| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Méndez-García, M Martínez-Castillo, N Villegas-Sepúlveda, L Orozco, E J Córdov. Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis. Human & experimental toxicology. vol 38. issue 8. 2019-12-31. PMID:31018701. |
thus, we studied the inactivation of nrf2 during oxidant-induced apoptosis in a p53 dysfunctional cellular model. |
2019-12-31 |
2023-08-13 |
Not clear |
| L A Méndez-García, M Martínez-Castillo, N Villegas-Sepúlveda, L Orozco, E J Córdov. Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis. Human & experimental toxicology. vol 38. issue 8. 2019-12-31. PMID:31018701. |
these data suggest that apoptosis-related inactivation of nrf2 could occur in a p53 dysfunctional background, opening the possible occurrence of p53-independent mechanism to explain nrf2 inactivation during apoptosis. |
2019-12-31 |
2023-08-13 |
Not clear |
| Alexander Cecil, Ivaylo Gentschev, Marion Adelfinger, Thomas Dandekar, Aladar A Szala. Vaccinia virus injected human tumors: oncolytic virus efficiency predicted by antigen profiling analysis fitted boolean models. Bioengineered. vol 10. issue 1. 2019-12-30. PMID:31142183. |
our model combines networks for apoptosis, mapk, p53, wnt, hedgehog, the t-killer cell mediated cell death, interferon and interleukin signaling networks. |
2019-12-30 |
2023-08-13 |
mouse |
| Jaganathan Anitha, Rajendran Selvakumar, Kadarkari Muruga. Chitosan capped ZnO nanoparticles with cell specific apoptosis induction through P53 activation and G2/M arrest in breast cancer cells - In vitro approaches. International journal of biological macromolecules. vol 136. 2019-12-30. PMID:31212046. |
chitosan capped zno nanoparticles with cell specific apoptosis induction through p53 activation and g2/m arrest in breast cancer cells - in vitro approaches. |
2019-12-30 |
2023-08-13 |
Not clear |
| Kpobari W Nkpaa, Ifeoluwa O Awogbindin, Benjamin A Amadi, Amos O Abolaji, Isaac A Adedara, Matthew O Wegwu, Ebenezer O Faromb. Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway. Biological trace element research. vol 191. issue 1. 2019-12-24. PMID:30488170. |
ethanol exacerbates manganese-induced neurobehavioral deficits, striatal oxidative stress, and apoptosis via regulation of p53, caspase-3, and bax/bcl-2 ratio-dependent pathway. |
2019-12-24 |
2023-08-13 |
rat |
| Kpobari W Nkpaa, Ifeoluwa O Awogbindin, Benjamin A Amadi, Amos O Abolaji, Isaac A Adedara, Matthew O Wegwu, Ebenezer O Faromb. Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway. Biological trace element research. vol 191. issue 1. 2019-12-24. PMID:30488170. |
taken together, it seems that etoh exacerbates mn-induced neurobehavioral deficits, oxidative stress, and apoptosis induction via the regulation of p53, caspase-3, and bax/bcl-2 ratio-dependent pathway in rat striatum. |
2019-12-24 |
2023-08-13 |
rat |
| Khaliunaa Lkhagvasuren, Jin-Kyung Ki. Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 59. 2019-12-23. PMID:31029785. |
apoptosis caused by p53 phosphorylation following ziyuglycoside ii treatment in hct116 cells involved activation of caspases, increased expression of bax, mitochondrial cytochrome c and apoptosis inducing factor (aif) release, while bcl-2 became down-regulated. |
2019-12-23 |
2023-08-13 |
human |
| Dennis Tappe, Jonas Schmidt-Chanasit, Jessica Rauch, Petra Allartz, Christiane Herde. Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011-2013. Emerging infectious diseases. vol 25. issue 6. 2019-12-23. PMID:31107210. |
immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to cd8+ cells and widespread p53 expression, hallmarks of apoptosis. |
2019-12-23 |
2023-08-13 |
human |
| De-Zhe Chen, Wei-Wei Wang, Yan-Ling Chen, Xia-Feng Yang, Min Zhao, Yan-Yan Yan. miR‑128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31173166. |
subsequently, results from an in vitro epilepsy model demonstrated that overexpression of mir‑128 promoted nerve cell apoptosis, increased the protein expression of tumor protein p53, bcl2 associated x (bax) and cytochrome c, and enhanced caspase‑3/9 activity, whereas it suppressed the protein expression of sirtuin 1 (sirt1). |
2019-12-23 |
2023-08-13 |
rat |
| Alexander V Sirotkin, Andrej Benco, Milos Mlyncek, Jan Kotwica, Saleh Alwasel, Abdel Halim Harrat. Transcription factor p53 regulates healthy human ovarian cells function. Comptes rendus biologies. vol 342. issue 5-6. 2019-12-23. PMID:31495738. |
the intracellular accumulation of p53, of the apoptosis marker bax, and of the proliferation marker pcna, as well as the release of progesterone (p4), insulin-like growth factor i (igf-i), oxytocin (ot), and prostaglandin f (pgf) and e2 (pge) were evaluated by quantitative immunocytochemistry and ria/irma. |
2019-12-23 |
2023-08-13 |
human |
| Alexander V Sirotkin, Andrej Benco, Milos Mlyncek, Jan Kotwica, Saleh Alwasel, Abdel Halim Harrat. Transcription factor p53 regulates healthy human ovarian cells function. Comptes rendus biologies. vol 342. issue 5-6. 2019-12-23. PMID:31495738. |
these observations are the first demonstration of the involvement of p53 in the control of healthy human ovarian cell functions, namely, in the downregulation of proliferation, in the upregulation of apoptosis, and in the alteration of pgf and pge release, but not of p4, igf-i, or ot. |
2019-12-23 |
2023-08-13 |
human |
| Boris Sabirzhanov, Alan I Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A Stoic. MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29774773. |
ang-1 treatment inhibits etoposide-induced upregulation of proapoptotic b-cell lymphoma 2 (bcl-2) family members noxa, p53 upregulated modulator of apoptosis (puma), bcl-2 interacting mediator of cell death (bim), and bcl-2-associated x protein (bax); reduces markers of caspase-dependent (cytochrome c release/caspase activation) and caspase-independent (apoptosis-inducing factor release) pathways; and limits neuronal cell death. |
2019-12-20 |
2023-08-13 |
mouse |
| Tamilselvam Rajavel, Gunasekeran Banu Priya, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Kasi Pandima Dev. Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism. European journal of pharmacology. vol 855. 2019-12-20. PMID:31059712. |
daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in a549 cells via targeting thioredoxin reductase by a p53 dependent mechanism. |
2019-12-20 |
2023-08-13 |
human |
| Sigrid Uxa, Stephan H Bernhart, Christina F S Mages, Martin Fischer, Robin Kohler, Steve Hoffmann, Peter F Stadler, Kurt Engeland, Gerd A Mülle. DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation. Nucleic acids research. vol 47. issue 17. 2019-12-20. PMID:31400114. |
the tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for arresting the cell cycle to facilitate dna repair or to initiate apoptosis. |
2019-12-20 |
2023-08-13 |
human |
| Minh Quan Pham, Thi Hoai Van Tran, Quoc Long Pham, Jean Edouard Gairi. In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells. Fundamental & clinical pharmacology. vol 33. issue 4. 2019-12-19. PMID:30628118. |
solasonine-induced apoptosis and cell death of hcc cell lines either expressing p53 (hepg2) or not (hep3b), indicating that apoptotic activities of solasonine can be mediated not only through p53-dependent but also p53-independent pathways. |
2019-12-19 |
2023-08-13 |
human |
| Hajar Sirous, Giulia Chemi, Giuseppe Campiani, Simone Brog. An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction. Computational biology and chemistry. vol 83. 2019-12-19. PMID:31473433. |
the p53 protein, also called guardian of the genome, plays a critical role in the cell cycle regulation and apoptosis. |
2019-12-19 |
2023-08-13 |
mouse |
| Hossein Fallahi, Rasoul Godin. System-level responses to cisplatin in pro-apoptotic stages of breast cancer MCF-7 cell line. Computational biology and chemistry. vol 83. 2019-12-19. PMID:31706153. |
it is well established that cisplatin alters the expression of many genes involved in several cellular processes and pathways including transcription, p53 signaling pathway, and apoptosis. |
2019-12-19 |
2023-08-13 |
Not clear |
| Dan Wang, Rui Zhao, Yuan-Yuan Qu, Xin-Yu Mei, Xuan Zhang, Qian Zhou, Yang Li, Shao-Bo Yang, Zhi-Gui Zuo, Yi-Ming Chen, Yan Lin, Wei Xu, Chao Chen, Shi-Min Zhao, Jian-Yuan Zha. Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. Cell reports. vol 25. issue 2. 2019-12-18. PMID:30304680. |
mechanistically, mars preferentially bound to and modified ataxia-telangiectasia and rad3-related protein (atr), inhibited atr and its downstream effectors checkpoint kinase-1 and p53, and relieved cell-cycle arrest and decreased dna damage-induced apoptosis by disrupting the binding of atr-interacting protein to atr. |
2019-12-18 |
2023-08-13 |
mouse |
| Dilip Shah, Pragnya Das, Mohammad Afaque Alam, Nidhi Mahajan, Freddy Romero, Mohd Shahid, Harpreet Singh, Vineet Bhandar. MicroRNA-34a Promotes Endothelial Dysfunction and Mitochondrial-mediated Apoptosis in Murine Models of Acute Lung Injury. American journal of respiratory cell and molecular biology. vol 60. issue 4. 2019-12-18. PMID:30512967. |
mechanistically, we show that mir-34a leads to translocation of p53 and bax to the mitochondrial compartment with disruption of mitochondrial membrane potential to release cytochrome c into the cytosol, initiating a cascade of mitochondrial-mediated apoptosis in lungs. |
2019-12-18 |
2023-08-13 |
mouse |
| Elham Assareh, Faramarz Mehrnejad, Kamran Mansouri, Ahmad Reza Esmaeili Rastaghi, Hossein Naderi-Manesh, S Mohsen Asghar. A cyclic peptide reproducing the α1 helix of VEGF-B binds to VEGFR-1 and VEGFR-2 and inhibits angiogenesis and tumor growth. The Biochemical journal. vol 476. issue 4. 2019-12-18. PMID:30700502. |
in a murine 4t1 mammary carcinoma model, vgb1 caused regression of tumors without causing weight loss in association with impaired cell proliferation (decreased ki67 expression) and angiogenesis (decreased cd31 and cd34 expression), and apoptosis induction (increased tunel staining and p53 expression, and decreased bcl-2 expression). |
2019-12-18 |
2023-08-13 |
human |