| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akamu J Ewunkem, Maya Deve, Scott H Harrison, Perpetua M Mugand. Diepoxybutane induces the expression of a novel p53-target gene XCL1 that mediates apoptosis in exposed human lymphoblasts. Journal of biochemical and molecular toxicology. vol 34. issue 3. 2020-10-07. PMID:31953984. |
these observations demonstrate, for the first time, that xcl1 is a novel deb-induced direct p53 transcriptional target gene that mediates apoptosis in deb-exposed human lymphoblasts. |
2020-10-07 |
2023-08-13 |
human |
| Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Pierre-Jacques Hamard, James J Manfredi, Tarik Mörö. A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31004086. |
a novel regulatory circuit between p53 and gfi1 controls induction of apoptosis in t cells. |
2020-10-06 |
2023-08-13 |
Not clear |
| Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Pierre-Jacques Hamard, James J Manfredi, Tarik Mörö. A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31004086. |
here we demonstrate a mode of reciprocal regulation between gfi1 and p53 that controls the induction of apoptosis in t cells. |
2020-10-06 |
2023-08-13 |
Not clear |
| Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Pierre-Jacques Hamard, James J Manfredi, Tarik Mörö. A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31004086. |
we show that gfi1 prevents induction of p53 dependent apoptosis by recruiting lsd1 to p53, which leads to the demethylation of its c-terminal domain. |
2020-10-06 |
2023-08-13 |
Not clear |
| Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Pierre-Jacques Hamard, James J Manfredi, Tarik Mörö. A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31004086. |
this is accompanied by a decrease of the acetylation of lysine 117 within the core domain of the murine p53 protein, which is required for transcriptional induction of apoptosis. |
2020-10-06 |
2023-08-13 |
Not clear |
| Saad M Alzahrani, Paul R Eber. Attenuation of radiation toxicity by the phosphine resistance factor dihydrolipoamide dehydrogenase (DLD). Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31015501. |
a radiation resistance mutation in cep-1, the p53 orthologue, that is deficient in double strand break repair of dna and is also deficient in apoptosis causes radiation-resistance results but sensitivity toward phosphine. |
2020-10-06 |
2023-08-13 |
Not clear |
| Marco Spreafico, Alicja M Gruszka, Debora Valli, Mara Mazzola, Gianluca Deflorian, Arianna Quintè, Maria Grazia Totaro, Cristina Battaglia, Myriam Alcalay, Anna Marozzi, Anna Pistocch. HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. vol 8. 2020-10-06. PMID:33015043. |
in addition, we demonstrated that aml cell lines respond differently to pci treatment: hdac8 inhibition elicits cytotoxic effect with cell cycle arrest followed by apoptosis in thp-1 cells, and cytostatic effect in hl60 cells that lack p53. |
2020-10-06 |
2023-08-13 |
zebrafish |
| Expression of Concern: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53. Cancer biology & therapy. vol 21. issue 8. 2020-10-02. PMID:32397868. |
expression of concern: resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. |
2020-10-02 |
2023-08-13 |
Not clear |
| Mohammad Motarab Hossain, Swapan Kumar Ra. EWS Knockdown and Taxifolin Treatment Induced Differentiation and Removed DNA Methylation from p53 Promoter to Promote Expression of Puma and Noxa for Apoptosis in Ewing's Sarcoma. Journal of cancer therapy. vol 5. issue 12. 2020-10-01. PMID:27547487. |
ews knockdown and taxifolin treatment induced differentiation and removed dna methylation from p53 promoter to promote expression of puma and noxa for apoptosis in ewing's sarcoma. |
2020-10-01 |
2023-08-13 |
human |
| Ji-Hyun Lim, Natasha S Latysheva, Richard D Iggo, Daniel Barke. Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions. Cancer informatics. vol 15. 2020-10-01. PMID:27812278. |
p53 is an important regulator of cell cycle arrest, senescence, apoptosis and metabolism, and is frequently mutated in tumors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stefania Trino, Luciana De Luca, Ilaria Laurenzana, Antonella Caivano, Luigi Del Vecchio, Giovanni Martinelli, Pellegrino Must. P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia. Frontiers in pharmacology. vol 7. 2020-10-01. PMID:28018226. |
the tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, dna repair, and genomic stability. |
2020-10-01 |
2023-08-13 |
human |
| Deuk-Won Jo, Young-Kyun Kim, Pil-Young Yu. The influence of p53 mutation status on the anti-cancer effect of cisplatin in oral squamous cell carcinoma cell lines. Journal of the Korean Association of Oral and Maxillofacial Surgeons. vol 42. issue 6. 2020-10-01. PMID:28053903. |
the purpose of this study was to evaluate the anti-cancer activity of cisplatin by studying its effects on cell viability and identifying the mechanisms underlying the induction of cell cycle arrest and apoptosis on oral squamous cell carcinoma (oscc) cell lines with varying p53 mutation status. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chih-Jung Yao, Jyh-Ming Chow, Pei-Chun Lin, Tsai-Shu Hu, Hui-Ching Kuo, Jhy-Shrian Huang, Kuan-Jen Bai, Gi-Ming La. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2020-10-01. PMID:28074102. |
mir-34a is an important p53 downstream tumor suppressor, which regulates apoptosis, cell-cycle, emt (epithelial mesenchymal transition), and so forth. |
2020-10-01 |
2023-08-13 |
human |
| Chih-Jung Yao, Jyh-Ming Chow, Pei-Chun Lin, Tsai-Shu Hu, Hui-Ching Kuo, Jhy-Shrian Huang, Kuan-Jen Bai, Gi-Ming La. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2020-10-01. PMID:28074102. |
treatment with jp-1 induces p53 and its downstream p21 and bax proteins as well as the mir-34a, resulting in growth inhibition, colony formation reduction, migration repression, and apoptosis induction. |
2020-10-01 |
2023-08-13 |
human |
| Reihaneh Keshavarz, Babak Bakhshinejad, Sadegh Babashah, Narges Baghi, Majid Sadeghizade. Dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells. Iranian journal of basic medical sciences. vol 19. issue 12. 2020-10-01. PMID:28096969. |
dendrosomal nanocurcumin and p53 overexpression synergistically trigger apoptosis in glioblastoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jie Qiao, Jie Liu, Kaiqiao Jia, Ning Li, Bin Liu, Qingyu Zhang, Runzhi Zh. Diosmetin triggers cell apoptosis by activation of the p53/Bcl-2 pathway and inactivation of the Notch3/NF-κB pathway in HepG2 cells. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28101238. |
in conclusion, the present results demonstrated that dios triggered cell apoptosis by activation of the p53 signaling pathway and inhibited the nf-κb cell survival pathway by downregulation of notch3 receptor expression. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shan Xu, Zheng Yang, Yizeng Fan, Bing Guan, Jing Jia, Yang Gao, Ke Wang, Kaijie Wu, Xinyang Wang, Pengsheng Zheng, Dalin He, Peng Gu. Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28105206. |
in conclusion, the present results indicate that combined curcumin and temsirolimus treatment has a synergistic effect on apoptosis in human rcc cells, through the activation of p53. |
2020-10-01 |
2023-08-13 |
human |
| Gao Liu, Tian Xiang, Quan-Feng Wu, Wei-Xing Wan. Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28105222. |
furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of bax/bcl-2, which are downstream molecules of p53, ectopic expression of h19 inhibited curcumin-induced cell apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan Li, Kai Wang, Shankai Yin, Hongliang Zheng, Daliu Mi. Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28105237. |
furthermore, xanthohumol treatment (40 µm) induced scc4 cell apoptosis, as indicated by the significant increase in activity and expression of caspase-3, caspase-8, caspase-9, parp, p53 and aif. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan Li, Kai Wang, Shankai Yin, Hongliang Zheng, Daliu Mi. Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28105237. |
taken together, the results of the present study indicated that xanthohumol mediates growth suppression and apoptosis induction, which was mediated via the suppression of bcl-2 and mcl-1 and activation of parp, p53 and aif signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |