| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yifan Wang, Wenying Li, Yahui Yang, Qinsong Zeng, Ka-Hing Wong, Xiaoling Li, Tianfeng Che. An integrin-targeting nanosystem as a carrier of the selenadiazole derivative to induce ROS-mediated apoptosis in bladder cancer cells, from rational design to action mechanisms. Journal of materials chemistry. B. vol 3. issue 48. 2020-04-08. PMID:32262936. |
further mechanistic studies using western blotting showed that bsec-pei-rgd triggered bladder cancer cell apoptosis by activating p38, jnk and p53 and by inactivating akt and erk. |
2020-04-08 |
2023-08-13 |
Not clear |
| Wei-Ting Kuo, Jian-Yuan Huang, Min-Hua Chen, Ching-Yun Chen, Yan-Jye Shyong, Ko-Chung Yen, Yu-Jun Sun, Cherng-Jyh Ke, Yung-Hsin Cheng, Feng-Huei Li. Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells. Journal of materials chemistry. B. vol 4. issue 14. 2020-04-08. PMID:32263194. |
in conclusion, gnp-(pha-e)-gem could induce growth inhibition and cytotoxicity, which was mediated through inhibition of egfr phosphorylation and the switching on of p53 that causes cell apoptosis of nsclc cells a-549 and h292. |
2020-04-08 |
2023-08-13 |
Not clear |
| Guan-Hai Wang, Guo-Liang Huang, Yi Zhao, Xing-Xiang Pu, Tong Li, Jun-Jie Deng, Jian-Tao Li. ATP triggered drug release and DNA co-delivery systems based on ATP responsive aptamers and polyethylenimine complexes. Journal of materials chemistry. B. vol 4. issue 21. 2020-04-08. PMID:32263321. |
the result demonstrated that the combinatorial delivery of dox and p53 by nanocarriers could induce synergistic actions and lead to effective cancer cell apoptosis. |
2020-04-08 |
2023-08-13 |
Not clear |
| Xing Li, Lu Zheng, Qian Xia, Lu Liu, Meng Mao, Huijuan Zhou, Yin Zhao, Jing Sh. A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29769639. |
the tat-nts peptide inhibited the transcriptional activity of p53, decreased bid expression, suppressed activation of the caspase-3 apoptosis pathway and improved the survival of hippocampal neurons subjected to oxygen-glucose deprivation and reperfusion in vitro. |
2020-04-07 |
2023-08-13 |
Not clear |
| Seung Hee Jung, Minyoung Lee, Hyun A Park, Hyung Chul Lee, Donghee Kang, Hyun Jung Hwang, Chanho Park, Dong-Min Yu, Yu Ri Jung, Mi-Na Hong, Yong-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Le. Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786073. |
finally, we show that sirna- or inhibitor-mediated blockade of integrin α6β4-src-akt signaling switches the post-irradiation fate from senescence to apoptosis, under p53 activated condition, in both cancer cells and tumor tissues of xenograft mice. |
2020-04-07 |
2023-08-13 |
mouse |
| Liang Zhou, Guoqiang X. Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30683842. |
cereblon attenuates dna damage-induced apoptosis by regulating the transcription-independent function of p53. |
2020-04-06 |
2023-08-13 |
Not clear |
| Li Li, Zijun Su, Zhimin Zou, Hongping Tan, Daozhang Cai, Lei Su, Zhengtao G. Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30718466. |
ser46 phosphorylation of p53 is an essential event in prolyl-isomerase pin1-mediated p53-independent apoptosis in response to heat stress. |
2020-04-06 |
2023-08-13 |
Not clear |
| Li Li, Zijun Su, Zhimin Zou, Hongping Tan, Daozhang Cai, Lei Su, Zhengtao G. Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30718466. |
our preliminary study revealed heat stress (hs)-induced apoptosis of vascular endothelial cells was associated with reactive oxygen species (ros)-induced p53 translocation into mitochondria. |
2020-04-06 |
2023-08-13 |
Not clear |
| Li Li, Zijun Su, Zhimin Zou, Hongping Tan, Daozhang Cai, Lei Su, Zhengtao G. Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30718466. |
based on these studies, we presumed pin1 is a key intermediate in regulation of mitochondrial p53 translocation through a hs-induced ros-p53 transcription-independent apoptosis pathway. |
2020-04-06 |
2023-08-13 |
Not clear |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
ethanol increases manganese-induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. |
2020-04-06 |
2023-08-13 |
rat |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
