| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yushuang Liu, Enxian Shao, Zhiyang Zhang, Daji Yang, Guanting Li, Hua Cao, Hongliang Huan. A Novel Indolizine Derivative Induces Apoptosis Through the Mitochondria p53 Pathway in HepG2 Cells. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31354481. |
a novel indolizine derivative induces apoptosis through the mitochondria p53 pathway in hepg2 cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuanxin Zhang, Yakun Ge, Wei Shi, Chenming Hu, Xu Bai, Jimin Rong, Ming Y. CDS-1548 induces apoptosis in HeLa cells by activating caspase 3. Oncology letters. vol 18. issue 2. 2020-09-30. PMID:31423257. |
additionally, cds-1548 treatment increased the expression levels of p53 and mouse double minute 2 homolog, as well as inducing apoptosis in hela cells. |
2020-09-30 |
2023-08-13 |
mouse |
| Hongming Zhang, Runzhe Chen, Xiyong Wang, Haijun Zhang, Xiaoli Zhu, Jibei Che. Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer. Frontiers in oncology. vol 9. 2020-09-30. PMID:31428569. |
this study is aimed to investigate the mechanisms of lbp-induced apoptosis in the a549 p53 wild-type cell line. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yayun Liang, Cynthia Besch-Williford, Matthew T Cook, Anthony Belenchia, Rolf A Brekken, Salman M Hyde. APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice. Breast cancer (Dove Medical Press). vol 11. 2020-09-30. PMID:31534364. |
whereas wild-type p53 (wtp53) promotes cell-cycle arrest and apoptosis and inhibits vascular endothelial growth factor-dependent angiogenesis, mtp53 fails to regulate these functions, resulting in tumor vascularization, growth, resistance to chemotherapy, and metastasis. |
2020-09-30 |
2023-08-13 |
mouse |
| Raziyeh Mazrouei, Elham Raeisi, Yves Lemoigne, Esfandiar Heidaria. Activation of p53 Gene Expression and Synergistic Antiproliferative Effects of 5-Fluorouracil and β-escin on MCF7 Cells. Journal of medical signals and sensors. vol 9. issue 3. 2020-09-30. PMID:31544060. |
the purpose of this study was to investigate the combined effects of 5-fu and β-escin on apoptosis, colony formation, bcl-2 signaling protein, and p53 gene expression in mcf7 breast cancer cell line. |
2020-09-30 |
2023-08-13 |
Not clear |
| Raziyeh Mazrouei, Elham Raeisi, Yves Lemoigne, Esfandiar Heidaria. Activation of p53 Gene Expression and Synergistic Antiproliferative Effects of 5-Fluorouracil and β-escin on MCF7 Cells. Journal of medical signals and sensors. vol 9. issue 3. 2020-09-30. PMID:31544060. |
the cytotoxic effects, the number of colonies, apoptosis, p53 gene expression, and bcl-2 signaling protein of the combined 5-fu and β-escin on mcf7 cells were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, clonogenic assay, flow cytometry, real-time quantitative polymerase chain reaction, and western blotting methods, respectively. |
2020-09-30 |
2023-08-13 |
Not clear |
| Raziyeh Mazrouei, Elham Raeisi, Yves Lemoigne, Esfandiar Heidaria. Activation of p53 Gene Expression and Synergistic Antiproliferative Effects of 5-Fluorouracil and β-escin on MCF7 Cells. Journal of medical signals and sensors. vol 9. issue 3. 2020-09-30. PMID:31544060. |
the expression of p53 and apoptosis increased in the combination of 5-fu and β-escin on mcf7 cells compared to that of control group ( |
2020-09-30 |
2023-08-13 |
Not clear |
| Hiromu Ito, Hiromi Kurokawa, Hideo Suzuki, Hiroko P Indo, Hideyuki J Majima, Hirofumi Matsu. 5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells. Journal of clinical biochemistry and nutrition. vol 65. issue 2. 2020-09-30. PMID:31592061. |
5-aminolevulinic acid treatment of rgm cells enhanced reactive oxygen species generation and induced apoptosis associated with p53, whereas rgk cells were unaffected. |
2020-09-30 |
2023-08-13 |
rat |
| Atefeh Satari, Sayed Asadollah Amini, Elham Raeisi, Yves Lemoigne, Esfandiar Heidaria. Synergetic Impact of Combined 5-Fluorouracil and Rutin on Apoptosis in PC3 Cancer Cells through the Modulation of P53 Gene Expression. Advanced pharmaceutical bulletin. vol 9. issue 3. 2020-09-30. PMID:31592435. |
synergetic impact of combined 5-fluorouracil and rutin on apoptosis in pc3 cancer cells through the modulation of p53 gene expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ling Huang, Chen Cai, Wei Dang, Jian-Hua Lu, Gang-Feng Hu, Jun G. Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion. Oncology letters. vol 18. issue 5. 2020-09-30. PMID:31612057. |
