| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gesche Frohwitter, Horst Buerger, Paul J VAN Diest, Eberhard Korsching, Johannes Kleinheinz, Thomas Fillie. Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways. Oncology letters. vol 12. issue 1. 2020-09-30. PMID:27347109. |
therefore, the present study investigated 193 cases of oral sccs using immunohistochemistry for α/β/γ-catenin, glucose transporter 1, caspase-3, x-linked inhibitor of apoptosis protein, hypoxia inducible factor-1α, carbonic anhydrase 9, heat shock protein (hsp) 70, mast/stem cell growth factor receptor, p21, p27, p16, p53, b-cell lymphoma 6, epidermal growth factor receptor, cyclin d1 and ck1, 5/6, 8/18, 10, 14 and 19. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shivani Sharma, Praveen K Patnaik, Stella Aronov, Ritu Kulshreshth. ApoptomiRs of Breast Cancer: Basics to Clinics. Frontiers in genetics. vol 7. 2020-09-30. PMID:27746811. |
recent studies have highlighted the role of mirnas in the control of apoptosis and their interplay with p53, the master guardian of apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ju-Hyun Shin, Sang-Hyun Mi. Novel functional roles of caspase-related genes in the regulation of apoptosis and autophagy. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 6. 2020-09-30. PMID:27847434. |
in conclusion, apoptosis and/or autophagy mediated by birc4 and tak1 may be regulated by p53 and caspase activity. |
2020-09-30 |
2023-08-13 |
human |
| Yohei Murakami, Shoji Takad. Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53. Biophysics (Nagoya-shi, Japan). vol 8. 2020-09-30. PMID:27857606. |
(2009) modeled the bax activation switch in the apoptosis signal transduction pathway that can rigorously "count" the number of uniform p53 pulses. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zheng Liu, Feng Wang, Zhi-Wei Zhou, He-Chun Xia, Xin-Yu Wang, Yin-Xue Yang, Zhi-Xu He, Tao Sun, Shu-Feng Zho. Alisertib induces G American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386317. |
als also bound key regulating proteins of cell cycle, apoptosis and autophagy, such as cyclin-dependent kinase 1 (cdk1/cdc2), cdk2, cyclin b1, p27 kip1, p53, cytochrome c, cleaved caspase 3, bax, bcl-2, bcl-xl, phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), mammalian target of rapamycin (mtor), 5'-adenosine monophosphate-activated protein kinase (ampk), p38 mitogen-activated protein kinase (mapk), beclin 1, phosphatase and tensin homolog (pten), and microtubule-associated protein light chain 3 (lc3). |
2020-09-30 |
2023-08-13 |
Not clear |
| Xiao-Ting Xu, Wen-Tao Hu, Ju-Ying Zhou, Yu T. Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386336. |
a combination of celecoxib and irradiation treatment induced much more γ-h2ax foci formation, higher levels of radiation injury-related proteins phosphorylation, g2/m arrest, apoptosis, and p53 and p21 expression, and lower levels of cyclin b1 in hct116 cells than those in cells treated with irradiation alone. |
2020-09-30 |
2023-08-13 |
human |
| J J Wamsley, C Gary, A Biktasova, M Hajek, G Bellinger, R Virk, N Issaeva, W G Yarbroug. Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner. Oncogenesis. vol 6. issue 4. 2020-09-30. PMID:28394357. |
interestingly, in response to dna damage, p53 seems to play an opposite role in normal and in the majority of cancer cells-wild-type p53 mediates apoptosis in healthy tissues, attributing to the side effects, whereas mutant p53 often is responsible for acquired cancer resistance to the treatment. |
2020-09-30 |
2023-08-13 |
human |
| Tian Tang, Duan-Lian Zhan. Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28529555. |
the aim of the present study was to investigate the role of b-cell lymphoma 2 (bcl-2) and tumor protein p53 (p53) in the proliferation and apoptosis of hemangioma cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Tian Tang, Duan-Lian Zhan. Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28529555. |
the higher expression of bcl-2 and p53 in proliferative hemangioma suggests that bcl-2 may cause an imbalance between endothelial cell proliferation and apoptosis through the inhibition of endothelial cell apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yu Fu, Xingqian Ye, Malcolm Lee, Gary Rankin, Yi Charlie Che. Prodelphinidins isolated from Chinese bayberry leaves induces apoptosis via the p53-dependent signaling pathways in OVCAR-3 human ovarian cancer cells. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28529565. |
