| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
however, nef mediated reduction in p53 induced apoptosis of h1299 cells was restored when nef was co-expressed with e6ap-c843a. |
2021-02-11 |
2023-08-13 |
human |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
thus, nef and e6ap co-operate to promote p53 ubiquitination and degradation in order to suppress p53 dependent apoptosis. |
2021-02-11 |
2023-08-13 |
human |
| Amjad Ali, Sabihur Rahman Farooqui, Jagdish Rai, Jyotsna Singh, Vivek Kumar, Ritu Mishra, Akhil C Banerje. HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP. Biochemical and biophysical research communications. vol 529. issue 4. 2021-02-11. PMID:32819562. |
these results establish that nef induces p53 degradation via cellular e3 ligase e6ap to inhibit apoptosis during hiv-1 infection. |
2021-02-11 |
2023-08-13 |
human |
| Vikram Shaw, Suyash Srivastava, Sanjay K Srivastav. Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy. Seminars in cancer biology. vol 68. 2021-02-10. PMID:31618686. |
antipsychotic drugs induce apoptosis and suppress metastasis in in vitro and in vivo models through mechanisms involving p53, stat3, stat5, protein phosphatase 2a, cholesterol homeostasis, integrins, autophagy, usp1, wnt/β-catenin signaling, and dna repair. |
2021-02-10 |
2023-08-13 |
Not clear |
| Shuai Gong, Shinji Maegawa, Yanwen Yang, Vidya Gopalakrishnan, Guangrong Zheng, Donghang Chen. Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6. The Biochemical journal. 2021-02-10. PMID:33245113. |
licochalcone a exhibited cytotoxicity towards human mcf-7 breast cancer cells, but not mcf-10a human breast epithelial cells, by upregulating p53 expression and blocking cell cycle progression at g2/m, followed by apoptosis. |
2021-02-10 |
2023-08-13 |
human |
| Wu-Li Zhao, Yan Xing, Cheng Ye, Yu-Han Qiu, Yi Li, Xiu-Jun Liu, Meng-Yan Wang, Chong-Wen Bi, Dan-Qing Song, Rong-Guang Sha. The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation. Acta pharmacologica Sinica. vol 41. issue 5. 2021-02-09. PMID:31932645. |
although previous studies have revealed that some sophoridine derivatives could induce dna breakage, the underlying mechanisms of inhibition of dna damage repair (atr inactivation) and the apoptosis independent of p53, have not been elucidated. |
2021-02-09 |
2023-08-13 |
Not clear |
| Vladimir J N Bykov, Natalia Issaeva, Nicole Zache, Alexandre Shilov, Monica Hultcrantz, Jan Bergman, Galina Selivanova, Klas G Wima. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. The Journal of biological chemistry. vol 292. issue 48. 2021-02-08. PMID:29196570. |
reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. |
2021-02-08 |
2023-08-13 |
human |
| Jia Huang, Tian Tu, Wenbo Wang, Guangdong Zhou, Wenjie Zhang, Xiaoli Wu, Wei Li. Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B-induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin. Photochemistry and photobiology. vol 96. issue 1. 2021-02-08. PMID:31483870. |
the results showed that aags alleviated uvb-induced cell proliferation inhibition by reducing g2 phase arrest and cell apoptosis rate as well as the gene expressions of p53, bax, caspase 3 and caspase 9, but enhancing bcl-2 expression. |
2021-02-08 |
2023-08-13 |
mouse |
| Bo Wang, Lingxia Wang, Jiahui Mao, Huiyan Wen, Longjiang Xu, Yang Ren, Hong Du, Huan Yan. Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics. Molecular medicine reports. vol 21. issue 5. 2021-02-08. PMID:32186775. |
the tumor suppressor gene, p53, is functionally involved in cell cycle control, apoptosis and genomic stability, and is mutated and inactivated in most human cancers. |
2021-02-08 |
2023-08-13 |
mouse |
| Jianjun Wang, Yunchun Li, Qianfeng Ma, Jiaxin Huan. miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth. Molecular medicine reports. vol 21. issue 6. 2021-02-08. PMID:32236628. |
moreover, mir‑378 increased the rate of apoptosis and upregulated the expression of bax and p53, and suppressed the cell cycle and downregulated the expression of cyclin d1, bcl‑2, akt, β‑catenin and survivin much more effectively in the hcc cell line by applying the combined method. |
2021-02-08 |
2023-08-13 |
Not clear |
| Mei Chou Lai, Wayne Young Liu, Shorong-Shii Liou, I-Min Li. The protective effects of moscatilin against methylglyoxal-induced neurotoxicity via the regulation of p38/JNK MAPK pathways in PC12 neuron-like cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 140. 2021-02-08. PMID:32325188. |
mgo induced cell apoptosis via the upregulation of p53, caspases 3 and poly(adp-ribose)polymerase, enhancement of cytochrome c release, and interruption of the bax/bcl-2 balance; these detrimental effects were ameliorated by moscatilin. |