treatment with pitc promoted total glutathione depletion in gc cell lines, leading to reactive oxygen species accumulation and dna damage, which activated the mitochondria-dependent and p53 signaling pathways to trigger apoptosis in gc cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| María Del Carmen Lagunas-Cruz, Arturo Valle-Mendiola, Jonathan Trejo-Huerta, Leticia Rocha-Zavaleta, María de Lourdes Mora-García, Adriana Gutiérrez-Hoya, Benny Weiss-Steider, Isabel Soto-Cru. IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis. Journal of oncology. vol 2019. 2020-09-30. PMID:31662754. |
il-2 upregulates the expression of p53 and p21 and downregulates cyclin d. in addition, we report the resistance of cervical cancer cells to treatments that induce apoptosis in hela and inbl cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Elif D Arisan, Remzi O Akar, Ozge Rencuzogullari, Pinar Obakan Yerlikaya, Ajda Coker Gurkan, Beyza Akın, Elif Dener, Ecem Kayhan, Narcin Palavan Unsa. The molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in PC3 prostate cancer cells. Prostate international. vol 7. issue 4. 2020-09-30. PMID:31970141. |
the molecular targets of diclofenac differs from ibuprofen to induce apoptosis and epithelial mesenchymal transition due to alternation on oxidative stress management p53 independently in pc3 prostate cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Frédéric Lessard, Emmanuelle Saint-Germain, Lian Mignacca, Gerardo Ferbeyr. SOCS1: phosphorylation, dimerization and tumor suppression. Oncoscience. vol 6. issue 11-12. 2020-09-30. PMID:31984217. |
moreover, socs1 and socs3 have been shown to be involved in tumor suppression through their ability to interact with p53 leading to the activation of its transcriptional program and showing the implication of socs family members in the regulation of apoptosis, ferroptosis and senescence. |
2020-09-30 |
2023-08-13 |
Not clear |
| Valentina Pileczki, Laura Pop, Cornelia Braicu, Livia Budisan, Gabriela Bolba Morar, Paloma Del C Monroig-Bosque, Robert V Sandulescu, Ioana Berindan-Neago. Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells. OncoTargets and therapy. vol 9. 2020-09-29. PMID:27956838. |
double gene sirna knockdown of mutant p53 and tnf induces apoptosis in triple-negative breast cancer cells. |
2020-09-29 |
2023-08-13 |
human |
| Valentina Pileczki, Laura Pop, Cornelia Braicu, Livia Budisan, Gabriela Bolba Morar, Paloma Del C Monroig-Bosque, Robert V Sandulescu, Ioana Berindan-Neago. Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells. OncoTargets and therapy. vol 9. 2020-09-29. PMID:27956838. |
simultaneous inhibition of p53 and tnf in hs578t tnbc human cell line revealed a panel of up- and downregulated genes involved in apoptosis. |
2020-09-29 |
2023-08-13 |
human |
| Jing Wang, Yue Zhang, Qiuzhen Zhu, Yulan Liu, Hao Cheng, Yuefan Zhang, Tiejun L. Data on the radioprotective effect of emodin Data in brief. vol 11. 2020-09-29. PMID:28275662. |
data on the radioprotective effect of emodin this paper contains the experiment data on the emodin, mice and cell survival rate, mice intestinal tissue h&e and tunel staining, the expression of p53 protein in mice small intestine, cell apoptosis, the expression of protein and rna |
2020-09-29 |
2023-08-13 |
mouse |
| Junhong Lv, Shaohuan Lin, Panli Peng, Changqing Cai, Jianming Deng, Mingzhi Wang, Xuejun Li, Rongsheng Lin, Yu Lin, Ailing Fang, Qiling L. Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo. OncoTargets and therapy. vol 10. 2020-09-29. PMID:28280360. |
arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shun Li, Yi Zhang, Qingyong Liu, Qingli Zhao, Liuyu Xu, Shengliang Huang, Shiming Huang, Xuebin We. Oxymatrine inhibits proliferation of human bladder cancer T24 cells by inducing apoptosis and cell cycle arrest. Oncology letters. vol 13. issue 6. 2020-09-29. PMID:28588714. |
oxymatrine also induced apoptosis and cell cycle arrest in the cells, in association with the upregulation of caspase-3 and bax, and the downregulation of survivin, bcl-2 and p53 expression. |
2020-09-29 |
2023-08-13 |
human |
| Aleksandra Szybińska, Wiesława Leśnia. P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes? Aging and disease. vol 8. issue 4. 2020-09-29. PMID:28840063. |
in this regard, a concept has been proposed that p53, as a transcription factor controlling many vital cellular pathways including apoptosis, may contribute to neuronal death common to all neurodegenerative disorders. |
2020-09-29 |
2023-08-13 |
Not clear |
| Peixiang Wang, Lori Israelian, Yunlin Xue, Siyuan Song, Liliana Attisano, Berge A Minassia. SGK1 (glucose transport), dishevelled2 (wnt signaling), LC3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in Lafora disease. The all results journals. Biol. vol 7. issue 3. 2020-09-29. PMID:29152446. |
sgk1 (glucose transport), dishevelled2 (wnt signaling), lc3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in lafora disease. |
2020-09-29 |
2023-08-13 |
Not clear |