| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerio Ciccone, Martina Monti, Enrico Monzani, Luigi Casella, Lucia Morbidell. The metal-nonoate Ni(SalPipNONO) inhibits Oncotarget. vol 9. issue 17. 2019-11-20. PMID:29568362. |
the antitumor activity was partly due to no-cgmp dependent pathway, contributing to reduced cell number and apoptosis, and partly to the salicylaldehyde moiety and reactive oxygen species (ros) activated erk1/2 signaling converging on p53 dependent caspase-3 cleavage. |
2019-11-20 |
2023-08-13 |
human |
| Hiroe Nakamura, Ayumi Taguchi, Kei Kawana, Satoshi Baba, Akira Kawata, Mitsuyo Yoshida, Asaha Fujimoto, Juri Ogishima, Masakazu Sato, Tomoko Inoue, Haruka Nishida, Hitomi Furuya, Aki Yamashita, Satoko Eguchi, Kensuke Tomio, Mayuyo Mori-Uchino, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fuji. Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL. Oncotarget. vol 9. issue 17. 2019-11-20. PMID:29568369. |
loss of p53 function due to human papillomavirus (hpv) infection induces resistance to apoptosis in cervical cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| Satoru Matsuda, Yukie Nakagawa, Yasuko Kitagishi, Atsuko Nakanishi, Toshiyuki Mura. Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation. Cells. vol 7. issue 5. 2019-11-20. PMID:29723979. |
phosphatase and tensin homologue deleted on chromosome 10/protein kinase b, pkb (pten/akt) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ros quenching. |
2019-11-20 |
2023-08-13 |
Not clear |
| Francesca Punzo, Iolanda Manzo, Chiara Tortora, Elvira Pota, Velia D' Angelo, Giulia Bellini, Alessandra Di Paola, Federica Verace, Fiorina Casale, Francesca Ross. Effects of CB2 and TRPV1 receptors' stimulation in pediatric acute T-lymphoblastic leukemia. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765535. |
we analyzed the effect on apoptosis and cell cycle progression by a cytofluorimetric assays and evaluated the expression level of several target genes (caspase 3, bax, bcl-2, akt, erk, pten, notch-1, cdk2, p53) involved in cell survival and apoptosis, by real-time pcr and western blotting. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiajie Shi, Linhua Pi, Shanlei Zhou, Xin Li, Fangyuan Min, Shan Wang, Zhenqi Liu, Jing W. Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:29892266. |
activation of sirtuin 1 attenuates high glucose-induced neuronal apoptosis by deacetylating p53. |
2019-11-20 |
2023-08-13 |
Not clear |
| Gyeong-Ji Kim, Hyeon-Ju Jo, Kwon-Jai Lee, Jeong Woo Choi, Jeung Hee A. Oleanolic acid induces p53-dependent apoptosis Oncotarget. vol 9. issue 41. 2019-11-20. PMID:29899865. |
this enhanced apoptosis was due to increases in p53, cytochrome c, bax, parp-1 and caspase-3 expression in du145, mcf-7 and u87 cell lines. |
2019-11-20 |
2023-08-13 |
human |
| Sony Pandey, Jennifer Bourn, Maria Cekanov. Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells. Oncotarget. vol 9. issue 47. 2019-11-20. PMID:29983877. |
in this study, we assessed the efficacy and mechanisms of anthracyclines-induced apoptosis and inhibition of cell viability in human bladder cancer cells expressing wild-type (wt) p53 (rt4 and sw780) and mutated (mt) p53 (um-uc-3, 5637, t-24, j82, and tccsup) protein. |
2019-11-20 |
2023-08-13 |
human |
| Zilong Li, Baoyu Chen, Wenhui Dong, Wenping Xu, Mingzi Song, Mingming Fang, Junli Guo, Yong X. Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells. Biochimica et biophysica acta. Gene regulatory mechanisms. 2019-11-20. PMID:30056131. |
a panel of well-documented pro-apoptotic genes, including p53 apoptosis effector related to pmp-22 (perp), are up-regulated and collectively mediate ros induced apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Franco Fortunato, Lawrence K Gate. Chronic Alcohol Consumption Attenuates Apoptosis by Down Regulation of P53 Expression in the Rat Pancreas. TheScientificWorldJournal. vol 1. 2019-11-20. PMID:30147539. |
chronic alcohol consumption attenuates apoptosis by down regulation of p53 expression in the rat pancreas. |
2019-11-20 |
2023-08-13 |
rat |
| Tong Dang, Cristina Modak, Xiemei Meng, Jinbao Wu, Reinier Narvaez, Jianyuan Cha. CCN1 induces apoptosis in esophageal adenocarcinoma through p53-dependent downregulation of survivin. Journal of cellular biochemistry. 2019-11-20. PMID:30318638. |
