11-08 |
zebrafish |
| Atakan Karagöz, Merih Beler, Büşra Dilara Altun, İsmail Ünal, Derya Cansız, Hüseyin Gündüz, Ahmet Ata Alturfan, Ebru Emekli-Alturfan, Şebnem Erçalık Yalçınkay. Panoramic dental X-ray exposure leads to oxidative stress, inflammation and apoptosis-mediated developmental defects in zebrafish embryos. Journal of stomatology, oral and maxillofacial surgery. vol 124. issue 6S. 2023-11-04. PMID:37866507. |
expressions of genes related with inflammation (tnfα, il6, ill15, il21), immunoregulation (ifng) and apoptosis (p53, bax, casp2, casp3, casp8) were determined by rt-pcr. |
2023-11-04 |
2023-11-08 |
zebrafish |
| Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevi. Apoptosis-inducing, anti-angiogenic and anti-migratory effects of a dinuclear Pd(II) complex on breast cancer: A promising novel compound. Microvascular research. vol 151. 2023-11-03. PMID:37898331. |
altered tnfr1 and tradd expression with caspase-8 cleavage followed by bcl-2 inactivation with loss of mitochondrial membrane potential confirmed the presence of apoptosis in mcf-7 and mda-mb-231, regardless of p53 expression status. |
2023-11-03 |
2023-11-08 |
Not clear |
| Durgesh Nandini Das, Bijesh Puthusseri, Venkadesaperumal Gopu, Venugopal Krishnan, Ashoka Kumar Bhagavath, Sudhir Bolla, Yogesh Saini, Gerald J Criner, Nathaniel Marchetti, Hua Tang, Nagarjun V Konduru, Liang Fan, Sreerama Shett. Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury. American journal of physiology. Lung cellular and molecular physiology. vol 325. issue 5. 2023-11-02. PMID:37642665. |
notably, induction of pai-1 expression via increased caveolin-1 and p53 contributed to mucous cell metaplasia and mucus hypersecretion in aecs, and reduced at2 viability, due to increased senescence and apoptosis, which was abrogated by csp7. |
2023-11-02 |
2023-11-08 |
mouse |
| Eman E Mohamed, Osama M Ahmed, Khairy M A Zoheir, Ahmed A G El-Shahawy, Shadi Tamur, Anwar Shams, Jack T Burcher, Anupam Bishayee, Adel Abdel-Monei. Naringin-Dextrin Nanocomposite Abates Diethylnitrosamine/Acetylaminofluorene-Induced Lung Carcinogenesis by Modulating Oxidative Stress, Inflammation, Apoptosis, and Cell Proliferation. Cancers. vol 15. issue 20. 2023-10-30. PMID:37894468. |
regarding the effect on apoptosis, both naringin and nar-dx-ncs significantly reduced bcl-2 and increased bax and p53 expressions. |
2023-10-30 |
2023-11-08 |
rat |
| Fang-Tsyr Lin, Kang Liu, Lidija A Wilhelms Garan, Helena Folly-Kossi, Yongcheng Song, Shwu-Jiuan Lin, Weei-Chin Li. A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 44. 2023-10-25. PMID:37878724. |
this leads to the activation of e2f1-mediated apoptosis and the inhibition of mutant p53 gain of function. |
2023-10-25 |
2023-11-08 |
Not clear |
| Tanaya Chatterjee, Deblina Guha, Jesmita Dhar, Taniya Saha, Debamita Paul, Gaurisankar Sa, Pinak Chakrabart. Adenosine dialdehyde, a methyltransferase inhibitor, induces colorectal cancer cells apoptosis by regulating PIMT:p53 interaction. Biochemical and biophysical research communications. vol 684. 2023-10-23. PMID:37871521. |
adenosine dialdehyde, a methyltransferase inhibitor, induces colorectal cancer cells apoptosis by regulating pimt:p53 interaction. |
2023-10-23 |
2023-11-08 |
Not clear |