| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ishii, de Tribolet . Are p53 mutations and p53 overexpression prognostic factors for astrocytic tumors? Critical reviews in neurosurgery : CR. vol 8. issue 5. 2020-09-28. PMID:9732540. |
since the main functions of normal p53 are cell-cycle regulation and induction of apoptosis, p53 mutations are considered to be associated with rapid tumor growth and resistance to radiation and chemotherapy. |
2020-09-28 |
2023-08-12 |
human |
| Anees A Ansari, T N Hasan, N A Syed, J P Labis, Ali A Alshatw. Saudi journal of biological sciences. vol 24. issue 6. 2020-09-28. PMID:28855837. |
further, the qpcr results also show that the mrna expressions of cell cycle checkpoint gene p53 and apoptosis related gene ( |
2020-09-28 |
2023-08-13 |
human |
| Sorah Yoon, Xiwei Wu, Brian Armstrong, Nagy Habib, John J Ross. An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. Molecular therapy. Nucleic acids. vol 14. 2020-09-28. PMID:30594071. |
pdr3 also upregulated serine phosphorylation of p53, which subsequently mediated apoptosis through the death receptors: tumor necrosis factor (tnf)-related apoptosis-inducing ligand receptors 1/2 (trail-r1/r2), fas-associated via death domain (fadd), and fas. |
2020-09-28 |
2023-08-13 |
human |
| Yi Yang, He Li, Zhifeng He, Deyao Xie, Jiangwei Ni, Xiaoming Li. MicroRNA-488-3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma. Journal of cellular biochemistry. vol 120. issue 11. 2020-09-28. PMID:31243806. |
in sum, this study revealed that mir-488-3p inhibited proliferation and induced apoptosis by targeting zbtb2 and activating p53 pathway in esophageal squamous cell carcinoma, providing a novel biological target for escc. |
2020-09-28 |
2023-08-13 |
human |
| Guo-Qian He, Wen-Ming Xu, Hui-Juan Liao, Chuan Jiang, Chang-Qing Li, Wei Zhan. Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion. Neural regeneration research. vol 14. issue 11. 2020-09-28. PMID:31290456. |
huwe1 is involved in the turnover of numerous substrates, including p53, mcl-1, cdc6 and n-myc, thereby playing a critical role in apoptosis and neurogenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiande Wu, Tarun Karthik Kumar Mamidi, Lu Zhang, Chindo Hick. Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer. Cancers. vol 11. issue 11. 2020-09-28. PMID:31683572. |
network and pathway analysis revealed molecule networks and signaling pathways enriched for germline, somatic and epigenomic variation, among them: role of brca1 in dna damage response, hereditary breast cancer signaling, molecular mechanisms of cancer, estrogen-dependent breast cancer, p53, myc mediated apoptosis, and pten signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marie-Elodie Spaety, Alexandre Gries, Amandine Badie, Aina Venkatasamy, Benoit Romain, Christophe Orvain, Kazuyoshi Yanagihara, Koji Okamoto, Alain C Jung, Georg Mellitzer, Sébastien Pfeffer, Christian Gaiddo. HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway. Cancers. vol 11. issue 11. 2020-09-28. PMID:31703394. |
pathway analysis of genes whose expression in patients correlated strongly with hdac4 highlighted dna damage, p53 stabilization, and apoptosis as processes downregulated by hdac4. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marinela Bostan, Georgiana Gabriela Petrică-Matei, Gabriela Ion, Nicoleta Radu, Mirela Mihăilă, Răzvan Hainăroşie, Lorelei Irina Braşoveanu, Viviana Roman, Carolina Constantin, Monica Teodora Neag. Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Experimental and therapeutic medicine. vol 18. issue 6. 2020-09-28. PMID:31798724. |
moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-erk1/2 activation-dependent in the apoptosis induced by combined treatments (cispt and crm). |
2020-09-28 |
2023-08-13 |
Not clear |
| Zhenhua Liu, Yue Wu, Yingqiu Zhang, Menglang Yuan, Xuelu Li, Jiyue Gao, Shanni Zhang, Chengjuan Xing, Huamin Qin, Hongbo Zhao, Zuowei Zha. TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer. Frontiers in oncology. vol 9. 2020-09-28. PMID:31799200. |
tigar (tp53-induced glycolysis and apoptosis regulator) is a fructose-2,6-bisphosphatase that is regulated by p53. |
2020-09-28 |
2023-08-13 |
Not clear |
| Regina Mirgayazova, Raniya Khadiullina, Rimma Mingaleeva, Vitaly Chasov, Marina Gomzikova, Ekaterina Garanina, Albert Rizvanov, Emil Bulato. Novel Isatin-based activator of p53 transcriptional functions in tumor cells. Molecular biology research communications. vol 8. issue 3. 2020-09-28. PMID:31998813. |
here, we report novel data on p53 activating isatin-based cu(ii) complex exhibiting cytotoxic properties towards hct116 and mcf7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Achuth Padmanabhan, M Kaushik, R Niranjan, JoAnne S Richards, Brandon Ebright, G Devanand Venkatasubb. Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status. Applied surface science. vol 487. 2020-09-28. PMID:32042215. |
