| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Rusi. The p53 protein - not only the guardian of the genome. Postepy biochemii. vol 70. issue 1. 2024-07-17. PMID:39016231. |
surprisingly, in mouse models, the activation of the best-studied p53 target genes encoding the inhibitor of the cell cycle (cdkn1a) or the inducers of apoptosis (e.g. noxa, puma) is dispensable for protection against cancers. |
2024-07-17 |
2024-07-19 |
mouse |
| Xiaobing Tian, Praveen R Srinivasan, Vida Tajiknia, Ashley F Sanchez Sevilla Uruchurtu, Attila A Seyhan, Benedito A Carneiro, Arielle De La Cruz, Maximilian Pinho-Schwermann, Andrew George, Shuai Zhao, Jillian Strandberg, Francesca Di Cristofano, Shengliang Zhang, Lanlan Zhou, Alexander G Raufi, Arunasalam Navaraj, Yiqun Zhang, Nataliia Verovkina, Maryam Ghandali, Dinara Ryspayeva, Wafik S El-Deir. Targeting apoptotic pathways for cancer therapy. The Journal of clinical investigation. vol 134. issue 14. 2024-07-15. PMID:39007268. |
apoptosis pathways also interact with other signaling mechanisms, such as the p53 signaling pathway and the integrated stress response (isr) pathway. |
2024-07-15 |
2024-07-18 |
Not clear |
| Koanhoi Kim, Hyok-Rae Cho, Yonghae So. Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000216. |
to elucidate the connection between apoptosis and p53, the levels of p53 and p21 proteins were assessed. |
2024-07-13 |
2024-07-15 |
human |
| Jonathan K M Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H Sorense. The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation. Cell death & disease. vol 15. issue 7. 2024-07-13. PMID:39003251. |
mechanistically, eef2k deficiency blunts the activation of the dna damage response associated atm and atr pathways, in turn preventing p53 activation and therefore compromising induction of cisplatin-induced apoptosis. |
2024-07-13 |
2024-07-16 |
caenorhabditis_elegans |
| Sanaa Musa, Noor Amara, Adan Selawi, Junbiao Wang, Cristina Marchini, Abed Agbarya, Jamal Mahajn. Overcoming Chemoresistance in Cancer: The Promise of Crizotinib. Cancers. vol 16. issue 13. 2024-07-13. PMID:39001541. |
crizotinib can cause the degradation of the p53 mutant, sensitizing these cancer cells to dna-damaging substances and triggering apoptosis. |
2024-07-13 |
2024-07-15 |
Not clear |
| Cai-Jing Mo, Xiao-Yuan Deng, Ru-Lan Ma, Kun Zhu, Lei Shi, Kang L. Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, CDKN1A and TNFRSF10B. World journal of gastrointestinal oncology. vol 16. issue 6. 2024-07-12. PMID:38994171. |
sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, cdkn1a and tnfrsf10b. |
2024-07-12 |
2024-07-14 |
Not clear |
| Zijie Lin, Zhiying Cai, Lingling Li, Yekai Wei, Qufei Lin. c-Jun N-terminal kinase 1/P53 signaling mediates intrinsic apoptosis of largemouth bass (Micropterus salmoides) hepatocytes under heat stress. The Science of the total environment. 2024-07-12. PMID:38997017. |
these results not only confirm that heat stress led to intrinsic apoptosis of hepatocytes but also indicated that jnk1 could mediate p53 expression and activate caspase-dependent intrinsic apoptosis in largemouth bass hepatocytes under such conditions. |
2024-07-12 |
2024-07-15 |
Not clear |
| Han Zhang, Taotao Zheng, Chuan Qin, Xinyue Zhang, Han Lin, Xiaoping Huang, Qiang Liu, Shichuan Chang, Li Zhang, Jing Guo, Yao Zhang, Chunxiang Bian, Huawen Li. CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status. Cancer gene therapy. 2024-07-12. PMID:38997438. |
cct6a plays a role in cellular process, including the cell cycle, p53, and apoptosis signaling pathways. |
2024-07-12 |
2024-07-15 |
Not clear |
| B Haridevamuthu, S P Ramya Ranjan Nayak, Raghul Murugan, Gokul Sudhakaran, Raman Pachaiappan, K Manikandan, Vellapandian Chitra, Mikhlid H Almutairi, Bader O Almutairi, M K Kathiravan, Jesu Arockiara. Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-07-11. PMID:38992409. |
critical genes related to the antioxidant response elements (nrf2, ho1, and nqo1), apoptosis activation (bcl2, bax, and p53), and pro/anti-inflammatory cytokines (nfkb, tnfa, il1b, tgfb, il10, and il12) displayed substantial changes, highlighting the molecular mechanisms. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Yide He, Jun Hu, Rosa Freitas, Jie Gu, Guixiang Ji, Yongjun Zhan. Trace-level Gabapentin can Induce Cardiovascular Developmental Toxicity through Apoptosis in Zebrafish Larvae. Environmental pollution (Barking, Essex : 1987). 2024-07-11. PMID:38992826. |
the vascular cell apoptosis was promoted through genes like p53, bad, and bcl2. |
2024-07-11 |
2024-07-14 |
zebrafish |
