| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nipa H Patel, Jingwen Xu, Tareq Saleh, Yingliang Wu, Santiago Lima, David A Gewirt. Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells. Biochemical pharmacology. vol 175. 2020-10-22. PMID:32135156. |
this enhanced sensitivity is due to cisplatin-induced apoptosis that occurs without necessitating the restoration of functional p53. |
2020-10-22 |
2023-08-13 |
Not clear |
| Nipa H Patel, Jingwen Xu, Tareq Saleh, Yingliang Wu, Santiago Lima, David A Gewirt. Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells. Biochemical pharmacology. vol 175. 2020-10-22. PMID:32135156. |
taken together, our current studies provide evidence that nonprotective autophagy in p53wt non-small cell lung cancer cells can be "switched" to protective autophagy in isogenic crp53 cells, and furthermore that inhibition of cytoprotective autophagy is sufficient to restore cisplatin sensitivity in the crp53 cells, largely through the increased promotion of apoptosis, despite the absence of functional p53. |
2020-10-22 |
2023-08-13 |
Not clear |
| Mei-Ying Xie, Ting Chen, Qian-Yun Xi, Lian-Jie Hou, Jun-Yi Luo, Bin Zeng, Meng Li, Jia-Jie Sun, Yong-Liang Zhan. Porcine milk exosome miRNAs protect intestinal epithelial cells against deoxynivalenol-induced damage. Biochemical pharmacology. vol 175. 2020-10-22. PMID:32145262. |
in vitro, exosomes up-regulated the expression of mir-181a, mir-30c, mir-365-5p and mir-769-3p in ipec-j2 cells and then down-regulated the expression of their targeting genes in p53 pathway, ultimately attenuating don-induced damage by promoting cell proliferation and tjs and by inhibiting cell apoptosis. |
2020-10-22 |
2023-08-13 |
mouse |
| Shunlong Meng, Xi Chen, Eric Gyimah, Hai Xu, Jiazhang Che. Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub-chronic exposure to BDE-47 and BDE-153. Environmental toxicology. vol 35. issue 11. 2020-10-20. PMID:32621570. |
furthermore, a monotonically upregulation of p53 and caspase3, which are apoptotic-regulated genes, and decreased expression ratio of the anti-apoptotic b-cell lymphoma/leukaemia-2 and bcl2-associated x protein genes for all bde-47 and bde-153 treatments at 7 and 15 days indicated apoptosis induction in zebrafish liver. |
2020-10-20 |
2023-08-13 |
zebrafish |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
we demonstrate that atm and p53 differentially regulate beta cell apoptosis induced upon fundamentally different types of diabetogenic beta cell stress, including dna damage, inflammation, lipotoxicity and endoplasmic reticulum (er) stress. |
2020-10-20 |
2023-08-13 |
rat |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
dna damage induced apoptosis by treatment with the commonly used diabetogenic agent streptozotocin (stz) is regulated by both atm and p53. |
2020-10-20 |
2023-08-13 |
rat |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
while both p53 and atm control lipotoxic beta cell apoptosis, atm but not p53 fails to alter inflammatory beta cell death. |
2020-10-20 |
2023-08-13 |
rat |
| Celina Uhlemeyer, Nadine Müller, Kerstin Grieß, Corinna Wessel, Caroline Schlegel, Jennifer Kuboth, Bengt-Frederik Belgard. ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PloS one. vol 15. issue 8. 2020-10-20. PMID:32810137. |
in contrast, tunicamycin induced (er stress associated) apoptosis is further increased by atm knockdown or inhibition, but not by p53 knockdown. |
2020-10-20 |
2023-08-13 |
rat |
| Miao Zhang, Zhiqiang Wang, Baojie Li, Fengyi Sun, Anzhong Chen, Mingzhi Gon. Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway. Molecular medicine reports. vol 21. issue 3. 2020-10-19. PMID:32016449. |
moreover, the inhibition of mir‑363‑3p expression increased the expression of nrf1 and protected chondrocytes from apoptosis in vitro and in vivo, whereas the overexpression of mir‑363‑3p downregulated nrf1 expression and promoted lps‑induced chondrocyte apoptosis through the p53 pathway in vitro. |
2020-10-19 |
2023-08-13 |
rat |
| Tianpeng Wang, Xiaoxi Li, Shu-Lan Su. EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway. Anti-cancer drugs. vol 31. issue 1. 2020-10-16. PMID:31490284. |
ex527, a sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway. |
2020-10-16 |
2023-08-13 |
Not clear |