while zno-nps caused depletion of both wild-type and gain-of-function (gof) mutant p53 protein in ovarian cancer cells, their ability to induce apoptosis was found to be independent of the p53-mutation status in these cells. |
2020-09-28 |
2023-08-13 |
human |
| Leïla T S Fusée, Mónica Marín, Robin Fåhraeus, Ignacio Lópe. Alternative Mechanisms of p53 Action During the Unfolded Protein Response. Cancers. vol 12. issue 2. 2020-09-28. PMID:32050651. |
the capacity of p53 to control cellular events such as cell cycle progression, dna repair, and apoptosis, to mention some, has been mostly linked to its role as a transcription factor. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ying Wang, Guilin Zeng, Yicheng Jian. The Emerging Roles of miR-125b in Cancers. Cancer management and research. vol 12. 2020-09-28. PMID:32104088. |
importantly, mir-125b is involved in regulating nf-κb, p53, pi3k/akt/mtor, erbb2, wnt, and another signaling pathways, thereby controlling cell proliferation, differentiation, metabolism, apoptosis, drug resistance and tumor immunity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yu Chen, Zhiqiang Liu, Yuequn Wang, Jian Zhuang, Yun Peng, Xiaoyang Mo, Jimei Chen, Yan Shi, Mengxiong Yu, Wanwan Cai, Yahuan Li, Xiaolan Zhu, Wuzhou Yuan, Yongqing Li, Fang Li, Zuoqiong Zhou, Guo Dai, Xiangli Ye, Yongqi Wan, Zhigang Jiang, Ping Zhu, Xiongwei Fan, Xiushan W. FKBP51 induces p53-dependent apoptosis and enhances drug sensitivity of human non-small-cell lung cancer cells. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104289. |
these results indicated that fkbp51 promoted a549 cell apoptosis via the p53 signaling pathway. |
2020-09-28 |
2023-08-13 |
human |
| Lei Gao, Chaochao Ge, Senzhen Wang, Xiaojuan Xu, Yongli Feng, Xinna Li, Chaojie Wang, Yuxia Wang, Fujun Dai, Songqiang Xi. The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative. Cancers. vol 12. issue 3. 2020-09-28. PMID:32106543. |
based on rna-seq data, further bioinformatic analyses suggest that 9f exerts its anticancer activities through p53 signaling, which is responsible for the altered expression of key regulators of the cell cycle, apoptosis, the epithelial-to-mesenchymal transition (emt), and angiogenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Zhen-Qi Qin, Qi-Guang Li, Hong Yi, Shan-Shan Lu, Wei Huang, Zhuo-Xian Rong, Yao-Yun Tang, Zhi-Qiang Xia. Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway. Frontiers in oncology. vol 10. 2020-09-28. PMID:32117754. |
in this study, we generated p53 knockout (ko) npc cell lines from cne2 cells carrying heterozygous p53 r280t (p53-r280t) mutation and c666-1 cells carrying wild-type p53 by crispr-cas9 gene editing system, and found that ko of heterozygous p53-r280t significantly decreased npc cell proliferation and increased npc cell apoptosis, whereas ko of wild-type p53 had opposite effects on npc cell proliferation and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ke Lin, Yi Rong, Dan Chen, Zizhuo Zhao, Huaben Bo, Aimin Qiao, Xiaojuan Hao, Jinquan Wan. Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway. Frontiers in oncology. vol 10. 2020-09-28. PMID:32133289. |
the expression of nf-κb and xiap decreased while the expression of p53 increased and associated with apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jinglan Jin, Hongqin Xu, Wanyu Li, Xiaotong Xu, Huan Liu, Feng We. LINC00346 Acts as a Competing Endogenous RNA Regulating Development of Hepatocellular Carcinoma via Modulating CDK1/CCNB1 Axis. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32133348. |
these results proved that linc00346 could regulate the expression of cdk1/ccnb1 through the competitive adsorption of mir-199a-3p, thereby affecting the p53 signaling pathway and finally regulating the apoptosis, invasion and cell cycle of hcc cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Manar Mansour, Shehab Ismail, Khaled Abou-Aish. Bacterial delivery of the anti-tumor azurin-like protein Laz to glioblastoma cells. AMB Express. vol 10. issue 1. 2020-09-28. PMID:32221741. |
in brain cancer cells, laz has been demonstrated to induce apoptosis through an interaction with the tumor suppressor protein p53. |
2020-09-28 |
2023-08-13 |
Not clear |
| Li Zhang, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Guoliang Zhan. Punicalagin promotes the apoptosis in human cervical cancer (ME-180) cells through mitochondrial pathway and by inhibiting the NF-kB signaling pathway. Saudi journal of biological sciences. vol 27. issue 4. 2020-09-28. PMID:32256171. |
this investigation was intended to examine the efficiency of punicalagin lying on cell viability so as to examine the molecular based punicalagin mechanism stimulated apoptosis via exploring the expression of bcl-2 family proteins, and caspases also the cell cycle regulatory proteins p53 and nf-κb signaling in human cervical cancer cells. |
2020-09-28 |
2023-08-13 |
human |