| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olanrewaju Ayodeji Durojaye, Abeeb Abiodun Yekeen, Mukhtar Oluwaseun Idris, Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Bennett Chima Nwangum. Investigation of the MDM2-binding potential of de novo designed peptides using enhanced sampling simulations. International journal of biological macromolecules. 2024-04-28. PMID:38679255. |
the tumor suppressor p53 plays a crucial role in cellular responses to various stresses, regulating key processes such as apoptosis, senescence, and dna repair. |
2024-04-28 |
2024-05-01 |
human |
| Jiawei Cai, Yunpeng Li, Bohao Zhao, Zhiyuan Bao, Jiali Li, Shaoning Sun, Yang Chen, Xinsheng W. N-Acetylcysteine Alleviates D-Galactose-Induced Injury of Ovarian Granulosa Cells in Female Rabbits by Regulating the PI3K/Akt/mTOR Signaling Pathway. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671832. |
in conclusion, nac can reduce the expression of bax, p53, and caspase-9 genes, inhibit the apoptosis of gcs, improve cell viability, and resist d-gal-induced oxidative stress by increasing the activity of cat, gsh, and sod. |
2024-04-27 |
2024-04-29 |
cat |
| Anbiao Wu, Chongbin Zhong, Xudong Song, Wen Yuan, Mintian Tang, Tao Shu, Houda Huang, Pingzhen Yang, Qicai Li. The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis. iScience. vol 27. issue 5. 2024-04-26. PMID:38660406. |
p53 was identified as a mutual downstream effector for both lbh-cryab-modulated apoptosis and ferroptosis inhibition. |
2024-04-26 |
2024-04-28 |
mouse |
| Peiqi Ding, Yan Zhang, Yuxi H. Risk factors for pterygium: latest research progress on major pathogenesis. Experimental eye research. 2024-04-18. PMID:38636803. |
we evaluated the pathogenetic factors ultraviolet radiation, viral infection, tumor suppressor genes p53, growth factors, oxidative stress, apoptosis and neuropeptides in the progression of the disease. |
2024-04-18 |
2024-04-21 |
Not clear |
| Tian Xia, Runzhi Zh. Multiple molecular and cellular mechanisms of the antitumour effect of dihydromyricetin (Review). Biomedical reports. vol 20. issue 5. 2024-04-17. PMID:38628627. |
in different types of cancer cells, dhm can regulate the pi3k/akt pathway, mtor, and nf-κb pathway components, such as p53, and endoplasmic reticulum stress can alter the accumulation of ros or induce autophagy to promote the apoptosis of tumour cells. |
2024-04-17 |
2024-04-19 |
Not clear |
| Zuzana Fabová, Barbora Loncová, Abdel Halim Harrath, Alexander V Sirotki. Does the miR-105-1-Kisspeptin Axis Promote Ovarian Cell Functions? Reproductive sciences (Thousand Oaks, Calif.). 2024-04-17. PMID:38632222. |
the expression levels of mir-105-1, viability, proliferation (accumulation of pcna, cyclin b1, xtt-, and brdu-positive cells), apoptosis (accumulation of bcl-2, bax, caspase 3, p53, tunel-positive cells), proportion of kisspeptin-positive cells, and the release of steroid hormones and igf-i were analyzed. |
2024-04-17 |
2024-04-20 |
Not clear |
| Jillian A Bristol, Scott E Nelson, Makoto Ohashi, Alejandro Casco, Mitchell Hayes, Erik A Ranheim, Abigail S Pawelski, Deo R Singh, Daniel J Hodson, Eric C Johannsen, Shannon C Kenne. Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice. PLoS pathogens. vol 20. issue 4. 2024-04-15. PMID:38620028. |
suppression of myc-induced apoptosis, often through mutation of the tp53 (p53) gene or inhibition of pro-apoptotic bcl2l11 (bim) gene expression, is required for development of myc-driven bls. |
2024-04-15 |
2024-04-18 |
mouse |
