| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie Antoun, David Atallah, Roula Tahtouh, Nada Alaaeddine, Malak Moubarak, Abir Khaddage, Eliane Nasr Ayoub, George Chahine, George Hila. Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles. Cancer cell international. vol 18. 2020-10-01. PMID:29422776. |
the aim of this study is to investigate the effect of various positions of mutations in tp53 gene on glycolysis, apoptosis and transcription of p53 target genes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lina Sun, Lei Zhao, Dan Li, Shuai Xu, Xuexin Hou, Zhenjun L. Low risk HPV-6E6 induces apoptosis in bone marrow-derived dendritic cells. Oncology letters. vol 15. issue 1. 2020-10-01. PMID:29422974. |
furthermore, the expression of apoptosis-associated proteins, including p53, bcl2 associated x apoptosis regulator (bax), bcl2 homologous antagonist/killer (bak) and cytochrome |
2020-10-01 |
2023-08-13 |
mouse |
| Ying Cao, Jianbo Cao, Binbin Yu, Shusheng Wang, Lili Liu, Li Tao, Wanping Su. Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434780. |
berbamine induces smmc-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Yao Shi, Chen Lv, Li Shi, Guanjun T. MEG3 inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434890. |
additionally, western blotting was used to detect the changes in expression of p53 and mdm2 proto-oncogene, which may be regulated by meg3, and proteins that associated with cell proliferation, invasion and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Xiong Min, Han Heng, Hua-Long Yu, Mao Dan, Chen Jie, Yun Zeng, He Ning, Zhi-Gang Liu, Zhi-Yong Wang, Wang Li. Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434958. |
anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome in order to evaluate the anticancer effect of 10-hydroxycamptothecin (hcpt) in terms of inducing the apoptosis of human osteosarcoma cells, its apoptosis-inducing molecular mechanisms were investigated. |
2020-10-01 |
2023-08-13 |
human |
| Feng Liu, Kaya Xu, Hua Yang, Yuming Li, Jian Liu, Jixiang Wang, Zhizhong Gua. A novel approach to glioma therapy using an oncolytic adenovirus with two specific promoters. Oncology letters. vol 15. issue 3. 2020-10-01. PMID:29435080. |
the p53 gene, as a tumor suppressor, regulates diverse cellular processes, including cell cycle arrest, cell autophagy, senescence and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Gholamreza Khamisipour, Elham Mansourabadi, Behrouz Naeimi, Ali Moazzeni, Rahim Tahmasebi, Mojtaba Hasanpour, Majid Mosahebi Mohammadi, Zahra Mansourabadi, Shakib Shamsia. Knockdown of microRNA-29a regulates the expression of apoptosis-related genes in MCF-7 breast carcinoma cells. Molecular and clinical oncology. vol 8. issue 2. 2020-10-01. PMID:29435304. |
the present study aimed to investigate the effects of mir-29a on the expression of genes involved in apoptosis, including p21, b-cell lymphoma 2 (bcl-2), p53 and survivin. |
2020-10-01 |
2023-08-13 |
Not clear |
| Honghong Liu, Pingping Liu, Xingxing Shi, Deling Yin, Jing Zha. NR4A2 protects cardiomyocytes against myocardial infarction injury by promoting autophagy. Cell death discovery. vol 4. 2020-10-01. PMID:29531824. |
further study showed that nr4a2 binds to p53 directly and decreases its levels when it inhibits apoptosis; thus, p53/bax is the downstream effector of nr4a2-mediated apoptosis, as previously reported. |
2020-10-01 |
2023-08-13 |
mouse |
| Shuo Tu, Xia-Li Zhang, Hui-Fang Wan, Yan-Qin Xia, Zhuo-Qi Liu, Xiao-Hong Yang, Fu-Sheng Wa. Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552188. |
western blot analysis was performed to examine the levels of p53 upregulated modulator of apoptosis (puma), bcl2, apoptosis regulator (bcl-2) and bcl2-associated x, apoptosis regulator (bax) in a549 cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhaodi Zheng, Wenzhen Zhu, Bingwu Yang, Rongfei Chai, Tingting Liu, Fenglin Li, Guanghui Ren, Shuhua Ji, Shan Liu, Guorong L. The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29552226. |
