| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunjung Kim, Jae-Young Kim, Joo-Yong Le. Mathematical Modeling of p53 Pathways. International journal of molecular sciences. vol 20. issue 20. 2020-03-03. PMID:31635420. |
when activated under dna damage stress, p53 regulates hundreds of genes that are involved in dna repair, cell cycle, and apoptosis. |
2020-03-03 |
2023-08-13 |
Not clear |
| Ssu-Yu Chen, Shu-Ting Liu, Wun-Rong Lin, Chi-Kang Lin, Shih-Ming Huan. The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1. International journal of molecular sciences. vol 20. issue 20. 2020-03-03. PMID:31652494. |
copper sulfate also increased the levels of apoptosis, senescence, mitochondrial dysfunction, autophagy, ros, and the expression of several stress proteins, including atf3, c-fos, dec1 (differentiated embryonic chondrocyte gene 1), p21, p53, and hif-1α (hypoxia-inducible factor 1 alpha). |
2020-03-03 |
2023-08-13 |
Not clear |
| Shan-Wei Shi, Bo Li, Yang Dong, Yang Ge, Xing Qu, Li-Guang Lu, Yi-Hang Yuan, Long-Jiang Li, Yi L. In Vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Malignant Melanoma. Human gene therapy. Clinical development. vol 30. issue 1. 2020-02-27. PMID:30618300. |
the invasive ability, apoptosis, cycle changes of the cells, and the expression of the p53, p21, and bax genes and proteins were significantly changed in the experimental group. |
2020-02-27 |
2023-08-13 |
mouse |
| Guo-Tian Ruan, Yi-Zhen Gong, Xi-Wen Liao, Shuai Wang, Wei Huang, Xiang-Kun Wang, Guang-Zhi Zhu, Cun Liao, Feng Ga. Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncology reports. vol 42. issue 5. 2020-02-27. PMID:31545503. |
furthermore, gsea indicated that the high expression of cxcl3 was closely associated with dna repair, cell cycle process, cell apoptosis process and the p53 regulation pathway. |
2020-02-27 |
2023-08-13 |
Not clear |
| Bhavesh K Ahir, Sajani S Lakk. Elucidating the microRNA-203 specific biological processes in glioblastoma cells from comprehensive RNA-sequencing transcriptome profiling. Cellular signalling. vol 53. 2020-02-26. PMID:30244172. |
the biological processes mostly influenced were p53 signaling pathway, foxo signaling pathway, dna replication, cell cycle, mapk signaling pathway, and apoptosis. |
2020-02-26 |
2023-08-13 |
Not clear |
| Thuc-Nghi Duc Pham, Weili Ma, David Miller, Lidia Kazakova, Samuel Benchimo. Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells. Cell death & disease. vol 10. issue 1. 2020-02-26. PMID:30622244. |
epo selectively modulates the expression of p53 target genes in response to dna damage preventing the induction of a number of noncoding rnas (ncrnas) previously associated with p53-dependent apoptosis. |
2020-02-26 |
2023-08-13 |
Not clear |
| Agnieszka Toma-Jonik, Natalia Vydra, Patryk Janus, Wiesława Widła. Interplay between HSF1 and p53 signaling pathways in cancer initiation and progression: non-oncogene and oncogene addiction. Cellular oncology (Dordrecht). vol 42. issue 5. 2020-02-26. PMID:31183804. |
the p53 protein, which is primarily activated in response to dna damage, causes cell cycle arrest allowing for dna repair or directs cells to apoptosis, thereby maintaining genome integrity. |
2020-02-26 |
2023-08-13 |
Not clear |
| Wenhan Wang, Hairui Yang, Jing Deng, Lina Zhu, Yan Yang, Zhendong Liu, Jing-Song Zhang, Chuanhong Tang, Zhong Zhang, Haining Zhuang, Henan Zhang, Wei Ji. Increased Inhibition Effect of Antrodin C from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), on A549 through Crosstalk between Apoptosis and Autophagy. International journal of medicinal mushrooms. vol 21. issue 6. 2020-02-26. PMID:31679231. |
flow cytometry revealed that antrodin c increased the percentages of cells in the g0/g1 phase at concentrations of 50 and 80 μg/ml and the apoptosis was related to upregulation of caspase-3, bax, p53 expression, downregulation of bcl-2, rapr expression, and the release of reactive oxygen species in the a549 cells. |
2020-02-26 |
2023-08-13 |
Not clear |
| Fisayo A Olotu, Mahmoud E S Solima. Dynamic perspectives into the mechanisms of mutation-induced p53-DNA binding loss and inactivation using active perturbation theory: Structural and molecular insights toward the design of potent reactivators in cancer therapy. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30160791. |
the dna-binding ability of p53 represents the crux of its tumor suppressive activities, which involves transcriptional activation of target genes responsible for apoptosis and cell-cycle arrest. |
2020-02-25 |
2023-08-13 |
Not clear |
| Lemlem Brook, Patricia Palade, Anas Maatough, Graham Kerr Whitfield, Lis San Emeterio, David Hsieh, Jui-Cheng Hsie. Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30191601. |
we found that hr indeed regulates p53 target genes, including those implicated in cell cycle progression and apoptosis in the gbm-derived u87 cell line, and restoring hr expression triggered g2/m arrest and apoptosis. |
2020-02-25 |
2023-08-13 |
human |
| Jianfeng Mu, Xiaodong Wang, Lihua Dong, Pengda Su. Curcumin derivative L6H4 inhibits proliferation and invasion of gastric cancer cell line BGC-823. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30242876. |
curcumin l6h4 can significantly inhibit the proliferation and induce the apoptosis of bgc-823 cells, thus enhancing the expression levels of p53, p21, bax, and bcl-2 noticeably in vivo and in vitro. |
2020-02-25 |
2023-08-13 |
mouse |
| Dandan Song, Hongsheng Liang, Bo Qu, Yijing Li, Jingjing Liu, Yanan Zhang, Lu Li, Li Hu, Xiangtong Zhang, Aili Ga. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo. Journal of cellular biochemistry. vol 120. issue 1. 2020-02-25. PMID:30596403. |
meanwhile, the results also revealed that ivm induced apoptosis by increasing caspase-3 and caspase-9 activity, upregulating the expressions of p53 and bax, downregulating bcl-2, activating cleaved caspase-3 and cleaved caspase-9, and blocking cell cycle in g0/g1 phase by downregulating levels of cdk2, cdk4, cdk6, cyclin d1, and cyclin e. these findings suggest that ivm has an inhibition effect on the proliferation of glioma cells by triggering cell cycle arrest and inducing cell apoptosis in vitro and in vivo, and probably represents promising agent for treating glioma. |
2020-02-25 |
2023-08-13 |
Not clear |
| Mohammed A Ramadan, Alaa E Shawkey, Mohamed A Rabeh, Ashraf O Abdellati. Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30599074. |
the present study aimed to investigate the cytotoxic effects of tto against two representative types of human skin cancer, namely malignant melanoma (a-375) and squamous cell carcinoma (hep-2).to outline the basic molecular mechanism involved in apoptosis induction in a-375 and hep-2 cell lines, annexin v/pi staining for apoptosis detection, cell cycle analysis were monitored using flow cytometry and mrna expression levels of the apoptosis-regulatory genes p53, bax, and bcl-2 were determined by real-time pcr and western blot after treatment with tto. |
2020-02-25 |
2023-08-13 |
human |
| Mohammed A Ramadan, Alaa E Shawkey, Mohamed A Rabeh, Ashraf O Abdellati. Expression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30599074. |
this cytotoxicity resulted from tto induced apoptosis in both a-375 and hep-2 cell lines as evidenced by morphological features of apoptosis and annexin v/pi staining results in addition to the activation of caspase-3/7 and -9, upregulation of pro-apoptotic genes (p53 and bax) and downregulation of the anti-apoptotic gene bcl-2. |
2020-02-25 |
2023-08-13 |
human |
| Tomasz Kowalczyk, Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Dariusz Pytel, Joanna Wieczfińska, Janusz Szemraj, Tomasz Śliwińsk. Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30610508. |
the growth inhibition of human grade iv glioma cells mediated by mtrv extract appears to be associated with apoptosis and g2/m phase cell cycle arrest, and altered expression of the pro- and anti-apoptotic genes (bax, bcl-2, cas-3 and tp53) and proteins (bax, bcl-2, cas-3 and p53), as well as decreased mitochondrial membrane potential. |
2020-02-25 |
2023-08-13 |
human |
| Man Li, Duzhen Zhang, Jintao Cheng, Jiamei Liang, Fenghua Y. Ginsenoside Rh2 inhibits proliferation but promotes apoptosis and autophagy by down-regulating microRNA-638 in human retinoblastoma cells. Experimental and molecular pathology. vol 108. 2020-02-25. PMID:30853612. |
meanwhile, expression levels of proteins associated with cell cycle, apoptosis, autophagy and the phosphatidylinositol-3-kinase (pi3k)/akt/mechanistic target of rapamycin (mtor) pathway as well as p53 were measured by western blot analysis. |
2020-02-25 |
2023-08-13 |
human |
| Man Li, Duzhen Zhang, Jintao Cheng, Jiamei Liang, Fenghua Y. Ginsenoside Rh2 inhibits proliferation but promotes apoptosis and autophagy by down-regulating microRNA-638 in human retinoblastoma cells. Experimental and molecular pathology. vol 108. 2020-02-25. PMID:30853612. |
the observations demonstrated that grh2 functioned in cell proliferation, apoptosis and autophagy in y79 and rbl-13 cells through mir-638-mediated up-regulation of p53 and inactivation of the pi3k/akt/mtor pathway. |
2020-02-25 |
2023-08-13 |
human |
| Yi Li, Meng-Chen Zhang, Xiao-Kang Xu, Yang Zhao, Chatoo Mahanand, Tao Zhu, Hong Deng, Eviatar Nevo, Ji-Zeng Du, Xue-Qun Che. Functional Diversity of p53 in Human and Wild Animals. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:30915036. |
the common understanding of p53 function is a genome guardian, which is activated by diverse stresses stimuli and mediates dna repair, apoptosis, and cell cycle arrest. |
2020-02-25 |
2023-08-13 |
human |
| Wei Ding, Wen-Guang Chang, Xiao-Ci Guo, Ying Liu, Dan-Dan Xiao, Dan Ding, Jian-Xun Wang, Xue-Juan Zhan. Exenatide Protects Against Cardiac Dysfunction by Attenuating Oxidative Stress in the Diabetic Mouse Heart. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31024445. |
moreover, exenatide decreased tumor protein p53 (p53) expression and prevented cell apoptosis in h9c2 cells. |
2020-02-25 |
2023-08-13 |
mouse |
| Artur Beberok, Dorota Wrześniok, Jakub Rok, Zuzanna Rzepka, Michalina Respondek, Ewa Buszma. Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53/Bax/Bcl-2 signaling pathway. International journal of oncology. vol 52. issue 5. 2020-02-24. PMID:29532860. |
the aim of the present study was to examine the effect of ciprofloxacin on the viability, redox balance, apoptosis, expression of p53, bax and bcl-2, cell cycle distribution and dna fragmentation of triple-negative mda-mb-231 breast cancer cells. |
2020-02-24 |
2023-08-13 |
human |