| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cong-Hui Zhang, Jun-Xia Wang, Mei-Lian Cai, Rongguang Shao, Hong Liu, Wu-Li Zha. The roles and mechanisms of G3BP1 in tumour promotion. Journal of drug targeting. vol 27. issue 3. 2020-06-18. PMID:30207743. |
g3bp1 promotes tumour cell proliferation and metastasis and inhibits apoptosis by regulating the ras, tgf-β/smad, src/fak and p53 signalling pathways. |
2020-06-18 |
2023-08-13 |
Not clear |
| Can Zhao, Jing Jiang, Yong-Liang Wang, Yong-Quan W. Overexpression of microRNA-590-3p promotes the proliferation of and inhibits the apoptosis of myocardial cells through inhibition of the NF-κB signaling pathway by binding to RIPK1. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:30321469. |
after transfection of overexpressed mir-590-3p or si-ripk1, declined ripk1, nf-κb, toll-like receptor 4, caspase-3, fasl, p53, and c-myc levels, increased b-cell lymphoma-2 level, promoted cell proliferation, promoted cell cycle distribution and inhibited apoptosis of myocardial cells were found. |
2020-06-17 |
2023-08-13 |
mouse |
| Saishu Yoshida, Kiyotsugu Yoshid. Multiple functions of DYRK2 in cancer and tissue development. FEBS letters. vol 593. issue 21. 2020-06-17. PMID:31505048. |
dyrk2, a member of the class ii dyrk family protein, is a key regulator of p53, and phosphorylates it at ser46 to induce apoptosis in response to dna damage. |
2020-06-17 |
2023-08-13 |
human |
| Anand Singh, Nisan Bhattacharyya, Abhishek Srivastava, Nathanael Pruett, R Taylor Ripley, David S Schrump, Chuong D Hoan. MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 27. issue 9. 2020-06-16. PMID:31227395. |
when mir-215-5p was ectopically re-expressed in mpm cells and delivered in vivo to tumor xenografts, it exerted significant cell killing by activating p53 function and inducing apoptosis. |
2020-06-16 |
2023-08-13 |
mouse |
| Dongshi Chen, Hong-Min Ni, Lei Wang, Xiaowen Ma, Jian Yu, Wen-Xing Ding, Lin Zhan. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology (Baltimore, Md.). vol 69. issue 5. 2020-06-15. PMID:30552702. |
p53 up-regulated modulator of apoptosis induction mediates acetaminophen-induced necrosis and liver injury in mice. |
2020-06-15 |
2023-08-13 |
mouse |
| Dongshi Chen, Hong-Min Ni, Lei Wang, Xiaowen Ma, Jian Yu, Wen-Xing Ding, Lin Zhan. p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice. Hepatology (Baltimore, Md.). vol 69. issue 5. 2020-06-15. PMID:30552702. |
in this study, we found that p53 up-regulated modulator of apoptosis (puma), a b-cell lymphoma-2 (bcl-2) homology domain 3 (bh3)-only bcl-2 family member, was markedly induced by apap in mouse livers and in isolated human and mouse hepatocytes. |
2020-06-15 |
2023-08-13 |
mouse |
| Qing Mao, Xiulin Liang, Yufu Wu, Yongxiang L. Resveratrol Attenuates Cardiomyocyte Apoptosis in Rats Induced by Coronary Microembolization Through SIRT1-Mediated Deacetylation of p53. Journal of cardiovascular pharmacology and therapeutics. vol 24. issue 6. 2020-06-15. PMID:31046448. |
resveratrol attenuates cardiomyocyte apoptosis in rats induced by coronary microembolization through sirt1-mediated deacetylation of p53. |
2020-06-15 |
2023-08-13 |
rat |
| Yichong Ning, Na Hui, Bei Qing, Yiming Zhuo, Wei Sun, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zho. ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation. Cell death & disease. vol 10. issue 6. 2020-06-15. PMID:31138778. |
the p53 inhibitor pifithrin-α attenuated the influences of zcchc10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator nutlin3 could reverse the effects of zcchc10 knockdown. |
2020-06-15 |
2023-08-13 |
Not clear |
| Bin Wang, Jiali Dong, Huiwen Xiao, Yuan Li, Yuxiao Jin, Ming Cui, Shu-Qin Zhang, Sai-Jun Fa. Metformin fights against radiation-induced early developmental toxicity. The Science of the total environment. vol 732. 2020-06-15. PMID:32438158. |
in addition, met degraded inflammatory reaction, hinders apoptosis response, and reprograms the development-related genes expression, such as sox2, sox3, sox19a and p53, in zebrafish embryos following radiation challenge. |
2020-06-15 |
2023-08-13 |
zebrafish |
| Takayoshi Matsumura, Ayako Nakamura-Ishizu, Kensuke Takaoka, Hiroaki Maki, Siva S N A Muddineni, Chelsia Q Wang, Hitoshi Suzushima, Makoto Kawakita, Norio Asou, Masao Matsuoka, Mineo Kurokawa, Motomi Osato, Toshio Sud. TUBB1 dysfunction in inherited thrombocytopenia causes genome instability. British journal of haematology. vol 185. issue 5. 2020-06-12. PMID:30854628. |
we found that the nuclear accumulation of p53 (also termed tp53) and the expression of pro-apoptotic genes triggered by genotoxic stress were blocked in tubb1-deficient cells and, accordingly, apoptosis after dna damage was diminished by knockdown of tubb1. |
