| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingchao Wang, Gaoxiong Wang, Xionghong Tan, Kun Ke, Bixing Zhao, Niangmei Cheng, Yuan Dang, Naishun Liao, Fei Wang, Xiaoyuan Zheng, Qin Li, Xiaolong Liu, Jingfeng Li. MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. Oncogenesis. vol 8. issue 12. 2021-01-10. PMID:31732712. |
the modulation of mt1g on p53 resulted in upregulation of p21 and bax, which leads cell cycle arrest and apoptosis, respectively. |
2021-01-10 |
2023-08-13 |
mouse |
| Consuelo Pitolli, Ying Wang, Eleonora Candi, Yufang Shi, Gerry Melino, Ivano Ameli. p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers. vol 11. issue 12. 2021-01-10. PMID:31835405. |
the tumor suppressor p53 regulates different cellular pathways involved in cell survival, dna repair, apoptosis, and senescence. |
2021-01-10 |
2023-08-13 |
Not clear |
| Cheng Feng, Hai-Lin Zhang, Ang Zeng, Ming Bai, Xiao-Jun Wan. Tumor-Suppressive MicroRNA-216b Binds to TPX2, Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma. Molecular therapy. Nucleic acids. vol 20. 2021-01-10. PMID:32169806. |
in response to overexpressed mir-216b or silenced tpx2, cscc cell proliferation, invasion, and migration were suppressed and apoptosis was stimulated, along with activated p53 signaling. |
2021-01-10 |
2023-08-13 |
human |
| Cheng Feng, Hai-Lin Zhang, Ang Zeng, Ming Bai, Xiao-Jun Wan. Tumor-Suppressive MicroRNA-216b Binds to TPX2, Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma. Molecular therapy. Nucleic acids. vol 20. 2021-01-10. PMID:32169806. |
thus, upregulated mir-216b was capable of promoting apoptosis and inhibiting proliferation, invasion, and migration of cscc cells by downregulating tpx2 through activation of the p53 signaling, highlighting a novel biomarker for novel treatment modalities against cscc. |
2021-01-10 |
2023-08-13 |
human |
| Yanan Wang, Jiamin Zhang, Yan Su, Chencong Wang, Gaochao Zhang, Xiao Liu, Qi Chen, Meng Lv, Yingjun Chang, Jun Peng, Ming Hou, Xiaojun Huang, Xiaohui Zhan. miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia. Molecular therapy. Nucleic acids. vol 20. 2021-01-10. PMID:32428701. |
mirna-98-5p targeting igf2bp1 induces mesenchymal stem cell apoptosis by modulating pi3k/akt and p53 in immune thrombocytopenia. |
2021-01-10 |
2023-08-13 |
mouse |
| Crystal Tonnessen-Murray, Nathan A Ungerleider, Sonia G Rao, Amanda R Wasylishen, Wesley D Frey, James G Jackso. p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer. Translational oncology. vol 11. issue 4. 2021-01-09. PMID:29852458. |
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. |
2021-01-09 |
2023-08-13 |
mouse |
| Francine Carla Cadoná, Alencar Kolinski Machado, Verônica Farina Azzolin, Fernanda Barbisan, Eduardo Bortoluzzi Dornelles, Werner Glanzner, Paulo Bayard Dias Gonçalves, Charles Elias Assmann, Euler Esteves Ribeiro, Ivana Beatrice Mânica da Cru. Guaraná a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. Anti-cancer agents in medicinal chemistry. vol 16. issue 8. 2021-01-09. PMID:26673759. |
apoptosis effect was analyzed by annexin v quantification using flow cytometry, while apoptosis pathway gene modulation (p53, bax/bcl-2 genes ratio, caspases 8 and 3) was determined by qrt-pcr analysis. |
2021-01-09 |
2023-08-13 |
Not clear |
| Francine Carla Cadoná, Alencar Kolinski Machado, Verônica Farina Azzolin, Fernanda Barbisan, Eduardo Bortoluzzi Dornelles, Werner Glanzner, Paulo Bayard Dias Gonçalves, Charles Elias Assmann, Euler Esteves Ribeiro, Ivana Beatrice Mânica da Cru. Guaraná a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation. Anti-cancer agents in medicinal chemistry. vol 16. issue 8. 2021-01-09. PMID:26673759. |
guaraná was able to induce apoptosis and up-regulate the p53 and bax/bcl-2 genes. |
2021-01-09 |
2023-08-13 |
Not clear |
| Linhe Lu, Jipeng Ma, Mingming Sun, Xiaowu Wang, Erhe Gao, Lintao Lu, Jun Ren, Lifang Yang, Jian Yan. Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus. Oxidative medicine and cellular longevity. vol 2020. 2021-01-08. PMID:32411318. |
furthermore, melatonin decreased jnk phosphorylation, reduced p53 levels, and suppressed apoptosis in hearts from the post-mi diabetic group. |
2021-01-08 |
2023-08-13 |
mouse |
| Na Zhang, Tinghui Jiang, Yitao Wang, Sen Wang, Lanyue Hu, Youquan B. BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis. Genes. vol 11. issue 2. 2021-01-07. PMID:32093041. |
btg4 is a novel p53 target gene that inhibits cell growth and induces apoptosis. |
2021-01-07 |
2023-08-13 |
mouse |
