| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oluwatoyin E Akande, Priyadarshan K Damle, Marius Pop, Nicholas E Sherman, Barbara B Szomju, Larisa V Litovchick, Steven R Grossma. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell reports. vol 26. issue 12. 2020-04-29. PMID:30893604. |
using mass spectrometry to identify nuclear and cytoplasmic cbp-interacting proteins that regulate compartmentalized cbp e4 activity, we identified deleted in breast cancer 1 (dbc1) as a stoichiometric cbp-interacting protein that negatively regulates cbp-dependent p53 polyubiquitination, stabilizes p53, and augments p53-dependent apoptosis. |
2020-04-29 |
2023-08-13 |
Not clear |
| D S Kutilin, T G Airapetova, P A Anistratov, S P Pyltsin, I A Leiman, N S Karnaukhov, O I Ki. Copy Number Variation in Tumor Cells and Extracellular DNA in Patients with Lung Adenocarcinoma. Bulletin of experimental biology and medicine. vol 167. issue 6. 2020-04-27. PMID:31655998. |
changed copy numbers were detected for genes responsible for apoptosis regulation (bax, p53, and casp3), proliferation (sox2), dna reparation (xrcc1), oxidative phosphorylation (hv2), egfr signaling pathway (grb2, sos1, mapk1, stat1, and braf), and for mir3678 gene in lung tumor cells and extracellular dna. |
2020-04-27 |
2023-08-13 |
Not clear |
| Kaori Fujit. p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions. International journal of molecular sciences. vol 20. issue 23. 2020-04-27. PMID:31795382. |
p53 functions as a transcription factor in cell-autonomous responses such as cell-cycle control, dna repair, apoptosis, and cellular senescence, and also non-cell-autonomous responses to dna damage by mediating the sasp function of immune system activation. |
2020-04-27 |
2023-08-13 |
human |
| Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Che. PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Apoptosis : an international journal on programmed cell death. vol 24. issue 1-2. 2020-04-20. PMID:30426280. |
pppde1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. |
2020-04-20 |
2023-08-13 |
human |
| Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang, Hongsong Che. PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Apoptosis : an international journal on programmed cell death. vol 24. issue 1-2. 2020-04-20. PMID:30426280. |
furthermore, we proved that pppde1 is a key modulator of p53 protein level and its down stream apoptosis pathway. |
2020-04-20 |
2023-08-13 |
human |
| N Kumar, O Awoyemi, A Willis, C Schmitt, L Ramalingam, N Moustaid-Moussa, J Crag. Comparative Lipid Peroxidation and Apoptosis in Embryo-Larval Zebrafish Exposed to 3 Azole Fungicides, Tebuconazole, Propiconazole, and Myclobutanil, at Environmentally Relevant Concentrations. Environmental toxicology and chemistry. vol 38. issue 7. 2020-04-20. PMID:30919521. |
relative mrna expressions of cytochrome p450 family 51 lanosterol-14α-demethylase, glutathione s-transferase, caspase 9, phosphoprotein p53, and bcl2-associated x protein were measured to assess toxicity attributable to fungicides at the mrna level, whereas caspase 3/7 (apoptosis) and 3,4-methylenedioxyamphetamine (lipid peroxidation) levels were measured at the enzymatic level. |
2020-04-20 |
2023-08-13 |
zebrafish |
| Yongxia Cheng, Jingchao Li, Chong Wang, Heran Yang, Ying Wang, Tao Zhan, Sufen Guo, Jun Liang, Yuxin Bai, Jianbo Yu, Guibo Li. Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p. Experimental animals. vol 69. issue 1. 2020-04-20. PMID:31353329. |
in addition, p53, a critical regulator of apoptosis, was validated to be a downstream target of mir-181a-5p. |
2020-04-20 |
2023-08-13 |
mouse |
| Petek Ballar Kirmizibayrak, Burcu Erbaykent-Tepedelen, Oguz Gozen, Yalcin Erzuruml. Divergent Modulation of Proteostasis in Prostate Cancer. Advances in experimental medicine and biology. vol 1233. 2020-04-20. PMID:32274755. |
alterations in various complex signaling pathways and cellular processes including cell cycle control, transcription, dna repair, apoptosis, cell adhesion, epithelial-mesenchymal transition (emt), and angiogenesis are critical factors influencing pca development through key molecular changes mainly by posttranslational modifications in pca-related proteins, including ar, nkx3.1, pten, p53, cyclin d1, and p27. |
2020-04-20 |
2023-08-13 |
Not clear |
| Darren Qiancheng Tan, Ying Li, Chong Yang, Jia Li, Shi Hao Tan, Desmond Wai Loon Chin, Ayako Nakamura-Ishizu, Henry Yang, Toshio Sud. PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Cell reports. vol 26. issue 9. 2020-04-16. PMID:30811983. |
consequently, loss of prmt5 activity leads to endogenous dna damage that triggers p53 activation, induces apoptosis, and culminates in rapid hsc exhaustion, which is significantly delayed by p53 depletion. |
2020-04-16 |
2023-08-13 |
Not clear |
| Basmina Parmakhtiar, Robert A Burger, Jai-Hyun Kim, John P Fruehau. HIF Inactivation of p53 in Ovarian Cancer Can Be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity. Molecular cancer research : MCR. vol 17. issue 8. 2020-04-16. PMID:31088908. |
hif1α is an adverse prognostic factor that may contribute to worse outcomes via its capacity to bind to p53, potentially blocking p53-mediated apoptosis. |
2020-04-16 |
2023-08-13 |
Not clear |
| Aiqing Ma, Xianhua Da. Exploring the Influence of Parameters on the p53 Response When Single-Stranded Breaks and Double-Stranded Breaks Coexist. Interdisciplinary sciences, computational life sciences. vol 11. issue 4. 2020-04-16. PMID:31222582. |
we find that pulse amplitude is most sensitive to atm-dependent p53 production rate (beta3), and apoptosis is more sensitive to damage-dependent atm production rate (beta1), wip1-dependent atm degradation rate (alf15), wip1 production rate (beta5) and wip1 degradation rate (alf5). |
2020-04-16 |
2023-08-13 |
Not clear |
| Ren-Jie Wei, Wen-Ren Wu, Cheng-Tang Pan, Chun-Yen Yu, Chien-Feng Li, Lih-Ren Chen, Shih-Shin Liang, Yow-Ling Shiu. Inhibition of the formation of autophagosome but not autolysosome augments ABT-751-induced apoptosis in TP53-deficient Hep-3B cells. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30367486. |
the objective was to investigate the upstream mechanisms of apoptosis which were triggered by a novel antimicrotubule drug, abt-751, in a tumor protein p53 ( tp53)-deficient hepatocellular carcinoma-derived hep-3b cells. |
2020-04-13 |
2023-08-13 |
Not clear |
| Jinzhi Zhao, Yingbing Tian, Huihui Zhang, Lianhua Qu, Yu Chen, Qing Liu, Ying Luo, Xiaoming W. p53 Mutant p53 International journal of biological sciences. vol 15. issue 9. 2020-04-13. PMID:31523200. |
p53 mutant p53 the p53 is one of the most important tumor suppressors through surveillance of dna damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. |
2020-04-13 |
2023-08-13 |
mouse |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. AEG-1/miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTEN/PI3K/AKT Signaling Pathway. International journal of molecular sciences. vol 20. issue 22. 2020-04-13. PMID:31698701. |
on the other hand, there were no significant expression changes of aeg-1 in mir-221 mimic and mir-221 inhibitor transfected hcc cells and inhibition of mir-221/aeg-1 axis decreased cell proliferation, invasion, migration, and angiogenesis and induced apoptosis, cell cycle arrest by upregulating p57, p53, pten, and rb and downregulating lsf, mmp9, opn, bcl-2, pi3k, akt, and lc3a in hcc cells. |
2020-04-13 |
2023-08-13 |
Not clear |
| Li Zhai, Wen-Lin Tai, Yu-Qing Pan, Jian-Bo Luo, Li Ma, Ya-Ting Zheng, Meng-Yue Guo, Xi Zhan. Expression of EZH2 and P53 and their correlation in ovarian cancer tissues. International journal of clinical and experimental pathology. vol 13. issue 3. 2020-04-11. PMID:32269682. |
p53 can regulate many cells signaling pathways and play an important role in cell cycle, cell apoptosis, and cell senescence. |
2020-04-11 |
2023-08-13 |
Not clear |
| Emiliano Matos-Perdomo, Félix Machí. Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer. Cells. vol 8. issue 8. 2020-04-09. PMID:31357498. |
the p53 protein also mediates nsr, leading ultimately to cell cycle arrest, apoptosis, senescence or differentiation. |
2020-04-09 |
2023-08-13 |
Not clear |
| Xingran Yang, Yan Han, Yun Mu, Pingping Yang, Wei Gu, Min Zhan. Multigenerational effects of cadmium on the lifespan and fertility of Drosophila melanogaster. Chemosphere. vol 245. 2020-04-09. PMID:31855751. |
the expression of p53 and caspase-3 was significantly up-regulated after exposure, suggesting that apoptosis contributes to the resistance mechanism. |
2020-04-09 |
2023-08-13 |
drosophila_melanogaster |
| Yuezhen Xue, Nick Barker, Shawn Hoon, Pingping He, Teena Thakur, Shifana Raja Abdeen, Priadarsini Maruthappan, Farid J Ghadessy, David P Lan. Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues Cancer research. vol 79. issue 14. 2020-04-08. PMID:31138526. |
bortezomib stabilizes and activates p53 in proliferative compartments of both normal and tumor tissues p53 protein, activated and stabilized by posttranslational modifications, performs its major functions by inducing dna repair, cell-cycle arrest, or apoptosis through transcriptional activation. |
2020-04-08 |
2023-08-13 |
mouse |
| Huan Yang, Ruizhao Li, Li Zhang, Shu Zhang, Wei Dong, Yuanhan Chen, Weidong Wang, Chunling Li, Zhiming Ye, Xingchen Zhao, Zhilian Li, Yanhua Wu, Mengxi Zhang, Shuangxin Liu, Zheng Dong, Xinling Lian. p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney injury. American journal of physiology. Renal physiology. vol 317. issue 5. 2020-04-08. PMID:31339772. |
inhibition of mptp opening using the cypd inhibitor cyclosporin a or sirna for p53 in atp-depleted hk-2 cells prevented mitochondrial membrane depolarization and reduced apoptosis. |
2020-04-08 |
2023-08-13 |
rat |
| Bo Yu, Xiaoling Li, Wenjie Zheng, Yanxian Feng, Yum-Shing Wong, Tianfeng Che. pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects. Journal of materials chemistry. B. vol 2. issue 33. 2020-04-08. PMID:32261761. |
internalized fac@curp-senps triggers intracellular ros overproduction, thus activates p53, mapks pathways and inhibits nfκb and to promote cell apoptosis. |
2020-04-08 |
2023-08-13 |
human |