| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun H Choi, James M Bogenberger, Raoul Tibe. Targeting Apoptosis in Acute Myeloid Leukemia: Current Status and Future Directions of BCL-2 Inhibition with Venetoclax and Beyond. Targeted oncology. vol 15. issue 2. 2020-12-04. PMID:32319019. |
furthermore, innovative approaches to target apoptosis via extrinsic pathways and p53 regulation have added new cytotoxic agents to the arsenal, including drugs that inhibit inhibitor of apoptosis protein (iap) family proteins and murine double minute 2 (mdm2). |
2020-12-04 |
2023-08-13 |
Not clear |
| Chanchal Garg, Hitender Sharma, Munish Gar. Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling-An overview. Ageing research reviews. vol 62. 2020-12-04. PMID:32721499. |
the contribution of phytochemicals to the downregulation of expression of oxidative-stress sensitive transcription factors (nrf2, nf-kb, ap-1 and p53) and protein kinases (msk, erk, jnk, p38 mapk, p90rsk2 and camks) involved in inflammation, apoptosis, immune suppression, extracellular matrix remodelling, senescence, photo ageing and photo-carcinogenesis, is also discussed. |
2020-12-04 |
2023-08-13 |
Not clear |
| Yue Lin, Fan Mao, Xiangyu Zhang, Duo Xu, Zhiying He, Jun Li, Zhiming Xiang, Yang Zhang, Ziniu Y. TRAF6 suppresses the apoptosis of hemocytes by activating pellino in Crassostrea hongkongensis. Developmental and comparative immunology. vol 103. 2020-12-01. PMID:31634519. |
furthermore, the apoptosis level of hemocytes increased after chpellino knockdown, and chpellino overexpression suppressed chtraf6-dependent p53 activation. |
2020-12-01 |
2023-08-13 |
Not clear |
| Fuquan Jin, Xueqin Chen, Hao Yan, Zhifei Xu, Bo Yang, Peihua Luo, Qiaojun H. Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory. European journal of pharmacology. vol 874. 2020-12-01. PMID:32088177. |
mechanistically, bdmc attenuates cisplatin-induced apoptosis of renal tubular epithelial cells by inhibiting cisplatin-induced up-regulation of p53. |
2020-12-01 |
2023-08-13 |
mouse |
| Mahdieh Khanahmadi, Babak Manafi, Heidar Tayebinia, Jamshid Karimi, Iraj Khodadad. Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease. EXCLI journal. vol 19. 2020-12-01. PMID:33250679. |
downregulation of sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease. |
2020-12-01 |
2023-08-13 |
human |
| Mahdieh Khanahmadi, Babak Manafi, Heidar Tayebinia, Jamshid Karimi, Iraj Khodadad. Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease. EXCLI journal. vol 19. 2020-12-01. PMID:33250679. |
since we hypothesized that the expression of p53 is modulated by sirt1, the aim of this study was to determine the expression levels of sirt1 and p53 and to investigate their correlation to apoptosis in eat of patients with coronary artery disease (cad). |
2020-12-01 |
2023-08-13 |
human |
| María-Aránzazu Martínez, Bernardo Lopez-Torres, José-Luis Rodríguez, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, Irma Are. Toxicologic evidence of developmental neurotoxicity of Type II pyrethroids cyfluthrin and alpha-cypermethrin in SH-SY5Y cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 137. 2020-11-30. PMID:32028016. |
we examine, in sh-sy5y cells, whether apoptosis and oxidative stress via reactive oxygen species (ros) generation, caspase 3/7 activation, gene expression (bax, bcl-2, casp-3, bnip3, p53 and nrf2) alterations and necrosis by release of cytosolic adenylate kinase (ak), underlie direct effects of the pyrethroids cyfluthrin and alpha-cypermethrin. |
2020-11-30 |
2023-08-13 |
Not clear |
| Tianxu Zhang, Zhenguang Yan, Xin Zheng, Shuping Wang, Juntao Fan, Zhengtao Li. Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea). Fish & shellfish immunology. vol 99. 2020-11-30. PMID:32092406. |
the results showed that ammonia poisoning could increase the activity of oxidative stress enzyme (sod and cat), inducing differentially expressed genes (dram2, gadd45, p53, bax, bcl2, casp8, casp9, casp3, hsp70 and hsp90) and different cytokines (il-1 beta, il-8, il-17 and tnf-alpha) of dna damage and apoptosis. |
2020-11-30 |
2023-08-13 |
cat |
| François Lallemand, Sophie Vacher, Leanne de Koning, Ambre Petitalot, Adrien Briaux, Keltouma Driouch, Céline Callens, Anne Schnitzler, Caroline Lecerf, Floriane Oulie-Bard, Aurélie Barbet, Anne Vincent, Sophie Zinn-Justin, Bernard S Lopez, Rosette Lidereau, Ivan Bieche, Sandrine M Caput. The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32332845. |
high expression of foxo3 protein, but not foxo1 protein, was a good prognostic marker, negatively correlated with ki67 and markers of activity of the pi3k/akt/mtor oncogenic pathway, and positively correlated with p53, a marker of apoptosis. |
2020-11-30 |
2023-08-13 |
human |
| Nathalie Satta, Rémy Weppe, Sabrina Pagano, Miguel Frias, Catherine Juillard, Nicolas Vuilleumie. Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis. Oncotarget. vol 11. issue 46. 2020-11-30. PMID:33245719. |
we observed that anti-apoa-1 antibodies induce growth arrest (in g2/m phase) and cell apoptosis through caspase 3 activation, accompanied by a selective p53 phosphorylation on serine 15. |
