| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziwei Fang, Jiandong Wang, Leslie H Clark, Wenchuan Sun, Yajie Yin, Weimin Kong, Stuart R Pierce, Lindsay West, Stephanie A Sullivan, Arthur-Quan Tran, Varun V Prabhu, Chunxiao Zhou, Victoria Bae-Jum. ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro. American journal of cancer research. vol 8. issue 8. 2020-09-30. PMID:30210923. |
the anti-proliferative activity of onc201 in ark1 and spec-2 cells was associated with induction apoptosis independent of p53 via both a trail mediated apoptotic pathway and a mitochondrial apoptosis pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiang-Jiang Qin, Xin Li, Courtney Hunt, Wei Wang, Hui Wang, Ruiwen Zhan. Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine. Genes & diseases. vol 5. issue 3. 2020-09-30. PMID:30320185. |
the p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and dna repair. |
2020-09-30 |
2023-08-13 |
human |
| Guomei Ye, Shifeng Kan, Jianfeng Chen, Xin L. Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655755. |
apoptosis in each group was detected via flow cytometry, and the expression of apoptosis-related proteins, and sirt1 and p53 proteins in each group was detected via western blotting. |
2020-09-30 |
2023-08-13 |
human |
| Guomei Ye, Shifeng Kan, Jianfeng Chen, Xin L. Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655755. |
compared with those in the control group, the apoptosis rate of t24 cells was remarkably increased after treatment with different doses of puerarin or ex527, and the expression level of apoptosis-related protein bcl-2-associated x protein (bax) was also significantly increased, but the expression level of b-cell lymphoma 2 (bcl-2) was decreased, and both the protein and mrna expression levels of sirt1 and p53 also significantly declined. |
2020-09-30 |
2023-08-13 |
human |
| Guomei Ye, Shifeng Kan, Jianfeng Chen, Xin L. Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655755. |
compared with those in the puerarin group, the apoptosis rate in the combination group was decreased, and the expression level of apoptosis-related protein bax was also significantly decreased, but the expression level of bcl-2 was increased, and sirt1 and p53 protein expression levels were also remarkably increased. |
2020-09-30 |
2023-08-13 |
human |
| Min-Lun Nan, Xue Wang, Hai-Jun Li, De-Hai Yu, Wen-Yi Sun, Hong-Mei Xu, Yu-Fang He, Quan-Cheng Zha. Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655810. |
rotundic acid induces cas3-mcf-7 cell apoptosis through the p53 pathway. |
2020-09-30 |
2023-08-13 |
human |
| Min-Lun Nan, Xue Wang, Hai-Jun Li, De-Hai Yu, Wen-Yi Sun, Hong-Mei Xu, Yu-Fang He, Quan-Cheng Zha. Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655810. |
the results from an mtt assay demonstrated that ra effectively inhibited cas3-mcf-7 cell viability in a dose-dependent manner and induced cell apoptosis via caspase-3 activity within 12 to 48 h. western blotting and fluorescence-activated cell sorting demonstrated that ra initiated cas3-mcf-7 cell apoptosis via p53 activation. |
2020-09-30 |
2023-08-13 |
human |
| Min-Lun Nan, Xue Wang, Hai-Jun Li, De-Hai Yu, Wen-Yi Sun, Hong-Mei Xu, Yu-Fang He, Quan-Cheng Zha. Rotundic acid induces Cas3-MCF-7 cell apoptosis through the p53 pathway. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655810. |
the silencing of the p53 gene in the cas3-mcf-7 cell line led to decreased ra-induced cas3-mcf-7 cell caspase-3 activity and cell apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Limeng Dai, Gang He, Kun Zhang, Xingying Guan, Yan Wang, Bo Zhan. Trichostatin A induces p53-dependent endoplasmic reticulum stress in human colon cancer cells. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655814. |
furthermore, cell viability and apoptosis were revealed to depend on p53 during tsa treatment. |
2020-09-30 |
2023-08-13 |
human |
| Na Qin, Fengli Han, Li Li, Yingwei Ge, Wei Lin, Jiang Wang, Lin Wu, Gang Zhao, Yanchun Deng, Jian Zhan. Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655854. |
following treatment with a p53 specific inhibitor, the results suggested that usp4 mediated chemoresistance through inhibiting apoptosis in a p53-dependent manner. |