| Jiansheng Zhu, Mingtao Huang, Peiyun Jiang, Jingyu Wang, Renfei Zhu, Chunlan Li. Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio). Chemosphere. 2024-04-15. PMID:38621487. |
besides, myc activated autophagy through enhanced expression of the lc3-ii protein and suppressed expression of the p62 protein and autophagosome formation, subsequently triggering apoptosis by upregulating apoptotic genes (p53, bax, bcl-2 and caspase 3) and the cleaved caspase-3 protein in zebrafish and pc12 cells. |
2024-04-15 |
2024-04-18 |
zebrafish |
| Lucas de Freitas Pedrosa, Dimitrios Kouzounis, Henk Schols, Paul de Vos, João Paulo Fab. Assessing high-temperature and pressure extraction of bioactive water-soluble polysaccharides from passion fruit mesocarp. Carbohydrate polymers. vol 335. 2024-04-14. PMID:38616103. |
it was observed that lw-mp3 and 4 upregulated the p53 protein, indicating cell-cycle arrest and the cleaved caspase-9 in one of the cell lines, with lw-mp4 enhancing cell death by apoptosis. |
2024-04-14 |
2024-04-17 |
Not clear |
| Yi Liu, Liyuan Lin, Haiyan Zheng, Huixue Huang, Zhong-Ji Qia. Microalgae Octapeptide IIAVEAGC Alleviates Oxidative Stress and Neurotoxicity in 6-OHDA-Induced SH-SY5Y Cells by Regulating the Nrf2/HO-1 and Jak2/Stat3 Pathways. Chemistry & biodiversity. 2024-04-09. PMID:38594219. |
regarding apoptosis, iec protected cells by increasing the bcl-2/bax ratio, inhibiting the caspase cascade, acting on p53, and modulating the jak2/stat3 pathway. |
2024-04-09 |
2024-04-12 |
Not clear |
| Mi-Yeun Kim, Eun-Ran Park, Eung-Ho Cho, Sun-Hoo Park, Chul Ju Han, Sang-Bum Kim, Man Bock Gu, Hyun-Jin Shin, Kee-Ho Le. Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status. Scientific reports. vol 14. issue 1. 2024-04-08. PMID:38580756. |
psmd1 depletion induced cell cycle arrest in g2/m phase, dna damage and apoptosis of cancer cells, irrespective of the p53 status. |
2024-04-08 |
2024-04-10 |
Not clear |
| Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S Mohaamed, Beneen M Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Morias. A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes. Cell biochemistry and function. vol 42. issue 3. 2024-04-08. PMID:38583080. |
the study's findings indicated that nar: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (bax, caspase9, and p53) and downregulation of the antiapoptotic gene bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin d1 levels, (6) reduces the expression of cyclin-dependent kinases (cdk4, cdk6, and cdk7) and antiapoptotic genes (bcl2, x-iap, and c-iap-2) in crc cells. |
2024-04-08 |
2024-04-10 |
human |
| Xiao-Yun Niu, Xi-Xiu Xie, Hou-Zhen Tuo, Cui-Ping Lv, Ya-Ru Huang, Jie Zhu, Shi-Yu Liang, Xiao-Yu Du, Cheng-Gang Yang, Sheng-Jie Hou, Xiao-Ying Sun, Ling-Jie Li, Fang Cui, Qi-Xin Huang, Ying-Bo Jia, Yu-Jiong Wang, Rui-Tian Li. Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson's disease. Cell death discovery. vol 10. issue 1. 2024-04-08. PMID:38589400. |
α-syn oligomers which formed from monomers increase the expression of p-p38, p53, c-caspase9, c-caspase3 and bax, decrease the level of bcl-2, cause mitochondrial damage and lead to oxidative stress, thus inducing neuronal apoptosis. |
2024-04-08 |
2024-04-11 |
mouse |
| Seyedeh Zahra Bahojb Mahdavi, Nasser Pouladi, Mohammad Amini, Behzad Baradaran, Souzan Najafi, Shiva Vaghef Mehrabani, Amirhossein Yari, Sania Ghobadi Alamdari, Amir Ali Mokhtarzade. Let-7a-3p overexpression increases chemosensitivity to carmustine and synergistically promotes autophagy and suppresses cell survival in U87MG glioblastoma cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-04-08. PMID:38587542. |
