| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Wang, Sun-Dong Zhang, Jiao Jiao, Wei Wang, Liang Yu, Xue-Lian Zhao, Li-Tao Wang, Dong Meng, Yu-Jie F. ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro. Toxicology and applied pharmacology. vol 379. 2020-06-01. PMID:31283929. |
ros -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro. |
2020-06-01 |
2023-08-13 |
Not clear |
| Maqusood Ahamed, Mohd Javed Akhtar, Hisham A Alhadla. Influence of silica nanoparticles on cadmium-induced cytotoxicity, oxidative stress, and apoptosis in human liver HepG2 cells. Environmental toxicology. vol 35. issue 5. 2020-06-01. PMID:31904905. |
coexposure of si nps and cd also augmented mitochondria-mediated apoptosis in hepg2 cells indicated by altered regulation of apoptotic genes (p53, bax, bcl-2, caspase-3, and caspase-9) along with reduced mitochondrial membrane potential. |
2020-06-01 |
2023-08-13 |
human |
| Sara Bravo-Navas, Lucrecia Yáñez, Íñigo Romón, Carlos Pipaó. Elevated FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31251079. |
fanconi anemia complementation (fanc) proteins have been related to chromosomal instability and alterations in the mechanisms of p53 activation, control of cell cycle, and apoptosis. |
2020-05-27 |
2023-08-13 |
Not clear |
| Rui Guo, Yang Li, Yanan Xue, Yingying Chen, Jiuling Li, Xinyue Deng, Jing Su, Yanan Liu, Liankun Su. SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis. Gene. vol 745. 2020-05-27. PMID:32229158. |
in the present study, we found that sirt3 can deacetylate mutant p53, thus reducing its expression, inducing apoptosis in sclc cells, and increasing sclc chemosensitivity. |
2020-05-27 |
2023-08-13 |
Not clear |
| Kari Högstrand, Alf Grandie. MYC-driven malignant transformation of mature murine B cells requires inhibition of both intrinsic apoptosis and p53 activity. European journal of immunology. vol 49. issue 3. 2020-05-26. PMID:30281155. |
myc-driven malignant transformation of mature murine b cells requires inhibition of both intrinsic apoptosis and p53 activity. |
2020-05-26 |
2023-08-13 |
mouse |
| Jessica M Miller, Nikhil M Mardhekar, Danielle Pretorius, Prasanna Krishnamurthy, Namakkal Soorappan Rajasekaran, Jianyi Zhang, Ramaswamy Kannappa. DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes. American journal of physiology. Heart and circulatory physiology. vol 318. issue 4. 2020-05-25. PMID:32057252. |
we determined whether dna-damage-free ipscs (ddf-ipscs) can be selected using stabilization of p53, a transcription factor that promotes apoptosis in dna-damaged cells, and differentiated them into functionally competent ddf cardiomyocytes (ddf-cms). |
2020-05-25 |
2023-08-13 |
Not clear |
| Qun Li, Qiongyu Hao, Wei Cao, Jieqing Li, Ke Wu, Yahya Elshimali, Donghui Zhu, Qiao-Hong Chen, Guanglin Chen, Jonathan R Pollack, Jay Vadgama, Yong W. PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer. Science advances. vol 5. issue 10. 2020-05-21. PMID:31663018. |
here, we found that aberrant pp2cδ activity decreases p53 acetylation and its transcriptional activity and suppresses doxorubicin-induced cell apoptosis. |
2020-05-21 |
2023-08-13 |
mouse |
| Keywan Mortezaee, Ensieh Salehi, Hanifeh Mirtavoos-Mahyari, Elahe Motevaseli, Masoud Najafi, Bagher Farhood, Rhonda J Rosengren, Amirhossein Sahebka. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. Journal of cellular physiology. vol 234. issue 8. 2020-05-20. PMID:30623450. |
curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. |
2020-05-20 |
2023-08-13 |
Not clear |
| Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han, Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Meiyu Geng, Yingming Zhao, Wei Gu, Wenhui Zha. p53 β-hydroxybutyrylation attenuates p53 activity. Cell death & disease. vol 10. issue 3. 2020-05-20. PMID:30858356. |
we show that p53 kbhb results in lower levels of p53 acetylation and reduced expression of the p53 downstream genes p21 and puma, as well as reduced cell growth arrest and apoptosis in cultured cells under p53-activating conditions. |
2020-05-20 |
2023-08-13 |
mouse |
| Yeyun Zhou, Robyn Millott, Hyeong Jin Kim, Shiyun Peng, Ross A Edwards, Tamara Skene-Arnold, Michal Hammel, Susan P Lees-Miller, John A Tainer, Charles F B Holmes, J N Mark Glove. Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. Structure (London, England : 1993). vol 27. issue 10. 2020-05-20. PMID:31402222. |
aspp (apoptosis-stimulating proteins of p53) proteins bind pp-1c (protein phosphatase 1) and regulate p53 impacting cancer cell growth and apoptosis. |