collectively, etoh increases mn - induced oxidative/nitrosative stress, neuro-inflammation and hippocampal apoptosis via mechanism involving oxidative damages of cellular constituents, neuronal inflammation and subsequent upregulation of bax and caspase-3 and downregulation of bcl-2 protein expression via p53 dependent/independent pathways to induced hippocampal apoptosis associated with impaired spatial learning and memory. |
2020-04-06 |
2023-08-13 |
rat |
| Honglei Zhan, He Zhao, Nazim Muhammad, Tongtong Li, Yujia Liu, Jihui Wan. Lytic peptide-grafted beta-cyclodextrin polymer based nano-scaled drug delivery system with enhanced camptothecin anti-cancer efficacy. Nanotechnology. vol 31. issue 7. 2020-04-06. PMID:31665708. |
our results suggested zh-bcdp-cpt inclusion complex induced cell apoptosis by up-regulation of bax and p53 and down-regulation of bcl-2, primarily involved in the mitochondrial pathways. |
2020-04-06 |
2023-08-13 |
Not clear |
| Václav Brázda, Miroslav Fojt. The Rich World of p53 DNA Binding Targets: The Role of DNA Structure. International journal of molecular sciences. vol 20. issue 22. 2020-04-03. PMID:31717504. |
the tumor suppressor functions of p53 and its roles in regulating the cell cycle, apoptosis, senescence, and metabolism are accomplished mainly by its interactions with dna. |
2020-04-03 |
2023-08-13 |
Not clear |
| Xinyuan Zhao, Yifan Wu, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han, Gang Che. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. vol 423. 2020-04-02. PMID:31082419. |
sirt1 overexpression dramatically decreased p53 acetylation and its cytoplasmic localisation, and this was accompanied by attenuated apoptosis in sinp-exposed cells. |
2020-04-02 |
2023-08-13 |
mouse |
| Xinyuan Zhao, Yifan Wu, Jinlong Li, Dongyu Li, Yang Jin, Piaoyu Zhu, Yingqi Liu, Yin Zhuang, Shali Yu, Weiming Cao, Haiyan Wei, Xiaoke Wang, Yu Han, Gang Che. JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation. Toxicology. vol 423. 2020-04-02. PMID:31082419. |
in summary, sinps downregulate nuclear sirt1 via jnk activation-mediated protein degradation, which leads to apoptosis via p53 acetylation and cytoplasmic localisation. |
2020-04-02 |
2023-08-13 |
mouse |
| Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Che. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerging microbes & infections. vol 9. issue 1. 2020-04-02. PMID:32228226. |
furthermore, sars-cov-2 induced activation of apoptosis and p53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. |
2020-04-02 |
2023-08-13 |
Not clear |
| Chueh-Hsuan Lu, Yu-Yi Kuo, Guan-Bo Lin, Wei-Ting Chen, Chih-Yu Cha. Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells. PloS one. vol 15. issue 1. 2020-04-01. PMID:31995555. |
the synergistic activity against the panc-1 cells was achieved by inducing g2/m phase arrest and apoptosis, which were associated with up-regulation of p53 and coupled with increased expression of downstream proteins p21 and bax. |
2020-04-01 |
2023-08-13 |
human |
| D B Kiselevsk. Granzymes and Mitochondria. Biochemistry. Biokhimiia. vol 85. issue 2. 2020-04-01. PMID:32093590. |
granzyme b initiates mitochondria-dependent apoptosis via (i) proapoptotic bid protein, (ii) mcl-1 and bim proteins, or (iii) p53 protein. |
2020-04-01 |
2023-08-13 |
Not clear |
| Faryal Khattak, Muhammad Haseeb, Sahar Fazal, A I Bhatti, Mukhtar Ulla. Mathematical Modeling of E6-p53 interactions in Cervical Cancer Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 4. 2020-03-31. PMID:28547941. |
as a result, p53 negative regulation and apoptosis relevant activities are abrogated, facilitating developmentof cervical cancer. |
2020-03-31 |
2023-08-13 |
Not clear |
| K M Ahsanul Kabir, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Hamida Khatun, Syed Rashel Kabi. Corrigendum to "Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression"[Int. J. Biol. Macromol. 125 (2019) 92-98]. International journal of biological macromolecules. vol 150. 2020-03-31. PMID:32171584. |
corrigendum to "geodorum densiflorum rhizome lectin inhibits ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of bax, p53 and nf-κb genes expression"[int. |
2020-03-31 |
2023-08-13 |
Not clear |