| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D Hickson, Andres J Lopez-Contrera. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell reports. vol 24. issue 12. 2019-12-09. PMID:30232008. |
however, despite the presence of chromosomal instability, extensive p53 activation, and increased apoptosis throughout the embryo, pich ko embryos survive until day 12.5 of embryonic development. |
2019-12-09 |
2023-08-13 |
mouse |
| Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D Hickson, Andres J Lopez-Contrera. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell reports. vol 24. issue 12. 2019-12-09. PMID:30232008. |
the absence of p53 failed to improve the viability of the pich ko embryos, suggesting that the observed developmental defects are not solely due to p53-induced apoptosis. |
2019-12-09 |
2023-08-13 |
mouse |
| Yanjie Wang, Junhua Zhang, Jian Li, Rong Gui, Xinmin Nie, Rong Huan. CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p. Bosnian journal of basic medical sciences. vol 19. issue 2. 2019-12-09. PMID:30640591. |
in conclusion，our findings demonstrated that circrna_014511 could inhibit the expression of p53 by binding mir-29b-2-5p, and decrease the radiosensitivity of bone marrow mesenchymal stem cells by affecting cell cycle and cell apoptosis. |
2019-12-09 |
2023-08-13 |
Not clear |
| Sara Gomes, Liliana Raimundo, Joana Soares, Joana B Loureiro, Mariana Leão, Helena Ramos, Madalena N Monteiro, Agostinho Lemos, Joana Moreira, Madalena Pinto, Petr Chlapek, Renata Veselska, Emília Sousa, Lucília Saraiv. New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma. Cancer letters. vol 446. 2019-12-09. PMID:30664963. |
notably, lem2 was able to release tap73 from its interaction with both mdm2 and mutant p53, enhancing tap73 transcriptional activity, cell cycle arrest, and apoptosis in p53-null and mutant p53-expressing tumor cells. |
2019-12-09 |
2023-08-13 |
Not clear |
| Wanglai Hu, Song Chen, Rick F Thorne, Mian W. TP53, TP53 Target Genes (DRAM, TIGAR), and Autophagy. Advances in experimental medicine and biology. vol 1206. 2019-12-06. PMID:31776983. |
induction and stabilization of p53 during dna damage and oncogene activation function to induce cell cycle arrest, apoptosis, or senescence. |
2019-12-06 |
2023-08-13 |
Not clear |
| Bolin Cai, Manting Ma, Biao Chen, Zhenhui Li, Bahareldin Ali Abdalla, Qinghua Nie, Xiquan Zhan. MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cell death & disease. vol 9. issue 3. 2019-12-03. PMID:29511169. |
mir-16-5p targets sesn1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. |
2019-12-03 |
2023-08-13 |
chicken |
| Bolin Cai, Manting Ma, Biao Chen, Zhenhui Li, Bahareldin Ali Abdalla, Qinghua Nie, Xiquan Zhan. MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cell death & disease. vol 9. issue 3. 2019-12-03. PMID:29511169. |
interestingly, we found sesn1 could regulate p53 by a feedback mechanism, thereby participating in the regulation of p53 signaling pathway, which suggests that this feedback is indispensable for myoblast proliferation and apoptosis. |
2019-12-03 |
2023-08-13 |
chicken |
| Bolin Cai, Manting Ma, Biao Chen, Zhenhui Li, Bahareldin Ali Abdalla, Qinghua Nie, Xiquan Zhan. MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation. Cell death & disease. vol 9. issue 3. 2019-12-03. PMID:29511169. |
altogether, these data demonstrated that mir-16-5p directly targets sesn1 to regulate the p53 signaling pathway, and therefore affecting myoblast proliferation and apoptosis. |
2019-12-03 |
2023-08-13 |
chicken |
| Omid Tavana, Hongbin Sun, Wei G. Targeting HAUSP in both p53 wildtype and p53-mutant tumors. Cell cycle (Georgetown, Tex.). vol 17. issue 7. 2019-12-02. PMID:29616860. |
here, we show that inhibitors of hausp and nutlin-3 can synergistically activate p53 function and induce p53-dependent apoptosis in human cancer cells. |
2019-12-02 |
2023-08-13 |
human |
| AmirReza Hesari, Faezeh Ghasemi, Arrigo F G Cicero, Mohammad Mohajeri, Omid Rezaei, Seyed Mohammad Gheibi Hayat, Amirhossein Sahebka. Berberine: A potential adjunct for the treatment of gastrointestinal cancers? Journal of cellular biochemistry. vol 119. issue 12. 2019-12-02. PMID:30125974. |
several mechanisms of action have been hypothesized and demonstrated: immunomodulation, inhibition of topoisomerase enzymes, suppression of the egf receptor, her2/neu, and the vegf receptor, induction of p53, cip1/p21, kip1/p27, rb expression, induction of apoptosis (by regulation of mmps pathway, caspases, bax, and smac/diablo), inhibition of arylamin n-acetyltransferase activity, and regulation of micrornas expression. |
2019-12-02 |
2023-08-13 |
human |
