| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tang-Jun Ai, Jian-Yong Sun, Lin-Juan Du, Chaoji Shi, Chao Li, Xue-Nan Sun, Yan Liu, Lihui Li, Zhixiong Xia, Lijun Jia, Jianmiao Liu, Sheng-Zhong Dua. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29027989. |
knockdown of either p53 or p62 mitigated the impacts of mln4924 on g2/m arrest and apoptosis. |
2019-08-19 |
2023-08-13 |
mouse |
| Tang-Jun Ai, Jian-Yong Sun, Lin-Juan Du, Chaoji Shi, Chao Li, Xue-Nan Sun, Yan Liu, Lihui Li, Zhixiong Xia, Lijun Jia, Jianmiao Liu, Sheng-Zhong Dua. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29027989. |
deficiency of p53 in smooth muscle blocked the effects of mln4924 on neointimal hyperplasia and apoptosis. |
2019-08-19 |
2023-08-13 |
mouse |
| Tang-Jun Ai, Jian-Yong Sun, Lin-Juan Du, Chaoji Shi, Chao Li, Xue-Nan Sun, Yan Liu, Lihui Li, Zhixiong Xia, Lijun Jia, Jianmiao Liu, Sheng-Zhong Dua. Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29027989. |
together, our results revealed that neddylation inhibition induces apoptosis through p53 and p62 in vsmcs and improves neointimal hyperplasia mainly by promoting apoptosis through smooth muscle p53 in mice. |
2019-08-19 |
2023-08-13 |
mouse |
| Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß, Regalla Kumarswamy, Katharina Schimmel, Christian Bär, Thomas Thu. A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation. Cell death and differentiation. vol 25. issue 2. 2019-08-19. PMID:29099486. |
mechanistically, we discovered that ntep is important to activate p53 concomitant with increased apoptosis and cell cycle blockade in late g2/m. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
treatment with efldo sensitized liver cancer cells to tnfsf10, and apoptosis was induced via the upregulation of tnf receptor superfamily member 10a (tnfrsf10a) and tnfrsf10b in a tumor protein p53 (p53)‑dependent manner, as detected by reverse transcription‑quantitative polymerase chain reaction and western blot analyses. |
2019-08-19 |
2023-08-13 |
Not clear |
| Xiang Ji, Xing Wei, Jie Qian, Xuejun Mo, Guoyin Kai, Faliang An, Yanhua L. 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 131. 2019-08-19. PMID:31150783. |
furthermore, dmc increased p53 level and inhibited nf-κb nuclear-localization via suppression of pi3k/akt signaling axis, which might be the underlying mechanism of dmc-induced apoptosis and cell cycle arrest in bel-7402/5-fu cells. |
2019-08-19 |
2023-08-13 |
Not clear |
| Sarathbabu Subbarayan, Selvi Subramanian, Nachimuthu Senthil Kuma. Recombinant Pierisin-5 Induces Apoptosis and Differential Expression of Bcl-2, Bax, and p53 in Human Cancer Cells. DNA and cell biology. vol 38. issue 8. 2019-08-19. PMID:31339741. |
recombinant pierisin-5 induces apoptosis and differential expression of bcl-2, bax, and p53 in human cancer cells. |
2019-08-19 |
2023-08-13 |
human |
| Wesam Kooti, Karo Servatyari, Masoud Behzadifar, Majid Asadi-Samani, Fatemeh Sadeghi, Bijan Nouri, Hadi Zare Marzoun. Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. Journal of evidence-based complementary & alternative medicine. vol 22. issue 4. 2019-08-16. PMID:28359161. |
enhancement p53 protein expression, reducing the expression of proteins p27, p21, nfκb expression and induction of apoptosis, inhibition of the pi3k/akt pathway, and reduction of the level of acid phosphatase and lipid peroxidation are the most effective mechanisms of herbal plants that can inhibit cell cycle and proliferation. |
2019-08-16 |
2023-08-13 |
Not clear |
| Sunetra Roy, Karl-Heinz Tomaszowski, Jessica W Luzwick, Soyoung Park, Jun Li, Maureen Murphy, Katharina Schlache. p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways. eLife. vol 7. 2019-08-16. PMID:29334356. |
classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. |
2019-08-16 |
2023-08-13 |
human |
| Lingqin Zhao, Huafeng Shou, Lu Chen, Wen Gao, Chenyan Fang, Ping Zhan. Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Oncology reports. vol 41. issue 6. 2019-08-15. PMID:31002353. |
