| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanjay de Mel, Joshua Zhi-Chien Tan, Anand D Jeyasekharan, Wee-Joo Chng, Siok-Bian N. Transcriptomic Abnormalities in Epstein Barr Virus Associated T/NK Lymphoproliferative Disorders. Frontiers in pediatrics. vol 6. 2020-10-01. PMID:30705877. |
pathways promoting proliferation, such as janus associated kinase/ signal transducer and activator of transcription (jak/stat) and nuclear factor kb, are upregulated in enktl while upregulation of survivin and deregulation of p53 inhibit apoptosis in both enktl and chronic active ebv infection (caebv). |
2020-10-01 |
2023-08-13 |
Not clear |
| Xueli Zhang, Xiao-Feng Sun, Bairong Shen, Hong Zhan. Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification. Cancers. vol 11. issue 2. 2020-10-01. PMID:30717315. |
moreover, the biomarkers played critical roles in cellular proliferation, apoptosis and angiogenesis and they were involved in ras, p53 and pi3k pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Pilar Acedo, Aristi Fernandes, Joanna Zawacka-Panka. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in Future science OA. vol 5. issue 2. 2020-10-01. PMID:30820346. |
activation of tap73 and inhibition of trxr by verteporfin for improved cancer therapy in tap73 is a tumor suppressor, which compensates for p53 loss and induces apoptosis in tumors in response to genotoxic stress or small-molecule treatments. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jingwen Song, Songqun Huang, Kaizhong Wang, Wei Li, Lizhi Pao, Feng Chen, Xianxian Zha. Long Non-coding RNA MEG3 Attenuates the Angiotensin II-Induced Injury of Human Umbilical Vein Endothelial Cells by Interacting With p53. Frontiers in genetics. vol 10. 2020-10-01. PMID:30838022. |
furthermore, overexpression of meg3 inhibited cell apoptosis, and increased cell migration by enhancing p53 transcription on its target genes, including crp, icam-1, vegf, and hif-1α. |
2020-10-01 |
2023-08-13 |
human |
| Qun Chen, Jeremy Thompson, Ying Hu, Anindita Das, Edward J Lesnefsk. Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage. Frontiers in cardiovascular medicine. vol 6. 2020-10-01. PMID:30838215. |
p53 is a tumor suppressor protein that regulates apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Zhonglun Liu, Xiaohong Wu, Jingjing Lv, Hui Sun, Feiqin Zho. Resveratrol induces p53 in colorectal cancer through SET7/9. Oncology letters. vol 17. issue 4. 2020-10-01. PMID:30881498. |
additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including bcl2 associated x, apoptosis regulator and bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhonglun Liu, Xiaohong Wu, Jingjing Lv, Hui Sun, Feiqin Zho. Resveratrol induces p53 in colorectal cancer through SET7/9. Oncology letters. vol 17. issue 4. 2020-10-01. PMID:30881498. |
collectively, these results reveal the molecular mechanisms by which resveratrol induces p53 stability in colon cancer that results in the activation of p53-mediated apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dan Gong, Zhiwen Zeng, Fengming Yi, Jianbing W. Inhibition of histone deacetylase 11 promotes human liver cancer cell apoptosis. American journal of translational research. vol 11. issue 2. 2020-10-01. PMID:30899397. |
this study tests a hypothesis that hdac11 prevents lc cell (lcc) apoptosis via modulating the p53 gene transcription. |
2020-10-01 |
2023-08-13 |
human |
| Hui Su, Qian Kang, Haihong Wang, Hui Yin, Linghui Duan, Yuli Liu, Ruying Fa. Changes in expression of p53 and inflammatory factors in patients with ulcerative colitis. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906432. |
the findings of the study show that, expression level of il-6 was increased in uc patients, which regulates the downregulation of p53 expression level and plays a role in tumorigenesis through enhancing cell proliferation and inhibiting apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Anna-Laura Kretz, Anna Trauzold, Andreas Hillenbrand, Uwe Knippschild, Doris Henne-Bruns, Silvia von Karstedt, Johannes Lemk. TRAILblazing Strategies for Cancer Treatment. Cancers. vol 11. issue 4. 2020-10-01. PMID:30935038. |
the ability of trail to also induce apoptosis independently of p53 makes trail a promising anticancer agent, especially in p53-mutated tumour entities. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Min-Hee Kang, Jin-Hoi Ki. Graphene Oxide⁻Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer. Polymers. vol 11. issue 4. 2020-10-01. PMID:31018506. |
