| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C O Contreras-Ochoa, M E López-Arellano, G Roblero-Bartolon, J Díaz-Chávez, G L Moreno-Banda, J Reyna-Figueroa, J A Munguía-Moreno, V Madrid-Marina, A Lagunas-Martíne. Molecular mechanisms of cell death induced in glioblastoma by experimental and antineoplastic drugs: New and old drugs induce apoptosis in glioblastoma. Human & experimental toxicology. vol 39. issue 4. 2020-11-02. PMID:31823663. |
caspases, bcl-2, inhibitors of apoptosis proteins (iap) family members, and p53 were identified as potential molecular targets for these drugs. |
2020-11-02 |
2023-08-13 |
mouse |
| Sidhali U Parsekar, Priyanka Velankanni, Shruti Sridhar, Paramita Haldar, Nayan A Mate, Arnab Banerjee, P K Sudhadevi Antharjanam, Aditya P Koley, Manjuri Kuma. Protein binding studies with human serum albumin, molecular docking and in vitro cytotoxicity studies using HeLa cervical carcinoma cells of Cu(ii)/Zn(ii) complexes containing a carbohydrazone ligand. Dalton transactions (Cambridge, England : 2003). vol 49. issue 9. 2020-11-02. PMID:32073070. |
compounds 1 and 2 but not 3 induced apoptosis through the mitochondrial pathway as suggested from the relative p53, caspase3 and bcl2 mrna levels measured by real-time quantitative pcr analysis. |
2020-11-02 |
2023-08-13 |
human |
| Jie Zhao, Cen Xie, Kanglong Wang, Shogo Takahashi, Kristopher W Krausz, Dasheng Lu, Qiong Wang, Yuhong Luo, Xianqiong Gong, Xiyan Mu, Qiao Wang, Suwen Su, Frank J Gonzale. Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. Toxicology letters. vol 333. 2020-11-02. PMID:32835833. |
transcriptomics profiles of the dose-dependent response to triptolide suggested that pi3k/akt, mapk, tnfα and p53 signaling pathways were the vital steps in triptolide-induced hepatocyte apoptosis. |
2020-11-02 |
2023-08-13 |
mouse |
| Tomasz Gębarowski, Benita Wiatrak, Katarzyna Gębczak, Beata Tylińska, Kazimierz Gąsiorowsk. Effect of new olivacine derivatives on p53 protein level. Pharmacological reports : PR. vol 72. issue 1. 2020-10-29. PMID:32016852. |
the p53 protein is a transcription factor for many genes, including genes involved in inhibiting cell proliferation and inducing apoptosis in genotoxically damaged and tumor-transformed cells. |
2020-10-29 |
2023-08-13 |
human |
| Ceren Sari, Ceren SÜmer, Figen Celep EyÜpoĞl. Caffeic acid phenethyl ester induces apoptosis in colorectal cancer cells via inhibition of survivin. Turkish journal of biology = Turk biyoloji dergisi. vol 44. issue 5. 2020-10-29. PMID:33110364. |
the results suggested that cape induced apoptosis by regulating p53 phosphorylation, leading to inhibition of the survivin expression. |
2020-10-29 |
2023-08-13 |
Not clear |
| Kang Zhang, Lijiang Ge, Shasha Dong, Ying Liu, Dong Wang, Chunyan Zhou, Cai Ma, Yanchao Wang, Feng Su, Yunliang Jian. Global miRNA, lncRNA, and mRNA Transcriptome Profiling of Endometrial Epithelial Cells Reveals Genes Related to Porcine Reproductive Failure Caused by Porcine Reproductive and Respiratory Syndrome Virus. Frontiers in immunology. vol 10. 2020-10-28. PMID:31231376. |
subsequently, the whole transcriptome was compared between mock- and prrsv-infected pecs and 54 differentially expressed micrornas (demirnas), 104 differentially expressed genes (degs), 22 differentially expressed lncrnas (delncrnas), and 109 isoforms were obtained, which were mainly enriched in apoptosis, necroptosis, and p53 signal pathways. |
2020-10-28 |
2023-08-13 |
Not clear |
| Lauren E Cowen, Hongwei Luo, Yi Tan. Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31511540. |
unexpectedly, loss of phosphoserine-dependent smg7 binding does not significantly affect p53 stabilization/activation, and p53-dependent cell growth arrest or apoptosis upon dna damage. |
2020-10-28 |
2023-08-13 |
Not clear |
| Qiuyun Luo, Wentao Pan, Suna Zhou, Guangfeng Wang, Hanjie Yi, Lin Zhang, Xianglei Yan, Luping Yuan, Zhenyi Liu, Jing Wang, Haibo Chen, MiaoZhen Qiu, DaJun Yang, Jian Su. A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. Oncology research. vol 28. issue 4. 2020-10-28. PMID:32093809. |
evasion of apoptosis through upregulating antiapoptotic b-cell lymphoma-2 (bcl-2) family members and p53 inactivation, and abnormal activation of b-cell receptor signaling pathway are two important pathogenic factors for dlbcl. |
2020-10-28 |
2023-08-13 |
mouse |
| Xinyu Zhou, Sietske N Zijlstra, Abel Soto-Gamez, Rita Setroikromo, Wim J Qua. Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53. Cancers. vol 12. issue 9. 2020-10-28. PMID:32899699. |
artemisinin derivatives stimulate dr5-specific trail-induced apoptosis by regulating wildtype p53. |
2020-10-28 |
2023-08-13 |
Not clear |
| Xinyu Zhou, Sietske N Zijlstra, Abel Soto-Gamez, Rita Setroikromo, Wim J Qua. Artemisinin Derivatives Stimulate DR5-Specific TRAIL-Induced Apoptosis by Regulating Wildtype P53. Cancers. vol 12. issue 9. 2020-10-28. PMID:32899699. |