| Liqiang Zhong, Sihao Yang, Yuming Jia, Kaijian Le. Inhibition of cyclin-dependent kinase 7 suppresses human hepatocellular carcinoma by inducing apoptosis. Journal of cellular biochemistry. vol 119. issue 12. 2019-12-02. PMID:30145799. |
thz1 exhibited anti-hcc effects through irreversibly inhibiting cdk7 activity, decreasing rnapii-ctd phosphorylation, inducing p53 expression and inhibiting antiapoptotic gene expressions, which subsequently induced apoptosis and inhibited proliferation of hcc cells. |
2019-12-02 |
2023-08-13 |
mouse |
| Dongwon Hwang, Minsun Kim, Hyejin Park, Myung In Jeong, Woojin Jung, Bonglee Ki. Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action. Nutrients. vol 11. issue 5. 2019-12-02. PMID:31058874. |
some compounds induced apoptosis by regulating unique mechanism like human telomerase reverse transcriptase (htert) or laminin receptor (67lr), while others modified caspases, poly (adp-ribose) polymerase (parp) and p53. |
2019-12-02 |
2023-08-13 |
human |
| Yantao Zhao, Lei Shi, Changling Hu, Shengmin San. Wheat Bran for Colon Cancer Prevention: The Synergy between Phytochemical Alkylresorcinol C21 and Intestinal Microbial Metabolite Butyrate. Journal of agricultural and food chemistry. vol 67. issue 46. 2019-12-02. PMID:31675233. |
further mechanistic studies demonstrated that the cotreatment of c21 and butyrate induced significant up-regulations in cleaved poly(adp-ribose) polymerase (parp), cleaved caspase 3, p53 upregulated modulator of apoptosis (puma), cytochrome c, lipid-conjugated membrane-bound form of microtubule-associated protein 1 |
2019-12-02 |
2023-08-13 |
human |
| Suguru Kurokawa, Akiko Okuda, Yuki Nishizawa, Kyoko Furukawa, Ayumi Sumihiro, Yuki Nakaji, Seigo Tanaka, Masanori Takehash. Suppression of cell cycle progression by poly(ADP-ribose) polymerase inhibitor PJ34 in neural stem/progenitor cells. Biochemical and biophysical research communications. vol 510. issue 1. 2019-11-29. PMID:30665718. |
inhibition of parp induces the expression of several genes in the p53 signaling pathway, including p21, which is critical for cell cycle control at the g1/s phase, triggers apoptosis, and suppresses cell cycle progression in nspcs. |
2019-11-29 |
2023-08-13 |
mouse |
| Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin H. p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31059007. |
exogenous p57kip2 overexpression significantly decreased the expression of pro‑apoptosis proteins, including p53, bax and cleaved caspase3, under hypoxic conditions for 24 h. in addition, knockdown of p57kip2 increased the response to apoptosis following hypoxia for 24 h. the present study revealed that overexpression of p57kip2 decreased the levels of phosphorylated‑jnk. |
2019-11-27 |
2023-08-13 |
human |
| Sarah K Beaver, Noel Mesa-Torres, Angel L Pey, David J Timso. NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms. Biochimica et biophysica acta. Proteins and proteomics. vol 1867. issue 7-8. 2019-11-27. PMID:31091472. |
nad(p)h quinone oxidoreductase 1 (nqo1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. |
2019-11-27 |
2023-08-13 |
Not clear |
| Hairui Yang, Xu Bai, Henan Zhang, Jingsong Zhang, Yingying Wu, Chuanhong Tang, Yanfang Liu, Yan Yang, Zhendong Liu, Wei Jia, Wenhan Wan. Antrodin C, an NADPH Dependent Metabolism, Encourages Crosstalk between Autophagy and Apoptosis in Lung Carcinoma Cells by Use of an AMPK Inhibition-Independent Blockade of the Akt/mTOR Pathway. Molecules (Basel, Switzerland). vol 24. issue 5. 2019-11-26. PMID:30870998. |
findings showed that adc potently inhibited the viability of spca-1, induced apoptosis triggered by ros, and arrested the cell cycle at the g2/m phase via a p53 signaling pathway. |
2019-11-26 |
2023-08-13 |
human |
| Elham Zendedel, Alexandra E Butler, Stephen L Atkin, Amirhossein Sahebka. Impact of curcumin on sirtuins: A review. Journal of cellular biochemistry. vol 119. issue 12. 2019-11-25. PMID:30145851. |
these protective effects of sirt1 activation are partly mediated by the deacetylation of p53 and reduction of apoptosis. |
2019-11-25 |
2023-08-13 |
Not clear |
| Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamin. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PloS one. vol 14. issue 2. 2019-11-25. PMID:30807606. |
the protein p53 is involved in cell cycle coordination, dna repair, apoptosis, and cellular senescence, but its role in pulmonary hypertension (ph) is not fully known. |
2019-11-25 |
2023-08-13 |
mouse |
| Xianfang Rong, Jun Rao, Dan Li, Qinghe Jing, Yi Lu, Yinghong J. TRIM69 inhibits cataractogenesis by negatively regulating p53. Redox biology. vol 22. 2019-11-25. PMID:30844644. |
the effects of trim69 overexpression in uvb-induced cell apoptosis and ros production was clearly weakened by p53 overexpression, thus suggesting a role for p53 in trim69 functions. |
2019-11-25 |
2023-08-13 |
human |