| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Sun, Xudong Zhao, Jianguang Ming, Xing Liu, Daming Liu, Chuanlu Jian. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. vol 38. issue 33. 2020-02-05. PMID:31289362. |
we also demonstrated that mir-10b and mir-222 co-target bim to induce apoptosis independent of p53 status. |
2020-02-05 |
2023-08-13 |
mouse |
| Hongge Zhu, Tianhai Wang, Zhou Xin, Yiyi Zhan, Guoming Gu, Xiaoqin Li, Xiuli Wang, Shune Yang, Chunling Li. An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro. Acta biochimica et biophysica Sinica. vol 51. issue 10. 2020-02-05. PMID:31518420. |
the results showed that opz significantly suppressed cell proliferation and strongly induced apoptosis in both tested lung cancer cells independent of p53 expression. |
2020-02-05 |
2023-08-13 |
Not clear |
| Xiangnan Guo, Xiaoyan Fu, Xiaona Liu, Jingqiu Wang, Zhongzhe Li, Lin Gao, Yuanyuan Li, Wei Zhan. Role of Pigment Epithelium-Derived Factor in Arsenic-Induced Vascular Endothelial Dysfunction in a Rat Model. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30392020. |
the oxidative stress level and key proteins associated with apoptosis such as fas, fasl, p53, and p-p38 were then detected to explore the detailed mechanisms. |
2020-02-04 |
2023-08-13 |
rat |
| Chun-Yang Han, Tao-Tao Sun, Guang-Pei Xv, Si-Si Wang, Jin-Gang Gu, Cui-Yan Li. Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432116. |
in conclusion, bbr exerts a protective action against ccl4‑induced acute liver injury in rats via effectively regulating the expression of nrf2‑keap1‑antioxidant responsive element‑related genes and proteins, and inhibiting p53 pathway‑mediated hepatocyte apoptosis. |
2020-02-04 |
2023-08-13 |
rat |
| Jianlin Chen, Liqun Xia, Wenji Wang, Zhiwen Wang, Suying Hou, Caixia Xie, Jia Cai, Yishan L. Identification of a mitochondrial-targeting secretory protein from Nocardia seriolae which induces apoptosis in fathead minnow cells. Journal of fish diseases. vol 42. issue 11. 2020-02-04. PMID:31482589. |
moreover, quantitative assays of mitochondrial membrane potential (ΔΨm) value, caspase-3 activity and apoptosis-related gene (bcl-2, bax, bad, bid and p53) mrna expression suggested that cell apoptosis was induced in fhm cells by the overexpression of both mtsp3141 and mtsp3141Δtp (with the n-terminal tp deleted) proteins. |
2020-02-04 |
2023-08-13 |
Not clear |
| Panyu Zhou, Demeng Xia, Yang Wang, Hongdi Lv, Ziqin Wang, Malcolm Xing, Qingjie Zhao, Shuogui X. Matrine derivate MASM protects murine MC3T3-E1 osteoblastic cells against dexamethasone-induced apoptosis via the regulation of USP14/p53. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-02-04. PMID:31523993. |
furthermore, pretreatment with iu1 or a p53 inhibitor (pft-α) partially blocked dexamethasone-induced apoptosis of mc3t3-e1 cells. |
2020-02-04 |
2023-08-13 |
Not clear |
| Zeyu Zhang, Xiaoting Li, Yingyan Han, Teng Ji, Xiaoyuan Huang, Qinglei Gao, Ding M. RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-04. PMID:31545289. |
gene set enrichment analysis (gsea) performed on dataset gse1456 demonstrated that gene expression signatures associated with survival, proliferation, cell cycle, apoptosis and p53 signaling were crucially enriched, when the level of rad54b was elevated. |
2020-02-04 |
2023-08-13 |
human |
| Katsuhiko Itoh, Takahiro Ebata, Hiroaki Hirata, Takeru Torii, Wataru Sugimoto, Keigo Onodera, Wataru Nakajima, Ikuno Uehara, Daisuke Okuzaki, Shota Yamauchi, Yemima Budirahardja, Takahito Nishikata, Nobuyuki Tanaka, Keiko Kawauch. DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death. Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-30. PMID:31480541. |
tumor suppressor p53 plays an integral role in dna-damage induced apoptosis, a biological process that protects against tumor progression. |
2020-01-30 |
2023-08-13 |
Not clear |
| Katsuhiko Itoh, Takahiro Ebata, Hiroaki Hirata, Takeru Torii, Wataru Sugimoto, Keigo Onodera, Wataru Nakajima, Ikuno Uehara, Daisuke Okuzaki, Shota Yamauchi, Yemima Budirahardja, Takahito Nishikata, Nobuyuki Tanaka, Keiko Kawauch. DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death. Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-30. PMID:31480541. |
cell shape dramatically changes when cells undergo apoptosis, which is associated with actomyosin contraction; however, it remains entirely elusive how p53 regulates actomyosin contraction in response to dna-damaging agents. |
2020-01-30 |
2023-08-13 |
Not clear |
| Yuwei Zhang, Jingjing Gao, Yong Lu. The effect of various durations of cigarette smoke exposure on muscle fibre remodeling in rat diaphragms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-28. PMID:31176169. |
cs exposure resulted in increased percentage of type i muscle fibres, enhanced apoptosis index, endoplasmic reticulum (er) dilation, elevated expression of glucose-regulated protein 78, c/ebp homologous protein, caspase-12, peroxisome proliferator-activated receptor γ coactivator 1α (pgc-1α), cytochrome c oxidase 4, sdhb, p53 and a reduction in fibre diameters in rat diaphragms. |
2020-01-28 |
2023-08-13 |
rat |
| Jing-Jing Zhang, Li-Ping Fa. Long non-coding RNA CRNDE enhances cervical cancer progression by suppressing PUMA expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-28. PMID:31202167. |
mechanistically, we verified that crnde bond to p53 upregulated modulator of apoptosis (puma), and puma was required for crnde to enhance cervical cancer cell growth. |
2020-01-28 |
2023-08-13 |
human |
| Chun-Chao Chen, Hong-Jye Hong, Wen-Rui Hao, Tzu-Hurng Cheng, Ju-Chi Liu, Li-Chin Sun. Nicorandil prevents doxorubicin-induced human umbilical vein endothelial cell apoptosis. European journal of pharmacology. vol 859. 2020-01-28. PMID:31319070. |
dox markedly increased reactive oxygen species production, p53 expression, caspase-3 activity, cleaved caspase-3 levels, and tunel-positive cell numbers but reduced bcl-2 expression and intracellular antioxidant enzyme levels; these effects were effectively antagonized through nicorandil (3 μm, 12 h) pretreatment, which resulted in huvecs being protected from dox-induced apoptosis. |
2020-01-28 |
2023-08-13 |
human |
| Zhen Chen, Haoqiang Lai, Liyuan Hou, Tianfeng Che. Rational design and action mechanisms of chemically innovative organoselenium in cancer therapy. Chemical communications (Cambridge, England). vol 56. issue 2. 2020-01-28. PMID:31782422. |
this review is mainly focused on the design and synthesis of various kinds of org-se, followed by their anticancer mechanisms such as the mitochondria mediated pathway induced by ros, death receptor mediated pathways involving p53 phosphorylation, and the activation of the ampk pathway to promote apoptosis. |
2020-01-28 |
2023-08-13 |
Not clear |
| Patrick L Leslie, Derek A Franklin, Yong Liu, Yanping Zhan. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell reports. vol 24. issue 6. 2020-01-27. PMID:30089260. |
p53 regulates the expression of lrp1 and apoptosis through a stress intensity-dependent microrna feedback loop. |
2020-01-27 |
2023-08-13 |
Not clear |
| Yingying Jin, Baofeng Wang, Yue Ke, Yi Li, Fang Li, Heng Luo, Xin Meng, Xinyue Cu. [THAP11 mediates the proliferation and apoptosis of esophageal cancer cells via inhibiting ubiquitination of p53]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 12. 2020-01-27. PMID:31969497. |
[thap11 mediates the proliferation and apoptosis of esophageal cancer cells via inhibiting ubiquitination of p53]. |
2020-01-27 |
2023-08-13 |
human |
| Fei Fu, Junjie Zhao, Xueyan X. Identification of genes involved in enterovirus 71 infected SK-N-SH cells. International journal of clinical and experimental pathology. vol 10. issue 12. 2020-01-26. PMID:31966515. |
the up-regulated gene mainly include the cytokine and chemokine, ubiquitin mediated proteolysis, toll-like receptor signaling pathway, p53 signaling pathway, apoptosis, leukocyte transendothelial migration, mapk signaling pathway and jak-stat signaling pathway, etc. |
2020-01-26 |
2023-08-13 |
human |
| Jixian Xiong, Shuiming Li, Xiandong Zen. High Rab25 expression associates with Ki67/TP53/CD133/VEGFR expression predicts poor prognosis in gastric cancer. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966627. |
in this study, we determined to investigate the potential association between rab25 and four tumor markers, including ki67 (a well-known hallmarker of tumor proliferation), tp53 (tumor p53, a master tumor regulator associated with cell apoptosis), cd133 (a common cancer stem cell marker) and vegfr (vascular endothelial growth factor receptor, an efficient therapy target for gastric cancer). |
2020-01-26 |
2023-08-13 |
Not clear |
| Wei Huang, Xinzhi Li, Lin Ca. Effects of ASPP2 on proliferation and apoptosis of malignant spinal tumor cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966654. |
apoptosis stimulating protein 2 of p53 (assp2) is one member of p53 binding protein family pro-apoptotic member, and can enhance apoptotic activity via modulating p53 pathway. |
2020-01-26 |
2023-08-13 |
Not clear |
| Wei Huang, Xinzhi Li, Lin Ca. Effects of ASPP2 on proliferation and apoptosis of malignant spinal tumor cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966654. |
aspp2-overexpression vector transfection tumor cells increased apoptosis and inhibited proliferation, accompanied with lower bcl-2, higher bax, caspase 3 and p53 (p<0.05 compared to control group). |
2020-01-26 |
2023-08-13 |
Not clear |
| Wei Huang, Xinzhi Li, Lin Ca. Effects of ASPP2 on proliferation and apoptosis of malignant spinal tumor cells. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966654. |
aspp2 can inhibit malignant spinal tumor cell proliferation via mediating p53 expression for cell apoptosis, thus can work as one molecular target for tumor diagnosis and prognostic analysis. |
2020-01-26 |
2023-08-13 |
Not clear |