2020-05-20 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Carl G Mak. Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer biology & therapy. vol 20. issue 3. 2020-05-19. PMID:30289354. |
activated p53 can promote apoptosis or cell cycle arrest. |
2020-05-19 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Carl G Mak. Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer biology & therapy. vol 20. issue 3. 2020-05-19. PMID:30289354. |
these studies indicate αkg levels, regulated by p53 and ogdh, determine autophagy and apoptosis in response to nutlin-3a. |
2020-05-19 |
2023-08-13 |
Not clear |
| James M Phan. Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses. Antioxidants & redox signaling. vol 30. issue 4. 2020-05-18. PMID:28990419. |
recent advances: although proline dehydrogenase/proline oxidase (prodh/pox) has been known as a tumor protein 53 (p53)-activated source of redox signaling for initiating apoptosis and autophagy, senescence has been added to the responses. |
2020-05-18 |
2023-08-13 |
Not clear |
| Otília Porubiaková, Natália Bohálová, Alberto Inga, Natália Vadovičová, Jan Coufal, Miroslav Fojta, Václav Brázd. The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms. International journal of molecular sciences. vol 21. issue 1. 2020-05-18. PMID:31878115. |
p53 is one of the most studied tumor suppressor proteins that plays an important role in basic biological processes including cell cycle, dna damage response, apoptosis, and senescence. |
2020-05-18 |
2023-08-13 |
human |
| Sanjay de Mel, Susan Swee-Shan Hue, Anand D Jeyasekharan, Wee-Joo Chng, Siok-Bian N. Molecular pathogenic pathways in extranodal NK/T cell lymphoma. Journal of hematology & oncology. vol 12. issue 1. 2020-05-15. PMID:30935402. |
deregulation of apoptosis through p53 mutations and upregulation of the anti-apoptotic protein, survivin, may provide a further growth advantage to this tumor. |
2020-05-15 |
2023-08-13 |
Not clear |
| Weiling Xu, Peihong Gao, Yan Zhang, Li Piao, Dong Don. microRNA-138 induces cell survival and reduces WNT/β-catenin signaling of osteoarthritis chondrocytes through NEK2. IUBMB life. vol 71. issue 9. 2020-05-15. PMID:31034758. |
the chondrocytes treated with mir-138 mimic and sirna-nek2 exhibited reduced expressions of nek2, β-catenin, mmp-13, bax, and p53 and elevated expressions of col2, aggrecan, and bcl-2 as well as phosphorylation levels of β-catenin along with enhanced chondrocytes' proliferation and suppressed cell apoptosis. |
2020-05-15 |
2023-08-13 |
mouse |
| Crystal A Tonnessen-Murray, Wesley D Frey, Sonia G Rao, Ashkan Shahbandi, Nathan A Ungerleider, Joy O Olayiwola, Lucas B Murray, Benjamin T Vinson, Douglas B Chrisey, Christopher J Lord, James G Jackso. Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival. The Journal of cell biology. vol 218. issue 11. 2020-05-13. PMID:31530580. |
in chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell population constituting residual disease that drives relapse and poor patient survival via the senescence-associated secretory phenotype. |
2020-05-13 |
2023-08-13 |
Not clear |
| Chao Song, Yunhe Xiong, Wenbiao Liao, Lingchao Meng, Sixing Yan. Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1. Journal of cellular physiology. vol 234. issue 8. 2020-05-12. PMID:30536843. |
to sum up, our study revealed that high expression of lncrna atb could accelerate the proliferative and migratory rates of rcc cells and inhibit cell apoptosis through downregulating p53 via binding to dnmt1. |
2020-05-12 |
2023-08-13 |
Not clear |
| Weifeng Huang, Yongmei Cao, Yujing Liu, Feng Ping, Jiawei Shang, Zhongwei Zhang, Yingchuan L. Activating Mas receptor protects human pulmonary microvascular endothelial cells against LPS-induced apoptosis via the NF-kB p65/P53 feedback pathways. Journal of cellular physiology. vol 234. issue 8. 2020-05-12. PMID:30537127. |
the results demonstrated that ang ii pretreatment resulted in downregulation of mas and upregulation of at1r, phosphorylated p65, and apoptosis in lps-treated human pulmonary microvascular endothelial cells (hpmvecs), but had no effect on p53 expression. |
2020-05-12 |
2023-08-13 |
human |
| Weifeng Huang, Yongmei Cao, Yujing Liu, Feng Ping, Jiawei Shang, Zhongwei Zhang, Yingchuan L. Activating Mas receptor protects human pulmonary microvascular endothelial cells against LPS-induced apoptosis via the NF-kB p65/P53 feedback pathways. Journal of cellular physiology. vol 234. issue 8. 2020-05-12. PMID:30537127. |
on the other hand, ang-(1-7) pretreatment lead to an increased in mas expression and a decrease in at1r, p53, and phosphorylated p65 expressions with suppressed apoptosis in lps-treated cells. |
2020-05-12 |
2023-08-13 |
human |