| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| He-Liang Zhang, Chong-Yuan Liu, Wei Ma, Lin Huang, Chang-Jian Li, Cheng-Song Li, Zhi-Wei Zhan. Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30008939. |
the present study demonstrated that these proteins in gastric mucosal atypical hyperplasia were involved in cancer-associated signaling pathways, including the p53, mitogen-activated protein kinase (mapk), cell cycle and apoptosis signaling pathways, and were involved in cellular growth, cellular proliferation, apoptosis and the humoral immune response. |
2020-10-01 |
2023-08-13 |
Not clear |
| He-Liang Zhang, Chong-Yuan Liu, Wei Ma, Lin Huang, Chang-Jian Li, Cheng-Song Li, Zhi-Wei Zhan. Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30008939. |
the results of the present study suggest that the 165 differentially expressed proteins, including s100 calcium-binding protein a6 (s100a6) and superoxide dismutase 3 (sod3) in the microenvironment of gastric mucosal atypical hyperplasia, are involved in the p53, mapk, cell cycle and apoptosis signaling pathways, and serve a function in the pathogenesis of gastric cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jing Chi, Zizhuo Li, Xiaojian Hong, Tong Zhao, Yueyue Bie, Wen Zhang, Jiaxing Yang, Ziming Feng, Zhouqi Yu, Qiannan Xu, Luqi Zhao, Weifan Liu, Yunan Gao, Hongxiao Yang, Jiemei Yang, Jiaren Liu, Wei Yan. Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats. Frontiers in physiology. vol 9. 2020-10-01. PMID:30108516. |
inhalation of hydrogen attenuates progression of chronic heart failure via suppression of oxidative stress and p53 related to apoptosis pathway in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Juling Lv, Yiqiao Xin. Effects of UV on apoptotic factors in lens epithelial cells of an animal model. Experimental and therapeutic medicine. vol 16. issue 3. 2020-10-01. PMID:30186472. |
expression levels of p53, bax, and bcl-2 in lec of rats are positively correlated with the time after uv irradiation, suggesting that uv could induce apoptosis of lec by promoting p53, bax and bcl-2 expression. |
2020-10-01 |
2023-08-13 |
rat |
| Lesetja Raymond Motadi, Mashianoke Marcia Lekganyane, Pontsho Moel. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer management and research. vol 10. 2020-10-01. PMID:30237738. |
rbbp6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lesetja Raymond Motadi, Mashianoke Marcia Lekganyane, Pontsho Moel. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer management and research. vol 10. 2020-10-01. PMID:30237738. |
however, it is not clearly defined whether the effect of rbbp6 on cell growth and apoptosis is cell line-dependent, more especially in breast cancer cell lines that have distinct p53 expression profiles. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lesetja Raymond Motadi, Mashianoke Marcia Lekganyane, Pontsho Moel. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer management and research. vol 10. 2020-10-01. PMID:30237738. |
this study aims at evaluating the effects of rbbp6 on cell growth and apoptosis in breast cancer cell lines with different p53 expressions. |
2020-10-01 |
2023-08-13 |
Not clear |
| Miran Rada, Nickolai Barlev, Salvador Maci. BTK modulates p73 activity to induce apoptosis independently of p53. Cell death discovery. vol 4. 2020-10-01. PMID:30245853. |
btk modulates p73 activity to induce apoptosis independently of p53. |
2020-10-01 |
2023-08-13 |
Not clear |
| Miran Rada, Nickolai Barlev, Salvador Maci. BTK modulates p73 activity to induce apoptosis independently of p53. Cell death discovery. vol 4. 2020-10-01. PMID:30245853. |
this effect allows btk to have pro-apoptotic functions independently of its effects on the p53 pathway and thus play an important role in the dna damage-related induction of apoptosis in the absence of p53. |
2020-10-01 |
2023-08-13 |
Not clear |
| Madhav Sankunny, Charis En. KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245854. |
klln-mediated dna damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Madhav Sankunny, Charis En. KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell death discovery. vol 4. 2020-10-01. PMID:30245854. |