| Kinjal D Patel, Yesha V Barasiya, Jayendra B Patel, Prabhudas S Pate. Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 m-RNA expression in oral cancer. Archives of oral biology. vol 119. 2021-01-07. PMID:32987288. |
apoptosis stimulating protein of p53 (aspp) 1 and aspp2 m-rna expression in oral cancer. |
2021-01-07 |
2023-08-13 |
Not clear |
| Kinjal D Patel, Yesha V Barasiya, Jayendra B Patel, Prabhudas S Pate. Apoptosis stimulating protein of p53 (ASPP) 1 and ASPP2 m-RNA expression in oral cancer. Archives of oral biology. vol 119. 2021-01-07. PMID:32987288. |
the present study was carried out to unfold the clinical significance of apoptosis stimulating protein of p53 (aspp) 1 and aspp2 expression in oral cancer (oc). |
2021-01-07 |
2023-08-13 |
Not clear |
| Yingqiu Cheng, Shipeng Li, Yi Liu, Jinghui Li, Ye Chen, Hexiang Zha. Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-06. PMID:32221271. |
conclusions the present study demonstrated that wogonoside prevents brain edema development and apoptosis of neurons in rats by promoting sirt1 expression and suppression of p53 activation. |
2021-01-06 |
2023-08-13 |
rat |
| Monica Pibiri, Pia Sulas, Tania Camboni, Vera Piera Leoni, Gabriella Simbul. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32345994. |
previously, we demonstrated that the treatment of hepatoma cells with α-la induced apoptosis, which was preceded by the generation of reactive oxygen species (ros) and activation of the p53 protein, a known inducer of mitochondria-mediated apoptosis. |
2021-01-06 |
2023-08-13 |
Not clear |
| Lei Zhu, Xiuzhen Zhang, Ziqin Su. SNRPB promotes cervical cancer progression through repressing p53 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-04. PMID:32106364. |
moreover, we found that snrpb could directly interact with p53, and the interaction showed an essential role in modulating cervical cancer cell proliferation, migration, invasion and apoptosis. |
2021-01-04 |
2023-08-13 |
human |
| Ziqi Peng, Boyang Xu, Feng Ji. Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p. Technology in cancer research & treatment. vol 19. 2021-01-04. PMID:32462972. |
the hub genes in the protein-protein interaction network were all targeted messenger rnas of mir-1285-3p that were significantly enriched in the ubiquitin-proteasome system, apoptosis, cell cycle arrest-related pathways, and cancer-related pathways involving smad specific e3 ubiquitin protein ligase 1, β-transducin repeat containing e3 ubiquitin protein ligase, tumor protein p53 among others. |
2021-01-04 |
2023-08-13 |
Not clear |
| Mitchell W Braun, Tomoo Iwakum. Regulation of cytotoxic T-cell responses by p53 in cancer. Translational cancer research. vol 5. issue 6. 2021-01-03. PMID:28944167. |
wild-type p53 (wtp53) communicates with ctls through proteins involved in the major histocompatibility complex (mhc) class i antigen presentation pathway [e.g., transporter associated with antigen processing 1 (tap1) and endoplasmic reticulum amino peptidase 1 (erap1)], the apoptosis signal receptor fas/apo-1, and the inhibitory immune-checkpoint programmed death-ligand 1 (pd-l1). |
2021-01-03 |
2023-08-13 |
human |
| Takumi Konno, Takayuki Kohno, Tadahi Okada, Hiroshi Shimada, Seiro Satohisa, Shin Kikuchi, Tsuyoshi Saito, Takashi Kojim. ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer. Histochemistry and cell biology. vol 154. issue 2. 2021-01-01. PMID:32266459. |
apoptosis-stimulating p53 protein 2 (aspp2) is an apoptosis inducer that acts via binding with p53 and epithelial polarity molecule par3. |
2021-01-01 |
2023-08-13 |
human |
| Jung-Yeon Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Par. Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice. Antioxidants (Basel, Switzerland). vol 9. issue 12. 2020-12-29. PMID:33327548. |
further, garcinol significantly inhibited apoptosis and caspase-3 activation, with a decrease in p53 acetylation in cisplatin-injected mice. |
2020-12-29 |
2023-08-13 |
mouse |
| Jessica Gambardella, Antonella Fiordelisi, Gaetano Santulli, Michele Ciccarelli, Federica Andrea Cerasuolo, Marina Sala, Eduardo Sommella, Pietro Campiglia, Maddalena Illario, Guido Iaccarino, Daniela Sorrient. Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis. Cancers. vol 12. issue 12. 2020-12-26. PMID:33256128. |
in bht-101 cells, the pharmacologic inhibition of grk2 by krx-c7 increased p53 levels and activated apoptosis through the mitochondrial release of cytochrome c. these krx-c7-mediated events were also confirmed in cancer allograft models in nude mice. |
2020-12-26 |
2023-08-13 |
mouse |