| Lin Lin, Jing Ding, Simeng Liu, Chunying Liu, Qing Li, Xiang Gao, Yamei Niu, Wei-Min Ton. Protein Phosphatase 2ACα Regulates ATR-Mediated Endogenous DNA Damage Response Against Microcephaly. Molecular neurobiology. 2024-07-08. PMID:38976130. |
importantly, atr/chk1 signaling dysregulation altered both the expression and activity of several critical downstream factors including p53, p21, bcl2, and bax, which led to decreased proliferation of cortical progenitor cells and increased apoptosis in developing cortical neurons. |
2024-07-08 |
2024-07-11 |
mouse |
| Qi Tian, Chengli Liu, Jianming Liao, Guijun Wang, Wenrui Han, Xiaoxing Xiong, Zhibiao Chen, Lijuan Gu, Mingchang L. ATF2/BAP1 Axis Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage via P53 Pathway. Stroke. 2024-07-05. PMID:38965653. |
atf2/bap1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via p53 pathway. |
2024-07-05 |
2024-07-11 |
Not clear |
| Mehmet Kadir Erdogan, Ramazan Gundogdu, Yusuf Toy, Ibrahim Halil Gecibesler, Yakup Yapar, Lutfi Behcet, Gokhan Zengi. Comparison of Anticancer, Antioxidant, Enzyme Inhibitory Effects and Phytochemical Contents between Edible Lettuce (Lactuca sativa) and A New Wild Species (Lactuca anatolica). Chemistry & biodiversity. 2024-07-03. PMID:38958194. |
it was revealed that la and ls treatment at 50 µg/ml concentrations in a549 cells completely suppressed the colony forming capacity, and treatment with ic50 doses inhibited cell migration, and triggered apoptosis by regulating caspase-3, cparp, p53 and p21. |
2024-07-03 |
2024-07-06 |
Not clear |
| Ignacio Ruz-Caracuel, Tamara Caniego-Casas, Teresa Alonso-Gordoa, Irene Carretero-Barrio, Carmen Ariño-Palao, Almudena Santón, Marta Rosas, Héctor Pian, Javier Molina-Cerrillo, Patricia Luengo, José Palacio. Transcriptomic Differences in Medullary Thyroid Carcinoma According to Grade. Endocrine pathology. 2024-07-03. PMID:38958823. |
major pathways differentially expressed between high-grade and low-grade mtcs were dna damage repair, p53 signaling, cell cycle, apoptosis, and myc signaling. |
2024-07-03 |
2024-07-06 |
Not clear |
| Qian Zhang, Shuting Li, Jing Fang, Yue Hao, Junge Lu, Lu Zhang, Minmin Zhang, Li Zhang, Yihe Wang, Yu Zhang, Hongying Du, Yuan Gao, Zuosen Yang, Wei Sun, Lingjun Yan, Guowei Pa. The combined effects of polystyrene of different sizes and cadmium in mouse kidney tissues. Ecotoxicology and environmental safety. vol 281. 2024-06-29. PMID:38944012. |
an increase in the bax/bcl2 ratio and overexpression of p53 and caspase-3 revealed that renal cell apoptosis might be induced via the mitochondrial pathway. |
2024-06-29 |
2024-07-02 |
mouse |
| Yue Ni, Hongce Chen, Qiuqiang Zhan, Zhengfei Zhuan. Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis. Cellular signalling. 2024-06-29. PMID:38944257. |
taken together, pml promotes apoptosis and ferroptosis, in which the mediation of p53 and the nuclear export of pml play important roles. |
2024-06-29 |
2024-07-02 |
Not clear |
| George R Flentke, Thomas E Wilkie, Josh Baulch, Yanping Huang, Susan M Smit. Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PloS one. vol 19. issue 6. 2024-06-28. PMID:38941348. |
this was followed by reduced proliferation, stabilization of nuclear p53, and apoptosis that was prevented by overexpression of mdm2 or dominant-negative p53. |
2024-06-28 |
2024-07-01 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
the combined action of the anticancer drug with p53 supplementation in cancer cells enhances cytotoxicity, which was correlated to apoptosis activation through quantification of caspase-3 activity. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Ana Neves, Tânia Albuquerque, Rúben Faria, Cecília R A Santos, Eric Vivès, Prisca Boisguérin, Diana Carneiro, Daniel F Bruno, Maria D Pavlaki, Susana Loureiro, Ângela Sousa, Diana Cost. Evidence That a Peptide-Drug/p53 Gene Complex Promotes Cognate Gene Expression and Inhibits the Viability of Glioblastoma Cells. Pharmaceutics. vol 16. issue 6. 2024-06-27. PMID:38931902. |
our findings demonstrated the great potential of peptide tmz/p53 co-delivery complexes for cellular transfection, p53 expression, and apoptosis induction, holding promising therapeutic value toward glioblastoma. |
2024-06-27 |
2024-06-29 |
zebrafish |
| Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen, Yu Che. Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis. Cell death & disease. vol 15. issue 6. 2024-06-27. PMID:38937439. |
in turn, coronin 2b-mediated nucleolar stress leads to p53 stabilization and activation, eventually resulting in neuronal apoptosis. |
2024-06-27 |
2024-06-30 |
Not clear |