| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcel Jentsch, Petra Snyder, Caibin Sheng, Elena Cristiano, Alexander Loewe. p53 dynamics in single cells are temperature-sensitive. Scientific reports. vol 10. issue 1. 2020-11-16. PMID:32001771. |
p53, the guardian of the genome, plays a crucial role in the cellular response to dna damage by triggering cell cycle arrest, apoptosis or senescence. |
2020-11-16 |
2023-08-13 |
human |
| Kejian Shi, Jiajia An, Kun Qian, Xin Zhao, Feng Li, Xiaowei Ma, Ying Wang, Yi Zhan. p53 controls the switch between autophagy and apoptosis through regulation of PLSCR1 in sodium selenite-treated leukemia cells. Experimental cell research. vol 389. issue 1. 2020-11-13. PMID:32017928. |
p53 controls the switch between autophagy and apoptosis through regulation of plscr1 in sodium selenite-treated leukemia cells. |
2020-11-13 |
2023-08-13 |
Not clear |
| Tatiana Cardinal, Karl-Frédérik Bergeron, Rodolphe Soret, Ouliana Souchkova, Christophe Faure, Amélina Guillon, Nicolas Pilo. Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression. PLoS genetics. vol 16. issue 9. 2020-11-13. PMID:32898154. |
mechanistically, other data including chromosome conformation captured-based assays and crispr/cas9-mediated deletions suggest that ddx3y upregulation in male tasht ens progenitors is due to increased transactivation by p53, which appears especially active in these cells yet without triggering apoptosis. |
2020-11-13 |
2023-08-13 |
mouse |
| Zhimin Zou, Zhengtao Gu, Li Li, Ming Zhao, Lei S. [Role of cytoplasmic p53-mediated suppression of autophagy in heat stress-induced injury of cultured mouse aortic endothelial cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 38. issue 7. 2020-11-13. PMID:33168505. |
to explore the association of cytoplasmic p53 with autophagy and apoptosis of primary aortic endothelial cells (maecs) exposed to heat stress. |
2020-11-13 |
2023-08-13 |
mouse |
| Li-Zhen Zhang, Jin-E Yang, Yu-Wei Luo, Feng-Ting Liu, Yun-Fei Yuan, Shi-Mei Zhuan. A p53/lnc-Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 7. issue 21. 2020-11-13. PMID:33173727. |
furthermore, lnc-ip53 impedes p53 acetylation by interacting with histone deacetylase 1 (hdac1) and e1a binding protein p300 (p300) to prevent hdac1 degradation and attenuate p300 activity, resulting in abrogation of p53 activity and subsequent cell proliferation and apoptosis resistance. |
2020-11-13 |
2023-08-13 |
mouse |
| Chin-Fang Chang, Atikul Islam, Pei-Fen Liu, Jun-Han Zhan, Pin Ju Chue. Capsaicin acts through tNOX (ENOX2) to induce autophagic apoptosis in p53-mutated HSC-3 cells but autophagy in p53-functional SAS oral cancer cells. American journal of cancer research. vol 10. issue 10. 2020-11-12. PMID:33163267. |
here, we investigated the interplay between apoptosis and autophagy in capsaicin-treated oral cancer cells with either functional or mutant p53. |
2020-11-12 |
2023-08-13 |
Not clear |
| Paramvijay Singh Dhalla, Arunima Kaul, Jian Garcia, Anusha Bapatla, Raheela Khalid, Ana S Armenta-Quiroga, Safeera Kha. Comparing the Role of the p53 Gene and Telomerase Enzyme in 'Accelerated Aging Due to Cancer': A Literature Review. Cureus. vol 12. issue 10. 2020-11-12. PMID:33163298. |
in this review, we aim to explain and summarize the interdependent nature of p53, telomeres, and other conventional mechanisms of aging and cancer like inflammation, oxidative stress, uncontrolled proliferation, angiogenesis, micro ribonucleic acids (rnas), and apoptosis, with a more synergistic approach that can help in developing new therapeutics and play a potential role in shaping modern human lifespan and revolutionize cancer treatment. |
2020-11-12 |
2023-08-13 |
human |
| Yeliz Demirci, Gokhan Cucun, Yusuf Kaan Poyraz, Suhaib Mohammed, Guillaume Heger, Irene Papatheodorou, Gunes Ozha. Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Frontiers in cell and developmental biology. vol 8. 2020-11-12. PMID:33163496. |
wnt/β-catenin signaling indeed appears to control a large number of genes associated primarily with the p53, apoptosis, forkhead box o (foxo), mitogen-activated protein kinase (mapk), and mammalian target of rapamycin (mtor) signaling pathways specifically at 20 hpl. |
2020-11-12 |
2023-08-13 |
zebrafish |
| Cheng-Wei Chou, Ching-Heng Lin, Tzu-Hung Hsiao, Chia-Chien Lo, Chih-Ying Hsieh, Cheng-Chung Huang, Yuh-Pyng She. Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis. Scientific reports. vol 9. issue 1. 2020-11-10. PMID:31892709. |
therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis. |
2020-11-10 |
2023-08-13 |
Not clear |
| Cheng-Wei Chou, Ching-Heng Lin, Tzu-Hung Hsiao, Chia-Chien Lo, Chih-Ying Hsieh, Cheng-Chung Huang, Yuh-Pyng She. Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis. Scientific reports. vol 9. issue 1. 2020-11-10. PMID:31892709. |