2020-09-30 |
2023-08-13 |
Not clear |
| Marijn T M van Jaarsveld, Difan Deng, Erik A C Wiemer, Zhike Z. Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21. iScience. vol 12. 2020-09-30. PMID:30665195. |
tissue-specific chk1 activation determines apoptosis by regulating the balance of p53 and p21. |
2020-09-30 |
2023-08-13 |
human |
| Jianguo Zhang, Lei Che, Wenkai Sun, Jian Shang, Min Hao, Mengzi Tia. Correlation of OGR1 with proliferation and apoptosis of breast cancer cells. Oncology letters. vol 17. issue 5. 2020-09-30. PMID:30944627. |
the proliferation and apoptosis of breast cancer cells are influenced by the changes of ogr1 expression, which are correlated with the gene expression levels of akt and p53 to some extent, but the detailed molecular mechanism requires additional study. |
2020-09-30 |
2023-08-13 |
Not clear |
| Samuel Kogan, Darren Carpiz. Pharmacological targeting of mutant p53. Translational cancer research. vol 5. issue 6. 2020-09-30. PMID:30956950. |
the p53 protein is a transcription factor that functions as a tumor suppressor, and a subset of its numerous roles include the arrest of proliferation, promotion of dna repair, and induction of apoptosis in cells with severe dna damage or stress. |
2020-09-30 |
2023-08-13 |
human |
| Fauriski Febrian Prapiska, Syah Mirsya Warl. P53 and Survival Rate in Penile Cancer. Open access Macedonian journal of medical sciences. vol 7. issue 7. 2020-09-30. PMID:31049102. |
p53 protein has the function to regulate apoptosis in the cell cycle. |
2020-09-30 |
2023-08-13 |
Not clear |
| Gayane Machkalyan, Terence E Hèbert, Gregory J Mille. PPIP5K1 Suppresses Etoposide-triggered Apoptosis. Journal of molecular signaling. vol 11. 2020-09-30. PMID:31051014. |
we further tested the impact of ppip5k1 overexpression on an array of apoptosis markers and observed that ppip5k1 decreased p53 phosphorylation on key residues, including ser-15, -46, and -392. |
2020-09-30 |
2023-08-13 |
Not clear |
| Anil K Giri, Tero Aittokalli. DNMT Inhibitors Increase Methylation in the Cancer Genome. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31068808. |
our analysis revealed that hypermethylated cpgs are involved in cancer cell proliferation and apoptosis by p53 and olfactory receptor pathways, hence influencing dnmti responses. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zilun Wei, Yihai Liu, Shuaihua Qiao, Xueling Li, Qiaoling Li, Jinxuan Zhao, Jiaxin Hu, Zhonghai Wei, Anqi Shan, Xuan Sun, Biao X. Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases. Oncology letters. vol 17. issue 6. 2020-09-30. PMID:31186759. |
enrichment analysis demonstrated that these genes were associated with gene ontology terms of cellular components and molecular functions, including regulation of apoptosis, stabilization of p53 and anaphase promoting complex/cyclosome (apc/c) (apc/c:cdc20)-mediated degradation of securin. |
2020-09-30 |
2023-08-13 |
human |
| Xing Wang, Yuting Bai, Ying Han, Jian Meng, Hongwei Li. Downregulation of GBAS regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway. OncoTargets and therapy. vol 12. 2020-09-30. PMID:31190874. |
downregulation of gbas regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Simran Kaur, Alo Nag, Gurudutta Gangenahalli, Kulbhushan Sharm. Peroxisome Proliferator Activated Receptor Gamma Sensitizes Non-small Cell Lung Carcinoma to Gamma Irradiation Induced Apoptosis. Frontiers in genetics. vol 10. 2020-09-30. PMID:31263479. |
these ligands can induce apoptosis via tp53 (tumor protein p53) or erk1/2 (extracellular signal-regulated kinases 1/2) (ephb2) pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liang Zhang, Yuwen Pang, Xiaobin Cui, Wei Jia, Wenwen Cui, Yang Liu, Chunxia Liu, Feng L. MicroRNA-410-3p upregulation suppresses proliferation, invasion and migration, and promotes apoptosis in rhabdomyosarcoma cells. Oncology letters. vol 18. issue 1. 2020-09-30. PMID:31289572. |
exogenous expression of mir-410-3p inhibited rms cell invasion, migration and proliferation, induced apoptosis, suppressed the expression of snail, slug, n-cadherin and bcl-2, and increased the expression of e-cadherin, bax, cleaved-caspase 3, cleaved parp and p53. |
2020-09-30 |
2023-08-13 |
Not clear |