furthermore, we demonstrated that this downregulation was dependent on p53 phosphorylation at ser20, and ccn1 induced eac cell apoptosis through the activation of p53. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smar. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019-11-20. PMID:30698678. |
p53 is activated by dna damage and oncogenic stimuli to regulate senescence, apoptosis and cell cycle arrest which are essential to prevent cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smar. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019-11-20. PMID:30698678. |
here, we utilized uvb radiation, a potent inducer of dna damage, p53, apoptosis and skin cancer to investigate the mechanism of c/ebpβ in regulating p53-mediated apoptosis in keratinocytes and to test whether the deletion of c/ebpβ in epidermis can protect mice from uvb-induced skin cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smar. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019-11-20. PMID:30698678. |
numerous proapoptotic isgs were up-regulated including some known to enhance p53 apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smar. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019-11-20. PMID:30698678. |
our results indicate that p53 and ifn pathways function together in response to dna damage to result in the activation of extrinsic apoptosis pathways and caspase 8 cleavage. |
2019-11-20 |
2023-08-13 |
mouse |
| Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smar. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019-11-20. PMID:30698678. |
our results suggest c/ebpβ represses apoptosis through keratinocyte autonomous suppression of the type 1 ifn response and p53 to increase cell survival and susceptibility to uvb-induced skin cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Kamia Tanwar, Uttam Pat. Inhibition of apoptosis via CHIP-mediated proteasomal degradation of TAp73α. Journal of cellular biochemistry. 2019-11-20. PMID:30714204. |
tap73, a homologous of tumor suppressor p53, regulates apoptosis in a p53-independent manner and its suppressive as well as stimulatory role in promoting angiogenesis has been reported. |
2019-11-20 |
2023-08-13 |
Not clear |
| Neetu Kalra, Kavita Seth, Sahdeo Prasad, Madhulika Singh, Aditya B Pant, Yogeshwer Shukl. Retraction notice to "Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways" [Life Sci. 18/23 (2007) 2137-2146]. Life sciences. vol 219. 2019-11-20. PMID:30744908. |
retraction notice to "theaflavins induced apoptosis of lncap cells is mediated through induction of p53, down-regulation of nf-kappa b and mitogen-activated protein kinases pathways" [life sci. |
2019-11-20 |
2023-08-13 |
Not clear |
| Correction to: LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity. Circulation. vol 139. issue 17. 2019-11-20. PMID:31013140. |
correction to: lincrna-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Phong Lu, Erica R Vander Mause, Katherine E Redd Bowman, Sarah M Brown, Lisa Ahne, Carol S Li. Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53. Journal of ovarian research. vol 12. issue 1. 2019-11-20. PMID:31092272. |
we have previously shown that fusing p53 (or its dna binding domain, dbd, alone) to the mitochondrial targeting signal (mts) from bak or bax can target p53 to the mitochondria and induce apoptosis in gynecological cancer cell lines including cervical cancer cells (hela; wt p53), ovarian cancer cells (skov-3; p53 267del non-expressing), and breast cancer cells (t47d; l194f p53 mutation). |
2019-11-20 |
2023-08-13 |
human |
| Angelica R Bonilla-Porras, Andrea Salazar-Ospina, Marlene Jimenez-Del-Rio, Andres Pereañez-Jimenez, Carlos Velez-Pard. Pro-apoptotic effect of Persea americana var. Hass (avocado) on Jurkat lymphoblastic leukemia cells. Pharmaceutical biology. 2019-11-20. PMID:24188375. |
results: endocarp, seed, whole seed, and leaf (0.1 mg/ml) extracts induced significant apoptosis in jurkat cells (p < 0.001) in an oxidative stress-dependent fashion via mitochondrial membrane depolarization (52-87%), activation of transcription factor p53 (6.3-25.4%), protease caspase-3 (8.3-20%) and predominance of aif reactivity (20.6-36%) in all extracts. |
2019-11-20 |
2023-08-12 |
Not clear |