| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziyin Lu, Chunli Chen, Zhiyong Wu, Yusong Miao, Ishfaq Muhammad, Liangjun Ding, Erjie Tian, Wanjun Hu, Huilin Ni, Rui Li, Bo Wang, Jichang L. A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells. Frontiers in pharmacology. vol 8. 2020-09-29. PMID:29163157. |
conclusively, the data supported that silencing of p53 promotes impaired autophagy, which acts as a pro-apoptotic induction factor in pc-12 cells treated with colistin for 24 h, and overexpression of p53 inhibits autophagy and accelerates apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Zhongcheng Zh. Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928326. |
miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hong Gao, Hai Dong, Guijun Li, Hui Ji. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928333. |
expression levels of apoptosis-related proteins, including bcl2 apoptosis regulator (bcl-2), bcl2 associated x (bax) and caspase-3, and of proliferation-related proteins, including proliferating cell nuclear antigen (pcna) and tumor protein p53 (p53), were detected using western blotting. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lin Li, Rong-Li Qiu, Yu Lin, Ying Cai, Yong Bian, Yan Fan, Xiao-Jun Ga. Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncology letters. vol 15. issue 6. 2020-09-29. PMID:29928358. |
resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. |
2020-09-29 |
2023-08-13 |
human |
| Lu Meng, Hongyu Hu, Huifang Zhi, Yue Liu, Fangyu Shi, Laiguang Zhang, Yanjun Zhou, Aixing Li. OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells. Oncology letters. vol 16. issue 1. 2020-09-29. PMID:29930717. |
oct4b regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lu Meng, Hongyu Hu, Huifang Zhi, Yue Liu, Fangyu Shi, Laiguang Zhang, Yanjun Zhou, Aixing Li. OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells. Oncology letters. vol 16. issue 1. 2020-09-29. PMID:29930717. |
the tumor suppressor p53 also has well characterized roles in suppressing proliferation and promoting apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Maria Lina Tornesello, Clorinda Annunziata, Anna Lucia Tornesello, Luigi Buonaguro, Franco Maria Buonagur. Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers. Cancers. vol 10. issue 7. 2020-09-29. PMID:29932446. |
several viral oncoproteins are able to functionally inactivate the tumor suppressor p53, causing deregulated expression of many genes orchestrated by p53, such as those involved in apoptosis, dna stability, and cell proliferation. |
2020-09-29 |
2023-08-13 |
human |
| Tasleem Arif, Avijit Paul, Yakov Krelin, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmat. Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States. Cancers. vol 10. issue 12. 2020-09-29. PMID:30544833. |
high expression of p53 and the pro-apoptotic proteins cytochrome c and caspases without induction of apoptosis points to functions for these proteins in promoting cell differentiation. |
2020-09-29 |
2023-08-13 |
mouse |
| Wamidh H Talib, Sonia A Al-Hadid, Mai B Wild Ali, Intisar Hadi Al-Yasari, Mohammed R Abd Al. Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action. Breast cancer (Dove Medical Press). vol 10. 2020-09-29. PMID:30568488. |
p53 is a tumor suppressor gene involved in various cellular mechanisms including dna repair, apoptosis, and cell cycle arrest. |
2020-09-29 |
2023-08-13 |
human |
| Hailong Zhao, Limin Han, Yi Jian, Yuntao Ma, Wanyue Yan, Xiaowen Chen, Haiyan Xu, Lijuan L. Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis. OncoTargets and therapy. vol 11. 2020-09-29. PMID:30588012. |
our previous study has shown that the apoptosis regulation of resveratrol in melanoma cells was independent of activation of classical apoptosis-related protein p53. |
2020-09-29 |
2023-08-13 |
human |
| Joana D Amaral, Dário Silva, Cecília M P Rodrigues, Susana Solá, Maria M M Santo. A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation. Frontiers in chemistry. vol 7. 2020-09-29. PMID:30766866. |
spiropyrazoline oxindoles have previously been shown to induce apoptosis and cell cycle arrest, as well as upregulate p53 steady-state levels, while decreasing its main inhibitor mdm2 in the hct116 human colorectal carcinoma cell line. |
2020-09-29 |
2023-08-13 |
human |
| Anat Iosub-Amir, Fang Bai, Yang-Sung Sohn, Luhua Song, Sagi Tamir, Henri-Baptiste Marjault, Guy Mayer, Ola Karmi, Patricia A Jennings, Ron Mittler, José N Onuchic, Assaf Friedler, Rachel Nechushta. The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells. Chemical science. vol 10. issue 3. 2020-09-29. PMID:30774867. |
