| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Zhong Liao, Ying Gao, Ling-Ling Sun, Jia-Hui Liu, Han-Rui Chen, Ling Yu, Zhuang-Zhong Chen, Wen-Hui Chen, Li-Zhu Li. Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway. Phytotherapy research : PTR. vol 34. issue 5. 2020-07-20. PMID:31985119. |
mechanistically, ra inhibited nsclc cell growth, arrested cell cycle, and induced apoptosis by activating mapk and inhibiting the expression of p-gp and mdr1, which correspondingly enhanced p21 and p53 expression. |
2020-07-20 |
2023-08-13 |
mouse |
| Z Y Luo, H Jiang, L Xu, X H Zhan. [Rita induce acute lymphoblostic leukemia cell apoptosis by activating P53 pathway]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 38. issue 2. 2020-07-17. PMID:28279043. |
[rita induce acute lymphoblostic leukemia cell apoptosis by activating p53 pathway]. |
2020-07-17 |
2023-08-13 |
Not clear |
| Zohreh Abdolvahabi, Mitra Nourbakhsh, Saman Hosseinkhani, Zahra Hesari, Mohsen Alipour, Meisam Jafarzadeh, Seyedeh Sara Ghorbanhosseini, Parvaneh Seiri, Zeynab Yousefi, Sahar Yarahmadi, Pegah Golpou. MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30520099. |
microrna-590-3p suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. |
2020-07-17 |
2023-08-13 |
human |
| Zohreh Abdolvahabi, Mitra Nourbakhsh, Saman Hosseinkhani, Zahra Hesari, Mohsen Alipour, Meisam Jafarzadeh, Seyedeh Sara Ghorbanhosseini, Parvaneh Seiri, Zeynab Yousefi, Sahar Yarahmadi, Pegah Golpou. MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30520099. |
the effects of mir-590-3p upregulation on the acetylation of p53 as well as cell viability and apoptosis were assessed by western blot analysis, wst-1 assay, and flow cytometry, respectively. |
2020-07-17 |
2023-08-13 |
human |
| Zohreh Abdolvahabi, Mitra Nourbakhsh, Saman Hosseinkhani, Zahra Hesari, Mohsen Alipour, Meisam Jafarzadeh, Seyedeh Sara Ghorbanhosseini, Parvaneh Seiri, Zeynab Yousefi, Sahar Yarahmadi, Pegah Golpou. MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30520099. |
in addition, there was an increase in p53 and its acetylated form that ultimately led to upregulation of bax and p21 expression, suppression of cell survival, and considerable induction of apoptosis in breast cancer cells. |
2020-07-17 |
2023-08-13 |
human |
| Ding Liu, Shu Li, Lina Gong, Yan Yang, Yaru Han, Miao Xie, Chen Zhan. Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30548678. |
suppression of microrna-141 suppressed p53 to protect against neural apoptosis in epilepsy by sirt1 expression. |
2020-07-17 |
2023-08-13 |
mouse |
| Ding Liu, Shu Li, Lina Gong, Yan Yang, Yaru Han, Miao Xie, Chen Zhan. Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30548678. |
overexpression of mirna-141 induced nerve cell apoptosis, suppressed proliferation, promoted caspase-3/9, bax and p53 protein expression, and reduced silent information regulator 1 (sirt1) protein expression in vitro model. |
2020-07-17 |
2023-08-13 |
mouse |
| Ding Liu, Shu Li, Lina Gong, Yan Yang, Yaru Han, Miao Xie, Chen Zhan. Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-17. PMID:30548678. |
in addition, the downexpression mirna-141 using si-mirna-141 reduced nerve cell apoptosis and increased proliferation, suppressed caspase-3/9, bax and p53 protein expression, induced sirt1 protein expression. |
2020-07-17 |
2023-08-13 |
mouse |
| Mariam Alsanafi, Samuel L Kelly, Melissa McNaughton, Alfred H Merrill, Nigel J Pyne, Susan Pyn. The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1865. issue 4. 2020-07-15. PMID:31954175. |
treatment of these cells with the sphingosine kinase inhibitor, ski, which fails to induce apoptosis, promoted the conversion of p53 into two proteins with molecular masses of 63 and 90 kda, and which was enhanced by over-expression of ubiquitin. |
2020-07-15 |
2023-08-13 |
human |
| Juan Liu, Cen Zhang, Wenwei Hu, Zhaohui Fen. Tumor suppressor p53 and metabolism. Journal of molecular cell biology. vol 11. issue 4. 2020-07-14. PMID:30500901. |
the tumor suppressive function of p53 has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence in cells. |
2020-07-14 |
2023-08-13 |
Not clear |
| Kai Zhang, Zhenqiang Fan, Jiena Weng, Jianfeng Zhao, Jiaying Wang, Hao Wu, Minhao Xie, Hong Zhou, Hao L. Peptide-Based Biosensing of Redox-Active Protein-Heme Complexes Indicates Novel Mechanism for Tumor Survival under Oxidative Stress. ACS sensors. vol 4. issue 10. 2020-07-14. PMID:31525915. |
