| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Zhou, Jie-Hui Tan, Rong-Chang Cao, Jia Xu, Xue-Mei Chen, Zhao-Chang Qi, Su-Ying Zhou, Su-Bing Li, Qi-Xin Mo, Zhi-Wei Li, Guo-Wei Zhan. ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis. Cell death & disease. vol 10. issue 9. 2020-07-30. PMID:31506423. |
acinar cell apoptosis was also significantly increased, accompanied by upregulated p53 expression. |
2020-07-30 |
2023-08-13 |
mouse |
| Katayoon Hafezi, Ali Asghar Hemmati, Hassan Abbaszadeh, Armita Valizadeh, Manoochehr Makvand. Anticancer activity and molecular mechanisms of α-conidendrin, a polyphenolic compound present in Taxus yunnanensis, on human breast cancer cell lines. Phytotherapy research : PTR. vol 34. issue 6. 2020-07-30. PMID:31971313. |
α-conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and bax, downregulation of bcl-2, depolarization of mitochondrial membrane potential (mmp), release of cytochrome c from mitochondria, and activation of caspases-3 and -9. |
2020-07-30 |
2023-08-13 |
human |
| Chandrasekharan Guruvayoorappan, Girija Kutta. β-Carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in B16F-10 melanoma cells. Nutrition research (New York, N.Y.). vol 27. issue 6. 2020-07-30. PMID:32726891. |
β-carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in b16f-10 melanoma cells. |
2020-07-30 |
2023-08-13 |
Not clear |
| Chandrasekharan Guruvayoorappan, Girija Kutta. β-Carotene down-regulates inducible nitric oxide synthase gene expression and induces apoptosis by suppressing bcl-2 expression and activating caspase-3 and p53 genes in B16F-10 melanoma cells. Nutrition research (New York, N.Y.). vol 27. issue 6. 2020-07-30. PMID:32726891. |
in conclusion, the observed results suggest that β-carotene could regulate no and tnf-α production and stimulates apoptosis in b16f-10 melanoma cells by regulating bcl-2, p53, and caspase-3 genes. |
2020-07-30 |
2023-08-13 |
Not clear |
| C Sarisozen, Y Tan, J Liu, C Bilir, L Shen, N Filipczak, T M Porter, V P Torchili. MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation. Journal of drug targeting. vol 27. issue 5-6. 2020-07-27. PMID:30656973. |
this antagonism results in increased p53 activity and can also re-activates the p53 pathway and resensitize the glioblastoma cells to apoptosis. |
2020-07-27 |
2023-08-13 |
human |
| C Sarisozen, Y Tan, J Liu, C Bilir, L Shen, N Filipczak, T M Porter, V P Torchili. MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation. Journal of drug targeting. vol 27. issue 5-6. 2020-07-27. PMID:30656973. |
these nanomedicine formulations successfully re-activated the p53 levels in cells, increased the apoptosis and showed strong synergistic cytotoxic effect. |
2020-07-27 |
2023-08-13 |
human |
| Baoying Qian, Liangyi Xue, Xin Qi, Yi Bai, Yubo W. Gene networks and toxicity/detoxification pathways in juvenile largemouth bass (Micropterus salmoides) liver induced by acute lead stress. Genomics. vol 112. issue 1. 2020-07-27. PMID:31247331. |
up- and downregulated genes were significantly enriched in numerous pathways, including the natural killer cell-mediated cytotoxicity pathway, the jak-stat and p53 signaling pathways, cancer and apoptosis. |
2020-07-27 |
2023-08-13 |
Not clear |
| Allison N Catizone, Gizem Karsli Uzunbas, Petra Celadova, Sylvia Kuang, Daniel Bose, Morgan A Sammon. Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Nucleic acids research. vol 48. issue 8. 2020-07-27. PMID:32133495. |
the master tumor suppressor p53 controls transcription of a wide-ranging gene network involved in apoptosis, cell cycle arrest, dna damage repair, and senescence. |
2020-07-27 |
2023-08-13 |
Not clear |
| Bo Sun, Yujia Ma, Fang Wang, Linli Hu, Yingpu Su. miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis. Stem cell research & therapy. vol 10. issue 1. 2020-07-24. PMID:31783913. |
mir-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis. |
2020-07-24 |
2023-08-13 |
Not clear |
| Peter Ruoff, Nobuaki Nishiyam. Frequency switching between oscillatory homeostats and the regulation of p53. PloS one. vol 15. issue 5. 2020-07-23. PMID:32433703. |
mdm2 on its side keeps p53 at a high but sub-apoptotic level to avoid premature apoptosis. |
2020-07-23 |
2023-08-13 |
Not clear |
| Peter Ruoff, Nobuaki Nishiyam. Frequency switching between oscillatory homeostats and the regulation of p53. PloS one. vol 15. issue 5. 2020-07-23. PMID:32433703. |
however, with on-going dna damage the mdm2 set-point is increased by hsp90 and other p53 stabilizers leading finally to apoptosis. |
2020-07-23 |
2023-08-13 |
Not clear |
| You-Cheng Hseu, Hsin-Ju Cho, Yugandhar Vudhya Gowrisankar, Varadharajan Thiyagarajan, Xuan-Zao Chen, Kai-Yuan Lin, Hui-Chi Huang, Hsin-Ling Yan. Kalantuboside B induced apoptosis and cytoprotective autophagy in human melanoma A2058 cells: An in vitro and in vivo study. Free radical biology & medicine. vol 143. 2020-07-22. PMID:31442557. |
a western blot indicated cell-cycle inhibition (cyclin a reduction), apoptosis induction (parp cleavage and bcl-2 inhibition), and cytoprotective autophagy (lc3-ii upregulation and p53 downregulation) in kb-treated a2058-xenografted mice. |
2020-07-22 |
2023-08-13 |
mouse |
| Yu-Qing Li, Marianne Koritzinsky, C Shun Won. Metabolic Regulation of Hippocampal Neuroprogenitor Apoptosis After Irradiation. Journal of neuropathology and experimental neurology. vol 79. issue 3. 2020-07-21. PMID:31738417. |
adult mice with targeted disruption of p53 or prkaa2 (gene that encodes ampkα) in the brain were used to determine the role of p53 and ampk, respectively, in radiation-induced apoptosis of npcs in the hippocampus. |
2020-07-21 |
2023-08-13 |
mouse |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
signaling crosstalk of fhit, p53, and p38 in etoposide-induced apoptosis in mcf-7 cells. |
2020-07-20 |
2023-08-13 |
Not clear |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
however, the signaling mechanisms and interactions of fhit with regard to apoptotic proteins including p53 and p38 in the dna damage-induced apoptosis are not well described. |
2020-07-20 |
2023-08-13 |
Not clear |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
fhit overexpression led to increase p53 expression, p38 activation, and augmented apoptosis following etoposide-induced dna damage compared to wild-type cells. |
2020-07-20 |
2023-08-13 |
Not clear |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
however, fhit knockdown blocked p53 expression, delayed p38 activation, and completely inhibited etoposide-induced apoptosis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
inhibition of p38 activity prevented induction of p53, fhit, and apoptosis in this model. |
2020-07-20 |
2023-08-13 |
Not clear |
| Azam Khedri, Shahnaz Khaghani, Alireza Kheirollah, Hossein Babaahmadi-Rezaei, Amir Shadboorestan, Mohammad Zangooei, Hajar Shokri Afra, Reza Meshkani, Mohammad Hossein Ghahreman. Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-20. PMID:30614034. |
in p53 knockdown cells, inhibition of p38 induced fhit expression and apoptosis. |
2020-07-20 |
2023-08-13 |
Not clear |
| Tae Wook Nam, Song Yi Park, Jae Hoon Lee, Jae Il Roh, Han-Woong Le. Effect of EI24 expression on the tumorigenesis of Apc Biochemical and biophysical research communications. vol 514. issue 4. 2020-07-20. PMID:31097220. |
effect of ei24 expression on the tumorigenesis of apc etoposide-induced 2.4 kb transcript (ei24, also known as pig8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. |
2020-07-20 |
2023-08-13 |
mouse |