| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Lees, Alexander J McIntyre, Nyree T Crawford, Fiammetta Falcone, Christopher McCann, Caitriona Holohan, Gerard P Quinn, Jamie Z Roberts, Tamas Sessler, Peter F Gallagher, Gemma M A Gregg, Katherine McAllister, Kirsty M McLaughlin, Wendy L Allen, Laurence J Egan, Aideen E Ryan, Melissa J Labonte-Wilson, Philip D Dunne, Mark Wappett, Vicky M Coyle, Patrick G Johnston, Emma M Kerr, Daniel B Longley, Simon S McDad. The pseudo-caspase FLIP(L) regulates cell fate following p53 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 30. 2020-09-17. PMID:32661168. |
p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. |
2020-09-17 |
2023-08-13 |
human |
| Andrea Lees, Alexander J McIntyre, Nyree T Crawford, Fiammetta Falcone, Christopher McCann, Caitriona Holohan, Gerard P Quinn, Jamie Z Roberts, Tamas Sessler, Peter F Gallagher, Gemma M A Gregg, Katherine McAllister, Kirsty M McLaughlin, Wendy L Allen, Laurence J Egan, Aideen E Ryan, Melissa J Labonte-Wilson, Philip D Dunne, Mark Wappett, Vicky M Coyle, Patrick G Johnston, Emma M Kerr, Daniel B Longley, Simon S McDad. The pseudo-caspase FLIP(L) regulates cell fate following p53 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 30. 2020-09-17. PMID:32661168. |
in the absence of caspase-8, another of its paralogs, caspase-10 (also transcriptionally up-regulated by p53), induced apoptosis in nutlin-3a-treated, flip(l)-depleted cells, albeit to a lesser extent than in caspase-8-proficient cells. |
2020-09-17 |
2023-08-13 |
human |
| Fengyan Liu, Ziyan Fan, Ning Song, Mingyong Han, Ming Yan, Liang-Hong Guo, Jia Jihui, Shili Li. XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity. Journal of cellular biochemistry. vol 120. issue 8. 2020-09-16. PMID:30834581. |
the cells deficient in xrcc4 generally exhibited reduced proliferation and premature aging in culture; however, our results indicated that pfda induced p53 inhibition rescued cells from the apoptosis that was triggered by nonhomologous end-joining (nhej) inactivation, and overexpression of p53 expression in pfda-treated cells enhanced their apoptosis. |
2020-09-16 |
2023-08-13 |
mouse |
| Gastón Repossi, Undurti N Das, Aldo Renato Eynar. Molecular Basis of the Beneficial Actions of Resveratrol. Archives of medical research. vol 51. issue 2. 2020-09-16. PMID:32111491. |
resveratrol modulates the transcription factor nf-κb, cytochrome p450 isoenzyme cyp1a1, expression and activity of cyclooxygenase (cox) enzymes, fas/fas ligand mediated apoptosis, p53, mtor and cyclins and various phospho-diesterases resulting in an increase in cytosolic camp levels. |
2020-09-16 |
2023-08-13 |
Not clear |
| Guy Mayer, Zohar Shpilt, Shachar Bressler, Orly Marcu, Ora Schueler-Furman, Edit Y Tshuva, Assaf Friedle. Targeting an Interaction Between Two Disordered Domains by Using a Designed Peptide. Chemistry (Weinheim an der Bergstrasse, Germany). vol 26. issue 45. 2020-09-16. PMID:32181542. |
here, we show that a designed peptide based on the disordered p53 linker domain can be used to target a partner idr from the anti-apoptotic iaspp protein, promoting apoptosis of cancer cells. |
2020-09-16 |
2023-08-13 |
Not clear |
| Zhong-Wu Lu, Duo Wen, Wen-Jun Wei, Li-Tao Han, Jun Xiang, Yu-Long Wang, Yu Wang, Tian Liao, Qing-Hai J. Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma. Oncology reports. vol 43. issue 3. 2020-09-15. PMID:31922231. |
the protein levels of phosphorylated p38 mitogen‑activated protein kinase (mapk), p53 and bax were increased in ppm1d‑knockdown cells, while inhibition of p38 phosphorylation restored cell migration, proliferation and cell apoptosis. |
2020-09-15 |
2023-08-13 |
human |
| Hongjing Zhao, Yu Wang, Menghao Guo, Mengyao Mu, Hongxian Yu, Mingwei Xin. Grass carps co-exposed to environmentally relevant concentrations of cypermethrin and sulfamethoxazole bear immunodeficiency and are vulnerable to subsequent Aeromonas hydrophila infection. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 3. 2020-09-15. PMID:32663629. |
cmn or/and smz exposure led to oxidative damage (consumption of antioxidant enzymes (superoxide dismutase and catalase)) and lipid peroxidation (accumulation of malondialdehyde), induced apoptosis (increases in tunel index, bax/bcl-2, p53, puma and caspase family expression). |
2020-09-15 |
2023-08-13 |
human |
| Aicheng Yang, Fanna Liu, Baozhang Guan, Zhi Luo, Jiehua Lin, Wan Fang, Longhui Liu, Wanli Zu. p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31148231. |
we find that p53 was upregulated in cisplatin-induced aki, yet, pifithrin-α inhibites the p53 expression to attenuated renal injury and cell apoptosis both in vivo cisplatin-induced aki mice and in vitro hk-2 human renal tubular epithelial cells. |
2020-09-14 |
2023-08-13 |
mouse |
| Siqi Zhou, Haiyan Wen, Haohuan L. Magnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53-mediated mitochondrial pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31155771. |
additionally, under the pretreatment of pifithrin-a (pft-a, a p53 inhibitor), the magnolol-induced apoptosis was significantly reversed. |
2020-09-14 |
2023-08-13 |
human |
| Yinghui Ren, Yan Li, Jienv Lv, Xiangdong Guo, Jieyou Zhang, Dongmei Zhou, Zimu Zhang, Zhenyi Xue, Guangze Yang, Qing Xi, Hongkun Liu, Zehan Liu, Lijuan Zhang, Qi Zhang, Zhi Yao, Rongxin Zhang, Yurong D. Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-11. PMID:31144365. |
parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in c2c12 myoblasts. |
2020-09-11 |
2023-08-13 |
Not clear |
| Dennis Özcelik, John Paul Pezack. Small Molecule Inhibition of Protein Disulfide Isomerase in Neuroblastoma Cells Induces an Oxidative Stress Response and Apoptosis Pathways. ACS chemical neuroscience. vol 10. issue 9. 2020-09-10. PMID:31343165. |
induction of the p53 signaling pathway and downregulation of myc are known to affect processes such as cell cycle, cellular repair, and apoptosis. |
2020-09-10 |
2023-08-13 |
Not clear |
| Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, Lori Schultz, Chun-I Sze, Nan-Shan Chan. A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism. Cell communication and signaling : CCS. vol 17. issue 1. 2020-09-09. PMID:31315632. |
tumor suppressor wwox physically binds p53 and tiaf1 and together induces apoptosis and tumor suppression. |
2020-09-09 |
2023-08-13 |
Not clear |
| Y X Li, X P Feng, H L Wang, C H Meng, J Zhang, Y Qian, J F Zhong, S X Ca. Transcriptome analysis reveals corresponding genes and key pathways involved in heat stress in Hu sheep. Cell stress & chaperones. vol 24. issue 6. 2020-09-09. PMID:31428918. |
our data indicated that heat stress induced calcium dyshomeostasis, blocked biogenesis, caused ros accumulation, impaired the antioxidant system and innate defense, and induced apoptosis through the p53 signaling pathway activated by peg3, decreased growth and development, and enhanced organ damage. |
2020-09-09 |
2023-08-13 |
Not clear |
| Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Marlene Jimenez-Del-Ri. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications. PloS one. vol 15. issue 5. 2020-09-09. PMID:32437347. |
furthermore, psen1 e280a chlns presented oxidative stress (os) as evidenced by the oxidation of dj-1cys106-sh into dj-1cys106-so3 and the detection of dcf-positive cells and apoptosis markers such as activated pro-apoptosis proteins p53, c-jun, puma and caspase-3 and the concomitant loss of the mitochondrial membrane potential and dna fragmentation. |
2020-09-09 |
2023-08-13 |
Not clear |
| Mohamed Ishan, Guiqian Chen, Chenming Sun, Shi-You Chen, Yoshihiro Komatsu, Yuji Mishina, Hong-Xiang Li. Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues. Genesis (New York, N.Y. : 2000). vol 58. issue 1. 2020-09-08. PMID:31571391. |
at e10.5, the tongue primordia (branchial arches 1-4) formed in wnt1-cre/caalk2 mutants while each branchial arch responded to elevated bmp signaling distinctly in gene expression of bmp targets (id1, snai1, snai2, and runx2), proliferation (cyclin-d1) and apoptosis (p53). |
2020-09-08 |
2023-08-13 |
Not clear |
| Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View. Current cancer drug targets. vol 19. issue 6. 2020-09-02. PMID:30073927. |
this review explores the candidature of various proteins involved in cellular trafficking (small gtpases, molecular motors, matrix-degrading enzymes, integrin), transcription (p53, cmyc), signalling (membrane receptor proteins), angiogenesis (vegfs) and apoptosis (bcl-2family), which could possibly serve as targets for developing effective anti-cancer regimen. |
2020-09-02 |
2023-08-13 |
Not clear |
| Yu-Long Lan, Yu-Jie Zou, Jia-Cheng Lou, Jin-Shan Xing, Xun Wang, Shuang Zou, Bin-Bin Ma, Yan Ding, Bo Zhan. The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway. Cell biology and toxicology. vol 35. issue 6. 2020-09-01. PMID:30739221. |
mechanistic studies confirmed the important roles of src and p53 signaling in mediating bufalin-induced apoptosis. |
2020-09-01 |
2023-08-13 |
human |
| Johannes Ristau, Vincent van Hoef, Sylvain Peuget, Jiawei Zhu, Bo-Jhih Guan, Shuo Liang, Maria Hatzoglou, Ivan Topisirovic, Galina Selivanova, Ola Larsso. RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity. Cell death & disease. vol 10. issue 11. 2020-09-01. PMID:31699971. |
one such agent is rita (reactivation of p53 and induction of tumor cell apoptosis), which restores p53 expression in cells with hyperactive hdm2 and induces apoptosis. |
2020-09-01 |
2023-08-13 |
Not clear |
| Ezgi Ozyerli-Goknar, Ilknur Sur-Erdem, Fidan Seker, Ahmet Cingöz, Alisan Kayabolen, Zeynep Kahya-Yesil, Fırat Uyulur, Melike Gezen, Nazife Tolay, Batu Erman, Mehmet Gönen, James Dunford, Udo Oppermann, Tugba Bagci-Onde. The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma. Cell death & disease. vol 10. issue 12. 2020-08-31. PMID:31772153. |
chaetocin mediated apoptosis sensitization was achieved through ros generation and consequent dna damage induction that involved p53 activity. |
2020-08-31 |
2023-08-13 |
Not clear |
| Seong-Ho Kang, Ji-Seon Cho. MicroRNA-661 upregulation in myelodysplastic syndromes induces apoptosis through p53 activation and associates with decreased overall survival. Leukemia & lymphoma. vol 60. issue 11. 2020-08-28. PMID:31056984. |
microrna-661 upregulation in myelodysplastic syndromes induces apoptosis through p53 activation and associates with decreased overall survival. |
2020-08-28 |
2023-08-13 |
Not clear |