in a malignant breast cancer cell line, it can be observed that oxidative stress-triggered nuclear co-translocations of heme and ferritin may lead to direct molecular contact of ferritin with p53, to pass heme to p53, which subsequently sequestered into the cytoplasm, therefore forming a possible new route of tumor survival under oxidative stress, by using the stress to circumvent oxidative stress-induced apoptosis. |
2020-07-14 |
2023-08-13 |
Not clear |
| Elizabeth Lieschke, Zilu Wang, Gemma L Kelly, Andreas Strasse. Discussion of some 'knowns' and some 'unknowns' about the tumour suppressor p53. Journal of molecular cell biology. vol 11. issue 3. 2020-07-13. PMID:30496435. |
moreover, it is not clear why upon activation of p53 some cells undergo cell cycle arrest and senescence whereas others die by apoptosis. |
2020-07-13 |
2023-08-13 |
Not clear |
| Margot E Bowen, Laura D Attard. The role of p53 in developmental syndromes. Journal of molecular cell biology. vol 11. issue 3. 2020-07-13. PMID:30624728. |
studies in mice suggest that p53 drives developmental defects by inducing apoptosis, restraining proliferation, or modulating other developmental programs in a cell type-dependent manner. |
2020-07-13 |
2023-08-13 |
mouse |
| Xiao-Wei Ye, Xiao-Peng Zhang, Feng Li. CSB modulates the competition between HIF-1 and p53 upon hypoxia. Mathematical biosciences and engineering : MBE. vol 16. issue 5. 2020-07-13. PMID:31499711. |
as a result, hif-1α induces pfkl and vegf to facilitate cellular adaptation to mild and moderate hypoxia respectively, while p53 is activated to induce apoptosis under severe hypoxia. |
2020-07-13 |
2023-08-13 |
Not clear |
| Jing Ji, Xiaoshuang Zhou, Ping Xu, Yafeng Li, Honglin Shi, Dexi Chen, Rongshan Li, Hongbo Sh. Deficiency of apoptosis-stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy. Journal of cellular and molecular medicine. vol 23. issue 4. 2020-07-10. PMID:30675758. |
apoptosis-stimulating protein two of p53 (aspp2) is a proapoptotic member that belongs to p53 binding protein family, which plays a key role in regulating apoptosis and cell growth. |
2020-07-10 |
2023-08-13 |
mouse |
| Hong Chen, Yixue Huang, Xiuqin Zhu, Chong Liu, Yangmian Yuan, Hua Su, Chun Zhang, Chengyu Liu, Mingrui Xiong, Yannan Qu, Peng Yun, Ling Zheng, Kun Huan. Histone demethylase UTX is a therapeutic target for diabetic kidney disease. The Journal of physiology. vol 597. issue 6. 2020-07-09. PMID:30516825. |
we found that utx demethylase activity-dependently regulated the transcription of inflammatory genes and apoptosis; moreover, utx bound with p53 and p53-dependently exacerbated dna damage. |
2020-07-09 |
2023-08-13 |
mouse |
| Yan Zhang, Jiang Wu, Hong Jing, Gui Huang, Zhulei Sun, Shouming X. Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-κB and p53. Journal of cellular biochemistry. vol 120. issue 4. 2020-07-09. PMID:30556250. |
together, these results suggest that meg3 inhibits breast cancer growth and induces breast cancer apoptosis, partially via the activation of the er stress, nf-κb and p53 pathways, and that nf-κb signaling is required for meg3-induced p53 activation in breast cancer cells. |
2020-07-09 |
2023-08-13 |
human |
| Yu Song, Qisang Guo, Shujun Gao, Keqin Hu. miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3. Biochemical and biophysical research communications. vol 516. issue 3. 2020-07-09. PMID:31270028. |
in the cervical cancer cell (hela) with endogenous high trim3 expression, increased expression of mir-454-3p obviously inhibited trim3 expression and then manipulating cell growth and apoptosis, down-regulating the expression of p53 and cleaved caspase-3 via p38 mapk signaling. |
2020-07-09 |
2023-08-13 |
human |
| Zhen You, Jingchang Xu, Bei Li, Hui Ye, Liping Chen, Yang Liu, Xianze Xion. The mechanism of ATF3 repression of epithelial-mesenchymal transition and suppression of cell viability in cholangiocarcinoma via p53 signal pathway. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-07-07. PMID:30648816. |
knockdown of atf3 promoted cell proliferation but reduced the rate of apoptosis by inhibiting p53 signalling. |
2020-07-07 |
2023-08-13 |
Not clear |
| Martina Magni, Giacomo Buscemi, Lucia Maita, Lei Peng, Siu Yuen Chan, Alessandra Montecucco, Domenico Delia, Laura Zannin. TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage. Cell death and differentiation. vol 26. issue 5. 2020-07-06. PMID:30050056. |
p300 activity toward p53 is negatively regulated by the nad-dependent deacetylase sirt1, which deacetylates p53 preventing its transcriptional activation and the induction of p53-dependent apoptosis. |
2020-07-06 |
2023-08-13 |
Not clear |