2021-02-08 |
2023-08-13 |
rat |
| Guanghua Li, Bo Li, Jingang Song, Na Wang, Zhuanglei Ga. Endomorphin-2 Analog Inhibits the Growth of DLD-1 and RKO Human Colon Cancer Cells by Inducing Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-05. PMID:32336747. |
results cell proliferation of dld-1 and rko cells was inhibited by the endomorphin-2 analog in a dose-dependent manner, and a 100 µm dose reduced dld-1 and rko cell proliferation by 28% and 23%, respectively, at 72 h. endomorphin-2 analog induced cell apoptosis and the generation of ros, activated caspase-3 and caspase-9, and increased the levels of p53 and cytochrome c release, and down-regulated of akt activation in dld-1 and rko cells in a dose-dependent manner. |
2021-02-05 |
2023-08-13 |
human |
| Priyankar Sanphui, Anoy Kumar Das, Subhas C Biswa. Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease. Journal of neurochemistry. vol 154. issue 5. 2021-02-04. PMID:31971251. |
it has been reported that the transcription factor forkhead box o3a (foxo3a) is activated and induces pro-apoptotic protein such as bcl-2-interacting mediator of cell death (bim) and p53 up-regulated modulator of apoptosis (puma) in variety of neuron death paradigms. |
2021-02-04 |
2023-08-13 |
rat |
| Lei Zhou, Jie-Hui Tan, Wan-Yan Zhou, Jia Xu, Shi-Jing Ren, Zhen-Yu Lin, Xue-Mei Chen, Guo-Wei Zhan. P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis. Digestive diseases and sciences. vol 65. issue 11. 2021-02-03. PMID:31974911. |
p53 activated by er stress aggravates caerulein-induced acute pancreatitis progression by inducing acinar cell apoptosis. |
2021-02-03 |
2023-08-13 |
Not clear |
| Nehal M Elsherbiny, Nada H Eisa, Mohamed El-Sherbiny, Eman Sai. Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways. Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942000. |
crocin administration significantly suppressed the hepatic content of c-jun n-terminal kinase (c-jnk) with significant upregulation in tnf-related apoptosis-inducing ligand (trail) and caspase-8 protein expression as well as p53 gene expression; biomarkers of apoptosis. |
2021-02-03 |
2023-08-13 |
rat |
| Nehal M Elsherbiny, Nada H Eisa, Mohamed El-Sherbiny, Eman Sai. Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways. Environmental toxicology and pharmacology. vol 80. 2021-02-03. PMID:32942000. |
namely, crocin induced hepatic expression of nrf2 with downstream modulation of endogenous ho-1 and keap-1 signaling with modulation of various key players of apoptosis including; c-jnk, p53, trail, caspase-8, bax, and bcl-2. |
2021-02-03 |
2023-08-13 |
rat |
| Sara Lago, Matteo Nadai, Emanuela Ruggiero, Martina Tassinari, Maja Marušič, Beatrice Tosoni, Ilaria Frasson, Filippo M Cernilogar, Valentina Pirota, Filippo Doria, Janez Plavec, Gunnar Schotta, Sara N Richte. The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma. Nucleic acids research. vol 49. issue 2. 2021-02-03. PMID:33410915. |
the mdm2 oncogene is the master regulator of p53: its overexpression enhances p53 degradation and inhibits apoptosis, leading to the tumoral phenotype. |
2021-02-03 |
2023-08-13 |
Not clear |
| Sara Lago, Matteo Nadai, Emanuela Ruggiero, Martina Tassinari, Maja Marušič, Beatrice Tosoni, Ilaria Frasson, Filippo M Cernilogar, Valentina Pirota, Filippo Doria, Janez Plavec, Gunnar Schotta, Sara N Richte. The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma. Nucleic acids research. vol 49. issue 2. 2021-02-03. PMID:33410915. |
cell treatment with g-quadruplex-ligands reduces mdm2 expression and p53 degradation, thus stimulating cancer cell cycle arrest and apoptosis. |
2021-02-03 |
2023-08-13 |
Not clear |
| Hai Li, Tadepally Lakshmikanth, Ennio Carbone, Galina Selivanov. A novel facet of tumor suppression by p53: Induction of tumor immunogenicity. Oncoimmunology. vol 1. issue 4. 2021-02-03. PMID:22754780. |
pharmacological reactivation of the p53 tumor suppressor is a promising strategy for anti-cancer therapy due to its high potential to elicit apoptosis or growth arrest in cancer cells. |
2021-02-03 |
2023-08-12 |
Not clear |
| Jie Yang, Yu-Hang Li, Ming-Tang He, Ju-Feng Qiao, Yuan Sang, Lek Hang Cheang, Fernando Cardoso Gomes, Yang Hu, Zhen-Yan Li, Ning Liu, Huan-Tian Zhang, Zhen-Gang Zh. HSP90 regulates osteosarcoma cell apoptosis by targeting the p53/TCF-1-mediated transcriptional network. Journal of cellular physiology. vol 235. issue 4. 2021-02-02. PMID:31595984. |
furthermore, we provided evidence that p53, but not mir-34a, plays a crucial role in the hsp90-regulated tcf-1 expression and subsequent apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |