| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangyao He, Anzhou Tang, Mao Xie, Wei Xia, Pengcheng Zhao, Jianglian Wei, Yongjing Lai, Xianglong Tang, Yi Ming Zou, Heng Li. Blood Gene Expression Profile Study Revealed the Activation of Apoptosis and p53 Signaling Pathway May Be the Potential Molecular Mechanisms of Ionizing Radiation Damage and Radiation-Induced Bystander Effects. Dose-response : a publication of International Hormesis Society. vol 18. issue 1. 2020-09-28. PMID:32284698. |
blood gene expression profile study revealed the activation of apoptosis and p53 signaling pathway may be the potential molecular mechanisms of ionizing radiation damage and radiation-induced bystander effects. |
2020-09-28 |
2023-08-13 |
human |
| Guangyao He, Anzhou Tang, Mao Xie, Wei Xia, Pengcheng Zhao, Jianglian Wei, Yongjing Lai, Xianglong Tang, Yi Ming Zou, Heng Li. Blood Gene Expression Profile Study Revealed the Activation of Apoptosis and p53 Signaling Pathway May Be the Potential Molecular Mechanisms of Ionizing Radiation Damage and Radiation-Induced Bystander Effects. Dose-response : a publication of International Hormesis Society. vol 18. issue 1. 2020-09-28. PMID:32284698. |
the analysis showed that the positively correlated modules were significantly involved in apoptosis and p53 signaling pathway, and esr1, atm, and myc were potential transcription factors regulating these modules. |
2020-09-28 |
2023-08-13 |
human |
| Guangyao He, Anzhou Tang, Mao Xie, Wei Xia, Pengcheng Zhao, Jianglian Wei, Yongjing Lai, Xianglong Tang, Yi Ming Zou, Heng Li. Blood Gene Expression Profile Study Revealed the Activation of Apoptosis and p53 Signaling Pathway May Be the Potential Molecular Mechanisms of Ionizing Radiation Damage and Radiation-Induced Bystander Effects. Dose-response : a publication of International Hormesis Society. vol 18. issue 1. 2020-09-28. PMID:32284698. |
thus, the study suggested that apoptosis and p53 signaling pathway may be the potential molecular mechanisms of ir damage and ribe, which could be driven by esr1, atm, and myc. |
2020-09-28 |
2023-08-13 |
human |
| Si-Min Qi, Gang Cheng, Xiang-Dong Cheng, Zhiyuan Xu, Beihua Xu, Wei-Dong Zhang, Jiang-Jiang Qi. Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet? Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32300595. |
the p53 tumor suppressor protein and its major negative regulators mdm2 and mdmx oncoproteins form the mdm2/mdmx-p53 circuitry, which plays critical roles in regulating cancer cell growth, proliferation, cell cycle progression, apoptosis, senescence, angiogenesis, and immune response. |
2020-09-28 |
2023-08-13 |
human |
| Si-Min Qi, Gang Cheng, Xiang-Dong Cheng, Zhiyuan Xu, Beihua Xu, Wei-Dong Zhang, Jiang-Jiang Qi. Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet? Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32300595. |
usp7 inhibition promotes the degradation of mdm2 and mdmx, activates the p53 signaling, and causes cell cycle arrest and apoptosis, making usp7 a potential target for cancer therapy. |
2020-09-28 |
2023-08-13 |
human |
| Cheng Wu, Ergang Guo, Jun Ming, Wei Sun, Xin Nie, Lu Sun, Shan Peng, Min Luo, Dongbo Liu, Linli Zhang, Qi Mei, Guoxian Long, Guangyuan Hu, Guoqing H. Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21. Molecular therapy oncolytics. vol 17. 2020-09-28. PMID:32382655. |
furthermore, silencing dnmt3b restored and activated p53 and p21 via dna demethylation, which led to cell cycle arrest and apoptosis, resulting in increased radiosensitivity of npc both |
2020-09-28 |
2023-08-13 |
Not clear |
| Ali Veisi, Ghaidafeh Akbari, Seyyed Ali Mard, Gholamreza Badfar, Vahid Zarezade, Mohammad Ali Mirsheka. Role of crocin in several cancer cell lines: An updated review. Iranian journal of basic medical sciences. vol 23. issue 1. 2020-09-28. PMID:32405344. |
crocin can induce apoptosis through activation of caspase 8, up-regulation of p53 expression, bax/bcl-2 ratio, and down-regulation expression of bcl-2, survivin, and cyclin d1. |
2020-09-28 |
2023-08-13 |
Not clear |
| Javier Vaquero, Florian Judée, Marie Vallette, Henri Decauchy, Ander Arbelaiz, Lynda Aoudjehane, Olivier Scatton, Ester Gonzalez-Sanchez, Fatiha Merabtene, Jérémy Augustin, Chantal Housset, Thierry Dufour, Laura Fouassie. Cold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma. Cancers. vol 12. issue 5. 2020-09-28. PMID:32438553. |
at molecular level, cap treatment induced double-strand dna breaks, followed by an increased phosphorylation and activation of the cell cycle master regulators chk1 and p53, leading to cell cycle arrest and cell death by apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyon. Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. EXCLI journal. vol 19. 2020-09-28. PMID:32483405. |
bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chawalit Chatupheeraphat, Chanin Nantasenamat, Kamolchanok Deesrisak, Sittiruk Roytrakul, Usanarat Anurathapan, Dalina Tanyon. Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway. EXCLI journal. vol 19. 2020-09-28. PMID:32483405. |
in addition, p53, bax and bcl2 could be involved in the apoptosis pathway of these leukemic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Paul B Tchounwo. Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. Journal of Cancer. vol 11. issue 15. 2020-09-28. PMID:32489456. |
we hypothesized that tx regulates cell cycle and apoptosis in apl mice by p53 activation, dna damage, and reduced expression of mdm2-daxx-hausp complex. |
2020-09-28 |
2023-08-13 |
mouse |
| Sanjay Kumar, Paul B Tchounwo. Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia. Journal of Cancer. vol 11. issue 15. 2020-09-28. PMID:32489456. |
our findings indicate that tx reduced the expression of pml-rarα and complex molecules, induced dna damage and activated p53 leading to cell cycle arrest and apoptosis in apl mice liver. |
2020-09-28 |
2023-08-13 |
mouse |
| Yiru Wang, Chengmin Li, Julang Li, Genlin Wang, Lian L. Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway. Antioxidants (Basel, Switzerland). vol 9. issue 6. 2020-09-28. PMID:32545880. |
meanwhile, nac pretreatment also blocked the phosphorylation of erk1/2 and p38 induced by nefa, and the nucleation of nrf2 and p53, suggesting that ros plays a crucial role in regulating the nefa-induced apoptosis of gcs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chaoxing Li, Wenwen Li, Xiyao Cheng, Dapeng Zhang, Xiang Sun, Jingjing Zhou, Yin Zhou, Yongqi Huang, Xianmin Xia, Qi Ma, Zhengding S. P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain. OncoTargets and therapy. vol 13. 2020-09-28. PMID:32606738. |
p55pik regulates p53-dependent apoptosis in cancer cells by interacting with p53 dna-specific domain. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chaoxing Li, Wenwen Li, Xiyao Cheng, Dapeng Zhang, Xiang Sun, Jingjing Zhou, Yin Zhou, Yongqi Huang, Xianmin Xia, Qi Ma, Zhengding S. P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain. OncoTargets and therapy. vol 13. 2020-09-28. PMID:32606738. |
this study aimed to explore the interaction of p55pik with p53 and the role of p55pik in regulating p53-dependent apoptosis in cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jung-Yeon Kim, Jaechan Leem, Hyo-Lim Hon. Protective Effects of SPA0355, a Thiourea Analogue, Against Lipopolysaccharide-Induced Acute Kidney Injury in Mice. Antioxidants (Basel, Switzerland). vol 9. issue 7. 2020-09-28. PMID:32635491. |
moreover, spa0355 attenuated lps-induced tubular cell apoptosis via inhibition of p53 signaling pathway. |
2020-09-28 |
2023-08-13 |
mouse |
| Ram Raj Prasad, Sandeep Paudel, Komal Raina, Rajesh Agarwa. Silibinin and non-melanoma skin cancers. Journal of traditional and complementary medicine. vol 10. issue 3. 2020-09-28. PMID:32670818. |
silibinin protects against uvb-induced thymine dimer formation and in turn promotes dna repair and/or initiates apoptosis in damaged cells via an increase in p53 levels. |
2020-09-28 |
2023-08-13 |
human |
| Xinping Gao, Qing Li, Guobin Chen, Haipeng He, Ying M. MAGEA3 promotes proliferation and suppresses apoptosis in cervical cancer cells by inhibiting the KAP1/p53 signaling pathway. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774721. |
further mechanistic study revealed that magea3 interacts with kap1, thereby suppressing p53 transcriptional activity, thus suppressing p53-mediated regulation of the expression of genes involved in the cell cycle (p21, cyclin d1) and apoptosis (bax, bcl-2, and puma). |
2020-09-28 |
2023-08-13 |
Not clear |
| Xian Wu, Zhengze Li, Yue Sun, Fang Li, Zili Gao, Jinkai Zheng, Hang Xia. Identification of Xanthomicrol as a Major Metabolite of 5-Demethyltangeretin in Mouse Gastrointestinal Tract and Its Inhibitory Effects on Colon Cancer Cells. Frontiers in nutrition. vol 7. 2020-09-28. PMID:32850933. |
we found that xan effectively inhibited the proliferation of hct116 cells by arresting cell cycle and inducing cellular apoptosis, which was further evidenced by upregulated p53 and p21 and downregulated cyclin d and cdk4/6 level. |
2020-09-28 |
2023-08-13 |
mouse |
| Manchao Li, Jintao Peng, Zhi Zen. Overexpression of long non-coding RNA nuclear enriched abundant transcript 1 inhibits the expression of p53 and improves premature ovarian failure. Experimental and therapeutic medicine. vol 20. issue 5. 2020-09-28. PMID:32963599. |
in addition, ovary cell apoptosis was inhibited following neat1 overexpression and stimulated following p53 overexpression. |
2020-09-28 |
2023-08-13 |
Not clear |