| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T W. McGarvey, R D. Meng, O Johnson, W El-Deiry, S B. Malkowic. Growth inhibitory effect of p21 and p53 containing adenoviruses on transitional cell carcinoma cell lines in vitro and in vivo. Urologic oncology. vol 6. issue 4. 2019-11-20. PMID:11418322. |
the objective of this investigation was to examine the effect of the introduction of a p53 or p21((waf1/cip1)) adenovirus on the proliferation and apoptosis of various human tcc cell lines in vitro and in vivo. |
2019-11-20 |
2023-08-12 |
mouse |
| U. Kellner, P. Rudolph, R. Parwaresc. Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer. Onkologie. vol 23. issue 5. 2019-11-20. PMID:11441236. |
such topo-mediated dna strand breaks likely induce repair or apoptosis mechanisms via p53 and/or p21(waf1/clip1). |
2019-11-20 |
2023-08-12 |
human |
| Ann Bode, Zigang Don. Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 3. issue 1. 2019-11-20. PMID:11498362. |
arsenic may be effective in counteracting drug resistance because it appears to induce apoptosis in tumor cells independently of p53 activation, thereby allowing it to be directed against p53-defective cancers. |
2019-11-20 |
2023-08-12 |
Not clear |
| David E. Fishe. Turning p53 on or off: either way may treat cancer. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 3. issue 2. 2019-11-20. PMID:11498370. |
the other utilizes a peptide derived from the c-terminus of p53 to activate wild-type or mutant p53 proteins, triggering apoptosis with selectivity for transformed cells. |
2019-11-20 |
2023-08-12 |
human |
| E. S. Hwang, J. Kim, J. S. Kim, C. Kao, S-C. Ko, L. Chung, J-H. Le. The effects of the adenovirus-mediated wild-type p53 delivery in human epithelial ovarian cancer cell line in vitro and in vivo. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 8. issue 1. 2019-11-20. PMID:11576284. |
cell lines skov3, 2774, and ovcar3, which bear mutations in the endogenous p53 gene, were all affected by avp53 treatment, undergoing growth suppression and apoptosis at a dose that had little effect on the growth of normal fibroblasts. |
2019-11-20 |
2023-08-12 |
mouse |
| Li-Dong Wang, Qi Zhou, Jun-Ping Wei, Wan-Cai Yang, Xin Zhao, Li-Xia Wang, Jian-Xiang Zou, Shan-Shan Gao, Yong-Xin Li, CS Yan. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World journal of gastroenterology. vol 4. issue 4. 2019-11-20. PMID:11819301. |
apoptosis and its relationship with cell proliferation, p53, waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern china. |
2019-11-20 |
2023-08-12 |
human |
| Li-Dong Wang, Qi Zhou, Jun-Ping Wei, Wan-Cai Yang, Xin Zhao, Li-Xia Wang, Jian-Xiang Zou, Shan-Shan Gao, Yong-Xin Li, CS Yan. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World journal of gastroenterology. vol 4. issue 4. 2019-11-20. PMID:11819301. |
aim:to determine the extent of apoptosis and its possible relationship with the changes of p53, waflp21, bcl-2, and c-myc at different stages of esophageal carcinogenesis.methods:two hundred and forty-one esophageal biopsy samples from symptom-free subjects and 38 surgically resected esophageal carcinoma tissues from a high-risk population for esophageal cancer in henan, china were used in this study.apoptotic cells and apoptotic bodies were identified by well-established morphological criteria. |
2019-11-20 |
2023-08-12 |
human |
| Li-Dong Wang, Qi Zhou, Jun-Ping Wei, Wan-Cai Yang, Xin Zhao, Li-Xia Wang, Jian-Xiang Zou, Shan-Shan Gao, Yong-Xin Li, CS Yan. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World journal of gastroenterology. vol 4. issue 4. 2019-11-20. PMID:11819301. |
the extent of apoptosis and its possible relationship with the rate of cell proliferation (pcna) and changes of p53, waf1p21, bcl-2,and c-myc were analyzed in samples with esophageal precancerous and cancerous lesions.results:the apoptotic cells, identified morphologically, were located in the same proliferative compartment of hyperproliferative cell population in the esophageal epithelia as the cells immunostaining-positive for p53, bcl-2, c-myc and pcna.the apoptotic indices (total number of apoptotic cells and apoptotic bodies per mm(2) of the tissue section) were low in the normal epithelia,and increased significantly as the lesions progressed from bch to dys and to scc.the extent of apoptosis correlated well with the cell proliferation indices based on pcna. |
2019-11-20 |
2023-08-12 |
human |
| Li-Dong Wang, Qi Zhou, Jun-Ping Wei, Wan-Cai Yang, Xin Zhao, Li-Xia Wang, Jian-Xiang Zou, Shan-Shan Gao, Yong-Xin Li, CS Yan. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World journal of gastroenterology. vol 4. issue 4. 2019-11-20. PMID:11819301. |