significantly higher levels of cellular apoptosis, inhibited cell growth, and regulated lipid raft content were observed in mutant p53 lung cancer cells treated with simvastatin. |
2020-11-10 |
2023-08-13 |
Not clear |
| Xiaoyi Liu, Lihong Fan, Chengrong Lu, Shutao Yin, Hongbo H. Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress. Oxidative medicine and cellular longevity. vol 2020. 2020-11-10. PMID:32190175. |
the nuclear transcription factor p53, discovered in 1979, has a broad range of biological functions, primarily the regulation of apoptosis, the cell cycle, and dna repair. |
2020-11-10 |
2023-08-13 |
Not clear |
| Giovanna Carrà, Marcello Francesco Lingua, Beatrice Maffeo, Riccardo Taulli, Alessandro Morott. P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa. Cellular and molecular life sciences : CMLS. vol 77. issue 22. 2020-11-10. PMID:32322927. |
the onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, dna repair and angiogenesis. |
2020-11-10 |
2023-08-13 |
Not clear |
| Giovanna Carrà, Marcello Francesco Lingua, Beatrice Maffeo, Riccardo Taulli, Alessandro Morott. P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa. Cellular and molecular life sciences : CMLS. vol 77. issue 22. 2020-11-10. PMID:32322927. |
while p53 activity is associated with apoptosis induction, the stimulation of nf-κb has been demonstrated to promote resistance to programmed cell death. |
2020-11-10 |
2023-08-13 |
Not clear |
| X U Jing, Shi Feng-Qin, D U Ke-Xin, Dong Jia, L I Dong-Yu. [Mechanism of "Scutellaria barbata-Hedyotis diffusa" against breast cancer based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 18. 2020-11-10. PMID:33164375. |
in kegg pathway analysis, 37 entries related to cancer, cell cycle, apoptosis, angioge-nesis and other pathways were found, including p53 signaling pathway, erbb signaling pathway, nod like receptor signaling pathway, mapk signaling pathway, vegf signaling pathway, wnt signaling pathway and mtor signaling pathway and other classic signaling pathways. |
2020-11-10 |
2023-08-13 |
Not clear |
| Liao Zi, Zhang Jia-Qiong, F U Xian-Yun, Wang Wei, Zhuang Ming-Ya. [Study on mechanism of Rhei Radix et Rhizoma-Persicae Semen in treatment of adenomyosis based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 17. 2020-11-10. PMID:33164395. |
animal experiments proved that the effective components of rhei radix et rhizoma and persicae semen can interfere with the p53 signaling pathway and the apoptotic signaling pathway at the junction of endometrial muscle layer, increase the expression of p53 and bax in muscle layer cells, and promote the apoptosis of cells with abnormal proliferation ability. |
2020-11-10 |
2023-08-13 |
mouse |
| Hee Sung Park, Nam Ho Jeoun. Autocrine motility factor secreted by HeLa cells inhibits the growth of many cancer cells by regulating AKT/ERK signaling. Biochemical and biophysical research communications. vol 525. issue 3. 2020-11-04. PMID:32113681. |
hela ramf effectively induced apoptosis in a549 cells, apparently by reducing the levels of bcl-2, gpi, and poly(adp-ribose) polymerase (parp)14 and activating caspase-3 and p53. |
2020-11-04 |
2023-08-13 |
Not clear |
| Tingting Zheng, Keke Chen, Xue Zhang, Huanhuan Feng, Yu Shi, Li Liu, Jun Zhang, Yun Che. Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation. Aging. vol 12. issue 18. 2020-11-04. PMID:32897242. |
knockdown of txndc9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation. |
2020-11-04 |
2023-08-13 |
Not clear |
| Tingting Zheng, Keke Chen, Xue Zhang, Huanhuan Feng, Yu Shi, Li Liu, Jun Zhang, Yun Che. Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation. Aging. vol 12. issue 18. 2020-11-04. PMID:32897242. |
the apoptosis, autophagy, and cell differentiation program were blocked by p53 inhibitor treatment. |
2020-11-04 |
2023-08-13 |
Not clear |
| Tingting Zheng, Keke Chen, Xue Zhang, Huanhuan Feng, Yu Shi, Li Liu, Jun Zhang, Yun Che. Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation. Aging. vol 12. issue 18. 2020-11-04. PMID:32897242. |
in conclusion, the silencing of txndc9 induces apoptosis and autophagy in glioma and promotes cell differentiation by controlling p53 and may function as a new mechanism in glioma. |
2020-11-04 |
2023-08-13 |
Not clear |
| Shadi Rabiee Motmaen, Shima Tavakol, Mohammad T Joghataei, Mahmoud Barat. Acidic pH derived from cancer cells as a double-edged knife modulates wound healing through DNA repair genes and autophagy. International wound journal. vol 17. issue 1. 2020-11-02. PMID:31714008. |
klf4 downregulation had a direct correlation with the p53 level while acidic microenvironment promotes cells towards cell death mechanisms including apoptosis and autophagy. |
2020-11-02 |
2023-08-13 |
Not clear |