a peptide corresponding to the iaspp 764-780 sequence stabilized the naf-1 cluster, inhibited naf-1 interaction with iaspp, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in pc-3 prostate cancer cells in which p53 is inactive. |
2020-09-29 |
2023-08-13 |
human |
| Jiongjia Cheng, Karl J Okolotowicz, Daniel Ryan, Evangeline Mose, Andrew M Lowy, John R Cashma. Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. American journal of cancer research. vol 9. issue 2. 2020-09-29. PMID:30906636. |
inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. |
2020-09-29 |
2023-08-13 |
human |
| Paul Hasty, Judith Campisi, Z Dave Shar. Do p53 stress responses impact organismal aging? Translational cancer research. vol 5. issue 6. 2020-09-29. PMID:30984573. |
to accelerate aging, p53 induces apoptosis or cell cycle arrest as a prerequisite to cellular senescence; both can impair the mobilization of stem and progenitor cell populations. |
2020-09-29 |
2023-08-13 |
mouse |
| Yang Xu, Shun Yao, Dongmei Gao, Wenhua Li, Di Zheng, Quan Zhan. Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol. American journal of translational research. vol 11. issue 5. 2020-09-29. PMID:31217873. |
subsequently, the nuclear morphology was observed by fluorescence staining of dapi dna, the apoptosis was detected by flow cytometry, the mitochondrial membrane potential was detected by jc-1 and the sirt1, p53, bax, bcl-2 protein expression level was detected by western blotting. |
2020-09-29 |
2023-08-13 |
rat |
| Wenzhen Du, Xiaohong Hao, Zhili Yuan, Ying Wang, Xueguang Zhang, Jie Li. Shikonin potentiates paclitaxel antitumor efficacy in esophageal cancer cells via the apoptotic pathway. Oncology letters. vol 18. issue 3. 2020-09-29. PMID:31452796. |
in summary, shikonin can sensitize esophageal cancer cells to paclitaxel-treatment by promoting cell mitotic arrest and reinforcing the susceptibility of esophageal cancer cells to apoptosis induced by paclitaxel, which is potentially associated with altered levels of bcl-2 and p53. |
2020-09-29 |
2023-08-13 |
Not clear |
| Bin Liu, Lixia Liu, Aimin Zang, Zizheng Song, Hua Yang, Zhiyu Wang, Yanhong Shang, Tao Ma, Yonggang Zhan. Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2. Oncology letters. vol 18. issue 3. 2020-09-29. PMID:31452810. |
in summary, the current results indicate that tanshinone iia inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via parp, p53, cyclin b1/cdc2 and caspase-3-mediated signaling. |
2020-09-29 |
2023-08-13 |
human |
| Mahyar Dorrigiv, Armin Zareiyan, Hossein Hosseinzade. Garlic (Allium sativum) as an antidote or a protective agent against natural or chemical toxicities: A comprehensive update review. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-29. PMID:32068926. |
it has been shown that garlic and its major components can ameliorate the toxicity of different agents in brain, kidney, blood, liver, embryo, spleen, pancreas, heart, reproductive system in part through radical scavenging, antioxidant effect, reducing lipid peroxidation, anti-inflammatory, chelating agent, cytoprotective activities, increase protein synthesis in damaged tissues, suppressing apoptosis, modulation of p53, phosphoinositide 3-kinase, akt, nuclear factor (erythroid-derived 2)-like 2, antioxidant responsive element, p38 mapk, inducible nitric oxide synthase, cyclooxygenase-2, cytosolic phospholipases a2, cleaved-caspase-9, cleaved-caspase-3 bcl-2, bcl-2-associated x, peroxisome proliferator-activated receptor gamma, nf-jb, nuclear factor-kappab signaling pathways and cytochrome p450 enzymes. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shuang Shuang Wang, Xiang Qin Zhu, Shao DI Yang, Lin Li Dong, Wen Li, Jianxin Tan. Association of p73 G4C14-to-A4T14 polymorphism with non-small cell lung cancer risk. Oncology letters. vol 10. issue 2. 2020-09-29. PMID:26622612. |
the p73 gene is a structural and functional homolog of the p53 gene, which has a crucial role in mediating cell cycle arrest and apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidi. Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Experimental and therapeutic medicine. vol 10. issue 5. 2020-09-29. PMID:26640580. |
the results revealed that lw6 was not toxic and decreased apoptosis and the levels of the pro-apoptotic tumor suppressor p53. |
2020-09-29 |
2023-08-13 |
human |