| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zukile Mbita, Rodney Hull, Mzwandile Mbele, Tshepiso Makhafola, Zodwa Dlamin. Expression Analysis of RbBP6 in human cancers: a Prospective biomarker. Anti-cancer drugs. vol 30. issue 8. 2020-09-25. PMID:31274515. |
isoform 1 been shown to regulate p53 through its ubiquitin ligase activity, thus implicating in cell cycle regulation and apoptosis. |
2020-09-25 |
2023-08-13 |
human |
| Xiaojie Chen, Qiuwen Zhu, Xiao Xu, Shiyang Shen, Ying Zhang, Ran M. Sequentially Site-Specific Delivery of Apoptotic Protein and Tumor-Suppressor Gene for Combination Cancer Therapy. Small (Weinheim an der Bergstrasse, Germany). vol 15. issue 40. 2020-09-25. PMID:31441204. |
the p53 dna is transported into the nucleus by the aid of the cationic protamine and thus generates expression of the p53 protein that enhances apoptosis combined with cytoc. |
2020-09-25 |
2023-08-13 |
mouse |
| Xiang-Lin Hao, Fei Han, Ning Zhang, Hong-Qiang Chen, Xiao Jiang, Li Yin, Wen-Bin Liu, Dan-Dan Wang, Jian-Ping Chen, Zhi-Hong Cui, Lin Ao, Jia Cao, Jin-Yi Li. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Cell death and differentiation. vol 26. issue 7. 2020-09-24. PMID:30254375. |
moreover, the blockade of p53 attenuates the function of tc2n knockdown in the regulation of cell proliferation and apoptosis. |
2020-09-24 |
2023-08-13 |
Not clear |
| Xiang-Lin Hao, Fei Han, Ning Zhang, Hong-Qiang Chen, Xiao Jiang, Li Yin, Wen-Bin Liu, Dan-Dan Wang, Jian-Ping Chen, Zhi-Hong Cui, Lin Ao, Jia Cao, Jin-Yi Li. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Cell death and differentiation. vol 26. issue 7. 2020-09-24. PMID:30254375. |
in addition, downregulated tc2n is involved in the apoptosis of lung cancer cells induced by doxorubicin, leading to p53 pathway activation. |
2020-09-24 |
2023-08-13 |
Not clear |
| Xiang-Lin Hao, Fei Han, Ning Zhang, Hong-Qiang Chen, Xiao Jiang, Li Yin, Wen-Bin Liu, Dan-Dan Wang, Jian-Ping Chen, Zhi-Hong Cui, Lin Ao, Jia Cao, Jin-Yi Li. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Cell death and differentiation. vol 26. issue 7. 2020-09-24. PMID:30254375. |
overall, these findings uncover a role for the p53 inactivator tc2n in regulating the proliferation and apoptosis of lung cancer cells. |
2020-09-24 |
2023-08-13 |
Not clear |
| Przemysław Liczbiński, Jaromir Michałowicz, Bożena Bukowsk. Molecular mechanism of curcumin action in signaling pathways: Review of the latest research. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-24. PMID:32141677. |
curcumin is considered to play a role in the regulation of t-lymphocytes function in the lymphoid tissue of the large intestine, apoptosis of the human papilloma and the activity of the 26s proteasome, and p53 level. |
2020-09-24 |
2023-08-13 |
human |
| Xiang-Zi Zhang, Mo-Han Zhang, Xue-Sen Fang, Xiang-Shu Cui, Zheng Ji. Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition. Bioscience reports. vol 39. issue 12. 2020-09-23. PMID:31769476. |
under high-glucose condition, activated ampk can directly or indirectly promote cells apoptosis by regulating the expression and activity of p53, akt, p70s6k, protein kinase a (pka), phospholipidol c (plc)-β3, camkii, camkiv and eukaryotic translation initiation factor 4e binding protein1 (4e-bp1) in rat gastric smooth muscle cells. |
2020-09-23 |
2023-08-13 |
rat |
| Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Che. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825845. |
tumor repressor p53 is required for heat-induced apoptosis at hyperthermia conditions (>41°c). |
2020-09-23 |
2023-08-13 |
human |
| Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Che. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825845. |
under hyperthermia conditions, atm is activated to phosphorylate p53 at s37, which increases bax expression to induce apoptosis. |
2020-09-23 |
2023-08-13 |
human |
| Alexander B Draganov, Xiaoxiao Yang, Abiodun Anifowose, Ladie Kimberly C De La Cruz, Chaofeng Dai, Nanting Ni, Weixuan Chen, Zeus De Los Santos, Lubing Gu, Muxiang Zhou, Binghe Wan. Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs. Bioorganic & medicinal chemistry. vol 27. issue 17. 2020-09-22. PMID:31324563. |
in a previous study, a novel anthraquinone analog bw-aq-101 was identified as a potent inducer of mdm2 degradation, leading to upregulation of p53 and apoptosis in cell culture studies. |
2020-09-22 |
2023-08-13 |
Not clear |