klln is a target of p53 involved in s-phase cell cycle regulation deemed necessary and sufficient for p53-mediated apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuying Liu, Jiadi Lv, Bo Huan. Mediating the death of dormant tumor cells. Molecular & cellular oncology. vol 5. issue 4. 2020-10-01. PMID:30250912. |
in out recent studies, we found that ifn-β induces tumor-repopulating cells (trc) into dormancy by activating indoleamine-pyrrole 2,3-dioxygenase (ido)-kynurenine-aryl hydrocarbon receptor (ahr)-cyclin-dependent kinase inhibitor 1b (p27) pathway, while blocking this pathway leads dormant trcs to apoptosis by switching to stat3-cellular tumor antigen p53 (p53) pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ahmed A Abd-Rabou, Emad F Eskander, Mervat S Mohamed, Shaymaa M M Yahya, Ashraf El Sherbini, Olfat G Shake. P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy. Genes & diseases. vol 2. issue 2. 2020-10-01. PMID:30258864. |
p53, a key regulator of apoptosis, induces cd95 gene expression and subsequently initiates apoptotic cascade to be activated. |
2020-10-01 |
2023-08-13 |
human |
| Hee Seop Lee, Won Chul Lim, Sung Jin Lee, Seung Hyun Lee, Heui Jong Yu, Jin Hyup Lee, Hong Yon Ch. Hepatoprotective effects of lactic acid-fermented garlic extract against acetaminophen-induced acute liver injury in rats. Food science and biotechnology. vol 25. issue 3. 2020-10-01. PMID:30263347. |
this function of lafge is linked to its capacity of suppressing aap-induced apoptosis in the liver, partly via the inhibition of mapk phosphorylation as well as down-regulation of p53. |
2020-10-01 |
2023-08-13 |
rat |
| Sofie Nebenfuehr, Florian Bellutti, Veronika Sex. Cdk6: At the interface of Rb and p53. Molecular & cellular oncology. vol 5. issue 5. 2020-10-01. PMID:30263948. |
therein cdk6 antagonizes p53 responses and subsequently shapes the critical decision between survival and apoptosis in pre-leukemic cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Soo-Youl Ki. New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds. Medical sciences (Basel, Switzerland). vol 6. issue 4. 2020-10-01. PMID:30297644. |
because the binding site of gk921 overlaps with the p53-binding site of tgase 2, the drug induces apoptosis in renal cell carcinoma by stabilizing p53. |
2020-10-01 |
2023-08-13 |
mouse |
| Chen Qian, Zhongluan Wu, Roy Chun-Laam Ng, Maria-Mercè Garcia-Barceló, Zheng-Wei Yuan, Kenneth Kak Yuen Wong, Paul Kwong Hang Tam, Vincent Chi Hang Lu. Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice. Cell death and differentiation. vol 26. issue 8. 2020-10-01. PMID:30323271. |
furthermore, we showed that pdgfra was required for the survival of urorectal mesenchyme, deletion of pdgfra caused apoptosis in the peri-cloacal, the peri-urethra and the urorectal septum mesenchyme of pdgfra-cko mutants, associated with an induction of p53, ndrg1 and activation of caspase-3 in pdgfra-cko embryos. |
2020-10-01 |
2023-08-13 |
mouse |
| Madalina Andreea Badea, Mariana Prodana, Anca Dinischiotu, Carmen Crihana, Daniela Ionita, Mihaela Bala. Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells. Pharmaceutics. vol 10. issue 4. 2020-10-01. PMID:30428555. |
we also found a significant decrease of caspase-3 and p53 expression after 48 h, accompanied by a down-regulation of nf-κb in cells exposed to mwcnt-cooh-cddp system which promotes apoptosis escape and thus failing to overcome the triple negative breast cancer (tnbc) cells resistance. |
2020-10-01 |
2023-08-13 |
Not clear |
| Seon-Hyeong Lee, Won-Kyu Lee, Nayeon Kim, Joon Hee Kang, Kyung-Hee Kim, Seul-Gi Kim, Jae-Seon Lee, Soohyun Lee, Jongkook Lee, Jungnam Joo, Woo Sun Kwon, Sun Young Rha, Soo-Youl Ki. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers. vol 10. issue 11. 2020-10-01. PMID:30463244. |
inhibition of tgase 2 using streptonigrin increased p53 stability, which resulted in p53-mediated apoptosis of rcc. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alicja Sznarkowska, Anna Kostecka, Anna Kawiak, Pilar Acedo, Mattia Lion, Alberto Inga, Joanna Zawacka-Panka. Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in Cell division. vol 13. 2020-10-01. PMID:30603043. |
reactivation of tap73 tumor suppressor by protoporphyrin ix, a metabolite of aminolevulinic acid, induces apoptosis in the p73 protein is a tumor suppressor that shares structural and functional similarity with p53. |
2020-10-01 |
2023-08-13 |
Not clear |