these observations demonstrate that p53 is a mediator of opa and ppa-induced apoptosis in ovcar-3 cells. |
2020-09-30 |
2023-08-13 |
human |
| Shun-Yao Ko, Hshin-An Ko, Tzong-Ming Shieh, Tzong-Cherng Chi, Hong-I Chen, Yi-Ting Chen, Ya-Hui Yu, Shu-Han Yang, Shu-Shing Chan. Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28529569. |
the results of the current study demonstrated that ages inhibit the expression of nrf-2, p53 and bcl-2 associated × apoptosis regulator, and increase the expression of apoptosis regulator bcl-x protein. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jessica Flöter, Irem Kaymak, Almut Schulz. Regulation of Metabolic Activity by p53. Metabolites. vol 7. issue 2. 2020-09-30. PMID:28531108. |
while loss of p53 function lifts an important barrier to cancer development by deleting cell cycle and apoptosis checkpoints, it also removes a crucial regulatory mechanism and can render cancer cells highly sensitive to metabolic perturbation. |
2020-09-30 |
2023-08-13 |
human |
| Chris Lucchesi, Jin Zhang, Xinbin Che. Modulation of the p53 family network by RNA-binding proteins. Translational cancer research. vol 5. issue 6. 2020-09-30. PMID:28794999. |
p53 functions as a transcription factor responding to a multitude of cellular stressors, regulating the transcription of many genes involved in cell-cycle arrest, senescence, autophagy, and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bodo C Melni. Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer. Nutrition & metabolism. vol 14. 2020-09-30. PMID:28814964. |
based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk mirna-regulated gene expression of the transcription factor p53 and dna methyltransferase 1 (dnmt1), two guardians of the human genome, that control transcriptional activity, cell survival, and apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Ye Gu, Yuan Wang, Xinling Wang, Lili Gao, Weiping Yu, Wei-Feng Don. Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells. Journal of Cancer. vol 8. issue 11. 2020-09-30. PMID:28819408. |
furthermore, we also demonstrated that set7/9 suppresses cell apoptosis via modulation of e2f1 under circumstance of p53 deficiency in nsclc cells. |
2020-09-30 |
2023-08-13 |
human |
| Ji-Yeon Lee, Muhammad Mustafa, Clara Yuri Kim, Myoung Hee Ki. Depletion of CTCF in Breast Cancer Cells Selectively Induces Cancer Cell Death via p53. Journal of Cancer. vol 8. issue 11. 2020-09-30. PMID:28819414. |
here we propose that the phenotypes observed in ctcf-depleted mcf-7 cancer cells, such as reduced cell proliferation, increased apoptosis, and cell cycle arrest, are closely linked with the activation of p53. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zhi-Peng Wang, Ye Tian, Jun Li. Role of wild-type p53-induced phosphatase 1 in cancer. Oncology letters. vol 14. issue 4. 2020-09-30. PMID:28959360. |
it has been reported to dephosphorylate p53, ataxia telangiectasia mutated, checkpoint kinase 1 and p38 mitogen activated protein kinases, forming negative feedback loops to inhibit apoptosis and cell cycle arrest. |
2020-09-30 |
2023-08-13 |
human |
| Zhiqin Li, Chunfang Han, Jing Fen. Relationship of the expression levels of XIAP and p53 genes in hepatocellular carcinoma and the prognosis of patients. Oncology letters. vol 14. issue 4. 2020-09-30. PMID:28959363. |
in this study, we measured mrna and protein expression levels of x-linked inhibitor of apoptosis protein (xiap) and p53 in hepatocellular carcinoma (hcc) and analyzed their relationships to clinicopathological parameters and the prognosis of the patients. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shatadal Ghosh, Sudip Bhattacharyya, Kahkashan Rashid, Parames C Si. Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways. Toxicology reports. vol 2. 2020-09-30. PMID:28962370. |
hyperglycemia induced hepatic pathophysiology also activated stress response pathways (involving phosphorylation of p38, erk1/2 mapks and p53) and reduced mitochondrial membrane potential which in turn led to cellular apoptosis as evidenced from increased hepatic dna fragmentation as well as facs analysis. |
2020-09-30 |
2023-08-13 |
human |
| Rania Abdel Rahman Elgawish, Haidy G Abdel Rahman, Heba M A Abdelraze. Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis. Toxicology reports. vol 2. 2020-09-30. PMID:28962456. |
lipid profile, hepatic enzyme levels and apoptosis molecular marker (p53) were investigated in hamsters. |
2020-09-30 |
2023-08-13 |
Not clear |