| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diya B Joseph, Anoop S Chandrashekar, Lisa L Abler, Li-Fang Chu, James A Thomson, Chad M Vezin. Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds. Developmental biology. vol 447. issue 2. 2019-09-04. PMID:30659795. |
dnmt1 mutant urethral cells exhibit dna hypomethylation, dna damage, p53 accumulation and undergo cell cycle arrest and apoptosis. |
2019-09-04 |
2023-08-13 |
mouse |
| Marina Keil, Maria T Meyer, David P Dannheisig, Lars D Maerz, Melanie Philipp, Astrid S Pfiste. Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events. Biochimica et biophysica acta. Molecular cell research. vol 1866. issue 5. 2019-09-04. PMID:30716409. |
strikingly, ppan depletion in human fibroblasts did neither provoke apoptosis nor h2a.x phosphorylation, but recapitulated p53 stabilization. |
2019-09-04 |
2023-08-13 |
human |
| Yanggang Yuan, Aiqing Zhang, Jia Qi, Hui Wang, Xi Liu, Min Zhao, Suyan Duan, Zhimin Huang, Chengning Zhang, Lin Wu, Bo Zhang, Aihua Zhang, Changying Xin. p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction. American journal of physiology. Renal physiology. vol 314. issue 5. 2019-09-03. PMID:28659272. |
knockdown of p53 inhibited aldosterone-induced drp1 expression, mitochondrial dysfunction, and podocyte apoptosis. |
2019-09-03 |
2023-08-13 |
Not clear |
| Débora Kristina Alves-Fernandes, Érica Aparecida de Oliveira, Fernanda Faião-Flores, Gretchen Alicea-Rebecca, Ashani T Weeraratna, Keiran S M Smalley, Silvia Berlanga de Moraes Barros, Silvya Stuchi Maria-Engle. ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC). Pharmacological research. vol 141. 2019-09-03. PMID:30550954. |
early results from our group indicated that 4-nerolidylcatechol (4-nc), a catechol compound extracted from pothomorphe umbellata, induces dna damage, ros production, increased p53 expression culminating in apoptosis in melanoma but with no data regarding the 4-nc effects in cells resistant to brafi or meki. |
2019-09-03 |
2023-08-13 |
human |
| Xiao-Cui Liu, Zhen-Yuan Zhu, Ying-Liang Liu, Hui-Qing Su. Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro. International journal of biological macromolecules. vol 130. 2019-09-03. PMID:30825564. |
both cmps-ii and cbps-ii can increase the protein and mrna expression level of cell apoptosis factors caspase-3, caspase-9, and p53, while reducing the protein and mrna expression levels of proliferating cell nuclear antigen (pcna), to induce tumor cells apoptosis. |
2019-09-03 |
2023-08-13 |
Not clear |
| Katherine Redd Bowman, Ji Hoon Kim, Carol S Li. Narrowing the field: cancer-specific promoters for mitochondrially-targeted p53-BH3 fusion gene therapy in ovarian cancer. Journal of ovarian research. vol 12. issue 1. 2019-09-03. PMID:31039796. |
due to the inherent toxicities of mitochondrial apoptosis, cancer-specificity for the p53 fusion constructs must be developed. |
2019-09-03 |
2023-08-13 |
Not clear |
| Young-Lan Park, Seung-Hun Kim, Sun-Young Park, Min-Woo Jung, Sang-Yoon Ha, Jung-Ho Choi, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Jo. Forkhead‑box A1 regulates tumor cell growth and predicts prognosis in colorectal cancer. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081047. |
foxa1 knockdown activated cleaved caspase‑poly (adp‑ribose) polymerase, upregulated the expression of p53 upregulated modulator of apoptosis, and downregulated bh3 interacting domain death agonist and myeloid cell leukemia‑1, leading to the induction of apoptosis. |
2019-08-30 |
2023-08-13 |
human |
| Ivana Roscoe, Michelle Parker, Daoyuan Dong, Xun Li, Zhiyu L. Human Serum Albumin and the p53-Derived Peptide Fusion Protein Promotes Cytotoxicity Irrespective of p53 Status in Cancer Cells. Molecular pharmaceutics. vol 15. issue 11. 2019-08-28. PMID:30226785. |
it has previously been shown that an hsa fusion protein containing a p53-reactivating peptide (rhsa-p53i) retains the binding activity to mdm2 and mdmx, resulting in p53 transcription-dependent apoptosis. |
2019-08-28 |
2023-08-13 |
mouse |
| Ivana Roscoe, Michelle Parker, Daoyuan Dong, Xun Li, Zhiyu L. Human Serum Albumin and the p53-Derived Peptide Fusion Protein Promotes Cytotoxicity Irrespective of p53 Status in Cancer Cells. Molecular pharmaceutics. vol 15. issue 11. 2019-08-28. PMID:30226785. |
this interaction displaces pro-apoptotic bak and subsequently leads to intrinsic apoptosis via mimicking a p53 transcription-independent pathway. |
2019-08-28 |
2023-08-13 |
mouse |
| Yu Gao, Huijuan Zhang, Yingying Zhang, Tingting Lv, Lu Zhang, Ziying Li, Xiaodong Xie, Fengqiao Li, Haijun Chen, Lee Ji. Erlotinib-Guided Self-Assembled Trifunctional Click Nanotheranostics for Distinguishing Druggable Mutations and Synergistic Therapy of Nonsmall Cell Lung Cancer. Molecular pharmaceutics. vol 15. issue 11. 2019-08-28. PMID:30296375. |
