| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Sook Jeon, Sora Kwon, Kiwon Ban, Young- Kwon Hong, Curie Ahn, Jung-Suk Sung, Inho Cho. Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2. Nutrition and cancer. vol 71. issue 5. 2020-05-11. PMID:30661409. |
quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (hcc) cells by the stabilization or induction of p53. |
2020-05-11 |
2023-08-13 |
Not clear |
| Yuanlong Ge, Shu Wu, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zha. Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers. Protein & cell. vol 10. issue 11. 2020-05-11. PMID:31115790. |
notably, alt cells expressing wild-type p53 show much lower apoptosis than p53-deficient alt cells. |
2020-05-11 |
2023-08-13 |
mouse |
| Yuanlong Ge, Shu Wu, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zha. Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers. Protein & cell. vol 10. issue 11. 2020-05-11. PMID:31115790. |
therefore, p53 and akt are the key factors that suppress spontaneous apoptosis in alt cells. |
2020-05-11 |
2023-08-13 |
mouse |
| Leonie Harmse, Nadia Gangat, Carla Martins-Furness, Jean Dam, Charles B de Konin. Copper-imidazo[1,2-a]pyridines induce intrinsic apoptosis and modulate the expression of mutated p53, haem-oxygenase-1 and apoptotic inhibitory proteins in HT-29 colorectal cancer cells. Apoptosis : an international journal on programmed cell death. vol 24. issue 7-8. 2020-05-08. PMID:31073781. |
copper-imidazo[1,2-a]pyridines induce intrinsic apoptosis and modulate the expression of mutated p53, haem-oxygenase-1 and apoptotic inhibitory proteins in ht-29 colorectal cancer cells. |
2020-05-08 |
2023-08-13 |
Not clear |
| Dan Luo, Zhipeng Peng, Le Yang, Mingren Qu, Xiaowen Xiong, Lanjiao Xu, Xianghui Zhao, Ke Pan, Kehui Ouyan. Niacin Protects against Butyrate-Induced Apoptosis in Rumen Epithelial Cells. Oxidative medicine and cellular longevity. vol 2019. 2020-05-08. PMID:31737165. |
thus, high concentrations of butyrate may induce rumen epithelial cell apoptosis by increasing oxidative stress and inducing caspase-9 and p53 expression. |
2020-05-08 |
2023-08-13 |
Not clear |
| Dan Luo, Zhipeng Peng, Le Yang, Mingren Qu, Xiaowen Xiong, Lanjiao Xu, Xianghui Zhao, Ke Pan, Kehui Ouyan. Niacin Protects against Butyrate-Induced Apoptosis in Rumen Epithelial Cells. Oxidative medicine and cellular longevity. vol 2019. 2020-05-08. PMID:31737165. |
cotreatment with niacin regulates apoptosis-related gene expression by reducing intracellular ros production and dna damage and downregulating caspase-3 and p53 expressions to protect rumen epithelial cells against butyrate-induced apoptosis. |
2020-05-08 |
2023-08-13 |
Not clear |
| Huidan Deng, Natsumi Fujiwara, Hengmin Cui, Gary M Whitford, John D Bartlett, Maiko Suzuk. Histone acetyltransferase promotes fluoride toxicity in LS8 cells. Chemosphere. vol 247. 2020-05-08. PMID:31927229. |
these results suggest that acetylation of p53 by hats contributes, at least in part, to fluoride-induced toxicity in ls8 cells via cell growth inhibition, apoptosis, dna damage and mitochondrial damage. |
2020-05-08 |
2023-08-13 |
mouse |
| Marion Robin, Abdul Raouf Issa, Cristiana C Santos, Francesco Napoletano, Céline Petitgas, Gilles Chatelain, Mathilde Ruby, Ludivine Walter, Serge Birman, Pedro M Domingos, Brian R Calvi, Bertrand Mollerea. Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30563404. |
drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. |
2020-05-07 |
2023-08-13 |
drosophila_melanogaster |
| Marion Robin, Abdul Raouf Issa, Cristiana C Santos, Francesco Napoletano, Céline Petitgas, Gilles Chatelain, Mathilde Ruby, Ludivine Walter, Serge Birman, Pedro M Domingos, Brian R Calvi, Bertrand Mollerea. Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30563404. |
moreover, autophagy and apoptosis were differentially regulated by the p53 (p53b) and Δnp53 (p53a) isoforms: while the former induced autophagy in differentiated neurons, which protected against cell death, the latter inhibited autophagy by activating the caspases dronc, drice, and dcp-1. |
2020-05-07 |
2023-08-13 |
drosophila_melanogaster |
| Marion Robin, Abdul Raouf Issa, Cristiana C Santos, Francesco Napoletano, Céline Petitgas, Gilles Chatelain, Mathilde Ruby, Ludivine Walter, Serge Birman, Pedro M Domingos, Brian R Calvi, Bertrand Mollerea. Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30563404. |
our results demonstrate that the differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress. |
2020-05-07 |
2023-08-13 |
drosophila_melanogaster |
| Rui Tang, Xiaohan Mei, Yung-Chun Wang, Xiao-Bing Cui, Gui Zhang, Wenjing Li, Shi-You Che. LncRNA GAS5 regulates vascular smooth muscle cell cycle arrest and apoptosis via p53 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 9. 2020-05-07. PMID:31167125. |
lncrna gas5 regulates vascular smooth muscle cell cycle arrest and apoptosis via p53 pathway. |
2020-05-07 |
2023-08-13 |
rat |
| Rui Tang, Xiaohan Mei, Yung-Chun Wang, Xiao-Bing Cui, Gui Zhang, Wenjing Li, Shi-You Che. LncRNA GAS5 regulates vascular smooth muscle cell cycle arrest and apoptosis via p53 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 9. 2020-05-07. PMID:31167125. |
importantly, local delivery of gas5 via adenoviral vector suppresses balloon injury-induced neointima formation along with an increased expression of p53 and apoptosis in neointimal smcs. |
2020-05-07 |
2023-08-13 |
rat |
| Ya-Nan Xue, Bing-Bing Yu, Jiu-Ling Li, Rui Guo, Li-Chao Zhang, Lian-Kun Sun, Ya-Nan Liu, Yang L. Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1. Experimental cell research. vol 374. issue 1. 2020-05-06. PMID:30528266. |
recent studies have shown that zinc and p53 not only induce tumor cell apoptosis, but also regulate tumor cell metabolism. |
2020-05-06 |
2023-08-13 |
Not clear |
| Xiuhua Xu, Qiao Liu, Chen Zhang, Shuai Ren, Limei Xu, Zixiao Zhao, Hao Dou, Peishan Li, Xiyu Zhang, Yaoqin Gong, Changshun Sha. Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence. Cell death & disease. vol 10. issue 4. 2020-05-05. PMID:30910997. |
activation of p53 may induce apoptosis or cellular senescence in stressed cells. |
2020-05-05 |
2023-08-13 |
Not clear |
| Fei Ren, Cheng Ji, Yujie Huang, Stanley Aniagu, Yan Jiang, Tao Che. AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos. The Science of the total environment. vol 719. 2020-05-05. PMID:31837856. |
incidentally, both ch and nac attenuated the eom-induced changes in the mrna expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax). |
2020-05-05 |
2023-08-13 |
cat |
| Xiaolei Xie, Guangan He, Zahid H Siddi. Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill. Molecular pharmacology. vol 97. issue 4. 2020-05-05. PMID:32063580. |
our results demonstrate that nutlin-3 but not rita (reactivation of p53 and induction of tumor cell apoptosis) effectively disrupted the p53-mdm2-mdm4 complex to activate p53, which increased robustly with cisplatin/nutlin-3 combination and enhanced antitumor effects more than either agent alone. |
2020-05-05 |
2023-08-13 |
Not clear |
| Sarah R Hosford, Kevin Shee, Jason D Wells, Nicole A Traphagen, Jennifer L Fields, Riley A Hampsch, Arminja N Kettenbach, Eugene Demidenko, Todd W Mille. Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer. Molecular oncology. vol 13. issue 8. 2020-05-04. PMID:31180176. |
such apoptosis was dependent upon the unfolded protein response, p53, and jnk signaling. |
2020-05-04 |
2023-08-13 |
Not clear |
| Guowu Yu, Hongwei Luo, Na Zhang, Yongbin Wang, Yangping Li, Huanhuan Huang, Yinghong Liu, Yufeng Hu, Hanmei Liu, Junjie Zhang, Yi Tang, Yubi Huan. Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation. International journal of molecular sciences. vol 20. issue 24. 2020-04-30. PMID:31842349. |
loss of p53 sensitizes cells to palmitic acid-induced apoptosis by reactive oxygen species accumulation. |
2020-04-30 |
2023-08-13 |
mouse |
| Guowu Yu, Hongwei Luo, Na Zhang, Yongbin Wang, Yangping Li, Huanhuan Huang, Yinghong Liu, Yufeng Hu, Hanmei Liu, Junjie Zhang, Yi Tang, Yubi Huan. Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation. International journal of molecular sciences. vol 20. issue 24. 2020-04-30. PMID:31842349. |
under various cellular stresses, the activation of p53 signaling can lead to cell cycle arrest, dna repair, senescence, or apoptosis, depending on the severity/type of stress. |
2020-04-30 |
2023-08-13 |
mouse |
| Guowu Yu, Hongwei Luo, Na Zhang, Yongbin Wang, Yangping Li, Huanhuan Huang, Yinghong Liu, Yufeng Hu, Hanmei Liu, Junjie Zhang, Yi Tang, Yubi Huan. Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation. International journal of molecular sciences. vol 20. issue 24. 2020-04-30. PMID:31842349. |
furthermore, loss of p53 makes cells sensitive to palmitic acid-induced apoptosis. |
2020-04-30 |
2023-08-13 |
mouse |