| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Archana Kumari Redhu, Jayadeva Paike Bha. Mitochondrial glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase abrogate p53 induced apoptosis in a yeast model: Possible implications for apoptosis resistance in cancer cells. Biochimica et biophysica acta. General subjects. vol 1864. issue 3. 2020-08-28. PMID:31862471. |
mitochondrial glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase abrogate p53 induced apoptosis in a yeast model: possible implications for apoptosis resistance in cancer cells. |
2020-08-28 |
2023-08-13 |
human |
| Archana Kumari Redhu, Jayadeva Paike Bha. Mitochondrial glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase abrogate p53 induced apoptosis in a yeast model: Possible implications for apoptosis resistance in cancer cells. Biochimica et biophysica acta. General subjects. vol 1864. issue 3. 2020-08-28. PMID:31862471. |
in this study, we showed that how s.cerevisiae escaped from p53 induced apoptosis in the presence of a fermentable carbon source (sucrose), but not on non-fermentable carbon source (glycerol). |
2020-08-28 |
2023-08-13 |
human |
| Sanjay Kumar, Andrea Brown, Paul B Tchounwo. Trisenox disrupts MDM2-DAXX-HAUSP complex and activates p53, cell cycle regulation and apoptosis in acute leukemia cells. Oncotarget. vol 9. issue 69. 2020-08-27. PMID:30237857. |
trisenox disrupts mdm2-daxx-hausp complex and activates p53, cell cycle regulation and apoptosis in acute leukemia cells. |
2020-08-27 |
2023-08-13 |
Not clear |
| Manjima Chatterjee, Febin Prabhu Dass J, Sonali Sengupt. Nuclear stress bodies: Interaction of its components in oncogenic regulation. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-27. PMID:31090102. |
an extended research on the regulations of satiii and p53 may open new avenues in the field of apoptosis in cancer and the early approach of molecular targeting. |
2020-08-27 |
2023-08-13 |
human |
| Marc Oria, Soner Duru, Rebeca L Figueira, Federico Scorletti, Lucas E Turner, Irati Fernandez-Alonso, Alejandra Fernandez-Martin, Mario Marotta, Lourenco Sbragia, Aimen F Shaaban, Jose L Peir. Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis. Cell death & disease. vol 10. issue 10. 2020-08-27. PMID:31558708. |
expression of apoptosis and senescence genes (p53, p21, p16, rbl2, casp3, casp9) was determined by qrt-pcr and protein expression analyzed by western blot. |
2020-08-27 |
2023-08-13 |
mouse |
| Tianliang Zhang, Haotai Chen, Xinsheng Liu, Linlin Qi, Xin Gao, Kailing Wang, Kaishen Yao, Jie Zhang, Yuefeng Sun, Yongguang Zhang, Run W. Basal Level p53 Suppresses Antiviral Immunity against Foot-and-Mouth Disease Virus. Viruses. vol 11. issue 8. 2020-08-24. PMID:31394868. |
tumor suppressor protein p53 (p53) is a master transcription factor that plays key roles in cell cycle arrest, apoptosis, senescence, and metabolism, as well as regulation of innate immunity during virus infection. |
2020-08-24 |
2023-08-13 |
mouse |
| Yang Li, Ting Li, Yuejia Tang, Zhiyan Zhan, Lixia Ding, Lili Song, Tingting Yu, Yi Yang, Jing Ma, Yingwen Zhang, Ying Zhou, Song Gu, Min Xu, Yijin Gao, Yanxin L. The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient. PloS one. vol 15. issue 6. 2020-08-24. PMID:32516327. |
p53 mutation facilitates the proliferation of tumor cells by inhibiting apoptosis and promoting cell division. |
2020-08-24 |
2023-08-13 |
Not clear |
| Chuncai Gu, Jianqun Cai, Zhijun Xu, Shiming Zhou, Liangying Ye, Qun Yan, Yue Zhang, Yuxin Fang, Yongfeng Liu, Chenge Tu, Xinke Wang, Juan He, Qingyuan Li, Lu Han, Xin Lin, Aimin Li, Side Li. MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/β-catenin signaling. Cell death & disease. vol 10. issue 10. 2020-08-21. PMID:31570702. |
moreover, it functioned as a sensitizer for chemotherapy in crc by inducing cell cycle arrest and early apoptosis via its activating effects on p53 and apoptotic signaling pathways. |
2020-08-21 |
2023-08-13 |
Not clear |
| Xinyu Tang, Yang Li, Long Liu, Rui Guo, Ping Zhang, Yihe Zhang, Yong Zhang, Jia Zhao, Jing Su, Liankun Sun, Yanan Li. Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31894331. |
sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer. |
2020-08-21 |
2023-08-13 |
human |
| Chuntuan Li, Yahong Xu, Pengliang Xin, Yan Zheng, Xiongpeng Zh. Role and mechanism of PTEN in Burkitt's lymphoma. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31922234. |
the results revealed that pten inhibited the proliferation of ca46 and raji cells by downregulating the expression of p‑akt, it was indicated that the upregulation of proapoptotic proteins (including bad and bax) induced apoptosis, regulated cyclin (including p53, p21, cdk4, cdk6, cyclin d3 and cyclin h) to inhibit cell cycle progression, and mediated epithelial‑mesenchymal transition‑like cell markers (including e‑cadherin, n‑cadherin, β‑catenin, tcf‑8, vimentin, slug and snail) to inhibit cell migration and invasion. |