the synergistic effect between erlotinib-targeted therapy and photodynamic therapy significantly up-regulates cancer suppressor p53 and inhibits survivin, which results in more apoptosis and cell cycle arrest. |
2019-08-28 |
2023-08-13 |
mouse |
| Longying Chen, Dianlong Zhang, Li Yu, He Don. Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia/reperfusion injury. Bioengineered. vol 10. issue 1. 2019-08-28. PMID:30971184. |
this study aims to investigate the role of targeting lncrna myocardial infarction-associated transcript (miat) in protection against hypoxia/reoxygenation (h/r) injury in h9c2 cells in vitro and myocardial ischemia/reperfusion (i/r) injury in vivo by regulating expression of nf-kb and p53 upregulated modulator of apoptosis (puma). |
2019-08-28 |
2023-08-13 |
human |
| Xiaoying Han, Jing Yang, Dong Li, Zewei Gu. Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells. Oncology research. vol 27. issue 5. 2019-08-27. PMID:29523220. |
probenecid inhibits slc2a9-mediated uric acid transport, which promotes cell proliferation, inhibits cell apoptosis, induces intracellular ros, and decreases the expression of p53 in hcc cells. |
2019-08-27 |
2023-08-13 |
human |
| Xiaoman Chen, Chenglin Liu, Ruilin Zhao, Ping Zhao, Ju Wu, Nanjin Zhou, Muying Yin. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Molecular pharmaceutics. vol 15. issue 11. 2019-08-26. PMID:30207732. |
analyzing jnk/pjnk, p53, phospho-p53, and tnf-α levels revealed an opposite association of jnk/pjnk with p53 while consistent with phospho-p53 and tnf-α, which supported the proposals that jnk/pjnk negatively regulated p53 level, while it mediated p53 phosphorylation to transcriptionally activate tnf-α expression of apoptotic gene and trigger apoptosis. |
2019-08-26 |
2023-08-13 |
Not clear |
| Xiaoman Chen, Chenglin Liu, Ruilin Zhao, Ping Zhao, Ju Wu, Nanjin Zhou, Muying Yin. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Molecular pharmaceutics. vol 15. issue 11. 2019-08-26. PMID:30207732. |
within the feedback loop, (1) ssd-induced apoptosis depended on jnk/pjnk activities mediating phospho-p53 that activated tnf-α expression; (2) by weakening the negative regulation of jnk/pjnk in p53, sp600125 enhanced p53 level and the ssd-induced inhibitory proliferation axes of tgfβ-p53/p21/p27/p15/p16. |
2019-08-26 |
2023-08-13 |
Not clear |
| Younglim Son, Younju An, Jaeyeon Jung, Sora Shin, InWha Park, Jungsug Gwak, Bong Gun Ju, Young-Hwa Chung, MinKyun Na, Sangtaek O. Protopine isolated from Nandina domestica induces apoptosis and autophagy in colon cancer cells by stabilizing p53. Phytotherapy research : PTR. vol 33. issue 6. 2019-08-23. PMID:30932278. |
protopine isolated from nandina domestica induces apoptosis and autophagy in colon cancer cells by stabilizing p53. |
2019-08-23 |
2023-08-13 |
Not clear |
| Younglim Son, Younju An, Jaeyeon Jung, Sora Shin, InWha Park, Jungsug Gwak, Bong Gun Ju, Young-Hwa Chung, MinKyun Na, Sangtaek O. Protopine isolated from Nandina domestica induces apoptosis and autophagy in colon cancer cells by stabilizing p53. Phytotherapy research : PTR. vol 33. issue 6. 2019-08-23. PMID:30932278. |
the tumor suppressor p53 plays essential roles in cellular protection mechanisms against a variety of stress stimuli and its activation induces apoptosis or autophagy in certain cancer cells. |
2019-08-23 |
2023-08-13 |
Not clear |
| Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg, Xinghui Su. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic acids research. vol 47. issue 3. 2019-08-20. PMID:30476192. |
in this study, we demonstrate that lncrna maternally expressed gene 3 (meg3) interacts with the rna binding protein polypyrimidine tract binding protein 3 (ptbp3) to regulate gene expression and endothelial function through p53 signaling ─ a major coordinator of apoptosis and cell proliferation triggered by the ddr. |
2019-08-20 |
2023-08-13 |
Not clear |
| Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg, Xinghui Su. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic acids research. vol 47. issue 3. 2019-08-20. PMID:30476192. |
meg3 silencing induces dna damage, activates p53 signaling, increases the expression of p53 target genes, promotes ec apoptosis, and inhibits ec proliferation. |
2019-08-20 |
2023-08-13 |
Not clear |
| Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg, Xinghui Su. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic acids research. vol 47. issue 3. 2019-08-20. PMID:30476192. |
ptbp3 silencing recapitulates the effects of meg3 deficiency on the expression of p53 target genes, ec apoptosis and proliferation. |
2019-08-20 |
2023-08-13 |
Not clear |
| Tang-Jun Ai, Jian-Yong Sun, Lin-Juan Du, Chaoji Shi, Chao Li, Xue-Nan Sun, Yan Liu, Lihui Li, Zhixiong Xia, Lijun Jia, Jianmiao Liu, Sheng-Zhong Dua. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29027989. |
inhibition of neddylation by mln4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. |
2019-08-19 |
2023-08-13 |
mouse |