| Tianpeng Wang, Xiaoxi Li, Shu-Lan Su. EX527, a Sirt-1 inhibitor, induces apoptosis in glioma via activating the p53 signaling pathway. Anti-cancer drugs. vol 31. issue 1. 2020-10-16. PMID:31490284. |
this result suggests that ex527 induced cell apoptosis by activating p53 in glioma. |
2020-10-16 |
2023-08-13 |
Not clear |
| Tuan Wang, Xia Wu, Mus'ab Al Rudaisat, Yinjing Song, Hao Chen. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. Journal of Cancer. vol 11. issue 22. 2020-10-16. PMID:33046993. |
our results showed that curcumin induced ros accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in siha cells. |
2020-10-16 |
2023-08-13 |
human |
| Miljana Nenkov, Yunxia Ma, Daniela Haase, Zhongwei Zhou, Yong Li, Iver Petersen, Guanghua Lu, Yuan Che. Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53. Oncology reports. vol 43. issue 6. 2020-10-15. PMID:32186773. |
in the present study, the effects of this compound on cell survival, cell cycle progression, induction of apoptosis and modulation of cell signaling in p53 mutant nsclc cells (h1975, h322 and h157) and p53 wild‑type nsclc cells (a549), was investigated. |
2020-10-15 |
2023-08-13 |
Not clear |
| Juan Wang, Zhi-Qian Zhang, Fang-Qiong Li, Jia-Ning Chen, Xiaoting Gong, Bei-Bei Cao, Wei Wan. Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncology reports. vol 43. issue 6. 2020-10-15. PMID:32236588. |
activation of p53 induced apoptosis and cell cycle arrest by enhancing the activation of p53 upregulated modulator of apoptosis, caspase 9 and caspase 3, and suppressing bcl2. |
2020-10-15 |
2023-08-13 |
mouse |
| Juan Wang, Zhi-Qian Zhang, Fang-Qiong Li, Jia-Ning Chen, Xiaoting Gong, Bei-Bei Cao, Wei Wan. Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells. Oncology reports. vol 43. issue 6. 2020-10-15. PMID:32236588. |
consequently, p53 is activated, which induces apoptosis and cell cycle arrest. |
2020-10-15 |
2023-08-13 |
mouse |
| Fan Zhang, Juan Zhang, Nian Shi, Tao L. Growth-promoting effects of low-level butyl benzyl phthalate exposure on human neuroblastoma SH-SY5Y cells. Journal of applied toxicology : JAT. vol 39. issue 8. 2020-10-13. PMID:31016752. |
additionally, we confirmed 0.1 μm bbp-induced cell proliferation caused the arrest of cells in s phase and inhibited apoptosis, which might be partially explained by the decreased expression of p53, the increased expression of proliferating cell nuclear antigen, bcl-2 and cell cycle regulator cyclin-d1, and the activation of aromatase. |
2020-10-13 |
2023-08-13 |
human |
| Shah Jehan, Chen Zhong, Guangyue Li, Syed Zulqarnain Bakhtiar, Dangdang Li, Guangchao Su. Thymoquinone Selectively Induces Hepatocellular Carcinoma Cell Apoptosis in Synergism With Clinical Therapeutics and Dependence of p53 Status. Frontiers in pharmacology. vol 11. 2020-10-13. PMID:33041795. |
thymoquinone selectively induces hepatocellular carcinoma cell apoptosis in synergism with clinical therapeutics and dependence of p53 status. |
2020-10-13 |
2023-08-13 |
Not clear |
| Shuai Li, Jiadi Han, Guili Guo, Yudi Sun, Tingting Zhang, Mingyi Zhao, Yijia Xu, Yong Cui, Yanfeng Liu, Jinghai Zhan. Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS letters. vol 594. issue 3. 2020-10-07. PMID:31626714. |
here, we show that vgscs auxiliary β3 subunit, encoded by the scn3b gene, promotes proliferation and suppresses apoptosis in hepg2 cells by promoting p53 degradation. |
2020-10-07 |
2023-08-13 |
mouse |
| Shuai Li, Jiadi Han, Guili Guo, Yudi Sun, Tingting Zhang, Mingyi Zhao, Yijia Xu, Yong Cui, Yanfeng Liu, Jinghai Zhan. Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS letters. vol 594. issue 3. 2020-10-07. PMID:31626714. |
we found that β3 knockdown stabilizes p53 protein, leading to potentiation of p53-induced cell cycle arrest, senescence, and apoptosis. |
2020-10-07 |
2023-08-13 |
mouse |
| Akamu J Ewunkem, Maya Deve, Scott H Harrison, Perpetua M Mugand. Diepoxybutane induces the expression of a novel p53-target gene XCL1 that mediates apoptosis in exposed human lymphoblasts. Journal of biochemical and molecular toxicology. vol 34. issue 3. 2020-10-07. PMID:31953984. |
the tumor-suppressor p53 protein is a transcription factor that regulates a wide variety of cellular processes, including apoptosis, through its various target genes. |
2020-10-07 |
2023-08-13 |
human |