| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Krishnamoorthy, A Witkowski, R O Rya. Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma Cells. Journal of nanomedicine & nanotechnology. vol 8. issue 4. 2020-09-30. PMID:28966869. |
nutlin-3a nanodisks induce p53 stabilization and apoptosis in a subset of cultured glioblastoma cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Duan, Carl G Mak. The IGF-1R/AKT pathway determines cell fate in response to p53. Translational cancer research. vol 5. issue 6. 2020-09-30. PMID:28966916. |
p53 that is activated in response to dna-damaging stress can induce apoptosis or either transient or permanent cell cycle arrests. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Duan, Carl G Mak. The IGF-1R/AKT pathway determines cell fate in response to p53. Translational cancer research. vol 5. issue 6. 2020-09-30. PMID:28966916. |
apoptosis and permanent cell cycle arrest (senescence) are bona-fide tumor suppressor mechanisms through which p53 inhibits cancer cell survival. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Duan, Carl G Mak. The IGF-1R/AKT pathway determines cell fate in response to p53. Translational cancer research. vol 5. issue 6. 2020-09-30. PMID:28966916. |
mechanisms that control the choice of response to p53 (apoptosis vs arrest) are not fully understood. |
2020-09-30 |
2023-08-13 |
Not clear |
| Eric Batchelor, Alexander Loewe. Recent progress and open challenges in modeling p53 dynamics in single cells. Current opinion in systems biology. vol 3. 2020-09-30. PMID:29062976. |
in mammalian cells, the tumor suppressor p53 is activated upon a variety of cellular stresses and ensures an appropriate response ranging from arrest and repair to the induction of senescence and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Anshika N Singh, Neeti Sharm. Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis. OncoTargets and therapy. vol 10. 2020-09-30. PMID:29066912. |
the gene ontology and functional enrichment analysis were performed, which showed that identified dmgs contribute to cellular and metabolic processes such as cell communication, cell cycle, response to drugs, apoptosis and p53 signaling. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ayano Hirako, Yuki Takeoka, Satoshi Furukawa, Akihiko Sugiyam. Effects of methotrexate exposure on medaka ( Journal of toxicologic pathology. vol 30. issue 4. 2020-09-30. PMID:29097838. |
in the present study, spermatogonia and spermatocytes of medaka testes were sensitive to mtx at 0.25 mg/ml in the culture water, and mtx-induced apoptosis in the testes was dependent on p53 expression; however, inhibition of mtx-induced cell proliferation was independent of p53 expression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Wei Yao, Neng Wang, Jin Qian, Lu Bai, Xiaoxin Zheng, Guo Hou, Xuan Qiu, Bo Yan. Renal sympathetic denervation improves myocardial apoptosis in rats with isoproterenol-induced heart failure by downregulation of tumor necrosis factor-α and nuclear factor-κB. Experimental and therapeutic medicine. vol 14. issue 5. 2020-09-30. PMID:29104628. |
the expression of factors associated with myocardial apoptosis, including p53, tumor necrosis factor-α (tnf-α), nuclear factor-κb (nf-κb), caspase-2 and -3, were measured using quantitative polymerase chain reaction and western blot analysis. |
2020-09-30 |
2023-08-13 |
human |
| Yang Gao, Kai Kang, Haitao Liu, Weilan Kong, Qiuyuan Han, Xing Zhang, Rui Huang, Jingdong Qu, Hongliang Wang, Sicong Wang, Ruijin Liu, Yansong Liu, Kaijiang Y. GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118926. |
the pathological examinations were performed on he stained renal tissues, apoptosis was determined using tunel assay, mrna expression of nf-kb p65, caspase-3, caspase-8, bcl-2, bax, p53 and a7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blots. |
2020-09-30 |
2023-08-13 |
mouse |
| Lingchuan Guo, Shan Huang, Xinwei Wan. PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells. OncoTargets and therapy. vol 10. 2020-09-30. PMID:29138581. |
we found that p73-mediated osimertinib-induced p53 upregulated modulator of apoptosis (puma) expression irrespective of p53 status following pi3k/akt pathway inhibition in crc cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xin Deng, Laijun Song, Wen Zhao, Ying Wei, Xin-Bin Gu. HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311840. |
