| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianxian Liu, Wenchao Tian, Jinying Cheng, Dongmei Li, Tonggang Liu, Liguo Zhan. Microsecond molecular dynamics simulations reveal the allosteric regulatory mechanism of p53 R249S mutation in p53-associated liver cancer. Computational biology and chemistry. vol 84. 2020-02-24. PMID:31881526. |
the tumor suppressor p53, a transcription factor, plays a critical role in many cellular processes, including dna repair and apoptosis and cell cycle arrest. |
2020-02-24 |
2023-08-13 |
human |
| Bruno Saleme, Vikram Gurtu, Yongneng Zhang, Adam Kinnaird, Aristeidis E Boukouris, Keshav Gopal, John R Ussher, Gopinath Sutendr. Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity. Science translational medicine. vol 11. issue 478. 2020-02-21. PMID:30728290. |
tetrameric pkm2 suppresses p53 transcriptional activity and apoptosis in a high oxidation state but enhances them in a low oxidation one. |
2020-02-21 |
2023-08-13 |
Not clear |
| Joohee Jung, Do Young Song, Jung Jin Hwang, Heon Joo Park, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Cho. Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1. Archives of pharmacal research. vol 42. issue 9. 2020-02-21. PMID:30879173. |
rh1 displayed dose-dependent biphasic effects in vitro, i.e., it induced apoptosis at higher dose and senescence at lower dose accompanied by marked activation of p53. |
2020-02-21 |
2023-08-13 |
human |
| Jianlou Zhang, Jinghui Fan, Yan Li, Shuang Liang, Shanshan Huo, Xing Wang, Yuzhu Zuo, Dan Cui, Wenyan Li, Zhenyu Zhong, Fei Zhon. Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis. Viruses. vol 11. issue 4. 2020-02-19. PMID:31027293. |
we have found that ns1-induced apoptosis was significantly inhibited by caspase 9 inhibitor, but not caspase 8 inhibitor, and transfection of ns1 gene into pk-15 cells significantly inhibited mitochondria-associated antiapoptotic molecules bcl-2 and mcl-1 expressions and enhanced proapoptotic molecules bax, p21, and p53 expressions, suggesting that ns1-induced apoptosis is mainly through the mitochondria-mediated intrinsic apoptosis pathway. |
2020-02-19 |
2023-08-13 |
Not clear |
| Bo Li, Junkai Zhang, Ya Su, Yiling Hou, Zhenguo Wang, Lin Zhao, Shengkai Sun, Hao F. Overexpression of PTEN may increase the effect of pemetrexed on A549 cells via inhibition of the PI3K/AKT/mTOR pathway and carbohydrate metabolism. Molecular medicine reports. vol 20. issue 4. 2020-02-19. PMID:31485626. |
result from the present study demonstrated that treatment with pemetrexed suppressed lung cancer cell proliferation, inhibited mrna and protein expression levels of anti‑apoptotic bcl2, and increased the mrna and the protein expression levels of pro‑apoptotic p53 and apoptosis regulator bax. |
2020-02-19 |
2023-08-13 |
Not clear |
| Bei Yang, Xinlu Wang, Yilin Ma, Lei Yan, Yuan Ren, Dainan Yu, Bo Qiao, Xin Shen, Hui Liu, Dalei Zhang, Haibin Kuan. Tri-ortho-cresyl phosphate (TOCP)-induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice. Environmental toxicology. vol 35. issue 1. 2020-02-18. PMID:31566301. |
moreover, tocp administration induced placental apoptosis and autophagy by upregulating p53, bax, beclin-1, ratio of lc3 ii/lc3 i and atg5 and downregulating bcl-2 protein. |
2020-02-18 |
2023-08-13 |
mouse |
| Koray Kırımtay, Ece Selçuk, Dolunay Kelle, Batu Erman, Arzu Karaba. p53 regulates katanin-p60 promoter in HCT 116 cells. Gene. vol 727. 2020-02-18. PMID:31715301. |
tumor suppressor protein p53, which functions in the cell cycle, apoptosis and neuronal differentiation via transcriptional regulations of target genes or interactions with several proteins, has been associated with neurite outgrowth through microtubule re-organization. |
2020-02-18 |
2023-08-13 |
Not clear |
| Koray Kırımtay, Ece Selçuk, Dolunay Kelle, Batu Erman, Arzu Karaba. p53 regulates katanin-p60 promoter in HCT 116 cells. Gene. vol 727. 2020-02-18. PMID:31715301. |
our results indicate that p53 is an activator of katna1 gene expression and we show that both p53 and katanin-p60 expression have strict regulations and are maintained at balanced levels as they are vital proteins to orchestrate either survival and apoptosis or differentiation. |
2020-02-18 |
2023-08-13 |
Not clear |
| Raquel Santana da Cruz, Fabia de Oliveira Andrade, Vivian Montes de Oca Carioni, Mariana Papaléo Rosim, Mayara Lilian Paulino Miranda, Camile Castilho Fontelles, Pedro Vitoriano de Oliveira, Luis Fernando Barbisan, Inar Alves Castro, Thomas Prates On. Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 134. 2020-02-17. PMID:31505237. |
this was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and rassf1, zfp382 and stat3 expression in mammary glands, as well as increased zinc status. |
2020-02-17 |
2023-08-13 |
mouse |
| Rui Kang, Guido Kroemer, Daolin Tan. The tumor suppressor protein p53 and the ferroptosis network. Free radical biology & medicine. vol 133. 2020-02-14. PMID:29800655. |
beyond its effects on apoptosis, autophagy, and cell cycle, p53 also regulates ferroptosis either through a transcriptional or posttranslational mechanism. |
2020-02-14 |
2023-08-13 |
Not clear |
| Manaswita Jain, Rainer W J Kaiser, Katrin Bohl, Martin Hoehne, Heike Göbel, Malte P Bartram, Sandra Habbig, Roman-Ulrich Müller, Agnes B Fogo, Thomas Benzing, Bernhard Schermer, Katja Höpker, Gisela G Slaat. Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis. Kidney international. vol 95. issue 4. 2020-02-14. PMID:30770218. |
we recently identified the kinase-regulated dna damage response target apoptosis antagonizing transcription factor (aatf) as a master regulator of the p53 response. |
2020-02-14 |
2023-08-13 |
mouse |
| Karina Hadrian, Harutyun Melkonyan, Stefan Schlatt, Joachim Wistuba, Susanne Wasmuth, Arnd Heiligenhaus, Solon Thanos, Michael R R Böh. Age-related distribution and potential role of SNCB in topographically different retinal areas of the common marmoset Callithrix jacchus, including the macula. Experimental eye research. vol 185. 2020-02-14. PMID:31128101. |
the observed dose-depended decreased apoptosis rates together with the pld2 mediated activation of the p53 pathway promotes senescence-related processes in sncb exposed common arpe-19 cells from human origin. |
2020-02-14 |
2023-08-13 |
human |
| Sara Ramezani, Nasim Vousooghi, Fatemeh Ramezani Kapourchali, Shahrokh Yousefzadeh-Chabok, Zoheir Reihanian, Ali Mohammad Alizadeh, Saeed Khodayari, Hamid Khodayar. Rolipram optimizes therapeutic effect of bevacizumab by enhancing proapoptotic, antiproliferative signals in a glioblastoma heterotopic model. Life sciences. vol 239. 2020-02-13. PMID:31678282. |
co-treatment maximally hampered the tumor progression and elongated survival along with the major vascular regression, hypoxia, apoptosis induction, p53 and caspase activities. |
2020-02-13 |
2023-08-13 |
mouse |
| M H Lin, X H Guo, L X Qiao, F Xie, Y Sh. [Effect of overexpression of apoptosis-stimulating protein 2 of p53 on activation and apoptosis of hepatic stellate cells induced by transforming growth factor-β1 and its mechanism]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 27. issue 11. 2020-02-13. PMID:31941245. |
[effect of overexpression of apoptosis-stimulating protein 2 of p53 on activation and apoptosis of hepatic stellate cells induced by transforming growth factor-β1 and its mechanism]. |
2020-02-13 |
2023-08-13 |
Not clear |
| Enguo Ju, Tingting Li, Suzane Ramos da Silva, Shou-Jiang Ga. Gold Nanocluster-Mediated Efficient Delivery of Cas9 Protein through pH-Induced Assembly-Disassembly for Inactivation of Virus Oncogenes. ACS applied materials & interfaces. vol 11. issue 38. 2020-02-12. PMID:31469541. |
as a proof-of-concept, the assembled spcas9-auncs nanoparticles are successfully used for efficient knockout of the e6 oncogene, restoring the function of tumor-suppressive protein p53 and inducing apoptosis in cervical cancer cells with little effect on normal human cells. |
2020-02-12 |
2023-08-13 |
human |
| Priyanka Upadhyay, Sushmita Sarker, Avijit Ghosh, Payal Gupta, Shaswati Das, Manisha Ahir, Saurav Bhattacharya, Sreya Chattopadhyay, Swatilekha Ghosh, Arghya Adhikar. Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16. Biomaterials science. vol 7. issue 10. 2020-02-10. PMID:31411213. |
we established tf-tq-np as a potent anti-tumorigenic agent through the involvement of p53 and the ros feedback loop in regulating the microrna (mirna) circuitry to control apoptosis and migration of nsclc cells. |
2020-02-10 |
2023-08-13 |
mouse |
| Priyanka Upadhyay, Sushmita Sarker, Avijit Ghosh, Payal Gupta, Shaswati Das, Manisha Ahir, Saurav Bhattacharya, Sreya Chattopadhyay, Swatilekha Ghosh, Arghya Adhikar. Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16. Biomaterials science. vol 7. issue 10. 2020-02-10. PMID:31411213. |
tf-tq-np-mediated p53 up-regulation favored the potential simultaneous activation of mir-34a and mir-16 targeting bcl2 to induce apoptosis in the a549 cells. |
2020-02-10 |
2023-08-13 |
mouse |
| Yangyang Han, Ming Lu, Jinsong Zho. Buforin IIb induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro. Toxicon : official journal of the International Society on Toxinology. vol 168. 2020-02-07. PMID:31229626. |
buforin iib induces androgen-independent prostate cancer cells apoptosis though p53 pathway in vitro. |
2020-02-07 |
2023-08-13 |
Not clear |
| Bo Lu, Ian T Christensen, Tao Yu, Chunxia Wang, Qichang Yan, Xinling Wan. SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts. Oxidative medicine and cellular longevity. vol 2019. 2020-02-07. PMID:31281592. |
previous studies have shown that tp53inp1 can arrest cell growth and induce apoptosis by modulating p53 transcriptional activity and that both tp53inp1 and p53 are substrates of sumoylation. |
2020-02-07 |
2023-08-13 |
human |
| Bo Sun, Xudong Zhao, Jianguang Ming, Xing Liu, Daming Liu, Chuanlu Jian. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. vol 38. issue 33. 2020-02-05. PMID:31289362. |
inhibition of mir-10b and mir-222 strongly suppress gbm cells growth, invasion, and induce apoptosis by co-targeting pten and leading to activation of p53 ultimately. |
2020-02-05 |
2023-08-13 |
mouse |