| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yibiao Chen, Xiaoye Hu, Yunong Li, Hongwei Zhang, Ruoqiu Fu, Yanxia Liu, Jinjiao Hu, Qin Deng, Qingsong Luo, Dunke Zhang, Ning Gao, Hongjuan Cu. Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30349053. |
mechanistic study revealed that knockdown of ars2 reduced the expression levels of mir-6798-3p, which was responsible for the up-regulation of p53 and p21, leading to apoptosis. |
2019-10-16 |
2023-08-13 |
mouse |
| Chiachen Chen, Mary Beth Breslin, Jessie J Guidry, Michael S La. 5'-Iodotubercidin represses The Journal of biological chemistry. vol 294. issue 14. 2019-10-16. PMID:30755485. |
the 5'-iodotubercidin treatment also suppressed β-catenin, lymphoid enhancer-binding factor 1 (lef-1), cyclin d1, n-myc, and insm1 levels, ultimately leading to apoptosis via caspase-3 and p53 activation. |
2019-10-16 |
2023-08-13 |
human |
| Ling Wu, Yuqing Hu, Yuhan He, Yonghong Xia, Hanwen Lu, Zhong Cao, Xinyao Yi, Jianxiu Wan. Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. The Analyst. vol 144. issue 13. 2019-10-16. PMID:31134974. |
however, the incorporation of mdm2 antagonist nutlin-3 could reactivate the transcriptional activity of p53, up-regulate caspase-3, and induce apoptosis. |
2019-10-16 |
2023-08-13 |
Not clear |
| Hongbo Shi, Yizhi Zhang, Jing Ji, Ping Xu, Honglin Shi, Xiujuan Yue, Feng Ren, Yu Chen, Zhongping Duan, Dexi Che. Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of rapamycin. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:30560875. |
apoptosis-stimulating protein two of p53 (aspp2) was discovered as a binding partner of p53 and plays an important role in regulating cell apoptosis and growth. |
2019-10-15 |
2023-08-13 |
mouse |
| Maryam Farzaneh Behelgardi, Saber Zahri, Farhad Mashayekhi, Kamran Mansouri, S Mohsen Asghar. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:30560942. |
administration of vgb4 led to the regression of 4t1 murine mct growth through decreased expression of p-vegfr1 and p-vegfr2 and abrogation of erk1/2 and akt activation followed by considerable decrease of tumor cell proliferation (ki67 expression) and angiogenesis (cd31 and cd34 expression), induction of apoptosis (increased p53 expression, tunel staining and decreased bcl2 expression), and suppression of metastasis (increased e-cadherin and decreased n-cadherin, nf-κb and mmp-9 expression). |
2019-10-15 |
2023-08-13 |
human |
| Hideyuki Komori, Yasuko Goto, Kenta Kurayoshi, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki, Kiyoshi Ohtan. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Scientific reports. vol 8. issue 1. 2019-10-14. PMID:29855511. |
here we show that, while knockdown of dp1 expression inhibited ectopic e2f1- or adenovirus e1a-induced expression of the cdc6 gene and cell proliferation, knockdown of dp1 and dp2 expression did not affect ectopic e2f1- or e1a-induced expression of the tumor suppressor arf gene, an upstream activator of the tumor suppressor p53, activation of p53 or apoptosis. |
2019-10-14 |
2023-08-13 |
Not clear |
| Luiza G Tunes, John M Allen, Ricardo M Zayas, Rubens L do Monte-Net. Planarians as models to investigate the bioactivity of gold(I) complexes in vivo. Scientific reports. vol 8. issue 1. 2019-10-14. PMID:30385794. |
the planarian schmidtea mediterranea possesses orthologues of tumor suppressor genes, such as p53, that, when silenced, cause deregulation of cell proliferation and apoptosis. |
2019-10-14 |
2023-08-13 |
Not clear |
| Hui Zou, Runying Zou, Keke Chen, Chengguang Zhu, Xin Tian, Yalan You, Xiangling H. miR-129 targets CDK1 and iASPP to modulate Burkitt lymphoma cell proliferation in a TAp63-dependent manner. Journal of cellular biochemistry. vol 119. issue 11. 2019-10-10. PMID:30105797. |
cyclin b/cyclin-dependent kinase 1 (cdk1) phosphorylates inhibitor of apoptosis stimulating protein of p53 (iaspp) to promote iaspp nucleus localization and its inhibitory effect on p53. |
2019-10-10 |
2023-08-13 |
Not clear |
| Martin L Read, Bhavika Modasia, Alice Fletcher, Rebecca J Thompson, Katie Brookes, Peter C Rae, Hannah R Nieto, Vikki L Poole, Sally Roberts, Moray J Campbell, Kristien Boelaert, Andrew S Turnell, Vicki E Smith, Hisham Mehanna, Christopher J McCab. PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer. Cancer research. vol 78. issue 20. 2019-10-07. PMID:30154144. |
lentiviral shrna attenuation of pttg or pbf expression in hnscc cells with either wild-type or mutant p53, and with and without hpv infection, led to dysregulated expression of p53 target genes involved in dna repair and apoptosis. |
2019-10-07 |
2023-08-13 |
Not clear |