the apoptotic cells were located in the same hyperproliferative cell compartment as cells immunostaining-positive for p53, bcl-2,c-myc and pcna,but no apparent correlation between apoptosis and these parameters was observed,possibly due to the complexities of molecular changes in esophageal carcinogenesis. |
2019-11-20 |
2023-08-12 |
human |
| Hyun Na Koo, Hyun Ja Jeong, Seung Heon Hong, Jin Ho Choi, Nyeon Hyoung An, Hyung Min Ki. High molecular weight water-soluble chitosan protects against apoptosis induced by serum starvation in human astrocytes. The Journal of nutritional biochemistry. vol 13. issue 4. 2019-11-20. PMID:11988407. |
these results suggest that wsc may prevent serum starvation-induced apoptosis of ccf-sttg1 cells via p53 inactivation. |
2019-11-20 |
2023-08-12 |
human |
| Liya Gu, Jianxin Wu, Lu Qiu, C Darrell Jennings, Guo Min L. Involvement of DNA mismatch repair in folate deficiency-induced apoptosis small star, filled. The Journal of nutritional biochemistry. vol 13. issue 6. 2019-11-20. PMID:12088801. |
our data also indicate that p53 is required for the folate depletion-induced apoptosis. |
2019-11-20 |
2023-08-12 |
human |
| Wenliang Wang, Henry Johansson, Ulla Bergholm, Erik Wilander, Lars Grimeliu. Apoptosis and Expression of the Proto-Oncogenes bcl-2 and p53 and the Proliferation Factor Ki-67 in Human Medullary Thyroid Carcinoma. Endocrine pathology. vol 7. issue 1. 2019-11-20. PMID:12114678. |
apoptosis and expression of the proto-oncogenes bcl-2 and p53 and the proliferation factor ki-67 in human medullary thyroid carcinoma. |
2019-11-20 |
2023-08-12 |
human |
| Wenliang Wang, Henry Johansson, Ulla Bergholm, Erik Wilander, Lars Grimeliu. Apoptosis and Expression of the Proto-Oncogenes bcl-2 and p53 and the Proliferation Factor Ki-67 in Human Medullary Thyroid Carcinoma. Endocrine pathology. vol 7. issue 1. 2019-11-20. PMID:12114678. |
apoptosis and immunoreactivity for bcl-2, p53, and ki-67 were studied in 21 patients with meduilary thyroid carcinoma (mtc). |
2019-11-20 |
2023-08-12 |
human |
| Wenliang Wang, Henry Johansson, Ulla Bergholm, Erik Wilander, Lars Grimeliu. Apoptosis and Expression of the Proto-Oncogenes bcl-2 and p53 and the Proliferation Factor Ki-67 in Human Medullary Thyroid Carcinoma. Endocrine pathology. vol 7. issue 1. 2019-11-20. PMID:12114678. |
bcl-2 was significantly (p = 0.014) associated with apoptosis even after taking both p53 and ki-67 into consideration, but these two factors were unrelated to apoptosis. |
2019-11-20 |
2023-08-12 |
human |
| Rus Zhou, Shi-Zhou A. A Novel cDNA Encoding Ubiquitin-conjugating Enzyme of Homo sapiens. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 30. issue 2. 2019-11-20. PMID:12174272. |
p53 interacts with a number of cellular proteins to form complexes which are probably crucial for its normal physiological function involving cell cycle control, gene regulation, cell differentiation, apoptosis and tumor suppression. |
2019-11-20 |
2023-08-12 |
human |
| M. Agostini, B. Di Marco, G. Nocentini, D. V. Delfin. Oxidative stress and apoptosis in immune diseases. International journal of immunopathology and pharmacology. vol 15. issue 3. 2019-11-20. PMID:12575915. |
the latter has been shown to elicit the activation of poly-adp-ribose transferase and the accumulation of p53, thus determining apoptosis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Min Liang, Yuan-Zhong Chen, Yong Wu, Xu-Wei Yang, Lian-Huang L. [Effects of Exogenous Wild-Type p53 Gene on K562 Cells] Zhongguo shi yan xue ye xue za zhi. vol 9. issue 2. 2019-11-20. PMID:12578616. |
it was indicated that exogenous of wt-p53 was capable of inhibiting the proliferation of k562 cells and inducing apoptosis of the cells at higher p53 level and interestingly, inducing the cells differentiation on erythroid lineage at lower p53 level. |
2019-11-20 |
2023-08-12 |
Not clear |
| Yi-Yun Yao, Guan-Lin Sun, Zong-Ru Guo, Wei-Li Wu, Yun Wang, Hui S. [New Retinoid SX-116 Induces Apoptosis of Acute Promyelocytic Leukemia Cell Line NB4] Zhongguo shi yan xue ye xue za zhi. vol 9. issue 1. 2019-11-20. PMID:12578641. |
the expression of apoptosis - related gene bcl-2 and p53 were examined. |
2019-11-20 |
2023-08-12 |
Not clear |
| Abdelali Haoudi, O John Semmes, James M Mason, Ronald E Canno. Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53. Journal of biomedicine & biotechnology. vol 2004. issue 4. 2019-11-20. PMID:15467158. |
retrotransposition-competent human line-1 induces apoptosis in cancer cells with intact p53. |
2019-11-20 |
2023-08-12 |
human |
| Abdelali Haoudi, O John Semmes, James M Mason, Ronald E Canno. Retrotransposition-Competent Human LINE-1 Induces Apoptosis in Cancer Cells With Intact p53. Journal of biomedicine & biotechnology. vol 2004. issue 4. 2019-11-20. PMID:15467158. |
in addition, we found that inactivation of p53 in cells, where l1 was undergoing retrotransposition, inhibited the induction of apoptosis. |
2019-11-20 |
2023-08-12 |
human |