activation of the key regulators p53 and p21 inhibited the cyclin-dependent kinases cdk2 and cdk4, suggesting that p53 and p21 activation in go-ptnp-treated cells caused genotoxic stress and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Ji Hoon Jung, Hyemin Lee, Ju-Ha Kim, Deok Yong Sim, Hyojin Ahn, Bonglee Kim, Suhwan Chang, Sung-Hoon Ki. p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and its Combination Effect with RITA or Doxorubicin. Cancers. vol 11. issue 4. 2020-10-01. PMID:31022952. |
also, puromycin enhanced the antitumor effect with reactivating p53 and inducing tumor apoptosis (rita) or doxorubicin in hct116 cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Ji Hoon Jung, Hyemin Lee, Ju-Ha Kim, Deok Yong Sim, Hyojin Ahn, Bonglee Kim, Suhwan Chang, Sung-Hoon Ki. p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and its Combination Effect with RITA or Doxorubicin. Cancers. vol 11. issue 4. 2020-10-01. PMID:31022952. |
these findings suggest that puromycin induces p53-dependent apoptosis via upregulation of rpl5 or rpl11 for binding with mdm2, and so can be used more effectively in p53 wild-type cancers by combination with rita or doxorubicin. |
2020-10-01 |
2023-08-13 |
mouse |
| Chengyin Weng, Yong Chen, Yong Wu, Xia Liu, Haibo Mao, Xisheng Fang, Baoxiu Li, Lina Wang, Mingmei Guan, Guolong Liu, Lin Lu, Yawei Yua. Silencing UBE4B induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53. OncoTargets and therapy. vol 12. 2020-10-01. PMID:31040698. |
silencing ube4b induces nasopharyngeal carcinoma apoptosis through the activation of caspase3 and p53. |
2020-10-01 |
2023-08-13 |
human |
| Lei Shang, Minjie We. Inhibition of SMYD2 Sensitized Cisplatin to Resistant Cells in NSCLC Through Activating p53 Pathway. Frontiers in oncology. vol 9. 2020-10-01. PMID:31106145. |
mechanistically, inhibition of smyd2 could enhance p53 pathway activity and induce cell apoptosis through regulating its target genes, including p21, gadd45, and bax. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rehmat Jan, Gul-E-Saba Chaudhr. Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. Advanced pharmaceutical bulletin. vol 9. issue 2. 2020-10-01. PMID:31380246. |
this review focused on the underlying mechanism of apoptosis and the dysregulation of apoptosis modulators involved in the extrinsic and intrinsic apoptotic pathway, which include death receptors (drs) proteins, cellular flice inhibitory proteins (c-flip), anti-apoptotic bcl-2 proteins, inhibitors of apoptosis proteins (iaps), tumor suppressor (p53) in cancer cells along with various current clinical approaches aimed to selectively induce apoptosis in cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jiayi Zhang, Rong Cong, Kai Zhao, Yi Wang, Ninghong Song, Min G. High TRIAP1 expression in penile carcinoma is associated with high risk of recurrence and poor survival. Annals of translational medicine. vol 7. issue 14. 2020-10-01. PMID:31475200. |
tp53-regulated inhibitor of apoptosis 1 (triap1), also known as p53 cell survival factor or p53csv, is reported to be associated with resistance of apoptosis in different human malignancies, but the potential role of triap1 in penile carcinoma (peca) has not been well studied. |
2020-10-01 |
2023-08-13 |
human |
| Cheng-Jung Ho, Ru-Wei Lin, Wei-Hua Zhu, Tsung-Kai Wen, Chieh-Ju Hu, Yi-Lin Lee, Ta-I Hung, Chihuei Wan. Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress. Cell death discovery. vol 5. 2020-10-01. PMID:31482012. |
we previously reported that p53-mediated apoptosis is determined by severity of dna damage, not by the level of p53, in doxorubicin-treated prostate cancer cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng-Jung Ho, Ru-Wei Lin, Wei-Hua Zhu, Tsung-Kai Wen, Chieh-Ju Hu, Yi-Lin Lee, Ta-I Hung, Chihuei Wan. Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress. Cell death discovery. vol 5. 2020-10-01. PMID:31482012. |
by using dominant negative p53 to compete with wild-type p53 in transcription activity, we demonstrated that p53-mediated apoptosis in response to doxorubicin- or camptothecin-induced genotoxic stress is transcription-independent. |
2020-10-01 |
2023-08-13 |
Not clear |