| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vinod Vijay Subhash, Mei Shi Yeo, Lingzhi Wang, Shi Hui Tan, Foong Ying Wong, Win Lwin Thuya, Woei Loon Tan, Praveen C Peethala, Mu Yar Soe, David S P Tan, Nisha Padmanabhan, Erkan Baloglu, Sharon Shacham, Patrick Tan, H Phillip Koeffler, Wei Peng Yon. Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Scientific reports. vol 8. issue 1. 2019-10-30. PMID:30115935. |
xpo1 inhibition by selinexor resulted in nuclear accumulation of p53, causing cell cycle arrest and apoptosis. |
2019-10-30 |
2023-08-13 |
Not clear |
| Anahita Lashgari, Myriam Fauteux, Alexandre Maréchal, Luc Gaudrea. Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells. Scientific reports. vol 8. issue 1. 2019-10-30. PMID:30237520. |
we further demonstrate that the p53 transcriptional pathway is activated in brd8-depleted cells, and this accounts for upregulation of not only p21 but also of pro-apoptotic genes, leading to subsequent apoptosis. |
2019-10-30 |
2023-08-13 |
Not clear |
| Ewelina Perdas, Robert Stawski, Dariusz Nowak, Maria Zubrzyck. Potential of Liquid Biopsy in Papillary Thyroid Carcinoma in Context of miRNA, BRAF and p53 Mutation. Current drug targets. vol 19. issue 14. 2019-10-29. PMID:29484992. |
p53 has an important role in cell cycle control, dna repair and apoptosis. |
2019-10-29 |
2023-08-13 |
Not clear |
| Wangdong Jin, Li Zhou, Bo Yan, Li Yan, Fucun Liu, Peijian Tong, Wenhua Yu, Xiaoqiao Dong, Li Xie, Jin Zhang, Yiqiao Xu, Chunqi Li, Qiang Yuan, Letian Shan, Thomas Effert. Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway. Journal of cellular and molecular medicine. vol 22. issue 9. 2019-10-29. PMID:29993186. |
the cellular data confirmed that tb-triggered dna damage and induced apoptosis of u2os cells by regulation of mki67, parp, caspase 3 and h2ax, and western blot assay showed an activation of p53 signalling pathway. |
2019-10-29 |
2023-08-13 |
human |
| Maria Mrakovcic, Johannes Kleinheinz, Leopold F Fröhlic. p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death. International journal of molecular sciences. vol 20. issue 10. 2019-10-29. PMID:31096697. |
correspondingly, we also summarized as yet established intertwined mechanisms, in particular with respect to the oncogenic tumor suppressor protein p53, that drive the interplay between apoptosis and autophagy in response to hdaci. |
2019-10-29 |
2023-08-13 |
human |
| Anja Müller, Bernd Gillissen, Antje Richter, Anja Richter, Cindrilla Chumduri, Peter T Daniel, Christian W Schol. Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53. Cell death & disease. vol 9. issue 3. 2019-10-28. PMID:29515122. |
pan-class i pi3-kinase inhibitor bkm120 induces mek1/2-dependent mitotic catastrophe in non-hodgkin lymphoma leading to apoptosis or polyploidy determined by bax/bak and p53. |
2019-10-28 |
2023-08-13 |
Not clear |
| Lena Haffo, Jun Lu, Vladimir J N Bykov, Sebastin S Martin, Xiaoyuan Ren, Lucia Coppo, Klas G Wiman, Arne Holmgre. Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30140002. |
the tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. |
2019-10-28 |
2023-08-13 |
human |
| Kaneez Fatima, Shilu Mathew, Muhammed Faheem, Tahir Mehmood, Hadi Mohamad Yassine, Asmaa A Al Thani, Hany Abdel-Hafiz, Khalid Al Ghamdy, Ishtiaq Qadr. The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer. Current pharmaceutical design. vol 24. issue 24. 2019-10-28. PMID:30205794. |
the foxo3 is a tumor suppressor gene and found to interact with p53, the trigger for apoptosis through bcl2 family genes and a regulator of notch signaling pathway for the self-renewal of stem cells. |
2019-10-28 |
2023-08-13 |
Not clear |
| Yasmeen M Attia, Dina M El-Kersh, Hebatallah A Wagdy, Mohamed M Elmaza. Verbascoside: Identification, Quantification, and Potential Sensitization of Colorectal Cancer Cells to 5-FU by Targeting PI3K/AKT Pathway. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30446678. |
enhanced apoptosis mainly by affecting bax and bcl-2 and to a lesser extent bcl-xl and p53 was also observed. |
2019-10-28 |
2023-08-13 |
Not clear |
| Danyang Chao, Lijun Pang, Ying Shi, Wenjing Wang, Kai Li. AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-28. PMID:30598263. |
in this positive feedback loop, p53 induced the expression of smad4 by directly promoting its transcription as shown by p53 could bind to smad4 promoter; smad4, in turn, promoted the nuclear translocation of p53, which increased the transcription of pro-apoptotic genes, including puma and bax (two p53 target genes) and finally resulted in apoptosis. |
2019-10-28 |
2023-08-13 |
Not clear |
| Lucia Haronikova, Vanesa Olivares-Illana, Lixiao Wang, Konstantinos Karakostis, Sa Chen, Robin Fåhraeu. The p53 mRNA: an integral part of the cellular stress response. Nucleic acids research. vol 47. issue 7. 2019-10-28. PMID:30828720. |
a large number of signalling pathways converge on p53 to induce different cellular stress responses that aim to promote cell cycle arrest and repair or, if the damage is too severe, to induce irreversible senescence or apoptosis. |
2019-10-28 |
2023-08-13 |
Not clear |
| Mei-Ying Xie, Lian-Jie Hou, Jia-Jie Sun, Bin Zeng, Qian-Yun Xi, Jun-Yi Luo, Ting Chen, Yong-Liang Zhan. Porcine Milk Exosome MiRNAs Attenuate LPS-Induced Apoptosis through Inhibiting TLR4/NF-κB and p53 Pathways in Intestinal Epithelial Cells. Journal of agricultural and food chemistry. vol 67. issue 34. 2019-10-24. PMID:31429552. |
porcine milk exosome mirnas attenuate lps-induced apoptosis through inhibiting tlr4/nf-κb and p53 pathways in intestinal epithelial cells. |
2019-10-24 |
2023-08-13 |
Not clear |
| Weinan Guo, Jinyuan Ma, Tianli Pei, Tao Zhao, Sen Guo, Xiuli Yi, Yu Liu, Shiyu Wang, Guannan Zhu, Zhe Jian, Tianwen Gao, Chunying Li, Wenjun Liao, Qiong Sh. Up-regulated deubiquitinase USP4 plays an oncogenic role in melanoma. Journal of cellular and molecular medicine. vol 22. issue 5. 2019-10-23. PMID:29542252. |
we subsequently showed that usp4 regulated cisplatin-induced cell apoptosis via p53 signalling. |
2019-10-23 |
2023-08-13 |
Not clear |
| Naglaa Fathi Agamia, Osama Mohamed Hussein, Rania ElSaied Abdelmaksoud, Dina Mohamed Abdalla, Iman Mamdouh Talaat, Eiman Ibrahim Zaki, Amira El Tawdy, Bodo C Melni. Effect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris. Experimental dermatology. vol 27. issue 12. 2019-10-22. PMID:30240097. |
it has been hypothesized that upregulation of nuclear foxo transcription factors and p53 mediate isotretinoin-induced sebocyte apoptosis in vivo. |
2019-10-22 |
2023-08-13 |
human |
| Anju Karki, Juan Putra, Stephanie S Kim, Michael J Laquaglia, Antonio R Perez-Atayde, Ghazaleh Sadri-Vakili, Khashayar Vakil. MDM4 expression in fibrolamellar hepatocellular carcinoma. Oncology reports. vol 42. issue 4. 2019-10-22. PMID:31322272. |
one mechanism has been attributed to the overexpression of mouse double minute 4 protein (mdm4), a negative regulator of p53, which inhibits the normal functions of p53 including induction of apoptosis and dna repair. |
2019-10-22 |
2023-08-13 |
mouse |
| Erratum: 20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]. Drug design, development and therapy. vol 13. 2019-10-22. PMID:31631976. |
erratum: 20(s)-ginsenoside rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway [corrigendum]. |
2019-10-22 |
2023-08-13 |
Not clear |
| Surendra Kumar Nayak, Gopal L Khatik, Rakesh Narang, Vikramdeep Monga, Harish Kumar Chopr. p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents. Current cancer drug targets. vol 18. issue 8. 2019-10-21. PMID:28669344. |
most of the clinically used anticancer agents induce apoptosis through genotoxic stress at various stages of cell cycle and activation of p53. |
2019-10-21 |
2023-08-13 |
Not clear |
| Mahesh M Gouda, Yashodhar P Bhandar. Curcumin down-regulates IL-17A mediated p53-fibrinolytic system in bleomycin induced acute lung injury in vivo. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-21. PMID:29775223. |
there was also decreased expression of chemokines, p53, and fibrinolytic components such as pai-1 and increased upa, upar expression, and decreased alveolar epithelial cell apoptosis, which indicates the il-17a mediated novel inflammatory pathway. |
2019-10-21 |
2023-08-13 |
mouse |
| Ping Xu, Jia Yao, Jing Ji, Honglin Shi, Yan Jiao, ShaSha Hao, Dexi Chen, Hongbo Sh. Deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by CCl Toxicology letters. vol 316. 2019-10-21. PMID:31513885. |
deficiency of apoptosis-stimulating protein 2 of p53 protects mice from acute hepatic injury induced by ccl apoptosis-stimulating protein 2 of p53 (aspp2) has a variety of biological functions, and is involved in cellular apoptosis, autophagy and inflammatory reaction. |
2019-10-21 |
2023-08-13 |
mouse |
| Jung Hyun Park, Hyeong Jun Ku, Jae Kyeom Kim, Jeen-Woo Park, Jin Hyup Le. Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:29930336. |
furthermore, naringin counteracted fructose-induced cardiomyocyte apoptosis, and this function of naringin was linked to its ability to inhibit ros-dependent atm-mediated p53 signaling. |
2019-10-16 |
2023-08-13 |
mouse |