2020-06-12 |
2023-08-13 |
Not clear |
| Yangyang Hu, Juanjuan Dai, Guanzhao Zong, Jingbo Xiao, Xingya Guo, Yiqi Dai, Zhanjun Lu, Rong Wa. Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice. Journal of cellular physiology. vol 234. issue 12. 2020-06-09. PMID:31058328. |
in this study, we found that the transcriptional activity of p53 was impaired and the expressions of its proapoptotic targets puma and cd95 were significantly decreased, which explains the apoptosis silencing during ap. |
2020-06-09 |
2023-08-13 |
mouse |
| Yangyang Hu, Juanjuan Dai, Guanzhao Zong, Jingbo Xiao, Xingya Guo, Yiqi Dai, Zhanjun Lu, Rong Wa. Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice. Journal of cellular physiology. vol 234. issue 12. 2020-06-09. PMID:31058328. |
treatment of the hdac inhibitor trichostatin-a restored p53 apoptosis pathway, resulted in a necrosis/apoptosis switch and protected mice from cerulein- or l-arg-induced ap. |
2020-06-09 |
2023-08-13 |
mouse |
| Chengfei Liu, Joy C Yang, Cameron M Armstrong, Wei Lou, Liangren Liu, Xiaomin Qiu, Binhao Zou, Alan P Lombard, Leandro S D'Abronzo, Christopher P Evans, Allen C Ga. AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer. Molecular cancer therapeutics. vol 18. issue 10. 2020-06-09. PMID:31308078. |
in addition, bioinformatical analysis of indomethacin-treated resistant cells revealed that indomethacin significantly activates the unfolded protein response, p53, and apoptosis pathways, and suppresses cell-cycle, myc, and ar/arv7 pathways. |
2020-06-09 |
2023-08-13 |
Not clear |
| Citong Zhang, Wei Wei, Minghan Chi, Yao Wan, Xue Li, Manlin Qi, Yanmin Zho. FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions. Journal of diabetes research. vol 2019. 2020-06-09. PMID:31886284. |
qpcr and western blot results have shown that age upregulates proapoptotic gene p53 and its downstream target gene bax, which leads to enhanced activation of caspase-3, thus inducing apoptosis in mlo-y4 cells. |
2020-06-09 |
2023-08-13 |
mouse |
| Xiaoyu Zhang, Qin Xia, Rui Wei, Hongfei Song, Jiaqi Mi, Zhaoyu Lin, Yang Yang, Zijie Sun, Kang Zo. Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free radical biology & medicine. vol 137. 2020-06-08. PMID:30986493. |
we further revealed that melatonin rescues spermatogonia from apoptosis by neutralizing reactive oxidative species (ros) induced by busulfan and recovered the phosphorylation of atm and p53 to normal levels, and as a result apoptosis in spermatogonial progenitor cells was avoided. |
2020-06-08 |
2023-08-13 |
mouse |
| Rackhyun Park, Hyunju Kim, Minsu Jang, Daum Jo, Yea-In Park, Sim Namkoong, Jin I Lee, Ik-Soon Jang, Junsoo Par. LNX1 contributes to tumor growth by down-regulating p53 stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 12. 2020-06-08. PMID:31533005. |
the well-known tumor suppressor p53 inhibits the formation of various cancers by inducing cell cycle arrest and apoptosis. |
2020-06-08 |
2023-08-13 |
Not clear |
| Shintaro Ochi, Yuichi Nishiyama, Akinori Morit. Development of p53-targeting drugs that increase radioresistance in normal tissues. The journal of medical investigation : JMI. vol 66. issue 3.4. 2020-06-08. PMID:31656277. |
in radiation-injured tissues, p53 induces apoptosis in hematopoietic lineages, whereas it plays a radioprotective role in the gastrointestinal epithelium. |
2020-06-08 |
2023-08-13 |
Not clear |
| Wanning Wang, Weixia Sun, Yanli Cheng, Zhonggao Xu, Lu Ca. Role of sirtuin-1 in diabetic nephropathy. Journal of molecular medicine (Berlin, Germany). vol 97. issue 3. 2020-06-05. PMID:30707256. |
mechanistically, sirtuin-1 has its renoprotective effects by modulating metabolic homeostasis and autophagy, resisting apoptosis and oxidative stress, and inhibiting inflammation through deacetylation of histones and the transcription factors p53, forkhead box group o, nuclear factor-κb, hypoxia-inducible factor-1α, and others. |
2020-06-05 |
2023-08-13 |
Not clear |
| Ruirong He, Shuya Ou, Shichun Chen, Shaobo Din. Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Compound Kushen Injection in Anti-Cancer Effect. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-06-05. PMID:31892693. |
active ingredients might also induce apoptosis in cancer cells via the p53 and pi3k-akt signaling pathway mechanism. |
2020-06-05 |
2023-08-13 |
human |
| M A Al Kahtan. Effect of both selenium and biosynthesized nanoselenium particles on cadmium-induced neurotoxicity in albino rats. Human & experimental toxicology. vol 39. issue 2. 2020-06-02. PMID:31619074. |
consequently, cd increases the formation of amyloid β, a neurotoxic index, and induces apoptosis by changing the quality and the quantity of bcl-2, bax and p53 proteins. |
2020-06-02 |
2023-08-13 |
rat |