| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael I Carr, Stephen N Jone. Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Translational cancer research. vol 5. issue 6. 2020-10-01. PMID:28690977. |
in cells undergoing high amounts of dna damage, p53 can promote apoptosis, whereas in cells undergoing less damage, p53 promotes senescence or transient cell growth arrest and the expression of genes involved in dna repair, depending upon the cell type and level of damage. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hong-Yan Zhang, Wei Yang, Ji-Bin L. Knockdown of GluA2 induces apoptosis in non-small-cell lung cancer A549 cells through the p53 signaling pathway. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693266. |
knockdown of glua2 induces apoptosis in non-small-cell lung cancer a549 cells through the p53 signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Lanzhen Huang, Ang Li, Guanzhen Liao, Feicheng Yang, Jing Yang, Xu Chen, Xiaoshan Jian. Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncology letters. vol 14. issue 1. 2020-10-01. PMID:28693277. |
curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer mda-mb 231 cells via activation of p73 and puma. |
2020-10-01 |
2023-08-13 |
human |
| Zhi-Hua Li, Jin Gao, Ping-Hua Hu, Jian-Ping Xion. Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28781641. |
anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer mcf-7 cells through the upregulation of p53 expression. |
2020-10-01 |
2023-08-13 |
human |
| Zhi-Hua Li, Jin Gao, Ping-Hua Hu, Jian-Ping Xion. Anticancer effects of liriodenine on the cell growth and apoptosis of human breast cancer MCF-7 cells through the upregulation of p53 expression. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28781641. |
therefore, the present results indicated that the anticancer effects of liriodenine suppress cell growth and induce the apoptosis of human breast cancer mcf-7 cells through inhibition of bcl-2, cyclin d1 and vegf expression, and upregulation of p53 expression. |
2020-10-01 |
2023-08-13 |
human |
| Fei Hu, Xian-Ling Guo, Shan-Shan Zhang, Qiu-Dong Zhao, Rong Li, Qing Xu, Li-Xin We. Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28789429. |
the activation of p53 is associated with various anti-neoplastic functions, including cell senescence, cell cycle arrest, apoptosis and inhibition of angiogenesis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bin Zhang, Ning Yang, Zhi-Ming Mo, Shao-Peng Lin, Feng Zhan. IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28912678. |
mass spectrometry demonstrated that il-17a functioned through a series of factors associated with oxidative stress and apoptosis and regulated caspase-3 activity and apoptosis in microglial cells via the p53 and pi3k/akt signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bin Zhang, Ning Yang, Zhi-Ming Mo, Shao-Peng Lin, Feng Zhan. IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28912678. |
these findings demonstrated that ros might be located upstream of il-17a and hmgb1 so that ros can regulate hmgb1/il-17a expression to affect the p53 and pi3k/akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yangping Ding, Bingcan Chen, Zili Gao, Huayi Suo, Hang Xia. Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line. Food & nutrition research. vol 61. issue 1. 2020-10-01. PMID:29200992. |
on the other hand, o-tfdg induced hct116 cells apoptosis mainly by increasing the expression of p53, p21, and cleaved caspase-3. |
2020-10-01 |
2023-08-13 |
Not clear |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zha. Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 11. 2020-10-01. PMID:29218102. |
the pathological examinations were performed on he- stained myocardium tissues, apoptosis was determined using tunel assay, mrna expression of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53 and α7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Bowen Li, Lu Wang, Zheng Li, Weizhi Wang, Xiaofei Zhi, Xiaoxu Huang, Qiang Zhang, Zheng Chen, Xuan Zhang, Zhongyuan He, Jianghao Xu, Lu Zhang, Hao Xu, Diancai Zhang, Zekuan X. miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10. Molecular therapy. Nucleic acids. vol 9. 2020-10-01. PMID:29246308. |
notably, arhgap10 promoted mitochondria-dependent apoptosis by enhancing p53 expression, which was followed by bax trans-activation and caspase cleavage. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sushma Kalmodia, Sowmya Parameswaran, Kalaivani Ganapathy, Wenrong Yang, Colin J Barrow, Jagat R Kanwar, Kislay Roy, Madavan Vasudevan, Kirti Kulkarni, Sailaja V Elchuri, Subramanian Krishnakuma. Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma. Molecular therapy. Nucleic acids. vol 9. 2020-10-01. PMID:29246314. |
global gene expression and in silico bioinformatic analysis of gnp-hdm2-treated cells suggested that upregulation of p53 might presumptively mediate apoptosis through the induction of p53-inducible mirnas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anne Perdrix, Ahmad Najem, Sven Saussez, Ahmad Awada, Fabrice Journe, Ghanem Ghanem, Mohammad Kraye. PRIMA-1 and PRIMA-1 Cancers. vol 9. issue 12. 2020-10-01. PMID:29258181. |
prima-1 and prima-1 p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Anne Perdrix, Ahmad Najem, Sven Saussez, Ahmad Awada, Fabrice Journe, Ghanem Ghanem, Mohammad Kraye. PRIMA-1 and PRIMA-1 Cancers. vol 9. issue 12. 2020-10-01. PMID:29258181. |
the most widely investigated compounds for this purpose are prima-1 (p53 reactivation and induction of massive apoptosis )and prima-1 |
2020-10-01 |
2023-08-13 |
human |
| V Gentile, M Nicotra, S Minucci, S Ambrosi, P Saccucci, F Gloria-Bottini, E Bottin. The relationship between p53 codon 72 genetic polymorphism and sperm parameters. A study of men with varicocele. Reproductive medicine and biology. vol 14. issue 1. 2020-10-01. PMID:29259398. |
p53 has a prominent function in apoptosis and recent data suggest a relationship between varicocele and p53 codon 72 polymorphism and male infertility. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xion. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285066. |
hyperthermia exposure induces apoptosis and inhibits proliferation in hct116 cells by upregulating mir-34a and causing transcriptional activation of p53. |
2020-10-01 |
2023-08-13 |
mouse |
| Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xion. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285066. |
a number of studies have documented that hyperthermia inhibits cancer progression through transcriptional activation of p53, which promotes cell cycle arrest and apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xion. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285066. |
however, the underlying molecular mechanisms of hyperthermia-regulated apoptosis and proliferation dependent on p53 remain largely unknown. |
2020-10-01 |
2023-08-13 |
mouse |
| Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xion. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285066. |
the transcriptional activity of p53 on its consensus sequence and downstream target genes, namely p21, b cell lymphoma 2-associated x protein, mouse double minute 2 homolog, p53 upregulated modulator of apoptosis and growth arrest and dna-damage-inducible 45α, was subsequently detected. |
2020-10-01 |
2023-08-13 |
mouse |
| Zan Luo, Kangxia Zheng, Qi Fan, Xinyao Jiang, Dehai Xion. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285066. |
collectively, these findings indicate that mir-34a may serve an important role in hyperthermia-regulated apoptosis and proliferation in hct116 cells by influencing the transcriptional activity of p53. |
2020-10-01 |
2023-08-13 |
mouse |