we also demonstrate that dha sensitizes hct116 cells to dher-induced apoptosis via p53 regulated dr5 expression in p53 knockdown assays. |
2020-10-28 |
2023-08-13 |
Not clear |
| Ji-Hong Park, Tram Thi Ngoc Nguyen, Eun-Mi Lee, Veronica Castro-Aceituno, Ram Wagle, Kwang-Soon Lee, Juyoung Choi, Young-Han Son. Role of p53 isoforms in the DNA damage response during Drosophila oogenesis. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31391501. |
the tumor suppressor p53 is involved in the dna damage response and induces cell cycle arrest or apoptosis upon dna damage. |
2020-10-27 |
2023-08-13 |
drosophila_melanogaster |
| Ji-Hong Park, Tram Thi Ngoc Nguyen, Eun-Mi Lee, Veronica Castro-Aceituno, Ram Wagle, Kwang-Soon Lee, Juyoung Choi, Young-Han Son. Role of p53 isoforms in the DNA damage response during Drosophila oogenesis. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31391501. |
drosophila p53 encodes two isoforms, p53a and p53b, that induce apoptosis in somatic cells. |
2020-10-27 |
2023-08-13 |
drosophila_melanogaster |
| Snahlata Singh, Shyamananda Singh Mayengbam, Surbhi Chouhan, Bhavana Deshmukh, Pranay Ramteke, Dipti Athavale, Manoj Kumar Bha. Role of TNFα and leptin signaling in colon cancer incidence and tumor growth under obese phenotype. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 5. 2020-10-27. PMID:31891805. |
mechanistically, we report that tnfα induces p53 independent cell death through up regulation of p53 upregulated modulator of apoptosis (puma). |
2020-10-27 |
2023-08-13 |
mouse |
| Rui Zhao, Qianyun Yu, Long Hou, Xiaoqing Dong, Hai Zhang, Xiaoling Chen, Zhihan Zhou, Jing Ma, Shile Huang, Long Che. Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells. The international journal of biochemistry & cell biology. vol 121. 2020-10-27. PMID:32035180. |
here, we show that cd-induced ros reduced the expression of xiap, which resulted in up-regulation of murine double minute 2 homolog (mdm2) and down-regulation of p53, leading to apoptosis in pc12 cells and primary neurons. |
2020-10-27 |
2023-08-13 |
Not clear |
| Wei Wei, Cun Li. Prognostic and predictive roles of microRNA‑411 and its target STK17A in evaluating radiotherapy efficacy and their effects on cell migration and invasion via the p53 signaling pathway in cervical cancer. Molecular medicine reports. vol 21. issue 1. 2020-10-26. PMID:31746360. |
increasing mir‑411 activated the p53 signaling pathway and promoted cell apoptosis, but inhibited cell proliferation, invasion and migration. |
2020-10-26 |
2023-08-13 |
human |
| Wei Wei, Cun Li. Prognostic and predictive roles of microRNA‑411 and its target STK17A in evaluating radiotherapy efficacy and their effects on cell migration and invasion via the p53 signaling pathway in cervical cancer. Molecular medicine reports. vol 21. issue 1. 2020-10-26. PMID:31746360. |
these findings indicate that the mir‑411‑mediated direct suppression of stk17a induces apoptosis and suppresses the proliferation, migration and invasion of human cervical cancer cells via the p53 signaling pathway. |
2020-10-26 |
2023-08-13 |
human |
| Owain Roberts, Luminita Paraoa. PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP. Biochimica et biophysica acta. Reviews on cancer. vol 1874. issue 1. 2020-10-26. PMID:32679166. |
the tetraspan plasma membrane protein perp (p53 apoptosis effector related to pmp22) is a lesser-known transcriptional target of p53 and p63. |
2020-10-26 |
2023-08-13 |
human |
| Owain Roberts, Luminita Paraoa. PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP. Biochimica et biophysica acta. Reviews on cancer. vol 1874. issue 1. 2020-10-26. PMID:32679166. |
a member of the pmp22/gas3/emp membrane protein family, perp was originally identified as a p53 target specifically trans-activated during apoptosis, but not during cell-cycle arrest. |
2020-10-26 |
2023-08-13 |
human |
| Riham I El-Gogary, Sara A Abdel Gaber, Maha Nas. Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31363132. |
apoptosis was the dominant cell death mechanism, with significant up-regulation of p53 in baicalin nanocapsules treated cells. |
2020-10-23 |
2023-08-13 |
Not clear |
| Hyelim Lee, Hyeonjin Cha, Ju Hyun Par. Derivation of Cell-Engineered Nanovesicles from Human Induced Pluripotent Stem Cells and Their Protective Effect on the Senescence of Dermal Fibroblasts. International journal of molecular sciences. vol 21. issue 1. 2020-10-23. PMID:31948013. |
treatment with ipsc-cenvs significantly reduced the activity of senescence-associated-β-galactosidase (sa-β-gal) in senescent hdfs, as well as suppressing the elevated expression of p53 and p21, key factors involved in cell cycle arrest, apoptosis, and cellular senescence signaling pathways. |
2020-10-23 |
2023-08-13 |
human |