| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martina Magni, Giacomo Buscemi, Lucia Maita, Lei Peng, Siu Yuen Chan, Alessandra Montecucco, Domenico Delia, Laura Zannin. TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage. Cell death and differentiation. vol 26. issue 5. 2020-07-06. PMID:30050056. |
indeed, in response to dna damage, cells silenced for tspyl2 were found to be defective in p53 activation and apoptosis induction and these events were shown to be dependent on sirt1 and p300 function. |
2020-07-06 |
2023-08-13 |
Not clear |
| Rui-Yuan Xu, Xing-Wang Xu, Yi-Zhang Deng, Zhao-Xia Ma, Xiao-Ran Li, Le Zhao, Le-Jia Qiu, Hao-Yue Liu, He-Ping Che. Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway. Biochemical and biophysical research communications. vol 514. issue 2. 2020-07-06. PMID:31053297. |
in conclusion, the current study demonstrated that resveratrol suppressed h/r-induced cell apoptosis, which may be conducted by up-regulating dj-1, and later activating sirt1 activity and subsequently inhibiting p53 acetylation level in the h9c2 cells. |
2020-07-06 |
2023-08-13 |
Not clear |
| Magdalena C Liebl, Thomas G Hofman. Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 41. issue 12. 2020-07-06. PMID:31621101. |
however, the molecular mechanism of action of the p53 ser46 phospho-isomer, the molecular timing of this phosphorylation event, and its activating effects on apoptosis and ferroptosis still await exploration. |
2020-07-06 |
2023-08-13 |
Not clear |
| Yue Yang, Jianxin He, Jing Chen, Li Lin, Yongqi Liu, Cunmin Zhou, Yun Su, Hulai We. Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression. BioMed research international. vol 2019. 2020-07-06. PMID:31976328. |
as a result, cells expressing p53 (r248q) displayed higher cell viability and lower cell apoptosis level upon adm treatment. |
2020-07-06 |
2023-08-13 |
Not clear |
| Yue Yang, Jianxin He, Jing Chen, Li Lin, Yongqi Liu, Cunmin Zhou, Yun Su, Hulai We. Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression. BioMed research international. vol 2019. 2020-07-06. PMID:31976328. |
however, combination of dha and adm treatment decreased cell viability and elevated cell apoptosis level in p53 (r248q)-expressing hep3b cells. |
2020-07-06 |
2023-08-13 |
Not clear |
| Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R Green, Jiri Bartek, Mads Daugaard, Dagmar Kulm. Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Molecular cell. vol 77. issue 5. 2020-07-06. PMID:31982308. |
depletion of caspase-8 causes g2/m arrest, stabilization of p53, and induction of p53-dependent intrinsic apoptosis in tumor cells. |
2020-07-06 |
2023-08-13 |
human |
| Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R Green, Jiri Bartek, Mads Daugaard, Dagmar Kulm. Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Molecular cell. vol 77. issue 5. 2020-07-06. PMID:31982308. |
this results in de facto p53 protein loss, switching cell fate from apoptosis toward mitosis. |
2020-07-06 |
2023-08-13 |
human |
| Anatoly B Uzdensk. Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins. Apoptosis : an international journal on programmed cell death. vol 24. issue 9-10. 2020-07-02. PMID:31256300. |
(2) similtaneous and concerted up-regulation in the ischemic penumbra of proteins that execute apoptosis (caspases 3, 6, 7; bcl-10, smac/diablo, aif, psr), signaling proteins that regulate different apoptosis pathways (p38, jnk, dyrk1a, neurotrophin receptor p75); transcription factors that control expression of various apoptosis regulation proteins (e2f1, p53, c-myc, gadd153); and proteins, which are normally involved in diverse cellular functions, but stimulate apoptosis in specific situations (nmdar2a, par4, gad65/67, caspase 11). |
2020-07-02 |
2023-08-13 |
human |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
furthermore, methotrexate induced the down-regulation of the anti-apoptotic protein, mcl-1, dna damage, and the activation of a p53 tumor suppressor, leading to apoptosis through the inhibition of stat3. |
2020-07-01 |
2023-08-13 |
Not clear |
| Xiaoge Gao, Mengxue Wei, Wenhua Shan, Qian Liu, Jian Gao, Yong Liu, Songlei Zhu, Hong Ya. An oral 2-hydroxypropyl-β-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma. Pharmacological research. vol 148. 2020-06-29. PMID:31425749. |
our mechanistic studies showed that cphsp treatment inhibited mdm2 protein expression and up-regulated p53 activity and activated mkk4/mkk7/jnk1/2/c-jun signaling pathway, which resulted in cell cycle arrest and apoptosis of hepg2 cells in vitro. |
2020-06-29 |
2023-08-13 |
mouse |
| Jun Li, Sha-Sha Zuo, Xiao-Xuan Qiu, Xi Xu, Ying-Ying Luo, Hong-Wei Gao, Yu-Lin Feng, Li-Jun DU, Qin Gon. [Expression characteristics of inflammatory and apoptosis factors and regulatory effect of anemoside B4 in mice with acute kidney injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 1. 2020-06-25. PMID:32237425. |
after the serum was separated, serum urea nitrogen(bun), creatinine(cre), total protein(tp), and albumin(alb) were tested by using an automatic biochemical analyzer; the changes of kidney pathological morphology were observed by pas staining; the protein expression levels of inflammatory factors including nucleotide binding oligomerization domain-like receptor(nlrp3), cysteinyl aspartate specific proteinase 1(caspase-1), interleukin-18(il-18), interleukin-1β(il-1β), tumor necrosis factor(tnf-α), and interleukin-6(il-6) and apoptosis factors including p53, caspase-3, cleaved-caspase-3, bcl-2 associated x protein(bax), and b-cell lymphoma-2(bcl-2) were analyzed by western blot. |
2020-06-25 |
2023-08-13 |
mouse |
| Heng Zeng, Jian-Xiong Che. Sirtuin 3, Endothelial Metabolic Reprogramming, and Heart Failure With Preserved Ejection Fraction. Journal of cardiovascular pharmacology. vol 74. issue 4. 2020-06-23. PMID:31425381. |
sirt3 deficiency also displayed striking increases in acetylation of p53, ec apoptosis, and senescence. |
2020-06-23 |
2023-08-13 |
Not clear |
| Saqer F Alsaqer, Mustafa M Tashkandi, Vinay K Kartha, Ya-Ting Yang, Yazeed Alkheriji, Andrew Salama, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti, Manish V Bai. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. vol 8. issue 43. 2020-06-22. PMID:29088714. |
in addition, gene set enrichment analysis revealed that gsk-lsd1 increased p53 expression and apoptosis while inhibiting c-myc, β-catenin and yap-induced oncogenic transcriptional networks. |
2020-06-22 |
2023-08-13 |
mouse |
| Hongping Wu, Shouping Zhang, Caiyun Huo, Shumei Zou, Zhengxing Lian, Yanxin H. iTRAQ-based proteomic and bioinformatic characterization of human mast cells upon infection by the influenza A virus strains H1N1 and H5N1. FEBS letters. vol 593. issue 18. 2020-06-22. PMID:31271652. |
bioinformatic analyses confirmed that h1n1 significantly regulates the rna degradation pathway via up-regulation of ccr4-not transcription complex subunit 4, whereas apoptosis could be suppressed by h5n1 via down-regulation of the tumor protein p53 signaling pathway with p ≤ 0.05 at 12 h post-infection. |
2020-06-22 |
2023-08-13 |
human |
| Ping Wang, Di Guan, Xiao-Peng Zhang, Feng Liu, Wei Wan. Modeling the regulation of p53 activation by HIF-1 upon hypoxia. FEBS letters. vol 593. issue 18. 2020-06-22. PMID:31282018. |
as a result, fully activated p53 triggers apoptosis. |
2020-06-22 |
2023-08-13 |
Not clear |
| Qing Sun, Yige Guo, Xiaohong Liu, Frank Czauderna, Michael I Carr, Frank T Zenke, Andree Blaukat, Lyubomir T Vassile. Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. Molecular cancer research : MCR. vol 17. issue 12. 2020-06-22. PMID:31551253. |
time-lapse imaging of cell death and measuring apoptosis in panels of p53 wild-type and p53-null/mutant cancer lines confirmed the clear differences in cell fate, dependent on p53 status. |
2020-06-22 |
2023-08-13 |
Not clear |
| Lei Yu, Zhongshan Liu, Ling Qiu, Linlin Hao, Jie Gu. Ipatasertib sensitizes colon cancer cells to TRAIL-induced apoptosis through ROS-mediated caspase activation. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31558316. |
in conclusion, p53 and puma may play a pivotal role in sensitizing colon cancer cell to trail-induced apoptosis by sub-toxic doses of ipatasertib treatment. |
2020-06-22 |
2023-08-13 |
Not clear |
| Fu Xiaomeng, Lv Lei, An Jinghong, Jiang Juan, Yue Qi, Yuan Danda. Treatment with β-elemene combined with paclitaxel inhibits growth, migration, and invasion and induces apoptosis of ovarian cancer cells by activation of STAT-NF-κB pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 6. 2020-06-22. PMID:32401925. |
results demonstrated that β-elemene+paclitaxel induced apoptosis of skov3 cells, down-regulated anti-apoptotic bcl-2 and bcl-xl gene expression and up-regulated pro-apoptotic p53 and apaf1 gene expression in skov3 cells. |
2020-06-22 |
2023-08-13 |
mouse |
| Cong-Hui Zhang, Jun-Xia Wang, Mei-Lian Cai, Rongguang Shao, Hong Liu, Wu-Li Zha. The roles and mechanisms of G3BP1 in tumour promotion. Journal of drug targeting. vol 27. issue 3. 2020-06-18. PMID:30207743. |
g3bp1 promotes tumour cell proliferation and metastasis and inhibits apoptosis by regulating the ras, tgf-β/smad, src/fak and p53 signalling pathways. |
2020-06-18 |
2023-08-13 |
Not clear |
| Can Zhao, Jing Jiang, Yong-Liang Wang, Yong-Quan W. Overexpression of microRNA-590-3p promotes the proliferation of and inhibits the apoptosis of myocardial cells through inhibition of the NF-κB signaling pathway by binding to RIPK1. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:30321469. |
after transfection of overexpressed mir-590-3p or si-ripk1, declined ripk1, nf-κb, toll-like receptor 4, caspase-3, fasl, p53, and c-myc levels, increased b-cell lymphoma-2 level, promoted cell proliferation, promoted cell cycle distribution and inhibited apoptosis of myocardial cells were found. |
2020-06-17 |
2023-08-13 |
mouse |