| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashish Kumar, T M Sivanandam, M K Thaku. Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells. Translational neuroscience. vol 7. issue 1. 2020-10-01. PMID:28123824. |
to ascertain the role of ps2 in apoptosis, mouse neuroblastoma cells (neuro2a) were transfected with a cdna construct encoding full length mouse ps2 and analyzed for viability, expression of ps1, ps2, bax and p53, bax protein, and status of chromatin condensation. |
2020-10-01 |
2023-08-13 |
mouse |
| Francesco Perri, Salvatore Pisconti, Giuseppina Della Vittoria Scarpat. P53 mutations and cancer: a tight linkage. Annals of translational medicine. vol 4. issue 24. 2020-10-01. PMID:28149884. |
main p53 functions consist in cell cycle arrest, dna repair, senescence and apoptosis induction in response to mutagenic stimuli, and, to exert those functions, p53 acts as transcriptional factor. |
2020-10-01 |
2023-08-13 |
human |
| Yi Han, Chongyu Su, Daping Yu, Shijie Zhou, Xiaoyun Song, Shuku Liu, Ming Qin, Yunsong Li, Ning Xiao, Xiaoqing Cao, Kang Shi, Xu Cheng, Zhidong Li. Cholecystokinin attenuates radiation-induced lung cancer cell apoptosis by modulating p53 gene transcription. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337291. |
cholecystokinin attenuates radiation-induced lung cancer cell apoptosis by modulating p53 gene transcription. |
2020-10-01 |
2023-08-13 |
mouse |
| Li Yang, Wei Zhao, Ping Wei, Wenshu Zuo, Shouhui Zh. Tumor suppressor p53 induces miR-15a processing to inhibit neuronal apoptosis inhibitory protein (NAIP) in the apoptotic response DNA damage in breast cancer cell. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337296. |
tumor suppressor p53 induces mir-15a processing to inhibit neuronal apoptosis inhibitory protein (naip) in the apoptotic response dna damage in breast cancer cell. |
2020-10-01 |
2023-08-13 |
human |
| Li Yang, Wei Zhao, Ping Wei, Wenshu Zuo, Shouhui Zh. Tumor suppressor p53 induces miR-15a processing to inhibit neuronal apoptosis inhibitory protein (NAIP) in the apoptotic response DNA damage in breast cancer cell. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337296. |
the results showed that neuronal apoptosis inhibitory protein (naip) was negatively regulated by p53 in mcf-7 cells, and naip expression was still high in bleomycin-treated mcf-7 cells. |
2020-10-01 |
2023-08-13 |
human |
| Nalini Mehta, Johnathan G Lyon, Ketki Patil, Nassir Mokarram, Christine Kim, Ravi V Bellamkond. Bacterial Carriers for Glioblastoma Therapy. Molecular therapy oncolytics. vol 4. 2020-10-01. PMID:28345020. |
these carriers can induce apoptosis via hypoxia-controlled expression of a tumor suppressor protein p53 and a pro-apoptotic drug, azurin. |
2020-10-01 |
2023-08-13 |
human |
| Rui Liu, Ping Ji, Bin Liu, Haishi Qiao, Xia Wang, Likun Zhou, Ting Deng, Yi B. Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis. Oncology letters. vol 13. issue 2. 2020-10-01. PMID:28356995. |
apigenin has been reported to elevate p53, a critical molecule in the induction of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rima Manafi Shabestari, Majid Safa, Mehdi Banan, Ahmad Kazem. Cyclic AMP-Induced p53 Destabilization is Independent of CREB in Pre-B Acute Lymphoblastic Leukemia Cells. International journal of molecular and cellular medicine. vol 5. issue 4. 2020-10-01. PMID:28357198. |
elevated camp levels in b-cell precursor acute lymphoblastic leukemia (bcp-all) cells attenuate the doxorubicin-induced p53 accumulation and protect cells against apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rima Manafi Shabestari, Majid Safa, Mehdi Banan, Ahmad Kazem. Cyclic AMP-Induced p53 Destabilization is Independent of CREB in Pre-B Acute Lymphoblastic Leukemia Cells. International journal of molecular and cellular medicine. vol 5. issue 4. 2020-10-01. PMID:28357198. |
in the present study, we investigated the role of creb on inhibitory effect of camp on apoptosis and p53 accumulation in bcp-all nalm-6 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rima Manafi Shabestari, Majid Safa, Mehdi Banan, Ahmad Kazem. Cyclic AMP-Induced p53 Destabilization is Independent of CREB in Pre-B Acute Lymphoblastic Leukemia Cells. International journal of molecular and cellular medicine. vol 5. issue 4. 2020-10-01. PMID:28357198. |