2020-08-21 |
2023-08-13 |
Not clear |
| Sara A Wahdan, Samar S Azab, Doaa A Elsherbiny, Ebtehal El-Demerdas. Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31197431. |
pic suppressed cisplatin-induced apoptosis by decreasing p53 and cytochrome c expression and caspase-3 activity. |
2020-08-20 |
2023-08-13 |
rat |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tbccao-treated mice, and esc treatment regulated the expression of mitophagy-related factors, including bnip3, beclin1, pink1, and parkin, the lc-3 ii/i ratio, and apoptosis-related factors, including p53, bax, and caspase 3. |
2020-08-19 |
2023-08-13 |
mouse |
| Ahmed Eleojo Musa, Dheyauldeen Shabeeb, Nnamdi O E Okoro, Alaba Tolulope Agbel. Radiation protection by Ex-RAD: a systematic review. Environmental science and pollution research international. vol 27. issue 27. 2020-08-19. PMID:32583118. |
furthermore, the inhibition of apoptosis through p53 signaling pathway was the main mechanism of radioprotection by ex-rad. |
2020-08-19 |
2023-08-13 |
Not clear |
| Pedram Kharaziha, Sophia Ceder, Olga Axell, Moritz Krall, Omid Fotouhi, Stefanie Böhm, Sonia Lain, Åke Borg, Catharina Larsson, Klas G Wiman, Emma Tham, Svetlana Bajalica-Lagercrant. Functional characterization of novel germline TP53 variants in Swedish families. Clinical genetics. vol 96. issue 3. 2020-08-17. PMID:31081129. |
the missense variant r110c retain p53 effects and the nonsense e349* shows at least partial transcription factor activity but has reduced ability to trigger apoptosis. |
2020-08-17 |
2023-08-13 |
Not clear |
| Fei Ren, Yujie Huang, Yizhou Tao, Cheng Ji, Stanley Aniagu, Yan Jiang, Tao Che. Resveratrol protects against PM2.5-induced heart defects in zebrafish embryos as an antioxidant rather than as an AHR antagonist. Toxicology and applied pharmacology. vol 398. 2020-08-14. PMID:32376357. |
furthermore, rsv attenuated eom-induced changes in the expression of genes involved in cardiac development (nkx2.5, sox9b, axin2), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod1, sod2, cat) and apoptosis (p53, bax). |
2020-08-14 |
2023-08-13 |
cat |
| Alexander V Sirotkin, Andrej Benco, Jan Kotwica, Saleh H Alwasel, Abdel H Harrat. Apoptosis signal-regulating kinase (ASK-1) controls ovarian cell functions. Reproduction, fertility, and development. vol 31. issue 11. 2020-08-10. PMID:31217073. |
we compared the accumulation of ask-1, proliferation marker proliferating cell nuclear antigen (pcna), apoptosis marker bax and apoptosis and proliferation regulating transcription factor p53 and the release of progesterone (p4), oxytocin (ot), insulin-like growth factor i (igf-i) and prostaglandins f (pgf) and e (pge) using cultured porcine ovarian granulosa cells transfected with ask-1 cdna and cultured with leptin or fsh. |
2020-08-10 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Andrej Benco, Jan Kotwica, Saleh H Alwasel, Abdel H Harrat. Apoptosis signal-regulating kinase (ASK-1) controls ovarian cell functions. Reproduction, fertility, and development. vol 31. issue 11. 2020-08-10. PMID:31217073. |
this study is the first to demonstrate that ask-1 does not affect cell apoptosis and viability in ovarian cells, but promotes cell proliferation, suppresses p53, alters the release of ovarian hormones (p4, ot, igf-i, pgf and pge) and defines their response to the upstream hormonal regulators leptin and fsh. |
2020-08-10 |
2023-08-13 |
Not clear |
| Jian-An Pan, Yong Tang, Jian-Ying Yu, Hui Zhang, Jun-Feng Zhang, Chang-Qian Wang, Jun G. miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity. Cell death & disease. vol 10. issue 9. 2020-08-10. PMID:31511497. |
further research proved that mir-146a targeted tata-binding protein (tbp) associated factor 9b (taf9b), a coactivator and stabilizer of p53, indirectly destroyed the stability of p53, thereby inhibiting apoptosis and improving autophagy in cardiomyocytes. |
2020-08-10 |
2023-08-13 |
mouse |
| Tamas Vancsik, Gertrud Forika, Andrea Balogh, Eva Kiss, Tibor Krenac. Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. Cancer medicine. vol 8. issue 9. 2020-08-03. PMID:31183995. |
modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro. |
2020-08-03 |
2023-08-13 |
human |
| Maja T Tomicic, Christian Steigerwald, Birgit Rasenberger, Anamaria Brozovic, Markus Christman. Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Archives of toxicology. vol 93. issue 8. 2020-07-31. PMID:31289894. |
the purpose of this study was to analyze the cytostatic/cytotoxic response of colorectal carcinoma (crc) cells to irinotecan, depending on the mismatch repair (mmr) and p53 status and to examine the impact of bv6, a bivalent antagonist of inhibitors of apoptosis c-iap1/c-iap2, alone or combined with irinotecan. |
2020-07-31 |
2023-08-13 |
Not clear |