when ovarian cells were treated with ginsenoside rg3, cell apoptosis was observed to be promoted, while cell metastasis and invasion were inhibited at 48 h. the results of the present study revealed that in the promoter regions of p53, p16 and hmlh1, the methylation levels decreased, while the mrna and protein levels significantly increased. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yujian Zheng, Pengxiang Lv, Shaoping Wang, Qing Cai, Bao Zhang, Feng Hu. LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. Gene. vol 712. 2019-08-15. PMID:31233763. |
lncrna plac2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yujian Zheng, Pengxiang Lv, Shaoping Wang, Qing Cai, Bao Zhang, Feng Hu. LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. Gene. vol 712. 2019-08-15. PMID:31233763. |
plac2 overexpression caused upregulated p53 and increase cancer cell apoptosis. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yujian Zheng, Pengxiang Lv, Shaoping Wang, Qing Cai, Bao Zhang, Feng Hu. LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis. Gene. vol 712. 2019-08-15. PMID:31233763. |
therefore, plac2 upregulated p53 to mediate cancer cell apoptosis. |
2019-08-15 |
2023-08-13 |
Not clear |
| Deepa R Avisetti, Niharika Amireddy, Shasi V Kalivend. The mitochondrial effects of embelin are independent of its MAP kinase regulation: Role of p53 in conferring selectivity towards cancer cells. Mitochondrion. vol 46. 2019-08-13. PMID:29715507. |
however, p38 mediated activation of p53 was found to play a pivotal role in governing the apoptotic activity of embelin due to the following observations: a time-dependent activation of p53 and apoptosis by embelin; selective inhibition of p38 inhibited embelin-induced p53 levels. |
2019-08-13 |
2023-08-13 |
Not clear |
| Mengqiu Dang, Xiangjun Zeng, Buxing Chen, Hongxia Wang, Huihua Li, Fenghe Du, Caixia Gu. Interferon-γ mediates the protective effects of soluble receptor for advanced glycation end-product in myocardial ischemia/reperfusion. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 3. 2019-08-13. PMID:30089851. |
our data suggest a novel mechanism for srage in preventing mi/r-induced apoptosis in heart: srage inhibits mi/r-induced apoptosis in cardiomyocytes by degrading p53 by β5i subunit that is increased via upregulation of ifn-γ. |
2019-08-13 |
2023-08-13 |
mouse |
| Yan-Nan Chen, Chen-Chen Ren, Li Yang, Man-Man Nai, Yi-Ming Xu, Feng Zhang, Yan Li. MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30816441. |
microrna let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via hmga1. |
2019-08-13 |
2023-08-13 |
human |
| Yan-Nan Chen, Chen-Chen Ren, Li Yang, Man-Man Nai, Yi-Ming Xu, Feng Zhang, Yan Li. MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30816441. |
the results in the present study provided evidence that let‑7d‑5p may suppress proliferation, and facilitate apoptosis and cisplatin chemosensitivity of oc cells by silencing hmga1 via the p53 signaling pathway. |
2019-08-13 |
2023-08-13 |
human |
| Jun Liu, Qingqing Li, Xiaoxin Li, Zhenzhen Qiu, Andrew Li, Wenhan Liang, Huangyao Chen, Xiangsheng Cai, Xinglu Chen, Xinyue Duan, Jingjing Li, Wangsheng Wu, Mingyu Xu, Yingying Mao, Huiying Chen, Jinlong Li, Weiwang Gu, Hongwei L. Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells. International journal of biological sciences. vol 14. issue 9. 2019-08-12. PMID:29989100. |
flow cytometry and western blot analysis showed that the apoptosis was associated with up-regulation of both p53 and p21 |
2019-08-12 |
2023-08-13 |
Not clear |
| Hongming Teng, Dayu Wang, Jiali Lu, Ying Zhou, Yue Pang, Qingwei L. Novel insights into the evolution of the caveolin superfamily and mechanisms of antiapoptotic effects and cell proliferation in lamprey. Developmental and comparative immunology. vol 95. 2019-08-12. PMID:30742851. |
the overexpression of pegfp-n1-l-caveolin-like led to the altered expression of factors related to apoptosis, such as decreased caspase-9, caspase-3, p53, and bax expression and increased bcl-2 expression. |
2019-08-12 |
2023-08-13 |
human |
| Yan Wang, Hui-Ze Liu, Yang Liu, Hui-Juan Wang, Wen-Wen Pang, Jian-Jun Zhan. Disordered p53-MALAT1 pathway is associated with recurrent miscarriage. The Kaohsiung journal of medical sciences. vol 35. issue 2. 2019-08-09. PMID:30848022. |
functional study by using human trophoblast cell htr-8/svneo, we observed that p53 overexpression lead to decreased cells proliferation, migration, invasion and increased apoptosis. |
2019-08-09 |
2023-08-13 |
human |