combination treatment of let-7a-3p and carmustine synergistically increased arrested cells and induced apoptosis through regulating involved genes including p53, caspase-3, bcl-2, and bax. |
2024-04-08 |
2024-04-10 |
human |
| Zhitong Lin, Chen Liu, Ziqin Yan, Jing Cheng, Xiancheng Wang, Feilong Zhou, Xilin Lyu, Shiyan Zhang, Daizhou Zhang, Xiangjing Meng, Yujun Zha. Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction. European journal of medicinal chemistry. vol 270. 2024-04-06. PMID:38581730. |
mechanistic studies show that 2 and 22 dose-dependently activated p53 and its target genes and induced apoptosis in cells based on the western blot, qpcr, and flow cytometry assays. |
2024-04-06 |
2024-04-10 |
Not clear |
| Heba A S El-Nashar, Mahmood A Al-Azzawi, Hassan Hadi Al-Kazzaz, Yasemin Khudiar Alghanimi, Shaden Mohamed Kocaebli, Moaz Alhmammi, Ahmed Asad, Tarek Salam, Mohamed El-Shazly, Mohamed A M Al. HPLC-ESI/MS-MS metabolic profiling of white pitaya fruit and cytotoxic potential against cervical cancer: Comparative studies, synergistic effects, and molecular mechanistic approaches. Journal of pharmaceutical and biomedical analysis. vol 244. 2024-04-06. PMID:38581932. |
besides, rt-pcr and western blotting analysis showed downregulation of bcl-2 and overexpression of p53, bax among hela cells treated with pitaya extracts, which eventually activated apoptosis process. |
2024-04-06 |
2024-04-10 |
Not clear |
| Fengdong Zhang, Yanrui Yue, Jian Chen, Pan Xiao, Hui Ma, Jia Feng, Mingming Yang, Yuna Mi. Albumen exosomes alleviate LPS-induced inflammation of intestinal epithelial cells via miR-22/ATM/p53/NF-κB axis. International journal of biological macromolecules. 2024-04-04. PMID:38574929. |
there were 278 mirnas and 45 proteins with higher expression levels in albumen exosomes, and they were mainly involved in immune responses and programmed cell death pathways, including apoptosis and p53 signaling pathway. |
2024-04-04 |
2024-04-07 |
Not clear |
| Meiwen Lv, Xuelian Li, Zhihua Yin, He Yang, Baosen Zho. Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer. PloS one. vol 19. issue 4. 2024-04-02. PMID:38564630. |
according to the in vitro mts and apoptotic assays, downregulated depdc1 expression targeting p53 signaling pathway inhibited the proliferation of nsclc cells while promoting apoptosis of nsclc cells. |
2024-04-02 |
2024-04-05 |
Not clear |
| Xiaotong Duan, Jingwen Ao, Ming Yu, Sali Li, Xiaofei Li, Jianyong Zhan. Shuganning Injection Suppresses Apoptosis for Protecting Against Cantharidin-Induced Liver Injury by Network Pharmacology and Experiment Validation. ACS omega. vol 9. issue 12. 2024-04-01. PMID:38559921. |
this study found that sgni could act with 62 core therapeutic targets, regulate multiple biological processes such as apoptosis, and oxidative stress, and influence apoptotic and p53 signaling pathways to treat ctd-dili. |
2024-04-01 |
2024-04-04 |
mouse |
| Eman Mansour, Ahmed A Abd-Rabou, Mohamed A El-Atawy, Hoda A Ahmed, Ahmed F El-Farargy, Heba K Abd El-Mawgou. Induction of breast cancer cell apoptosis by novel thiouracil-fused heterocyclic compounds through boosting of Bax/Bcl-2 ratio and DFT study. Bioorganic chemistry. vol 146. 2024-03-31. PMID:38555798. |
compounds 17, 11, and 19 recorded a significant increase of p53 upregulated modulator of apoptosis (puma) expression levels in the cancerous cells. |
2024-03-31 |
2024-04-03 |
Not clear |