| Ji Eun Park, Do-Hee Kim, Eunyoung Ha, Seung Mi Choi, Joon-Seok Choi, Kyung-Soo Chun, Sang Hoon Jo. Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31433961. |
treatment of a431 cells with tq-induced apoptosis, which was associated with the induction of p53 and bax, inhibition of mdm2, bcl-2, and bcl-xl expression, and activation of caspase-9, -7, and -3. |
2019-10-07 |
2023-08-13 |
mouse |
| Hui Zhang, Xuan Zhang, Xun Li, Wen-Bo Meng, Zhong-Tian Bai, Shao-Zhen Rui, Zheng-Feng Wang, Wen-Ce Zhou, Xiao-Da Ji. Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. Journal of cellular physiology. vol 234. issue 1. 2019-10-04. PMID:30069972. |
effect of ccnb1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. |
2019-10-04 |
2023-08-13 |
Not clear |
| Hui Zhang, Xuan Zhang, Xun Li, Wen-Bo Meng, Zhong-Tian Bai, Shao-Zhen Rui, Zheng-Feng Wang, Wen-Ce Zhou, Xiao-Da Ji. Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer. Journal of cellular physiology. vol 234. issue 1. 2019-10-04. PMID:30069972. |
this study is designed to investigate the effects of ccnb1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pc. |
2019-10-04 |
2023-08-13 |
Not clear |
| Parisa Ghiasi, Saman Hosseinkhani, Hassan Ansari, Nasser Aghdami, Saeed Balalaei, Sara Pahlavan, Hossein Baharvan. Reversible permeabilization of the mitochondrial membrane promotes human cardiomyocyte differentiation from embryonic stem cells. Journal of cellular physiology. vol 234. issue 1. 2019-10-04. PMID:30071126. |
we assessed the hallmarks of apoptosis during cardiomyocyte differentiation of human embryonic stem cells and found remarkable changes in p53, reactive oxygen species, apoptotic protease-activating factor 1, poly[adp-ribose]polymerase 1, cellular adenosine triphosphate, and mitochondrial complex i activity. |
2019-10-04 |
2023-08-13 |
human |
| Shuhu Zhou, Baojun Qiao, Xu Chu, Qingxia Kon. Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196826. |
water maze was measured; cell apoptosis was assessed by doing tunel assay and detecting the expression of p53, bax, and cleaved-caspase-3; autophagy were assessed by measuring the expression of lc3 and p62. |
2019-10-03 |
2023-08-13 |
rat |
| Xiangcheng Tang, Zhigang Chen, Mi Deng, Ling Wang, Qian Nie, Jia-Wen Xiang, Yuan Xiao, Lan Yang, Yizhi Liu, David Wan-Cheng L. The Sumoylation Modulated Tumor Suppressor p53 Regulates Cell Cycle Checking Genes to Mediate Lens Differentiation. Current molecular medicine. vol 18. issue 8. 2019-10-03. PMID:30636605. |
the tumor suppressor p53 is a master regulator of apoptosis and also plays a key role in cell cycle checking. |
2019-10-03 |
2023-08-13 |
mouse |
| Xiangcheng Tang, Zhigang Chen, Mi Deng, Ling Wang, Qian Nie, Jia-Wen Xiang, Yuan Xiao, Lan Yang, Yizhi Liu, David Wan-Cheng L. The Sumoylation Modulated Tumor Suppressor p53 Regulates Cell Cycle Checking Genes to Mediate Lens Differentiation. Current molecular medicine. vol 18. issue 8. 2019-10-03. PMID:30636605. |
in our previous studies, we demonstrated that p53 directly regulates bak in mouse jb6 cells and that p53-bak signaling axis plays an important role in mediating egcg-induced apoptosis. |
2019-10-03 |
2023-08-13 |
mouse |
| Lucia de Stephanis, Alessandra Mangolini, Miriam Servello, Peter C Harris, Lucio Dell'Atti, Paolo Pinton, Gianluca Aguiar. MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29323708. |
however, the role of mirs in adpkd pathogenesis has not been fully understood, but also the function of p53 is quite obscure, especially its regulatory contribution on cell proliferation and apoptosis. |
2019-09-30 |
2023-08-13 |
Not clear |
| Saba Shahin, Surya P Singh, Chandra M Chaturved. 1800 MHz mobile phone irradiation induced oxidative and nitrosative stress leads to p53 dependent Bax mediated testicular apoptosis in mice, Mus musculus. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29637556. |
1800 mhz mobile phone irradiation induced oxidative and nitrosative stress leads to p53 dependent bax mediated testicular apoptosis in mice, mus musculus. |
2019-09-30 |
2023-08-13 |
mouse |
| Li-Qian Liu, Fu-Jun Tian, Ying Xiong, Yan Zhao, Jian-Bo Son. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29663367. |
gadd45a gene silencing by rnai promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. |
2019-09-30 |
2023-08-13 |
mouse |
| Li-Qian Liu, Fu-Jun Tian, Ying Xiong, Yan Zhao, Jian-Bo Son. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling pathway. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29663367. |
for that, the study aims to investigate the mechanism of gadd45a gene silencing on cell proliferation, apoptosis, and senescence in nude mice with skin scc through the p53 signaling pathway. |
2019-09-30 |
2023-08-13 |
mouse |