2020-11-30 |
2023-08-13 |
Not clear |
| Nathalie Satta, Rémy Weppe, Sabrina Pagano, Miguel Frias, Catherine Juillard, Nicolas Vuilleumie. Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis. Oncotarget. vol 11. issue 46. 2020-11-30. PMID:33245719. |
rna sequencing indicated that anti-apoa-1 iggs affect the expression of more than 950 genes belonging to five major groups of genes and respectively involved in i) cell proliferation inhibition, ii) p53 stabilisation and regulation, iii) apoptosis regulation, iv) inflammation regulation, and v) oxidative stress. |
2020-11-30 |
2023-08-13 |
Not clear |
| Yingxue Li, Bo Jiang, Ruiyin Wang, Jingyun Wang, Yachen Li, Yongming Ba. Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways. Pharmacological reports : PR. vol 72. issue 2. 2020-11-27. PMID:32048269. |
synergistic effects of tanshinone iia and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways. |
2020-11-27 |
2023-08-13 |
Not clear |
| Kaviyarasi Renu, Anusha Saravanan, Anushree Elangovan, Sineka Ramesh, Sivakumar Annamalai, Arunraj Namachivayam, Praveena Abel, Harishkumar Madhyastha, Radha Madhyastha, Masugi Maruyama, Vellingiri Balachandar, Abilash Valsala Gopalakrishna. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Life sciences. vol 260. 2020-11-27. PMID:32949585. |
oxidative stress induces mitochondrial dysfunction via apoptosis (akt-pkb, mapk, pi3/akt, pkcδ-jnk, akt/erk, p53 pathways), fibrosis (tgf-β/smad pathway), and necrosis and inflammation (tnf-α, nf-ĸb, il-1, and il-6). |
2020-11-27 |
2023-08-13 |
Not clear |
| Runze Zhao, Wanqian Liu, Mengyue Wang, Yu Zhang, Lianhong Pan, Fan Feng, Tingting Xia, Li Yan. Lysyl oxidase inhibits TNF-α induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways. Life sciences. vol 260. 2020-11-27. PMID:32979358. |
lysyl oxidase inhibits tnf-α induced rat nucleus pulposus cell apoptosis via regulating fas/fasl pathway and the p53 pathways. |
2020-11-27 |
2023-08-13 |
human |
| Qiong Man, Yi Deng, Pengjie Li, Jun Ma, Zhijun Yang, Xiujuan Yang, Yan Zhou, Xiao Ya. Licorice Ameliorates Cisplatin-Induced Hepatotoxicity Through Antiapoptosis, Antioxidative Stress, Anti-Inflammation, and Acceleration of Metabolism. Frontiers in pharmacology. vol 11. 2020-11-27. PMID:33240085. |
the experimental results indicated that gc can recover functional indices and pathological liver injury, inhibit hepatocyte apoptosis, upregulate b-cell lymphoma/leukemia 2 (bcl-2) and superoxide dismutase (sod) levels, and downregulate cellular tumor antigen p53 (p53), caspase-3, malondialdehyde high mobility group protein b1 (hmgb1), tumor necrosis factor alpha (tnf-α), and interleukin 1β (il-1β) levels. |
2020-11-27 |
2023-08-13 |
Not clear |
| Linli Wang, Xiaoqian Chen, Yingchao Wang, Lu Zhao, Xiaoping Zhao, Yi Wan. MiR-30c-5p mediates the effects of panax notoginseng saponins in myocardial ischemia reperfusion injury by inhibiting oxidative stress-induced cell damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2020-11-26. PMID:32036220. |
overexpression of mir-30c-5p increased cell viability, decreased ldh release, and reduced cell apoptosis of cardiomyocytes after tbhp stimulation, accompanied with downregulated p53 expression. |
2020-11-26 |
2023-08-13 |
human |
| Shuai Zhou, Chendi Ding, Cheng Wang, Jiajun F. UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer grafted mesoporous silica nanoparticles for drug and gene co-delivery in vitro. Materials science & engineering. C, Materials for biological applications. vol 108. 2020-11-25. PMID:31923958. |
importantly, the cytotoxicity and cell apoptosis assays confirmed that co-delivery of 5-fu and p53 gene by the cross-linked msn-g-pcaamc-b-pdmaema@5-fu/p53 induced enhanced chemotherapeutic efficacy as compared to 5-fu delivery alone. |
2020-11-25 |
2023-08-13 |
Not clear |
| Islam M Saadeldin, Fariba Moulavi, Ayman Abdel-Aziz Swelum, Sokhangouy Saiede Khorshid, Hossini-Fahraji Hamid, Sayyed Morteza Hossein. Vitrification of camel oocytes transiently impacts mitochondrial functions without affecting the developmental potential after intracytoplasmic sperm injection and parthenogenetic activation. Environmental science and pollution research international. vol 27. issue 35. 2020-11-25. PMID:33029771. |
at the molecular level, vitrification reduced mrna expression of many genes, including those related to mitochondrial function (tfam, mt-co1, mfn1, atp1a1, nrf1), pluripotency (sox2 and pou5f1), and apoptosis (p53 and bax). |
2020-11-25 |
2023-08-13 |
Not clear |
| Ji Hoon Jung, Hyemin Lee, Bo Cao, Peng Liao, Shelya X Zeng, Hua L. RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53. Oncogene. vol 39. issue 5. 2020-11-24. PMID:31591476. |
rna-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53. |
2020-11-24 |
2023-08-13 |
mouse |
| Ji Hoon Jung, Hyemin Lee, Bo Cao, Peng Liao, Shelya X Zeng, Hua L. RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53. Oncogene. vol 39. issue 5. 2020-11-24. PMID:31591476. |
here, we for the first time report that rbm10 can induce apoptosis and inhibit cancer cell proliferation by activating p53. |
2020-11-24 |
2023-08-13 |
mouse |