the combination decreased the protein expression of mdmx, activated p53 through the pi3k/akt signaling pathway, regulated p53 downstream target genes bcl-2 apoptosis regulator, bcl2 associated x apoptosis regulator and cleaved caspase3, subsequently inducing apoptosis in mda-mb-231 and mcf-7 breast cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Muxing Kang, Yaoyi Zhang, Xiaoli Jin, Guofeng Chen, Yi Huang, Dan Wu, Guogang Li, Jianzhen Shan, Pintong Huang, Jian Che. Concurrent Treatment with Anti-DLL4 Enhances Antitumor and Proapoptotic Efficacy of a γ-Secretase Inhibitor in Gastric Cancer. Translational oncology. vol 11. issue 3. 2020-10-01. PMID:29571073. |
following in vivo treatments, apoptosis of tumor cells and the expression of apoptosis-related genes bax, bcl-2, and p53 were detected by tunel and immunohistochemical staining. |
2020-10-01 |
2023-08-13 |
mouse |
| Ismail Ahmed Ismail, Hanan A El-Bakry, Safaa S Solima. Melatonin and tumeric ameliorate aging-induced changes: implication of immunoglobulins, cytokines, DJ-1/NRF2 and apoptosis regulation. International journal of physiology, pathophysiology and pharmacology. vol 10. issue 2. 2020-10-01. PMID:29755640. |
we also found that aging induced apoptosis promoting genes p53 and bax mrna in thymus tissues. |
2020-10-01 |
2023-08-13 |
Not clear |
| Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Hidenobu Suzuki, Ayana Nakajima, Naomi Abe, Arata Tomiyama, Koichi Ichimura, Koichi Matsuda, Toshiki Watanabe, Takahiro Ochiya, Hitoshi Nakagama, Ryuichi Sakai, Masato Enar. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell death discovery. vol 4. 2020-10-01. PMID:29760954. |
either alk inhibition or p53 activator treatment induced cell cycle arrest, whereas combination treatment induced apoptosis, and prevented tumour relapse both in vitro and in vivo. |
2020-10-01 |
2023-08-13 |
Not clear |
| Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Hidenobu Suzuki, Ayana Nakajima, Naomi Abe, Arata Tomiyama, Koichi Ichimura, Koichi Matsuda, Toshiki Watanabe, Takahiro Ochiya, Hitoshi Nakagama, Ryuichi Sakai, Masato Enar. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell death discovery. vol 4. 2020-10-01. PMID:29760954. |
this shift toward apoptosis, and away from cell-cycle arrest, in the presence of an alk inhibitor and a p53 activator, is mediated by inhibition of the alk-akt-foxo3a axis leading to a specific upregulation of sox4. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tatiana V Denisenko, Anastasia D Pivnyuk, Boris Zhivotovsk. p53-Autophagy-Metastasis Link. Cancers. vol 10. issue 5. 2020-10-01. PMID:29783720. |
p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. |
2020-10-01 |
2023-08-13 |
human |
| Lucie Bienfait, Nicky D'Haene, Xavier Catteau, Jean-Christophe Noë. PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium. Case reports in pathology. vol 2018. 2020-10-01. PMID:29854528. |
nevertheless, in endometrial lymphoepithelioma-like carcinoma, the alterations on cell cycle, apoptosis, and/or senescence secondary to p53 mutations could potentially be counterbalanced by the antitumoral response induced by cd8 cytotoxic t-lymphocytes numerous in these tumors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mokhtar Ibrahim Yousef, Dina K A M Khalil, Heba M Abdo. Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology. Toxicology reports. vol 5. 2020-10-01. PMID:29854627. |
gspe co-treatment with thalidomide and carboplatin reduced their brain and renal damage, oxidative stress, diminished cytokines, p53, neurotransmitters and biochemical parameters, and inhibited brain and renal cell apoptosis. |
2020-10-01 |
2023-08-13 |
cat |
| Omanma Adighibe, Francesco Pezzell. The Role of JMY in p53 Regulation. Cancers. vol 10. issue 6. 2020-10-01. PMID:29857553. |
following the event of dna damage, the level of tumour suppressor protein p53 increases inducing either cell cycle arrest or apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Omanma Adighibe, Francesco Pezzell. The Role of JMY in p53 Regulation. Cancers. vol 10. issue 6. 2020-10-01. PMID:29857553. |
this co-activator complex then binds to and increases the ability of p53 to induce transcription of proteins triggering apoptosis but not cell cycle arrest. |
2020-10-01 |
2023-08-13 |
Not clear |
| Omanma Adighibe, Francesco Pezzell. The Role of JMY in p53 Regulation. Cancers. vol 10. issue 6. 2020-10-01. PMID:29857553. |
this then suggests that the increase of jmy levels due to dna damage putatively "directs" p53 activity toward triggering apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |