| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Wang, Hongjing Zhao, Xin Yang, Mengyao Mu, Hui Zong, Liyang Luo, Mingwei Xin. Excessive Cu Chemosphere. vol 239. 2020-01-14. PMID:31514009. |
consequently, nuclear damage and organelle lesions, especially mitochondria were observed under cu or/and as stress, in which positive regulation of key proteins, dynamin-related protein 1 (drp1), cytochrome c (cyt c), bcl2-associated x (bax), caspases 3 and p53 was detected by qrcr and western blot analyses, indicating disturbed mitochondrial dynamic equilibrium and apoptosis execution. |
2020-01-14 |
2023-08-13 |
Not clear |
| Wei Cui, Jinhua Dai, Jianbo Ma, Hao G. circCDYL/microRNA-105-5p participates in modulating growth and migration of colon cancer cells. General physiology and biophysics. vol 38. issue 6. 2020-01-14. PMID:31829306. |
in circcdyl-transfected sw480 and sw620 cells, circcdyl decreased viability and promoted apoptosis with down-regulation of c-myc and cyclin d1, up-regulation of p53, and cleavage of caspase-3 and parp. |
2020-01-14 |
2023-08-13 |
Not clear |
| Xuemei Yang, Qian Zhang, Xiaofeng Yang, Minyi Zhao, Ting Yang, Anmei Yao, Xiaofei Tia. PACT cessation overcomes ovarian cancer cell chemoresistance to cisplatin by enhancing p53-mediated apoptotic pathway. Biochemical and biophysical research communications. vol 511. issue 4. 2020-01-13. PMID:30827507. |
intriguingly, blocking the p53 pathway notably reversed pact inhibition-increased cell sensitivity to cisplatin in a2780 cells by elevating cell viability and depressing cell apoptosis. |
2020-01-13 |
2023-08-13 |
Not clear |
| Sungmin Kwak, Seung-Hyun Lee, Eun-Jung Han, Soo-Yeon Park, Mi-Hyeon Jeong, Jaesung Seo, Seung-Ho Park, Gi-Jun Sung, Jung-Yoon Yoo, Ho-Geun Yoon, Kyung-Chul Cho. Serine/threonine kinase 31 promotes PDCD5-mediated apoptosis in p53-dependent human colon cancer cells. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30144069. |
importantly, stk31 activated the p53 signaling pathway by genotoxic stress through positive regulation of pdcd5-mediated apoptosis. |
2020-01-09 |
2023-08-13 |
human |
| Lili Zhuang, Hongmei Qu, Jianxiang Cong, Huangguan Dai, Xiaoyan Li. MiR-181c affects estrogen-dependent endometrial carcinoma cell growth by targeting PTEN. Endocrine journal. vol 66. issue 6. 2020-01-09. PMID:30971627. |
besides, overexpression of pten markedly promoted the apoptosis of e2-induced rl95-2 cells through regulating the bax and bcl-2 expression, and modulated the expression of akt pathway, p53 and cyclin d. in conclusion, our findings revealed that mir-181c affected the estrogen-dependent endometrial carcinoma cell growth by targeting pten. |
2020-01-09 |
2023-08-13 |
human |
| Naoko Hashimoto, Hidekazu Nagano, Tomoaki Tanak. The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases. Endocrine journal. vol 66. issue 6. 2020-01-09. PMID:31105124. |
when the cells receives stimuli such as dna damage, oncogene activation, oxidative stress or undernutrition, p53 gives rise to a number of cellular responses, including cell cycle arrest, apoptosis, cellular senescence and metabolic adaptation. |
2020-01-09 |
2023-08-13 |
human |
| Yong Hee Lee, Ji Yeon Son, Kyeong Seok Kim, Yoo Jung Park, Hae Ri Kim, Jae Hyeon Park, Kyu-Bong Kim, Kwang Youl Lee, Keon Wook Kang, In Su Kim, Sam Kacew, Byung Mu Lee, Hyung Sik Ki. Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats. International journal of molecular sciences. vol 20. issue 15. 2020-01-09. PMID:31362375. |
apoptosis significantly increased in taa-treated ovx rats, as reflected by elevated p53, bcl-2, and cleaved caspase 3 levels. |
2020-01-09 |
2023-08-13 |
rat |
| Florian Nietzold, Stefan Rubner, Thorsten Ber. The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a. Chemical communications (Cambridge, England). vol 55. issue 95. 2020-01-09. PMID:31720601. |
nutlin-3a-ht, created by fusing the hydrophobic tag hyt13 to the mdm2-p53 interaction inhibitor nutlin-3a, prevented cellular accumulation of mdm2 upon p53 reactivation, and had a stronger effect on cell viability and the induction of apoptosis than nutlin-3a. |
2020-01-09 |
2023-08-13 |
Not clear |
| Carlos Flores, Raquel T Lima, Alessandra Adessi, Aureliana Sousa, Sara B Pereira, Pedro L Granja, Roberto De Philippis, Paula Soares, Paula Tamagnin. Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant. International journal of biological macromolecules. vol 136. 2020-01-08. PMID:31233798. |
we demonstrated that the Δsigf polymer has strong biological activity, decreasing the viability of melanoma, thyroid and ovary carcinoma cells by inducing high levels of apoptosis, through p53 and caspase-3 activation. |
2020-01-08 |
2023-08-13 |
Not clear |
| Zeinab Tavakkol Afshari, Zahra Gholizadeh, Amin Reza Nikpoor, Jalil Tavakkol Afshari, Rashin Ganjali, Fatemeh Homaei Shandiz, Khadijeh Jamialahmad. A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population. Iranian journal of public health. vol 48. issue 10. 2020-01-08. PMID:31850263. |
ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. |
2020-01-08 |
2023-08-13 |
Not clear |
| Jingjin Liu, Yongshun Wang, Jinjin Cui, Meng Sun, Zhongyue Pu, Chao Wang, Wenjuan Du, Xinxin Liu, Jian Wu, Jingbo Hou, Shuo Zhang, Bo Y. Correction to: miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop. Stem cell research & therapy. vol 10. issue 1. 2020-01-08. PMID:31862017. |
correction to: mir199a-3p regulates p53 by targeting cables1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop. |
2020-01-08 |
2023-08-13 |
mouse |
| Ali A Shat. Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Systems biology in reproductive medicine. vol 65. issue 3. 2020-01-06. PMID:30507263. |
in addition, activation of er stress, p53, erk1/2, jnk, and akt and markers of apoptosis were evaluated in rats' testis. |
2020-01-06 |
2023-08-13 |
rat |
| Ali A Shat. Resveratrol improves sperm parameter and testicular apoptosis in cisplatin-treated rats: Effects on ERK1/2, JNK, and Akt pathways. Systems biology in reproductive medicine. vol 65. issue 3. 2020-01-06. PMID:30507263. |
in conclusion, res protects against cis-induced testicular damage and reproductive dysfunction via improving testosterone levels, increasing sperm count, reducing testicular apoptosis via an antioxidant potential, inhibition of er stress, p53, erk1/2, jnk, and activation of akt. |
2020-01-06 |
2023-08-13 |
rat |
| Ling Zhu, Qunli Wang, Yi Hu, Fan Wan. The Circadian Gene Per1 Plays an Important Role in Radiation-Induced Apoptosis and DNA Damage in Glioma. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 7. 2020-01-06. PMID:31350984. |
rt-pcr and western blot analysis bothrevealed decreased expression of chk2 and p53, which regulate dna damage and repair via the chk2-p53 pathway,and decreased expression of c-myc, which is related to cell apoptosis. |
2020-01-06 |
2023-08-13 |
human |
| Kwang-Ha Park, Jeong-Hae Choi, Yeon-Suk Song, Gyoo-Cheon Kim, Jin-Woo Hon. Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53. BMC complementary and alternative medicine. vol 19. issue 1. 2020-01-06. PMID:31462222. |
ethanol extract of asiasari radix preferentially induces apoptosis in g361 human melanoma cells by differential regulation of p53. |
2020-01-06 |
2023-08-13 |
human |
| Qiaojian Zhang, Shufang Zheng, Shengchen Wang, Wei Wang, Houjuan Xing, Shiwen X. Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp. Fish & shellfish immunology. vol 93. 2020-01-03. PMID:31310849. |
furthermore, the detection of apoptosis and autophagy relative genes showed that the expressions of tsc complex subunit 2 (tsc2), light chain 3 (lc3), dynein, tumor protein 53 (p53), bcl-2 associated x protein (bax), caspase-3 and caspase-9 were enhanced and the expressions of nechanistic target of rapamycin (mtor), ras homolog mtorc1 binding (rheb) and b-cell lymphoma (bcl-2) were reduced in dose-dependent way. |
2020-01-03 |
2023-08-13 |
Not clear |
| Lihong Chai, Yijie Yang, Hongyu Yang, Yonghua Zhao, Hongyuan Wan. Transcriptome analysis of genes expressed in the earthworm Eisenia fetida in response to cadmium exposure. Chemosphere. vol 240. 2020-01-03. PMID:31563721. |
among these degs, six genes (metallothionein-2, phytochelatin synthase 1a, cuzn superoxide dismutase, sex determining region y-box 2, sex determining region y-box 4b, tp53-regulated inhibitor of apoptosis 1-like) up-regulated and 2 genes (beta-1,4-endoglucanase, apoptosis-stimulating of p53 protein 2-like) down-regulated in response to cd exposure. |
2020-01-03 |
2023-08-13 |
Not clear |
| S Gheena, D Ezhilarasa. Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells. Human & experimental toxicology. vol 38. issue 6. 2020-01-02. PMID:30924378. |
apoptotic markers such as caspases 3 and 9, cytochrome c, apaf-1, bax, and p53 gene expressions were significantly increased upon sa treatment indicating the possibility of apoptosis induction in hepg2 cells. |
2020-01-02 |
2023-08-13 |
human |
| Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzol. Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells. PloS one. vol 14. issue 4. 2020-01-02. PMID:30947287. |
our data demonstrate that the contribution of p53 in regulating trail-r-induced apoptosis does not correlate to the levels of trail-rs at the plasma membrane, but rather to p53-mediated upregulation of bax, favouring the mitochondrial amplification loop. |
2020-01-02 |
2023-08-13 |
Not clear |
| Anna Willms, Hella Schittek, Sascha Rahn, Justyna Sosna, Ufuk Mert, Dieter Adam, Anna Trauzol. Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells. PloS one. vol 14. issue 4. 2020-01-02. PMID:30947287. |
in conclusion, we found that wild-type p53 increases trail-r-mediated apoptosis but simultaneously augments non-apoptotic signaling. |
2020-01-02 |
2023-08-13 |
Not clear |