| Xueling Li, Jinxuan Zhao, Jin Geng, Fu Chen, Zilun Wei, Chen Liu, Xinlin Zhang, Qiaoling Li, Jingmei Zhang, Ling Gao, Jun Xie, Biao X. Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31631486. |
long non-coding rna meg3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction. |
2020-09-22 |
2023-08-13 |
mouse |
| Xueling Li, Jinxuan Zhao, Jin Geng, Fu Chen, Zilun Wei, Chen Liu, Xinlin Zhang, Qiaoling Li, Jingmei Zhang, Ling Gao, Jun Xie, Biao X. Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31631486. |
at last, we provided evidence that p53 was identified as a protein target of lncrna meg3 to regulate nf-κb- and ers-associated apoptosis. |
2020-09-22 |
2023-08-13 |
mouse |
| Xueling Li, Jinxuan Zhao, Jin Geng, Fu Chen, Zilun Wei, Chen Liu, Xinlin Zhang, Qiaoling Li, Jingmei Zhang, Ling Gao, Jun Xie, Biao X. Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31631486. |
taken collectively, our findings demonstrated that lncrna meg3 knockdown exerted cardioprotection by reducing ers-mediated apoptosis through targeting p53 post-mi. |
2020-09-22 |
2023-08-13 |
mouse |
| Xuemei Fu, Shouhai Wu, Bo Li, Yang Xu, Jingfeng Li. Functions of p53 in pluripotent stem cells. Protein & cell. vol 11. issue 1. 2020-09-22. PMID:31691903. |
in response to dna damage or oncogenic stress, p53 plays multiple roles in maintaining genomic stability of somatic cells by inducing cell cycle arrest, apoptosis, and senescence to prevent the passage of genetic mutations to the daughter cells. |
2020-09-22 |
2023-08-13 |
Not clear |
| Md Shiblur Rahaman, Mahmuda Akter, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasak. Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism. Environmental toxicology and pharmacology. vol 74. 2020-09-22. PMID:31786496. |
protein expression of western blot analysis showed that co-exposure of d-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mtor, p-mtor, akt, p-akt, nf-кb, nrf2, erk1, gr, bcl-x and down-regulation of death factors; p53, bax, cytochrome c, lc3, although arsenic regulated those factors negatively. |
2020-09-22 |
2023-08-13 |
human |
| Shuai Huang, Shuang-Mei Zhao, Lian-Hai Shan, Xian-Li Zho. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells. Chinese journal of natural medicines. vol 18. issue 2. 2020-09-22. PMID:32172951. |
nervosine vii simultaneously induced autophagy and apoptosis by activated mapks signaling pathway including jnk, erk1/2 and p38, suppressing the p53 signaling pathway. |
2020-09-22 |
2023-08-13 |
human |
| Ni Cheng, Haoan Zhao, Sinan Chen, Qiong He, Wei Ca. Jujube honey induces apoptosis in human hepatocellular carcinoma HepG2 cell via DNA damage, p53 expression, and caspase activation. Journal of food biochemistry. vol 43. issue 11. 2020-09-21. PMID:31373040. |
jujube honey induces apoptosis in human hepatocellular carcinoma hepg2 cell via dna damage, p53 expression, and caspase activation. |
2020-09-21 |
2023-08-13 |
human |
| Ni Cheng, Haoan Zhao, Sinan Chen, Qiong He, Wei Ca. Jujube honey induces apoptosis in human hepatocellular carcinoma HepG2 cell via DNA damage, p53 expression, and caspase activation. Journal of food biochemistry. vol 43. issue 11. 2020-09-21. PMID:31373040. |
in conclusion, this study showed that jujube honey induces hepg2 cell apoptosis via dna damage, p53 expression, and caspase activation. |
2020-09-21 |
2023-08-13 |
human |
| Xin-Rong Zhou, Ning Song, Jun-Yi Luo, Hui Zhai, Xiang-Mei Li, Qian Zhao, Fen Liu, Xiao-Mei Li, Yi-Ning Yan. Expression profiles and potential functions of long non-coding RNA in stable angina pectoris patients from Uyghur population of China. Bioscience reports. vol 39. issue 9. 2020-09-18. PMID:31413167. |
among screened lncrnas, the annotation result of their co-expressed mrnas showed that the most significantly related pathways were the nf-κb signalling pathway, apoptosis and the p53 signalling pathway, while the main significantly related diseases were the cholesterol, calcium and coronary disease. |
2020-09-18 |
2023-08-13 |
human |
| Meng Wang, Jing Yang, Chen Wan. Shen Shuai II Recipe Attenuates Apoptosis in 5/6 Renal Ablation/Infarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis. Oxidative medicine and cellular longevity. vol 2020. 2020-09-17. PMID:32089777. |
shen shuai ii recipe attenuates apoptosis in 5/6 renal ablation/infarction rats by inhibiting p53 and the mitochondrial pathway of apoptosis. |
2020-09-17 |
2023-08-13 |
rat |