p53 protein level and apoptosis were assessed by western blot analysis and flow cytometry, respectively. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rima Manafi Shabestari, Majid Safa, Mehdi Banan, Ahmad Kazem. Cyclic AMP-Induced p53 Destabilization is Independent of CREB in Pre-B Acute Lymphoblastic Leukemia Cells. International journal of molecular and cellular medicine. vol 5. issue 4. 2020-10-01. PMID:28357198. |
although, creb plays a particularly important role in camp signaling pathway our data suggest that creb does not mediate the inhibitory effect of camp on doxorubicin-induced apoptosis and p53 accumulation in bcp-all nalm-6 cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun, Zhenli Ga. PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology letters. vol 13. issue 3. 2020-10-01. PMID:28454339. |
puma (p53 upregulated modulator of apoptosis), a member of the b-cell lymphoma 2 (bcl-2) protein family, is a pro-apoptotic protein. |
2020-10-01 |
2023-08-13 |
human |
| Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun, Zhenli Ga. PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology letters. vol 13. issue 3. 2020-10-01. PMID:28454339. |
to evaluate whether p53 is required for puma-mediated apoptosis in prostate cancer cells, p53 protein was silenced in human prostate cancer pc-3 cells by using p53 small interfering rna (sirna). |
2020-10-01 |
2023-08-13 |
human |
| Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun, Zhenli Ga. PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology letters. vol 13. issue 3. 2020-10-01. PMID:28454339. |
these results suggest that puma may mediate apoptosis of prostate cancer pc-3 cells, potentially independently of p53. |
2020-10-01 |
2023-08-13 |
human |
| Zhengfei Shan, Qingzuo Liu, Yuling Li, Jitao Wu, Dekang Sun, Zhenli Ga. PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology letters. vol 13. issue 3. 2020-10-01. PMID:28454339. |
furthermore, puma gene treatment to induce cancer cell apoptosis may be more efficient compared with p53-dependent apoptosis, where loss of p53 expression or function may lead to limited efficacy of puma expression. |
2020-10-01 |
2023-08-13 |
human |
| Jian Wu, Xiaohong Yang, Hongfei Lu, Liqiao Liu, Baohua Xu, Shuangyan Zheng, Bo Yu, Kemin Jie, Fusheng Wa. Inhibitory effect and mechanism of exogenous mammalian sterile 20-like kinase 1 on the growth of human colorectal cancer. Oncology letters. vol 13. issue 4. 2020-10-01. PMID:28454447. |
an mts colorimetric assay was used to detect cell viability, hoechst 33342 staining was used to observe cell apoptosis, and western blotting and immunohistochemistry were used to detect the levels of the proteins mst1, yes-associated protein (yap), phospho-yap1 (ser127), p53 and p53 upregulated modulator of apoptosis (puma). |
2020-10-01 |
2023-08-13 |
mouse |
| Jian Wu, Xiaohong Yang, Hongfei Lu, Liqiao Liu, Baohua Xu, Shuangyan Zheng, Bo Yu, Kemin Jie, Fusheng Wa. Inhibitory effect and mechanism of exogenous mammalian sterile 20-like kinase 1 on the growth of human colorectal cancer. Oncology letters. vol 13. issue 4. 2020-10-01. PMID:28454447. |
compared with the control group, the growth inhibition and apoptosis rates, the levels of mst1, p53 and puma, and the ratios of phospho-yap1/yap in the pegfp-mst1 and pegfp-mst1 + 5-fu groups were increased significantly (p<0.01). |
2020-10-01 |
2023-08-13 |
mouse |
| Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hick. Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia. Biomarker insights. vol 12. 2020-10-01. PMID:28469402. |
in addition, we identified molecular networks and biological pathways, among them pi3/akt, jak/stat, il-17, tgf-β, apoptosis, il-15, stat3, igf-1, fgf, mtor, vegf, nf-kb, and p53 signaling pathways, enriched for or targeted by mirnas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rabah Rashad Falah, Wamidh H Talib, Seba Jamal Shbaila. Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis. Therapeutic advances in medical oncology. vol 9. issue 4. 2020-10-01. PMID:28491145. |
combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu-Han Sun, Qiang Su, Lang Li, Xian-Tao Wang, Yuan-Xi Lu, Jia-Bao Lian. Expression of p53 in myocardium following coronary microembolization in rats and its significance. Journal of geriatric cardiology : JGC. vol 14. issue 5. 2020-10-01. PMID:28630604. |
p53 induces cell growth retardation and apoptosis through stress pathway. |
2020-10-01 |
2023-08-13 |
rat |