the knock-out of hax-1 leads to the inactivity of the ak1t/mdm2 axis, which leads to increased levels of p53, and finally generates cell cycle arrest and results in the apoptosis of glioblastoma cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hui Xiong, Jiangnan Zhan. Expression and clinical significance of ATM and PUMA gene in patients with colorectal cancer. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344228. |
the expression of ataxia-telangiectasia mutated (atm) and p53 upregulated modulator of apoptosis (puma) genes in patients with colorectal cancer were investigated, to explore the correlation between the expression of atm and puma and tumor development, to evaluate the clinical significance of atm and puma in the treatment of colorectal cancer. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Al-Buhadill. p53 Gene (NY-CO-13) Levels in Patients with Chronic Myeloid Leukemia: The Role of Imatinib and Nilotinib. Diseases (Basel, Switzerland). vol 6. issue 1. 2020-09-30. PMID:29370077. |
the main functions of the p53 gene are an anticancer effect and cellular genomic stability via various pathways including activation of dna repair, induction of apoptosis, and arresting of cell growth at the g1/s phase. |
2020-09-30 |
2023-08-13 |
mouse |
| Sevasti Manousakidi, Arnaud Guillaume, Caroline Pirou, Sylvina Bouleau, Bernard Mignotte, Flore Renaud, Nathalie Le Floc. FGF1 induces resistance to chemotherapy in ovarian granulosa tumor cells through regulation of p53 mitochondrial localization. Oncogenesis. vol 7. issue 2. 2020-09-30. PMID:29467390. |
indeed, p53 accumulates at mitochondria upon etoposide treatment and inhibition of p53 mitochondrial localization using pifithrin-µ inhibits apoptosis of cov434 cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nadine Schuler, Jan Palm, Sabine Schmitz, Yvonne Lorat, Claudia E Rüb. Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. Clinical and translational radiation oncology. vol 7. 2020-09-30. PMID:29594232. |
in response to dna damage, p53 stimulates protective cellular processes including cell-cycle arrest and apoptosis to prevent aberrant cell proliferation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yefeng Dai, Xufei Zha. Therapeutic effects of simvastatin combined with kallistatin treatment for pediatric burn patients with sepsis. Experimental and therapeutic medicine. vol 15. issue 3. 2020-09-30. PMID:29599842. |
the study further demonstrated that combined treatment significantly decreased hec apoptosis through the upregulation of b-cell lymphoma 2 (bcl-2) and p53 expression levels, as well as downregulation of bcl-2-associated x protein and caspase-3 levels. |
2020-09-30 |
2023-08-13 |
human |
| Yayun Liang, Benford Mafuvadze, Cynthia Besch-Williford, Salman M Hyde. A combination of p53-activating APR-246 and phosphatidylserine-targeting antibody potently inhibits tumor development in hormone-dependent mutant p53-expressing breast cancer xenografts. Breast cancer (Dove Medical Press). vol 10. 2020-09-30. PMID:29606888. |
wild-type p53 tumor suppressor protein promotes cell-cycle arrest and apoptosis and inhibits vascular endothelial growth factor-dependent angiogenesis, whereas mutant p53 protein (mtp53) lacks these functions, resulting in tumor cell survival and metastasis. |
2020-09-30 |
2023-08-13 |
human |
| Ge Yu, Na Li, Yan Zhao, Wei Wang, Xiao-Ling Fen. Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780 cells through the p53 signaling pathway. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29616120. |
salidroside induces apoptosis in human ovarian cancer skov3 and a2780 cells through the p53 signaling pathway. |
2020-09-30 |
2023-08-13 |
human |
| Xiao-Mei Gao, Ying Zhu, Jian-Hua Li, Xiang-Yu Wang, Xiao-Fei Zhang, Chen-He Yi, Xin Yan. microRNA-26a induces a mitochondrial apoptosis mediated by p53 through targeting to inhibit Mcl1 in human hepatocellular carcinoma. OncoTargets and therapy. vol 11. 2020-09-30. PMID:29719405. |
microrna-26a induces a mitochondrial apoptosis mediated by p53 through targeting to inhibit mcl1 in human hepatocellular carcinoma. |
2020-09-30 |
2023-08-13 |
human |
| Xiaoyong Fan, Hongzhen Lu, Youqiang Cui, Xianzeng Hou, Chuanjiang Huang, Guangcun Li. Overexpression of p53 delivered using recombinant NDV induces apoptosis in glioma cells by regulating the apoptotic signaling pathway. Experimental and therapeutic medicine. vol 15. issue 5. 2020-09-30. PMID:29731836. |
overexpression of p53 delivered using recombinant ndv induces apoptosis in glioma cells by regulating the apoptotic signaling pathway. |
2020-09-30 |
2023-08-13 |
Not clear |